RGD Reference Report - Promotion of a functional B cell germinal center response after Leishmania species co-infection is associated with lesion resolution. - Rat Genome Database

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Promotion of a functional B cell germinal center response after Leishmania species co-infection is associated with lesion resolution.

Authors: Gibson-Corley, Katherine N  Boggiatto, Paola M  Bockenstedt, Marie M  Petersen, Christine A  Waldschmidt, Thomas J  Jones, Douglas E 
Citation: Gibson-Corley KN, etal., Am J Pathol. 2012 May;180(5):2009-17. doi: 10.1016/j.ajpath.2012.01.012. Epub 2012 Mar 17.
RGD ID: 127285547
Pubmed: PMID:22429963   (View Abstract at PubMed)
PMCID: PMC3349825   (View Article at PubMed Central)
DOI: DOI:10.1016/j.ajpath.2012.01.012   (Journal Full-text)

Co-infection of C3HeB/FeJ (C3H) mice with both Leishmania major and Leishmania amazonensis leads to a healed footpad lesion, whereas co-infection of C57BL/6 (B6) mice leads to non-healing lesions. This inability to heal corresponds to a deficiency in B cell stimulation of the macrophage-mediated killing of L. amazonensis in vitro and a less robust antibody response. The mechanism that leads to healing of these lesions is not completely known, although our studies implicate the B cell response as having an important effector function in killing L. amazonensis. To understand more completely this disparate clinical outcome to the same infection, we analyzed the draining lymph node germinal center B cell response between co-infected C3H and B6 mice. There were more germinal center B cells, more antibody isotype-switched germinal center B cells, more memory B cells, and more antigen-specific antibody-producing cells in co-infected C3H mice compared to B6 mice as early as 2 weeks postinfection. Interleukin (IL)-21 production and IL-21 receptor expression in both mouse strains, however, were similar at 2 weeks, suggesting that the difference in the anti-Leishmania response in these mouse strains may be due to differences in T follicular cell commitment or intrinsic B cell differences. These data support the idea that functional B cells are important for healing L. amazonensis in this infectious disease model.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL21Humanleishmaniasis exacerbatesISOIl21 (Mus musculus)protein:increased expression:popliteal lymph node (mouse)RGD 
Il21Ratleishmaniasis exacerbatesISOIl21 (Mus musculus)protein:increased expression:popliteal lymph node (mouse)RGD 
Il21Mouseleishmaniasis exacerbatesIEP protein:increased expression:popliteal lymph node (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il21  (interleukin 21)

Genes (Mus musculus)
Il21  (interleukin 21)

Genes (Homo sapiens)
IL21  (interleukin 21)


Additional Information