IL21 (interleukin 21) - Rat Genome Database

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Gene: IL21 (interleukin 21) Homo sapiens
Analyze
Symbol: IL21
Name: interleukin 21
RGD ID: 1316553
HGNC Page HGNC
Description: Enables interleukin-2 receptor binding activity. Involved in several processes, including positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; and tyrosine phosphorylation of STAT protein. Acts upstream of or within positive regulation of B cell proliferation; positive regulation of T cell proliferation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular region. Implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Biomarker of several diseases, including anogenital venereal wart; autoimmune disease (multiple); dengue hemorrhagic fever; human immunodeficiency virus infectious disease; and tropical spastic paraparesis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CVID11; IL-21; interleukin-21; interleukin-21 isoform; Za11
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4122,610,108 - 122,621,066 (-)EnsemblGRCh38hg38GRCh38
GRCh384122,610,108 - 122,621,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374123,531,263 - 123,542,221 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,739,272 - 123,761,662 (-)NCBINCBI36hg18NCBI36
Build 344123,891,388 - 123,899,817NCBI
Celera4120,916,832 - 120,925,261 (-)NCBI
Cytogenetic Map4q27NCBI
HuRef4119,260,228 - 119,268,550 (-)NCBIHuRef
CHM1_14123,510,250 - 123,518,679 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abe K, etal., Springerplus. 2016 Jun 18;5(1):777. doi: 10.1186/s40064-016-2512-y. eCollection 2016.
2. Abu El-Hamd M, etal., Dermatol Ther. 2019 Sep;32(5):e13063. doi: 10.1111/dth.13063. Epub 2019 Aug 29.
3. Andersson A, etal., PLoS One. 2008;3(11):e3682. Epub 2008 Nov 10.
4. Bobbala D, etal., Cytokine. 2016 Sep;85:83-91. doi: 10.1016/j.cyto.2016.06.011. Epub 2016 Jun 11.
5. Caruso R, etal., J Immunol. 2007 May 1;178(9):5957-65. doi: 10.4049/jimmunol.178.9.5957.
6. Chatterjee R, etal., Int Arch Allergy Immunol. 2009;148(2):137-46. Epub 2008 Sep 19.
7. Einarsdottir E, etal., Tissue Antigens. 2011 Dec;78(6):428-37. doi: 10.1111/j.1399-0039.2011.01791.x.
8. Eto D, etal., PLoS One. 2011 Mar 14;6(3):e17739. doi: 10.1371/journal.pone.0017739.
9. Feng G, etal., Mol Cells. 2013 Oct;36(4):362-7. doi: 10.1007/s10059-013-0181-z. Epub 2013 Oct 22.
10. Gibson-Corley KN, etal., Am J Pathol. 2012 May;180(5):2009-17. doi: 10.1016/j.ajpath.2012.01.012. Epub 2012 Mar 17.
11. GOA_HUMAN data from the GO Consortium
12. Hanari N, etal., Anticancer Res. 2007 Jul-Aug;27(4B):2305-10.
13. He X, etal., Immunol Res. 2012 Jun;52(3):240-9. doi: 10.1007/s12026-012-8332-4.
14. Hejr S, etal., Viral Immunol. 2013 Jun;26(3):201-6. doi: 10.1089/vim.2013.0007. Epub 2013 May 8.
15. Hiromura Y, etal., J Immunol. 2007 Nov 15;179(10):7157-65.
16. Holm C, etal., Cytokine. 2006 Jan 7;33(1):41-5. doi: 10.1016/j.cyto.2005.11.014. Epub 2006 Jan 5.
17. Hu K, etal., Immunol Invest. 2011;40(3):265-78. doi: 10.3109/08820139.2010.534219. Epub 2011 Jan 4.
18. Hu X, etal., J Viral Hepat. 2011 Jul;18(7):458-67. doi: 10.1111/j.1365-2893.2011.01475.x. Epub 2011 Jun 1.
19. Kratholm SK, etal., PLoS One. 2013 Dec 16;8(12):e81790. doi: 10.1371/journal.pone.0081790. eCollection 2013.
20. Leng RX, etal., PLoS One. 2012;7(12):e51090. doi: 10.1371/journal.pone.0051090. Epub 2012 Dec 7.
21. Li J, etal., J Interferon Cytokine Res. 2015 Feb;35(2):134-42. doi: 10.1089/jir.2013.0119. Epub 2014 Sep 22.
22. Li N, etal., Hum Immunol. 2013 May;74(5):567-73. doi: 10.1016/j.humimm.2013.01.005. Epub 2013 Jan 24.
23. Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
24. Liu X, etal., J Interferon Cytokine Res. 2016 Jun;36(6):367-73. doi: 10.1089/jir.2015.0129. Epub 2016 Feb 3.
25. Moretto MM and Khan IA, J Immunol. 2016 Jan 1;196(1):375-84. doi: 10.4049/jimmunol.1501258. Epub 2015 Nov 23.
26. OMIM Disease Annotation Pipeline
27. Pan Q, etal., J Viral Hepat. 2014;21(9):e78-88. doi: 10.1111/jvh.12242. Epub 2014 Mar 10.
28. Pipeline to import KEGG annotations from KEGG into RGD
29. Pérez-Mazliah D, etal., PLoS Pathog. 2015 Mar 12;11(3):e1004715. doi: 10.1371/journal.ppat.1004715. eCollection 2015 Mar.
30. Rajaei T, etal., Med Microbiol Immunol. 2017 Jun;206(3):195-201. doi: 10.1007/s00430-017-0492-3. Epub 2017 Apr 4.
31. Ren G, etal., AIDS. 2012 Nov 13;26(17):2145-53. doi: 10.1097/QAD.0b013e328359b7ae.
32. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. RGD automated import pipeline for gene-chemical interactions
34. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
35. Rodrigues L, etal., Mol Immunol. 2009 Apr;46(7):1494-504. doi: 10.1016/j.molimm.2008.12.033. Epub 2009 Feb 23.
36. Rydén AK, etal., J Autoimmun. 2017 Nov;84:65-74. doi: 10.1016/j.jaut.2017.07.006. Epub 2017 Jul 12.
37. Shen Z, etal., Theranostics. 2019 May 31;9(13):3798-3811. doi: 10.7150/thno.35331. eCollection 2019.
38. Shen Z, etal., Theranostics. 2020 Apr 25;10(12):5600-5612. doi: 10.7150/thno.44715. eCollection 2020.
39. Spolski R, etal., J Immunol. 2012 Feb 15;188(4):1924-32. Epub 2012 Jan 11.
40. Stumhofer JS, etal., PLoS One. 2013 May 7;8(5):e62889. doi: 10.1371/journal.pone.0062889. Print 2013.
41. Sun Z, etal., J Tradit Chin Med. 2020 Feb;40(1):38-48.
42. Tang L, etal., J Infect Dis. 2019 Feb 15;219(5):750-759. doi: 10.1093/infdis/jiy576.
43. Tang R, etal., Immunotherapy. 2018 Mar;10(3):189-200. doi: 10.2217/imt-2017-0060.
44. Vivanco-Cid H, etal., Immunol Lett. 2014 Sep;161(1):89-95. doi: 10.1016/j.imlet.2014.05.006. Epub 2014 May 22.
45. Vyas AK, etal., Liver Int. 2018 Jan;38(1):38-49. doi: 10.1111/liv.13475. Epub 2017 Jun 1.
46. Wang X, etal., Gastroenterology. 2018 Jun;154(8):2222-2236. doi: 10.1053/j.gastro.2018.03.021. Epub 2018 Mar 12.
47. Wang X, etal., Medicine (Baltimore). 2018 Jun;97(23):e10891. doi: 10.1097/MD.0000000000010891.
48. Wu A, etal., Can J Neurol Sci. 2012 Nov;39(6):813-20. doi: 10.1017/s0317167100015663.
49. Yang F, etal., Virol J. 2015 Feb 11;12:20. doi: 10.1186/s12985-015-0257-9.
50. Yao JY, etal., World J Gastroenterol. 2015 Apr 14;21(14):4232-9. doi: 10.3748/wjg.v21.i14.4232.
51. Yasmin S, etal., Infect Immun. 2019 Oct 18;87(11). pii: IAI.00237-19. doi: 10.1128/IAI.00237-19. Print 2019 Nov.
52. Ye X, etal., Cancer Prev Res (Phila). 2017 Jul;10(7):398-409. doi: 10.1158/1940-6207.CAPR-16-0178. Epub 2017 May 8.
53. Yoo JK and Braciale TJ, PLoS One. 2014 Sep 24;9(9):e105872. doi: 10.1371/journal.pone.0105872. eCollection 2014.
Additional References at PubMed
PMID:8626603   PMID:11081504   PMID:11267886   PMID:11418623   PMID:12244150   PMID:12477932   PMID:12504082   PMID:12759422   PMID:12893770   PMID:14635054   PMID:15100251   PMID:15147560  
PMID:15178704   PMID:15207081   PMID:15489334   PMID:15494482   PMID:15546387   PMID:15684054   PMID:15765404   PMID:15919378   PMID:16002671   PMID:16081794   PMID:16138102   PMID:16339522  
PMID:16424177   PMID:16482511   PMID:16551679   PMID:17015683   PMID:17015709   PMID:17130531   PMID:17142735   PMID:17178921   PMID:17207965   PMID:17241869   PMID:17462506   PMID:17509926  
PMID:17558408   PMID:17565991   PMID:17624663   PMID:17672918   PMID:17673207   PMID:17698559   PMID:17703412   PMID:17712836   PMID:17713571   PMID:17720724   PMID:17785794   PMID:17888893  
PMID:17921346   PMID:17938255   PMID:17947662   PMID:17988587   PMID:18005035   PMID:18056361   PMID:18182577   PMID:18209077   PMID:18222514   PMID:18259184   PMID:18296629   PMID:18299268  
PMID:18311140   PMID:18418394   PMID:18469800   PMID:18482208   PMID:18593762   PMID:18641314   PMID:18684866   PMID:18773086   PMID:18788946   PMID:18805825   PMID:18829491   PMID:18947877  
PMID:18981102   PMID:19022821   PMID:19026702   PMID:19073967   PMID:19201773   PMID:19234181   PMID:19258923   PMID:19302705   PMID:19322899   PMID:19404967   PMID:19447148   PMID:19471255  
PMID:19523143   PMID:19561536   PMID:19592276   PMID:19592644   PMID:19608866   PMID:19617351   PMID:19648290   PMID:19675172   PMID:19684581   PMID:19693089   PMID:19762555   PMID:19774453  
PMID:19797296   PMID:19949086   PMID:19997967   PMID:19998455   PMID:20048285   PMID:20049410   PMID:20072139   PMID:20079789   PMID:20103765   PMID:20112382   PMID:20186935   PMID:20190192  
PMID:20190752   PMID:20203524   PMID:20219786   PMID:20233754   PMID:20237496   PMID:20423656   PMID:20444755   PMID:20453842   PMID:20498205   PMID:20503287   PMID:20519650   PMID:20553587  
PMID:20571486   PMID:20594126   PMID:20596022   PMID:20817119   PMID:20848219   PMID:20848568   PMID:20871161   PMID:20881011   PMID:20888735   PMID:20962850   PMID:21048031   PMID:21055341  
PMID:21064084   PMID:21116820   PMID:21129248   PMID:21175418   PMID:21181220   PMID:21227406   PMID:21269573   PMID:21281812   PMID:21297633   PMID:21304239   PMID:21357266   PMID:21375519  
PMID:21391901   PMID:21425124   PMID:21430229   PMID:21441456   PMID:21524651   PMID:21531891   PMID:21648020   PMID:21685912   PMID:21688385   PMID:21724243   PMID:21736561   PMID:21768062  
PMID:21873635   PMID:21938013   PMID:21945025   PMID:21959034   PMID:21968544   PMID:21987656   PMID:22009762   PMID:22030011   PMID:22032620   PMID:22038405   PMID:22039266   PMID:22057994  
PMID:22122790   PMID:22235133   PMID:22238455   PMID:22250083   PMID:22261234   PMID:22279576   PMID:22430249   PMID:22450323   PMID:22491065   PMID:22532637   PMID:22554193   PMID:22649468  
PMID:22705151   PMID:22748465   PMID:22752563   PMID:22753386   PMID:22763176   PMID:22840497   PMID:22922252   PMID:22922259   PMID:22930279   PMID:22948743   PMID:22976953   PMID:23064011  
PMID:23097377   PMID:23128233   PMID:23137515   PMID:23172754   PMID:23176102   PMID:23215754   PMID:23278180   PMID:23280509   PMID:23288348   PMID:23296193   PMID:23312859   PMID:23325890  
PMID:23396946   PMID:23407551   PMID:23479229   PMID:23480181   PMID:23553807   PMID:23571506   PMID:23579027   PMID:23607532   PMID:23645042   PMID:23676143   PMID:23710828   PMID:23738704  
PMID:23741351   PMID:23817571   PMID:23818845   PMID:23825648   PMID:23940030   PMID:24014238   PMID:24043893   PMID:24126614   PMID:24138885   PMID:24187103   PMID:24214876   PMID:24287789  
PMID:24289584   PMID:24389496   PMID:24390342   PMID:24409674   PMID:24430489   PMID:24434811   PMID:24445858   PMID:24495300   PMID:24510007   PMID:24673562   PMID:24702489   PMID:24746753  
PMID:24757284   PMID:24789434   PMID:24796415   PMID:24823512   PMID:24879484   PMID:24999842   PMID:25074442   PMID:25117075   PMID:25126827   PMID:25129403   PMID:25172491   PMID:25241761  
PMID:25343703   PMID:25351608   PMID:25377634   PMID:25495679   PMID:25500255   PMID:25604047   PMID:25647271   PMID:25652388   PMID:25758713   PMID:25780036   PMID:25784172   PMID:25801685  
PMID:25894310   PMID:25941359   PMID:26055806   PMID:26151690   PMID:26166388   PMID:26194763   PMID:26239551   PMID:26305332   PMID:26345892   PMID:26358223   PMID:26377996   PMID:26416419  
PMID:26466984   PMID:26482544   PMID:26535636   PMID:26566861   PMID:26646149   PMID:26646950   PMID:26742440   PMID:26748727   PMID:26802931   PMID:26818544   PMID:26825047   PMID:26917059  
PMID:26945832   PMID:26990619   PMID:27122304   PMID:27124305   PMID:27157859   PMID:27233967   PMID:27242164   PMID:27269940   PMID:27295539   PMID:27306193   PMID:27435400   PMID:27611173  
PMID:27733582   PMID:27884624   PMID:28043029   PMID:28057742   PMID:28112376   PMID:28130496   PMID:28233079   PMID:28259000   PMID:28427414   PMID:28514442   PMID:28650673   PMID:28685527  
PMID:28798470   PMID:28802832   PMID:28887120   PMID:28918288   PMID:29103189   PMID:29119640   PMID:29131072   PMID:29247327   PMID:29503347   PMID:29683891   PMID:29717110   PMID:29728406  
PMID:29987050   PMID:30005016   PMID:30106099   PMID:30111631   PMID:30183349   PMID:30205088   PMID:30343493   PMID:30451792   PMID:30464201   PMID:30537793   PMID:30587125   PMID:30672610  
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PMID:31536480   PMID:31545959   PMID:31573051   PMID:31780735   PMID:31816393   PMID:32130409   PMID:32296183   PMID:32704112   PMID:32855360   PMID:32971931   PMID:33173427   PMID:33247940  
PMID:33584666   PMID:33673829   PMID:33815416   PMID:33936071   PMID:34027881  


Genomics

Comparative Map Data
IL21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4122,610,108 - 122,621,066 (-)EnsemblGRCh38hg38GRCh38
GRCh384122,610,108 - 122,621,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374123,531,263 - 123,542,221 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,739,272 - 123,761,662 (-)NCBINCBI36hg18NCBI36
Build 344123,891,388 - 123,899,817NCBI
Celera4120,916,832 - 120,925,261 (-)NCBI
Cytogenetic Map4q27NCBI
HuRef4119,260,228 - 119,268,550 (-)NCBIHuRef
CHM1_14123,510,250 - 123,518,679 (-)NCBICHM1_1
Il21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,276,908 - 37,286,785 (-)NCBIGRCm39mm39
GRCm39 Ensembl337,276,908 - 37,286,785 (-)Ensembl
GRCm38337,222,759 - 37,232,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,222,759 - 37,232,636 (-)EnsemblGRCm38mm10GRCm38
MGSCv37337,121,681 - 37,131,540 (-)NCBIGRCm37mm9NCBIm37
MGSCv36337,107,141 - 37,117,000 (-)NCBImm8
MGSCv36337,414,308 - 37,424,167 (-)NCBImm8
Celera337,106,874 - 37,116,609 (-)NCBICelera
Cytogenetic Map3BNCBI
Il21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22120,119,598 - 120,126,941 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2120,119,444 - 120,126,996 (-)Ensembl
Rnor_6.02123,965,021 - 123,972,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,965,021 - 123,972,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,573,215 - 143,580,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,774,331 - 123,781,697 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12123,697,822 - 123,750,231 (-)NCBI
Celera2115,067,969 - 115,075,326 (-)NCBICelera
Cytogenetic Map2q25NCBI
Il21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,057,096 - 18,065,492 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542818,057,096 - 18,065,492 (+)NCBIChiLan1.0ChiLan1.0
IL21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14125,940,979 - 125,951,915 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,943,495 - 125,951,915 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04114,795,979 - 114,806,936 (-)NCBIMhudiblu_PPA_v0panPan3
IL21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,641,833 - 17,651,275 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1917,641,833 - 17,651,266 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,860,011 - 17,869,452 (+)NCBI
ROS_Cfam_1.01917,760,158 - 17,769,609 (+)NCBI
UMICH_Zoey_3.11917,712,780 - 17,722,226 (+)NCBI
UNSW_CanFamBas_1.01917,993,018 - 18,002,469 (+)NCBI
UU_Cfam_GSD_1.01918,463,313 - 18,472,753 (+)NCBI
Il21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530165,422,896 - 65,429,900 (+)NCBI
SpeTri2.0NW_0049366621,689,879 - 1,696,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,530,949 - 101,540,738 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,532,742 - 101,540,712 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,688,772 - 108,696,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1769,859,793 - 69,872,237 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl769,863,535 - 69,872,025 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603748,822,863 - 48,834,392 (-)NCBIVero_WHO_p1.0
Il21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247773,054,368 - 3,061,304 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
G33978  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,522,121 - 123,522,218UniSTSGRCh37
Build 364123,741,571 - 123,741,668RGDNCBI36
Celera4120,905,169 - 120,905,266RGD
Cytogenetic Map4q26-q27UniSTS
HuRef4119,248,565 - 119,248,662UniSTS
D4S1279  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374123,522,019 - 123,522,171UniSTSGRCh37
Build 364123,741,469 - 123,741,621RGDNCBI36
Celera4120,905,067 - 120,905,219RGD
Cytogenetic Map4q26-q27UniSTS
HuRef4119,248,463 - 119,248,615UniSTS
TNG Radiation Hybrid Map477516.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:53
Interacting mature miRNAs:53
Transcripts:ENST00000264497
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 28 2
Low 26 4 15 4 60 4 6 1 4 312 27 1
Below cutoff 152 72 99 39 186 36 83 28 53 29 111 156 3 33 47

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_031966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001207006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC053545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF254069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY763518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD559460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD559613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS080568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS237090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS450761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS582814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ645417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB677173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM619752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB976773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC196689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC203173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC203434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC686913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA104585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC133256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000611104   ⟹   ENSP00000477555
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4122,612,710 - 122,621,011 (-)Ensembl
RefSeq Acc Id: ENST00000647784
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4122,612,283 - 122,618,894 (-)Ensembl
RefSeq Acc Id: ENST00000648588   ⟹   ENSP00000497915
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4122,610,108 - 122,621,066 (-)Ensembl
RefSeq Acc Id: NM_001207006   ⟹   NP_001193935
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384122,612,628 - 122,621,066 (-)NCBI
GRCh374123,533,783 - 123,542,212 (-)NCBI
HuRef4119,260,228 - 119,268,550 (-)NCBI
CHM1_14123,510,250 - 123,518,679 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021803   ⟹   NP_068575
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384122,610,108 - 122,621,066 (-)NCBI
GRCh374123,533,783 - 123,542,212 (-)NCBI
Build 364123,739,272 - 123,761,662 (-)NCBI Archive
HuRef4119,260,228 - 119,268,550 (-)NCBI
CHM1_14123,510,250 - 123,518,679 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_068575   ⟸   NM_021803
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9HBE4 (UniProtKB/Swiss-Prot),   A0A224B028 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001193935   ⟸   NM_001207006
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9HBE4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000497915   ⟸   ENST00000648588
RefSeq Acc Id: ENSP00000477555   ⟸   ENST00000611104

Promoters
RGD ID:6868418
Promoter ID:EPDNEW_H7374
Type:single initiation site
Name:IL21_1
Description:interleukin 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384122,621,066 - 122,621,126EPDNEW
RGD ID:6802380
Promoter ID:HG_KWN:49059
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:OTTHUMT00000256713,   UC010INT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364123,761,266 - 123,761,766 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3 copy number gain See cases [RCV000051785] Chr4:118065569..190042639 [GRCh38]
Chr4:118986724..190828225 [GRCh37]
Chr4:119206172..191200788 [NCBI36]
Chr4:4q26-35.2
pathogenic
GRCh38/hg38 4q27-35.2(chr4:121518223-190062270)x3 copy number gain See cases [RCV000051786] Chr4:121518223..190062270 [GRCh38]
Chr4:122439378..190828225 [GRCh37]
Chr4:122658828..191220419 [NCBI36]
Chr4:4q27-35.2
pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3
pathogenic
GRCh38/hg38 4q26-31.21(chr4:116630862-145429900)x1 copy number loss See cases [RCV000053321] Chr4:116630862..145429900 [GRCh38]
Chr4:117552018..146351052 [GRCh37]
Chr4:117771466..146570502 [NCBI36]
Chr4:4q26-31.21
pathogenic
NM_021803.4(IL21):c.146T>C (p.Leu49Pro) single nucleotide variant Common variable immunodeficiency 11 [RCV000114995] Chr4:122620866 [GRCh38]
Chr4:123542021 [GRCh37]
Chr4:4q27
pathogenic
GRCh38/hg38 4q26-28.3(chr4:117351881-133565667)x1 copy number loss See cases [RCV000143207] Chr4:117351881..133565667 [GRCh38]
Chr4:118273037..134486822 [GRCh37]
Chr4:118492485..134706272 [NCBI36]
Chr4:4q26-28.3
pathogenic
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3 copy number gain See cases [RCV000240392] Chr4:119437495..190904301 [GRCh37]
Chr4:4q26-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_021803.4(IL21):c.234C>T (p.Cys78=) single nucleotide variant not provided [RCV001511552]|not specified [RCV000454435] Chr4:122615808 [GRCh38]
Chr4:123536963 [GRCh37]
Chr4:4q27
benign
NM_021803.4(IL21):c.127A>T (p.Ile43Leu) single nucleotide variant not provided [RCV000983879]|not specified [RCV000455102] Chr4:122620885 [GRCh38]
Chr4:123542040 [GRCh37]
Chr4:4q27
likely benign|uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
Chr4:4q25-35.2
pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q26-28.2(chr4:116307857-129302960)x1 copy number loss not provided [RCV000682448] Chr4:116307857..129302960 [GRCh37]
Chr4:4q26-28.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_021803.4(IL21):c.204+7C>T single nucleotide variant not provided [RCV000982735] Chr4:122620694 [GRCh38]
Chr4:123541849 [GRCh37]
Chr4:4q27
likely benign
NM_021803.4(IL21):c.451C>T (p.His151Tyr) single nucleotide variant not provided [RCV000822357] Chr4:122612748 [GRCh38]
Chr4:123533903 [GRCh37]
Chr4:4q27
uncertain significance
Single allele deletion Neurodevelopmental disorder [RCV000787448] Chr4:116624547..126168646 [GRCh37]
Chr4:4q26-28.1
likely pathogenic
NM_021803.4(IL21):c.83G>A (p.Ser28Asn) single nucleotide variant not provided [RCV001059465] Chr4:122620929 [GRCh38]
Chr4:123542084 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.273C>A (p.Asn91Lys) single nucleotide variant not provided [RCV001225911] Chr4:122615769 [GRCh38]
Chr4:123536924 [GRCh37]
Chr4:4q27
uncertain significance
null single nucleotide variant not provided [RCV001635944] Chr4:122613258 [GRCh38]
Chr4:123534413 [GRCh37]
Chr4:4q27
benign
NM_015120.4(ALMS1):c.6085T>C (p.Ser2029Pro) duplication not provided [RCV001597961] Chr4:122615527..122615528 [GRCh38]
Chr4:123536682..123536683 [GRCh37]
Chr4:4q27
benign
null deletion not provided [RCV001621896] Chr4:122615528..122615532 [GRCh38]
Chr4:123536683..123536687 [GRCh37]
Chr4:4q27
benign
NM_000085.5(CLCNKB):c.101-50G>C single nucleotide variant not provided [RCV001683777] Chr4:122612665 [GRCh38]
Chr4:123533820 [GRCh37]
Chr4:4q27
benign
NM_021803.4(IL21):c.471C>T (p.His157=) single nucleotide variant not provided [RCV000888975] Chr4:122612728 [GRCh38]
Chr4:123533883 [GRCh37]
Chr4:4q27
benign
NM_021803.4(IL21):c.319C>G (p.Pro107Ala) single nucleotide variant not provided [RCV001220116] Chr4:122615723 [GRCh38]
Chr4:123536878 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.47T>C (p.Met16Thr) single nucleotide variant not provided [RCV001209249] Chr4:122620965 [GRCh38]
Chr4:123542120 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.475A>C (p.Ser159Arg) single nucleotide variant not provided [RCV001064490] Chr4:122612724 [GRCh38]
Chr4:123533879 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.2T>C (p.Met1Thr) single nucleotide variant not provided [RCV000998290] Chr4:122621010 [GRCh38]
Chr4:123542165 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.168+8T>C single nucleotide variant not provided [RCV000890476] Chr4:122620836 [GRCh38]
Chr4:123541991 [GRCh37]
Chr4:4q27
likely benign
NM_021803.4(IL21):c.277G>A (p.Glu93Lys) single nucleotide variant not provided [RCV001061517] Chr4:122615765 [GRCh38]
Chr4:123536920 [GRCh37]
Chr4:4q27
uncertain significance
null single nucleotide variant not provided [RCV001612240] Chr4:122612679 [GRCh38]
Chr4:123533834 [GRCh37]
Chr4:4q27
benign
NM_021803.4(IL21):c.470A>T (p.His157Leu) single nucleotide variant not provided [RCV001237259] Chr4:122612729 [GRCh38]
Chr4:123533884 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.119G>A (p.Arg40His) single nucleotide variant Common variable immunodeficiency 11 [RCV001335107]|not provided [RCV001216053] Chr4:122620893 [GRCh38]
Chr4:123542048 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.282G>T (p.Arg94Ser) single nucleotide variant not provided [RCV001235295] Chr4:122615760 [GRCh38]
Chr4:123536915 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.118C>G (p.Arg40Gly) single nucleotide variant not provided [RCV001360860] Chr4:122620894 [GRCh38]
Chr4:123542049 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.37A>G (p.Ile13Val) single nucleotide variant not provided [RCV001344913] Chr4:122620975 [GRCh38]
Chr4:123542130 [GRCh37]
Chr4:4q27
uncertain significance
GRCh37/hg19 4q26-28.2(chr4:116833638-130232122) copy number loss Behavioral abnormality [RCV001352657] Chr4:116833638..130232122 [GRCh37]
Chr4:4q26-28.2
pathogenic
NM_021803.4(IL21):c.117G>A (p.Met39Ile) single nucleotide variant not provided [RCV001367800] Chr4:122620895 [GRCh38]
Chr4:123542050 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.222A>G (p.Ser74=) single nucleotide variant not provided [RCV001396426] Chr4:122615820 [GRCh38]
Chr4:123536975 [GRCh37]
Chr4:4q27
likely benign
NM_021803.4(IL21):c.337G>A (p.Gly113Arg) single nucleotide variant not provided [RCV001352572] Chr4:122615705 [GRCh38]
Chr4:123536860 [GRCh37]
Chr4:4q27
uncertain significance
NM_021803.4(IL21):c.205-10T>C single nucleotide variant not provided [RCV001401259] Chr4:122615847 [GRCh38]
Chr4:123537002 [GRCh37]
Chr4:4q27
likely benign
NM_021803.4(IL21):c.324T>C (p.Pro108=) single nucleotide variant not provided [RCV001435130] Chr4:122615718 [GRCh38]
Chr4:123536873 [GRCh37]
Chr4:4q27
likely benign
NM_021803.4(IL21):c.168+9A>G single nucleotide variant not provided [RCV001407390] Chr4:122620835 [GRCh38]
Chr4:123541990 [GRCh37]
Chr4:4q27
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6005 AgrOrtholog
COSMIC IL21 COSMIC
Ensembl Genes ENSG00000138684 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000477555 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000497915 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000611104 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000648588 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000138684 GTEx
HGNC ID HGNC:6005 ENTREZGENE
Human Proteome Map IL21 Human Proteome Map
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-15/IL-21_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:59067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 59067 ENTREZGENE
OMIM 605384 OMIM
  615767 OMIM
PANTHER PTHR14356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29820 PharmGKB
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A224B028 ENTREZGENE, UniProtKB/TrEMBL
  IL21_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A5J0L4 UniProtKB/Swiss-Prot