RGD Reference Report - Cerebrospinal fluid IL-21 levels in Neuromyelitis Optica and multiple sclerosis. - Rat Genome Database

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Cerebrospinal fluid IL-21 levels in Neuromyelitis Optica and multiple sclerosis.

Authors: Wu, Aimin  Zhong, Xiaonan  Wang, Honghao  Xu, Wen  Cheng, Chen  Dai, Yongqiang  Bao, Jian  Qiu, Wei  Lu, Zhengqi  Hu, Xueqiang 
Citation: Wu A, etal., Can J Neurol Sci. 2012 Nov;39(6):813-20. doi: 10.1017/s0317167100015663.
RGD ID: 127285589
Pubmed: PMID:23041403   (View Abstract at PubMed)
DOI: DOI:10.1017/s0317167100015663   (Journal Full-text)


BACKGROUND: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are inflammatory demyelinating diseases of human central nervous system (CNS) with complex pathogenesis. IL-21/IL-21R regulates activation, proliferation and survival of both T cells and B cells, which are involved in the pathogenesis of NMO and MS. High levels of serum IL-21 were observed in NMO patients. However, concentration of cerebrospinal fluid (CSF) IL-21 in MS and NMO patients still remain unknown.
OBJECT: To detect the CSF concentration of IL-21 in NMO and MS patients and to evaluate its relationship with disease activity, particularly concerned about its impact on humoral immunity.
METHODS: CSF IL-21 was detected by an enzyme-linked immunosorbent assay (ELISA) in NMO patients (n=21), MS patients (n=20) and controls (n=16).
RESULTS: CSF concentration of the IL-21 was noticeably elevated in NMO (p=0.012) and borderline significantly increased in MS (p=0.115). In addition, this occurrence was associated with humoral immune activity as shown by a correlation between IL-21 and complement in NMO cohort (p=0.023) and high IL-21 levels in autoantibody-positive subgroup (p=0.027).
CONCLUSIONS: The concentration of CSF IL-21 was noticeably elevated and might have a positive correlation with humoral immune activity in NMO.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL21Humanneuromyelitis optica  IEP protein:increased expression:cerebrospinal fluid (human)RGD 
Il21Ratneuromyelitis optica  ISOIL21 (Homo sapiens)protein:increased expression:cerebrospinal fluid (human)RGD 
Il21Mouseneuromyelitis optica  ISOIL21 (Homo sapiens)protein:increased expression:cerebrospinal fluid (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il21  (interleukin 21)

Genes (Mus musculus)
Il21  (interleukin 21)

Genes (Homo sapiens)
IL21  (interleukin 21)


Additional Information