FABP2 (fatty acid binding protein 2) - Rat Genome Database

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Gene: FABP2 (fatty acid binding protein 2) Sus scrofa
Analyze
Symbol: FABP2
Name: fatty acid binding protein 2
RGD ID: 14107465
Description: ENCODES a protein that exhibits fatty acid binding (ortholog); long-chain fatty acid transmembrane transporter activity (ortholog); INVOLVED IN fatty acid metabolic process (ortholog); fatty acid transport (ortholog); intestinal absorption (ortholog); ASSOCIATED WITH alcoholic liver cirrhosis (ortholog); carotid stenosis (ortholog); coronary artery disease (ortholog); FOUND IN apical cortex (ortholog); microvillus (ortholog); INTERACTS WITH glutathione; paraquat
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fatty acid-binding protein, intestinal; I-FABP; intestinal fatty acid binding protein; intestinal-type fatty acid-binding protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8104,464,342 - 104,470,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18104,464,342 - 104,468,059 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28112,120,922 - 112,124,639 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FABP2Pigalcoholic liver cirrhosis onsetISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:amino acid A54T and homozygosity of the T allele associated with later onsetRGDPMID:16289894 and REF_RGD_ID:1578455
FABP2Pigcarotid stenosis  ISOFABP2 (Homo sapiens)9068941 RGDPMID:16013194 and REF_RGD_ID:1582392
FABP2Pigcoronary artery disease  ISOFABP2 (Homo sapiens)9068941DNA:SNP:CDS:2445G>A more ...RGDPMID:15059615 and REF_RGD_ID:1626412
FABP2PigDiabetic Nephropathies  ISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:amino acid A54T and in a Brazilian populationRGDPMID:16249461 and REF_RGD_ID:1578457
FABP2Pigend stage renal disease  ISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:amino acid A54T more ...RGDPMID:16249461 and REF_RGD_ID:1578457
FABP2PigExperimental Diabetes Mellitus treatmentISOFabp2 (Rattus norvegicus)9068941 RGDPMID:28085064 and REF_RGD_ID:598130069
FABP2PigHypertriglyceridemia  ISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:amino acid A54T and in a normal glucose tolerant population from urban south IndiaRGDPMID:16919542 and REF_RGD_ID:1626401
FABP2PigHypertriglyceridemia  ISOFABP2 (Homo sapiens)9068941associated with Diabetes Mellitus more ...RGDPMID:10999802 and REF_RGD_ID:1300313
FABP2PigInsulin Resistance no_associationISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:amino acid A54T and in Chilean Aymara and Mapuche ethnic groupsRGDPMID:17211557 and REF_RGD_ID:1626407
FABP2PigInsulin Resistance  ISOFABP2 (Homo sapiens)9068941DNA:SNP:CDS:p.A54T (human)RGDPMID:7883976 and REF_RGD_ID:1300314
FABP2PigInsulin Resistance  ISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:p.A54T (human)RGDPMID:14981227 and REF_RGD_ID:1626400
FABP2PigInsulin Resistance  ISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:amino acid A54T more ...RGDPMID:16311100 and REF_RGD_ID:1578456
FABP2PigMetabolic Syndrome  ISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:amino acid A54T and in a normal glucose tolerant population from urban south IndiaRGDPMID:16919542 and REF_RGD_ID:1626401
FABP2Pigobesity onsetISOFABP2 (Homo sapiens)9068941Early onset of obesity and resistance to reducing visceral white adipose tissue more ...RGDPMID:15620432 and REF_RGD_ID:1578458
FABP2Pigobesity  ISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:p.A54T (human)RGDPMID:14981227 and REF_RGD_ID:1626400
FABP2Pigobesity no_associationISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:amino acid A54T and in Chilean Aymara and Mapuche ethnic groupsRGDPMID:17211557 and REF_RGD_ID:1626407
FABP2PigStroke  ISOFABP2 (Homo sapiens)9068941DNA:missense mutation:cds:p.A54T (human)RGDPMID:10946885 and REF_RGD_ID:1300312
FABP2Pigtype 2 diabetes mellitus no_associationISOFABP2 (Homo sapiens)9068941DNA:polymorphism:CDS:amino acid A54T and in a population from urban south IndiaRGDPMID:16919542 and REF_RGD_ID:1626401
1 to 18 of 18 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FABP2PigNeurodevelopmental Disorders  ISOFABP2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
FABP2Pigtype 2 diabetes mellitus  ISOFABP2 (Homo sapiens)8554872ClinVar Annotator: match by term: FABP2 POLYMORPHISMClinVarPMID:10946885 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FABP2PigExperimental Liver Cirrhosis  ISOFABP2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25380136


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FABP2Pigglutathione multiple interactionsEXP 6480464Glutathione inhibits the reaction [Paraquat results in increased activity of FABP2 protein]CTDPMID:36615853
FABP2Pigparaquat multiple interactionsEXP 6480464Glutathione inhibits the reaction [Paraquat results in increased activity of FABP2 protein]CTDPMID:36615853
FABP2Pigparaquat increases activityEXP 6480464Paraquat results in increased activity of FABP2 proteinCTDPMID:36615853


Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FABP2Pigapical cortex  ISOFabp2 (Rattus norvegicus)9068941 RGDPMID:10666570 and REF_RGD_ID:1582399
FABP2Pigcytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
FABP2Pigcytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
FABP2Pigcytosol is_active_inIBAMGI:101790 more ...150520179 GO_CentralGO_REF:0000033
FABP2Pigmicrovillus  ISOFabp2 (Rattus norvegicus)9068941 RGDPMID:10666570 and REF_RGD_ID:1582399
FABP2Pignucleus is_active_inIBAMGI:101790 more ...150520179 GO_CentralGO_REF:0000033

Molecular Function
1 to 11 of 11 rows

  
1 to 11 of 11 rows

PMID:16529296   PMID:18708596   PMID:19207930   PMID:22301074   PMID:30032202  



FABP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8104,464,342 - 104,470,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18104,464,342 - 104,468,059 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28112,120,922 - 112,124,639 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FABP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384119,317,250 - 119,322,138 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4119,317,250 - 119,322,138 (-)EnsemblGRCh38hg38GRCh38
GRCh374120,238,405 - 120,243,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364120,457,853 - 120,462,766 (-)NCBINCBI36Build 36hg18NCBI36
Build 344120,596,008 - 120,600,921NCBI
Celera4117,600,001 - 117,604,911 (-)NCBICelera
Cytogenetic Map4q26NCBI
HuRef4115,960,235 - 115,965,143 (-)NCBIHuRef
CHM1_14120,214,972 - 120,219,883 (-)NCBICHM1_1
T2T-CHM13v2.04122,622,352 - 122,627,246 (-)NCBIT2T-CHM13v2.0
Fabp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,688,721 - 122,693,155 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3122,688,721 - 122,693,155 (+)EnsemblGRCm39 Ensembl
GRCm383122,895,072 - 122,899,506 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,895,072 - 122,899,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv373122,598,310 - 122,602,424 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363122,887,414 - 122,891,528 (+)NCBIMGSCv36mm8
Celera3129,305,754 - 129,309,868 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map353.74NCBI
Fabp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82213,724,629 - 213,728,686 (+)NCBIGRCr8
mRatBN7.22211,040,032 - 211,044,089 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2211,040,032 - 211,044,089 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,717,756 - 218,721,725 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02216,625,543 - 216,629,512 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02211,471,755 - 211,475,828 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02227,080,912 - 227,083,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2227,080,924 - 227,083,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02246,442,292 - 246,445,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42219,591,502 - 219,605,097 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12219,554,563 - 219,568,159 (+)NCBI
Celera2203,465,826 - 203,473,400 (+)NCBICelera
RH 3.4 Map21537.1RGD
Cytogenetic Map2q42NCBI
Fabp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542820,930,479 - 20,933,950 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542820,930,512 - 20,933,950 (+)NCBIChiLan1.0ChiLan1.0
FABP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23117,095,776 - 117,098,841 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14117,388,095 - 117,395,765 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04111,505,269 - 111,510,197 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14122,055,544 - 122,060,461 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4122,055,544 - 122,060,461 (-)Ensemblpanpan1.1panPan2
FABP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13238,244,065 - 38,248,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.03238,465,352 - 38,497,153 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3238,465,346 - 38,492,684 (-)EnsemblROS_Cfam_1.0 Ensembl
Fabp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530167,281,463 - 67,284,661 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936869146,844 - 149,902 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936869146,567 - 149,929 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FABP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1766,797,832 - 66,803,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl766,798,990 - 66,802,738 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603745,658,385 - 45,663,315 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in FABP2
79 total Variants



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 2 23 3 2 5 12 10 23 3 5 3



Ensembl Acc Id: ENSSSCT00000040297   ⟹   ENSSSCP00000040315
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8104,464,342 - 104,470,480 (+)Ensembl
RefSeq Acc Id: NM_001031780   ⟹   NP_001026950
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18104,464,342 - 104,468,059 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001026950   ⟸   NM_001031780
- UniProtKB: Q56G53 (UniProtKB/Swiss-Prot),   Q45KW7 (UniProtKB/Swiss-Prot),   A8W348 (UniProtKB/TrEMBL),   A0A4X1V3R8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000040315   ⟸   ENSSSCT00000040297
Cytosolic fatty-acid binding proteins   Lipocalin/cytosolic fatty-acid binding



1 to 40 of 48 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000037272 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00015035376 UniProtKB/Swiss-Prot
  ENSSSCG00025072440 UniProtKB/Swiss-Prot
  ENSSSCG00030000197 UniProtKB/Swiss-Prot
  ENSSSCG00035044137 UniProtKB/Swiss-Prot
  ENSSSCG00040054179 UniProtKB/Swiss-Prot
  ENSSSCG00045009670 UniProtKB/Swiss-Prot
  ENSSSCG00050038128 UniProtKB/Swiss-Prot
  ENSSSCG00055014467 UniProtKB/Swiss-Prot
  ENSSSCG00060050880 UniProtKB/Swiss-Prot
  ENSSSCG00065016241 UniProtKB/Swiss-Prot
  ENSSSCG00070022309 UniProtKB/Swiss-Prot
  ENSSSCG00110031905 UniProtKB/Swiss-Prot
  ENSSSCG00115013454 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000040297 ENTREZGENE
  ENSSSCT00000040297.2 UniProtKB/Swiss-Prot
  ENSSSCT00015047140.1 UniProtKB/Swiss-Prot
  ENSSSCT00025099584.1 UniProtKB/Swiss-Prot
  ENSSSCT00030000310.1 UniProtKB/Swiss-Prot
  ENSSSCT00035058651.1 UniProtKB/Swiss-Prot
  ENSSSCT00040073465.1 UniProtKB/Swiss-Prot
  ENSSSCT00045016426.1 UniProtKB/Swiss-Prot
  ENSSSCT00050051410.1 UniProtKB/Swiss-Prot
  ENSSSCT00055028547.1 UniProtKB/Swiss-Prot
  ENSSSCT00060069225.1 UniProtKB/Swiss-Prot
  ENSSSCT00065021537.1 UniProtKB/Swiss-Prot
  ENSSSCT00070044357.1 UniProtKB/Swiss-Prot
  ENSSSCT00110060976 UniProtKB/Swiss-Prot
  ENSSSCT00115023301 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
InterPro Calycin UniProtKB/Swiss-Prot
  FABP2 UniProtKB/Swiss-Prot
  Fatty_acid-bd UniProtKB/Swiss-Prot
  ILBP UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
KEGG Report ssc:595106 UniProtKB/Swiss-Prot
NCBI Gene FABP2 ENTREZGENE
PANTHER PTHR11955 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot
1 to 40 of 48 rows