ADRB2 (adrenoceptor beta 2) - Rat Genome Database

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Gene: ADRB2 (adrenoceptor beta 2) Sus scrofa
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Symbol: ADRB2
Name: adrenoceptor beta 2
RGD ID: 14228427
Description: ENCODES a protein that exhibits B2 bradykinin receptor binding (ortholog); beta2-adrenergic receptor activity (ortholog); enzyme binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); aging (ortholog); PARTICIPATES IN adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; epinephrine signaling pathway via adrenergic receptor beta; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH acute kidney failure (ortholog); AIDS Dementia Complex (ortholog); Angina Pectoris (ortholog); FOUND IN axon (ortholog); caveola (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adrenergic, beta-2-, receptor, surface; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; beta-2-adrenergic receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,032,782 - 150,035,591 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,032,649 - 150,035,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
AIDS Dementia Complex  (ISO)
Angina Pectoris  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
bronchiolitis  (ISO)
cardiomyopathy  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
dermatitis  (ISO)
dilated cardiomyopathy  (ISO)
disease of metabolism  (ISO)
end stage renal disease  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis 1  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
Graves' disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hypertension  (ISO)
hypokalemia  (ISO)
hypothyroidism  (ISO)
Insulin Resistance  (ISO)
interstitial cystitis  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
lung disease  (ISO)
Metabolic Syndrome  (ISO)
myasthenia gravis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
nervous system disease  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
Paroxysmal Dyspnea  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
Reperfusion Injury  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Stomach Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Tremor  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urticaria  (ISO)
Ventricular Dysfunction, Left  (ISO)
Vestibulocochlear Nerve Injuries  (ISO)
viral encephalitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (IEA,ISS)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
adrenergic receptor signaling pathway  (IEA)
aging  (ISO)
associative learning  (ISO)
blood vessel diameter maintenance  (IEA)
bone resorption  (IEA,ISO)
brown fat cell differentiation  (IEA,ISO)
cellular response to amyloid-beta  (IEA)
cellular response to hypoxia  (ISO)
desensitization of G protein-coupled receptor signaling pathway by arrestin  (IEA,ISS)
diaphragm contraction  (ISO)
diet induced thermogenesis  (IEA,ISO)
estrous cycle  (ISO)
excitatory postsynaptic potential  (ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
heat generation  (IEA,ISO)
liver development  (ISO)
liver regeneration  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of multicellular organism growth  (IEA,ISO)
negative regulation of ossification  (ISO)
negative regulation of platelet aggregation  (ISO)
negative regulation of smooth muscle contraction  (IBA,ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of urine volume  (ISO)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IBA,ISO)
positive regulation of AMPA receptor activity  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of ATPase activity  (ISO)
positive regulation of autophagosome maturation  (IEA,ISS)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of heart contraction  (ISO)
positive regulation of lipophagy  (IEA,ISS)
positive regulation of MAPK cascade  (IEA,ISS)
positive regulation of mini excitatory postsynaptic potential  (IEA)
positive regulation of potassium ion transport  (ISO)
positive regulation of protein kinase A signaling  (IEA)
positive regulation of protein serine/threonine kinase activity  (IEA)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of sodium ion transport  (ISO)
positive regulation of the force of heart contraction by epinephrine  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
receptor-mediated endocytosis  (IEA,ISS)
regulation of calcium ion transport  (ISO)
regulation of sensory perception of pain  (ISO)
regulation of smooth muscle contraction  (IEA)
regulation of sodium ion transport  (IEA,ISO)
regulation of synaptic vesicle exocytosis  (ISO)
regulation of systemic arterial blood pressure by norepinephrine-epinephrine  (ISO)
response to cold  (IEA,ISO)
response to dexamethasone  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to monoamine  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
synaptic transmission, glutamatergic  (ISO)
vasodilation  (ISO)
wound healing  (ISO)

References
Additional References at PubMed
PMID:9331889   PMID:10229356   PMID:14681463   PMID:17463060   PMID:19696365   PMID:20035031   PMID:25050597   PMID:25078038   PMID:27330078  


Genomics

Comparative Map Data
ADRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,032,782 - 150,035,591 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,032,649 - 150,035,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ADRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5148,826,611 - 148,828,623 (+)EnsemblGRCh38hg38GRCh38
GRCh385148,826,611 - 148,828,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375148,206,174 - 148,208,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,186,349 - 148,188,381 (+)NCBINCBI36hg18NCBI36
Build 345148,186,368 - 148,188,379NCBI
Celera5144,288,206 - 144,290,248 (+)NCBI
Cytogenetic Map5q32NCBI
HuRef5143,352,751 - 143,354,793 (+)NCBIHuRef
CHM1_15147,638,640 - 147,640,684 (+)NCBICHM1_1
Adrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391862,310,784 - 62,313,052 (-)NCBIGRCm39mm39
GRCm39 Ensembl1862,310,887 - 62,313,030 (-)Ensembl
GRCm381862,177,713 - 62,179,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1862,177,816 - 62,179,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371862,337,470 - 62,339,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv361862,303,185 - 62,305,328 (-)NCBImm8
Celera1863,462,804 - 63,464,949 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1835.1NCBI
Adrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21855,642,459 - 55,644,501 (-)NCBI
Rnor_6.0 Ensembl1857,513,793 - 57,515,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01857,513,792 - 57,515,834 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01856,739,990 - 56,742,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41858,174,958 - 58,177,000 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11858,247,190 - 58,249,232 (-)NCBI
Celera1853,789,848 - 53,791,890 (-)NCBICelera
RH 3.4 Map18542.9RGD
Cytogenetic Map18q12.1NCBI
Adrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554155,515,697 - 5,516,980 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554155,515,157 - 5,517,198 (-)NCBIChiLan1.0ChiLan1.0
ADRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15150,267,321 - 150,269,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,267,554 - 150,315,892 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05144,259,756 - 144,398,421 (+)NCBIMhudiblu_PPA_v0panPan3
ADRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1460,048,502 - 60,050,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,941,517 - 60,050,298 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,812,943 - 59,814,888 (-)NCBI
ROS_Cfam_1.0460,537,283 - 60,539,228 (-)NCBI
UMICH_Zoey_3.1460,317,278 - 60,319,223 (-)NCBI
UNSW_CanFamBas_1.0460,444,286 - 60,446,231 (-)NCBI
UU_Cfam_GSD_1.0460,962,485 - 60,964,430 (-)NCBI
Adrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213144,411,444 - 144,414,154 (-)NCBI
SpeTri2.0NW_0049365045,985,407 - 5,987,453 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12351,445,920 - 51,447,942 (+)NCBI
ChlSab1.1 Ensembl2351,446,154 - 51,447,401 (+)Ensembl
Vero_WHO_p1.0NW_02366603426,307,284 - 26,309,305 (-)NCBI
Adrb2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247748,211,723 - 8,215,962 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 4 1 5 2 18 1 3 3
Below cutoff 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000044104   ⟹   ENSSSCP00000049170
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2150,032,782 - 150,035,591 (+)Ensembl
RefSeq Acc Id: NM_001128436   ⟹   NP_001121908
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12150,033,796 - 150,035,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021081158   ⟹   XP_020936817
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12150,032,649 - 150,035,591 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020936817   ⟸   XM_021081158
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001121908   ⟸   NM_001128436
- UniProtKB: Q28997 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000049170   ⟸   ENSSSCT00000044104
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000049170 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000044104 ENTREZGENE, UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRB2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397357 UniProtKB/Swiss-Prot
NCBI Gene ADRB2 ENTREZGENE
PANTHER PTHR24248:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ADRENERGICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRENRGCB2AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A7BJW0_PIG UniProtKB/TrEMBL
  A7BJW1_PIG UniProtKB/TrEMBL
  ADRB2_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q9BFX1_PIG UniProtKB/TrEMBL
UniProt Secondary O02779 UniProtKB/Swiss-Prot
  Q6QTF6 UniProtKB/Swiss-Prot
VGNC ID VGNC:85159 ENTREZGENE