DPYS (dihydropyrimidinase) - Rat Genome Database
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Gene: DPYS (dihydropyrimidinase) Sus scrofa
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Symbol: DPYS
Name: dihydropyrimidinase
RGD ID: 13950491
Description: ENCODES a protein that exhibits amino acid binding (ortholog); dihydropyrimidinase activity (ortholog); identical protein binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); CMP catabolic process (ortholog); dCMP catabolic process (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH dihydropyrimidinase deficiency (ortholog); Experimental Liver Cirrhosis (ortholog); purine-pyrimidine metabolic disorder (ortholog); FOUND IN cytosol (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl432,789,460 - 32,879,489 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1432,791,152 - 32,879,489 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2435,528,834 - 35,616,166 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
DPYS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl432,789,460 - 32,879,489 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1432,791,152 - 32,879,489 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2435,528,834 - 35,616,166 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8104,330,324 - 104,467,055 (-)EnsemblGRCh38hg38GRCh38
GRCh388104,379,429 - 104,467,074 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378105,391,659 - 105,479,283 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh378105,391,652 - 105,479,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368105,460,829 - 105,548,453 (-)NCBINCBI36hg18NCBI36
Build 348105,460,828 - 105,548,453NCBI
Celera8101,578,319 - 101,665,933 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef8100,592,683 - 100,680,266 (-)NCBIHuRef
CHM1_18105,432,468 - 105,520,073 (-)NCBICHM1_1
Dpys
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391539,631,881 - 39,720,866 (-)NCBIGRCm39mm39
GRCm381539,768,485 - 39,857,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1539,768,487 - 39,857,470 (-)EnsemblGRCm38mm10GRCm38
MGSCv371539,600,031 - 39,689,016 (-)NCBIGRCm37mm9NCBIm37
MGSCv361539,598,559 - 39,687,541 (-)NCBImm8
Celera1540,252,611 - 40,341,397 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Dpys
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2770,822,648 - 70,929,255 (-)NCBI
Rnor_6.0 Ensembl778,769,807 - 78,847,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0778,769,918 - 78,847,941 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0778,796,405 - 78,873,615 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4775,368,238 - 75,446,160 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1775,449,118 - 75,466,890 (-)NCBI
Celera767,904,867 - 67,982,691 (-)NCBICelera
Cytogenetic Map7q31NCBI
Dpys
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541728,185,407 - 28,244,307 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541728,183,771 - 28,244,309 (-)NCBIChiLan1.0ChiLan1.0
DPYS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18103,160,922 - 103,248,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8103,160,922 - 103,248,303 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08101,008,090 - 101,096,234 (-)NCBIMhudiblu_PPA_v0panPan3
DPYS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl135,583,801 - 5,659,463 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1135,583,795 - 5,659,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dpys
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647039,564,431 - 39,637,394 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1899,216,623 - 99,303,969 (-)NCBI
ChlSab1.1 Ensembl899,216,354 - 99,303,282 (-)Ensembl
Dpys
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476320,618,515 - 20,680,790 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 2 3 1 1 1
Below cutoff 5 3 3 2 12 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000037104   ⟹   ENSSSCP00000043882
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl432,789,460 - 32,879,489 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000047501   ⟹   ENSSSCP00000057175
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl432,791,950 - 32,879,489 (+)Ensembl
RefSeq Acc Id: XM_001925251   ⟹   XP_001925286
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1432,791,921 - 32,879,484 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013996559   ⟹   XP_013852013
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1432,791,908 - 32,879,489 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021089028   ⟹   XP_020944687
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1432,791,152 - 32,878,396 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001925286 (Get FASTA)   NCBI Sequence Viewer  
  XP_013852013 (Get FASTA)   NCBI Sequence Viewer  
  XP_020944687 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020944687   ⟸   XM_021089028
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013852013   ⟸   XM_013996559
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_001925286   ⟸   XM_001925251
- Peptide Label: isoform X1
- UniProtKB: F1S1E7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000043882   ⟸   ENSSSCT00000037104
RefSeq Acc Id: ENSSSCP00000057175   ⟸   ENSSSCT00000047501
Protein Domains
Amidohydro-rel


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006040 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000043882 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000057175 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000037104 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000047501 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.40.10 UniProtKB/TrEMBL
InterPro Amidohydro-rel UniProtKB/TrEMBL
  Hydantoinase/dihydroPyrase UniProtKB/TrEMBL
  Metal-dep_hydrolase_composite UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
KEGG Report ssc:100156500 UniProtKB/TrEMBL
NCBI Gene DPYS ENTREZGENE
Pfam Amidohydro_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51338 UniProtKB/TrEMBL
  SSF51556 UniProtKB/TrEMBL
TIGRFAMs D-hydantoinase UniProtKB/TrEMBL
UniProt A0A287BLX5_PIG UniProtKB/TrEMBL
  A0A480J570_PIG UniProtKB/TrEMBL
  F1S1E7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87429 ENTREZGENE