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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:innate immune response pathway
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Accession:PW:0000234 term browser browse the term
Definition:The innate immune response - a universal and ancient form of host defense against infection - is a first line of response to various pathogens and also to damaged cells. It plays a role in stimulating adaptive immunity; molecules generated during innate responses act as second signals that can impact on both the magnitude and the nature of the adaptive response.
Synonyms:related_synonym: Innate Immune System;   innate immune response


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innate immune response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule ISO RGD PMID:15310678 RGD:1580257 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
classical complement pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 IMP RGD PMID:16367929 RGD:1580273 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4a complement C4A IMP RGD PMID:16367929 RGD:1580273 NCBI chr20:4,010,306...4,024,707
Ensembl chr20:4,005,731...4,020,080 		JBrowse link
G Crp C-reactive protein IMP RGD PMID:16367929 RGD:1580273 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
complement system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IEA KEGG rno:04610 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Bdkrb1 bradykinin receptor B1 IEA KEGG rno:04610 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 IEA KEGG rno:04610 NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G C1qa complement C1q A chain IEA KEGG rno:04610 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain IEA KEGG rno:04610 NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qc complement C1q C chain IEA KEGG rno:04610 NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C1r complement C1r IEA KEGG rno:04610 NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:157,412,692...157,423,484 		JBrowse link
G C1s complement C1s IEA KEGG rno:04610 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C2 complement C2 IEA KEGG rno:04610 NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3 complement C3 IEA KEGG rno:04610 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C3ar1 complement C3a receptor 1 IEA KEGG rno:04610 NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:156,075,389...156,084,701 		JBrowse link
G C4b complement C4B IEA KEGG rno:04610 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G C4bpa complement component 4 binding protein, alpha IEA KEGG rno:04610 NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta IEA KEGG rno:04610 NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G C5 complement C5 IEA KEGG rno:04610 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C5ar1 complement C5a receptor 1 IEA KEGG rno:04610 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G C6 complement C6 IEA KEGG rno:04610 NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C7 complement C7 IEA KEGG rno:04610 NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:54,088,116...54,158,535 		JBrowse link
G C8a complement C8 alpha chain IEA KEGG rno:04610 NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain IEA KEGG rno:04610 NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C8g complement C8 gamma chain IEA KEGG rno:04610 NCBI chr 3:28,718,648...28,720,232
Ensembl chr 3:8,305,920...8,323,495 		JBrowse link
G C9 complement C9 IEA KEGG rno:04610 NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cd46 CD46 molecule IEA KEGG rno:04610 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) IDA
IEA		 KEGG
RGD		 PMID:10929073 rno:04610, RGD:2326180 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd59b CD59b molecule IEA KEGG rno:04610 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cfb complement factor B IEA KEGG rno:04610 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfd complement factor D IEA KEGG rno:04610 NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:9,813,150...9,815,053 		JBrowse link
G Cfh complement factor H IEA KEGG rno:04610 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cfi complement factor I IEA KEGG rno:04610 NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Cpb2 carboxypeptidase B2 IEA KEGG rno:04610 NCBI chr15:56,967,128...57,015,964
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like IEA KEGG rno:04610 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cr2 complement C3d receptor 2 IEA KEGG rno:04610 NCBI chr13:109,207,034...109,244,980
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
G F10 coagulation factor X IEA KEGG rno:04610 NCBI chr16:83,170,973...83,190,280
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F12 coagulation factor XII IEA KEGG rno:04610 NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G F13a1 coagulation factor XIII A1 chain IEA KEGG rno:04610 NCBI chr17:28,021,197...28,197,960
Ensembl chr17:27,815,702...27,992,700 		JBrowse link
G F13b coagulation factor XIII B chain IEA KEGG rno:04610 NCBI chr13:51,130,908...51,156,383
Ensembl chr13:51,130,920...51,156,381 		JBrowse link
G F2 coagulation factor II, thrombin IEA KEGG rno:04610 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor IEA KEGG rno:04610 NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G F3 coagulation factor III, tissue factor IEA KEGG rno:04610 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G F5 coagulation factor V IEA KEGG rno:04610 NCBI chr13:79,046,657...79,116,247
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G F7 coagulation factor VII IEA KEGG rno:04610 NCBI chr16:83,191,896...83,202,775
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G F8 coagulation factor VIII IEA KEGG rno:04610 NCBI chr18:155,237...187,186
Ensembl chr18:140,955...171,857 		JBrowse link
G F9 coagulation factor IX IEA KEGG rno:04610 NCBI chr  X:143,388,642...143,433,143
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Fga fibrinogen alpha chain IEA KEGG rno:04610 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain IEA KEGG rno:04610 NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgg fibrinogen gamma chain IEA KEGG rno:04610 NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Klkb1 kallikrein B1 IEA KEGG rno:04610 NCBI chr16:53,690,180...53,714,570
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Kng2 kininogen 2 IEA KEGG rno:04610 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Kng2l1 kininogen 2-like 1 IEA KEGG rno:04610 NCBI chr11:77,978,795...78,002,976
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Masp1 MBL associated serine protease 1 IEA KEGG rno:04610 NCBI chr11:90,839,081...90,909,922
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
G Masp2 MBL associated serine protease 2 IEA KEGG rno:04610 NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
G Mbl1 mannose binding lectin 1 IEA KEGG rno:04610 NCBI chr16:17,063,232...17,069,271
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mbl2 mannose binding lectin 2 IEA KEGG rno:04610 NCBI chr 1:237,429,873...237,465,567 JBrowse link
G Plat plasminogen activator, tissue type IEA KEGG rno:04610 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase IEA KEGG rno:04610 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plaur plasminogen activator, urokinase receptor IEA KEGG rno:04610 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Plg plasminogen IEA KEGG rno:04610 NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa IEA KEGG rno:04610 NCBI chr18:24,038,596...24,049,061
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Pros1 protein S IEA KEGG rno:04610 NCBI chr11:13,676,310...13,757,858
Ensembl chr11:230,696...311,286 		JBrowse link
G Serpina1 serpin family A member 1 IEA KEGG rno:04610 NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339 		JBrowse link
G Serpina5 serpin family A member 5 IEA KEGG rno:04610 NCBI chr 6:123,009,224...123,028,412
Ensembl chr 6:123,023,306...123,028,407 		JBrowse link
G Serpinc1 serpin family C member 1 IEA KEGG rno:04610 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Serpind1 serpin family D member 1 IEA KEGG rno:04610 NCBI chr11:97,168,753...97,179,830
Ensembl chr11:83,664,518...83,675,519 		JBrowse link
G Serpine1 serpin family E member 1 IEA KEGG rno:04610 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf2 serpin family F member 2 IEA KEGG rno:04610 NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Serping1 serpin family G member 1 IEA KEGG rno:04610 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
G Tfpi tissue factor pathway inhibitor IEA KEGG rno:04610 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Thbd thrombomodulin IEA KEGG rno:04610 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Vwf von Willebrand factor IEA KEGG rno:04610 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
inflammatory response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISS RGD PMID:11498265 RGD:1549857 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Edn1 endothelin 1 IDA RGD PMID:20409845 RGD:4892591 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:20409845 RGD:4892591 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B IMP RGD PMID:20409845 RGD:4892591 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IDA RGD PMID:11435459 RGD:1582329 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
interleukin-1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aim2 absent in melanoma 2 ISO RGD PMID:20303873 RGD:5490211 NCBI chr13:88,397,516...88,439,325
Ensembl chr13:85,866,284...85,906,975 		JBrowse link
G Casp1 caspase 1 ISO PID
RGD		 PMID:19302047 PMID:20303873 PID:200089, RGD:5490210, RGD:5490211 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200089 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 ISO PID PID:200089 NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200089 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200089 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il1a interleukin 1 alpha ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 ISO
IMP		 PID
RGD		 PMID:20081871 PMID:20967881 PID:200089, RGD:5490209, RGD:5130945 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:42,384,433...42,424,725 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein ISO RGD PMID:20081871 RGD:5490209 NCBI chr11:87,567,813...87,704,346
Ensembl chr11:74,070,304...74,199,530 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 ISO RGD PMID:20086235 RGD:5490215 NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO PID PID:200089 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:125,682,488...125,717,837 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200089 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200089 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO PID PID:200089 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200089 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO PID PID:200089 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A ISO RGD PMID:20303873 RGD:5490211 NCBI chr10:56,277,134...56,332,229
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO RGD PMID:19302047 PMID:20303873 RGD:5490210, RGD:5490211 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 ISO RGD PMID:20086235 RGD:5490215 NCBI chr14:99,455,970...99,510,474
Ensembl chr14:95,254,589...95,308,285
Ensembl chr 1:95,254,589...95,308,285 		JBrowse link
G Peli2 pellino E3 ubiquitin protein ligase family member 2 ISO RGD PMID:20086235 RGD:5490215 NCBI chr15:21,393,262...21,537,737
Ensembl chr15:21,393,262...21,535,106 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO RGD PMID:20086235 RGD:5490215 NCBI chr 1:211,659,416...211,672,280
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200089 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200089 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Prkci protein kinase C, iota ISO PID PID:200089 NCBI chr 2:114,250,398...114,310,784
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkcz protein kinase C, zeta ISO PID PID:200089 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Pycard PYD and CARD domain containing ISO RGD PMID:19302047 PMID:20303873 RGD:5490210, RGD:5490211 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO PID PID:200089 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sigirr single Ig and TIR domain containing ISO RGD PMID:20081871 RGD:5490209 NCBI chr 1:205,625,742...205,637,883
Ensembl chr 1:196,199,462...196,202,269 		JBrowse link
G Sqstm1 sequestosome 1 ISO PID PID:200089 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:2,375,490...2,424,756 		JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:18535784 RGD:5490218 NCBI chr  X:53,923,473...53,995,777
Ensembl chr  X:49,972,330...50,042,056 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 ISO PID PID:200089 NCBI chr18:41,481,057...41,498,065
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
G Tollip toll interacting protein ISO PID
RGD		 PMID:18535784 PID:200089, RGD:5490218 NCBI chr 1:206,391,120...206,413,809
Ensembl chr 1:196,950,771...196,983,625 		JBrowse link
G Traf6 TNF receptor associated factor 6 ISO
IMP		 PID
RGD		 PMID:20086235 PMID:20967881 PMID:18535784 PID:200089, RGD:5490215, RGD:5130945, RGD:5490218 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 7:32,041,190...32,071,252
Ensembl chr 7:30,154,616...30,184,355 		JBrowse link
G Ube2v1 ubiquitin conjugating enzyme E2 V1 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 3:176,736,325...176,759,174
Ensembl chr 3:156,316,781...156,340,273 		JBrowse link
interleukin-6 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO PID PID:200146 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 ISO RGD PMID:21145125 RGD:5686846 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO RGD PMID:22029668 PMID:21145125 RGD:5686834, RGD:5686846 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200146 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta ISO PID PID:200146 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta ISO PID PID:200146 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:84,764,565...84,765,829 		JBrowse link
G Crp C-reactive protein ISO PID PID:200146 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Fgg fibrinogen gamma chain ISO PID PID:200146 NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200146 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo1 forkhead box O1 ISO PID PID:200146 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO PID PID:200146 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:27,131,262...27,239,236 		JBrowse link
G Gab2 GRB2-associated binding protein 2 ISO PID PID:200146 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID
RGD		 PMID:22029668 PID:200146, RGD:5686834 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200146 NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:141,571,587...141,614,693 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO PID PID:200146 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Il6 interleukin 6 ISO
IDA		 PID
RGD		 PMID:12773095 PMID:28186964 PMID:23825534 PMID:21881215 PMID:22029668 PID:200146, RGD:1580493, RGD:127229952, RGD:11062097, RGD:5686839, RGD:5686834 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor ISO PID
RGD		 PMID:22029668 PMID:21881215 PID:200146, RGD:5686834, RGD:5686839 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer ISO
IMP		 PID
RGD		 PMID:22029668 PMID:18280048 PMID:21881215 PID:200146, RGD:5686834, RGD:5686900, RGD:5686839 NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Irf1 interferon regulatory factor 1 ISO PID PID:200146 NCBI chr10:38,417,935...38,424,946
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Jak1 Janus kinase 1 ISO PID
RGD		 PMID:21881215 PID:200146, RGD:5686839 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 ISO PID
RGD		 PMID:21881215 PID:200146, RGD:5686839 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200146 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200146 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Lbp lipopolysaccharide binding protein ISO PID PID:200146 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Lmo4 LIM domain only 4 ISO PID PID:200146 NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 ISO PID PID:200146 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200146 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO PID PID:200146 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200146 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member ISO PID PID:200146 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mitf melanocyte inducing transcription factor ISO PID PID:200146 NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO PID PID:200146 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 ISO PID PID:200146 NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:63,338,150...63,438,905 		JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 ISO PID PID:200146 NCBI chr 2:186,921,384...186,930,292
Ensembl chr 2:184,232,571...184,241,480 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200146 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200146 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Prkcd protein kinase C, delta ISO PID PID:200146 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID
RGD		 PMID:22029668 PID:200146, RGD:5686834 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200146 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO PID PID:200146 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID
RGD		 PMID:22029668 PMID:9815779 PID:200146, RGD:5686834, RGD:155631264 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 ISO RGD PMID:22029668 RGD:5686834 NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID
RGD		 PMID:22029668 PMID:21881215 PID:200146, RGD:5686834, RGD:5686839 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO PID
RGD		 PMID:22029668 PMID:21881215 PID:200146, RGD:5686834, RGD:5686839 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO PID PID:200146 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnfsf11 TNF superfamily member 11 ISO PID PID:200146 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tyk2 tyrosine kinase 2 ISO PID
RGD		 PMID:21881215 PID:200146, RGD:5686839 NCBI chr 8:27,918,054...27,943,319
Ensembl chr 8:19,641,884...19,667,044 		JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 ISO PID PID:200146 NCBI chr 9:2,248,856...2,295,905
Ensembl chr 9:2,157,900...2,208,937 		JBrowse link
lectin complement pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mbl2 mannose binding lectin 2 IDA RGD PMID:9920905 RGD:4889148 NCBI chr 1:237,429,873...237,465,567 JBrowse link
NOD-like receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 IEA KEGG rno:04621 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 IEA KEGG rno:04621 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Card6 caspase recruitment domain family, member 6 IEA KEGG rno:04621 NCBI chr 2:54,194,343...54,206,902
Ensembl chr 2:54,195,739...54,206,846 		JBrowse link
G Card9 caspase recruitment domain family, member 9 IEA KEGG rno:04621 NCBI chr 3:29,569,907...29,578,402
Ensembl chr 3:9,171,815...9,180,237 		JBrowse link
G Casp1 caspase 1 IEA KEGG rno:04621 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp8 caspase 8 IEA KEGG rno:04621 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 IEA KEGG rno:04621 NCBI chr10:67,567,876...67,569,426
Ensembl chr10:67,070,230...67,071,780 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEA KEGG rno:04621 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG rno:04621 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEA KEGG rno:04621 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 IEA KEGG rno:04621 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 IEA KEGG rno:04621 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 IEA KEGG rno:04621 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 IEA KEGG rno:04621 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:04621 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG rno:04621 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il18 interleukin 18 IEA KEGG rno:04621 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta IEA KEGG rno:04621 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 IEA KEGG rno:04621 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 IEA KEGG rno:04621 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:04621 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:04621 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 IEA KEGG rno:04621 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 IEA KEGG rno:04621 NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:120,206,271...120,216,664 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 IEA KEGG rno:04621 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 IEA KEGG rno:04621 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:04621 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA KEGG rno:04621 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:04621 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mefv MEFV innate immunity regulator, pyrin IEA KEGG rno:04621 NCBI chr10:12,288,514...12,303,337
Ensembl chr10:11,787,422...11,796,973 		JBrowse link
G Naip5 NLR family, apoptosis inhibitory protein 5 IEA KEGG rno:04621 NCBI chr 2:33,289,785...33,342,807
Ensembl chr 2:31,557,817...31,608,634 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEA KEGG rno:04621 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha IEA KEGG rno:04621 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta IEA KEGG rno:04621 NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A IEA KEGG rno:04621 NCBI chr10:56,277,134...56,332,229
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nlrp1b NLR family, pyrin domain containing 1B IEA KEGG rno:04621 NCBI chr10:56,336,957...56,412,796
Ensembl chr10:55,843,001...55,912,774 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 IEA KEGG rno:04621 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 IEA KEGG rno:04621 NCBI chr 4:85,391,142...85,442,281
Ensembl chr 4:84,060,880...84,111,404 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 IDA
IEA		 KEGG
RGD		 PMID:16973131 rno:04621, RGD:1643119 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 IEA KEGG rno:04621 NCBI chr 8:65,395,328...65,434,616
Ensembl chr 8:56,499,590...56,538,580 		JBrowse link
G Pycard PYD and CARD domain containing IEA KEGG rno:04621 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEA KEGG rno:04621 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 IEA KEGG rno:04621 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Sugt1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone IEA KEGG rno:04621 NCBI chr15:61,400,478...61,441,303
Ensembl chr15:54,990,672...55,069,150 		JBrowse link
G Tnf tumor necrosis factor IEA KEGG rno:04621 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Traf6 TNF receptor associated factor 6 IEA KEGG rno:04621 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Xiap X-linked inhibitor of apoptosis IEA KEGG rno:04621 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
pro-inflammatory cytokine mediated pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tnf tumor necrosis factor IDA RGD PMID:29091898 RGD:15090820 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
receptor for advanced glycation end-products signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IMP RGD PMID:22293957 RGD:7245565 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg12 autophagy related 12 IEA KEGG rno:04622 NCBI chr18:41,638,841...41,649,311
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg5 autophagy related 5 IEA KEGG rno:04622 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Azi2 5-azacytidine induced 2 IEA KEGG rno:04622 NCBI chr 8:126,651,268...126,674,795
Ensembl chr 8:117,773,279...117,797,847 		JBrowse link
G Casp8 caspase 8 IEA KEGG rno:04622 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG rno:04622 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEA KEGG rno:04622 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase IEA KEGG rno:04622 NCBI chr19:34,487,491...34,547,311
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Ddx3 DEAD-box helicase 3 IEA KEGG rno:04622 NCBI chr13:98,520,538...98,523,707
Ensembl chr13:98,520,201...98,524,176 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked IEA KEGG rno:04622 NCBI chr  X:12,152,346...12,165,983
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Ddx3y DEAD box helicase 3, Y-linked IEA KEGG rno:04622 NCBI chr  Y:1,190,042...1,210,699
Ensembl chr  Y:1,116,309...1,135,706 		JBrowse link
G Dhx58 DEXH-box helicase 58 IEA KEGG rno:04622 NCBI chr10:86,120,677...86,132,095
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G Fadd Fas associated via death domain IEA KEGG rno:04622 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 IEA KEGG rno:04622 NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:47,227,364...47,275,456 		JBrowse link
G Ifna1 interferon, alpha 1 IEA KEGG rno:04622 NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ifna2 interferon alpha 2 IEA KEGG rno:04622 NCBI chr 5:103,258,617...103,259,195 JBrowse link
G Ifna4 interferon, alpha 4 IEA KEGG rno:04622 NCBI chr 5:108,115,064...108,116,010
Ensembl chr 5:103,069,483...103,070,052 		JBrowse link
G Ifna4l1 interferon, alpha 4 like 1 IEA KEGG rno:04622 NCBI chr 5:108,640,546...108,641,115
Ensembl chr 5:103,524,733...103,525,302 		JBrowse link
G Ifna5 interferon, alpha 5 IEA KEGG rno:04622 NCBI chr 5:108,233,736...108,234,314 JBrowse link
G Ifnb1 interferon beta 1 IEA KEGG rno:04622 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifnk interferon kappa IEA KEGG rno:04622 NCBI chr 5:54,528,304...54,530,511
Ensembl chr 5:49,732,073...49,734,281 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:04622 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon IEA KEGG rno:04622 NCBI chr13:45,264,404...45,290,737
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG rno:04622 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il12a interleukin 12A IEA KEGG rno:04622 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B IEA KEGG rno:04622 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Irf3 interferon regulatory factor 3 IEA KEGG rno:04622 NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Irf7 interferon regulatory factor 7 IEA KEGG rno:04622 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier IEA KEGG rno:04622 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 IEA KEGG rno:04622 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 IEA KEGG rno:04622 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:04622 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 IEA KEGG rno:04622 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 IEA KEGG rno:04622 NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:120,206,271...120,216,664 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 IEA KEGG rno:04622 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 IEA KEGG rno:04622 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA KEGG rno:04622 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:04622 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mavs mitochondrial antiviral signaling protein IEA KEGG rno:04622 NCBI chr 3:138,904,673...138,919,129
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEA KEGG rno:04622 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha IEA KEGG rno:04622 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta IEA KEGG rno:04622 NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nlrx1 NLR family member X1 IEA KEGG rno:04622 NCBI chr 8:53,486,866...53,503,498
Ensembl chr 8:44,590,048...44,606,484 		JBrowse link
G Otud5 OTU deubiquitinase 5 IEA KEGG rno:04622 NCBI chr  X:17,296,750...17,331,257
Ensembl chr  X:14,626,164...14,659,573 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 IEA KEGG rno:04622 NCBI chr 8:27,465,538...27,477,016
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEA KEGG rno:04622 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rig1 RNA sensor RIG-1 IEA KEGG rno:04622 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:55,321,235...55,370,819 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 IEA KEGG rno:04622 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Rnf125 ring finger protein 125 IEA KEGG rno:04622 NCBI chr18:12,528,995...12,550,646
Ensembl chr18:12,253,852...12,275,983 		JBrowse link
G Tank TRAF family member-associated NFKB activator IEA KEGG rno:04622 NCBI chr 3:66,522,834...66,598,864
Ensembl chr 3:46,114,274...46,190,264 		JBrowse link
G Tbk1 TANK-binding kinase 1 IEA KEGG rno:04622 NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:57,077,830...57,110,892 		JBrowse link
G Tbkbp1 TBK1 binding protein 1 IEA KEGG rno:04622 NCBI chr10:82,616,978...82,632,169
Ensembl chr10:82,120,564...82,134,352 		JBrowse link
G Tkfc triokinase and FMN cyclase IEA KEGG rno:04622 NCBI chr 1:216,664,446...216,677,815
Ensembl chr 1:207,236,557...207,252,737 		JBrowse link
G Tnf tumor necrosis factor IEA KEGG rno:04622 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tradd TNFRSF1A-associated via death domain IEA KEGG rno:04622 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 IEA KEGG rno:04622 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 IEA KEGG rno:04622 NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
G Traf6 TNF receptor associated factor 6 IEA KEGG rno:04622 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Trim25 tripartite motif-containing 25 IEA KEGG rno:04622 NCBI chr10:74,310,024...74,328,473
Ensembl chr10:73,812,818...73,831,257 		JBrowse link
Toll-like receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:04620 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:04620 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04620 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Casp8 caspase 8 IEA KEGG rno:04620 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 IEA KEGG rno:04620 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEA KEGG rno:04620 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd14 CD14 molecule IEA
ISO		 KEGG
RGD		 PMID:22119168 rno:04620, RGD:7247704 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd40 CD40 molecule IEA KEGG rno:04620 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd80 Cd80 molecule IEA KEGG rno:04620 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule IEA KEGG rno:04620 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG rno:04620 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Ctsk cathepsin K IEA KEGG rno:04620 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEA KEGG rno:04620 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 IEA KEGG rno:04620 NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 IEA KEGG rno:04620 NCBI chr14:16,007,166...16,012,077
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Fadd Fas associated via death domain IEA KEGG rno:04620 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEA KEGG rno:04620 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Ifna1 interferon, alpha 1 IEA KEGG rno:04620 NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ifna2 interferon alpha 2 IEA KEGG rno:04620 NCBI chr 5:103,258,617...103,259,195 JBrowse link
G Ifna4 interferon, alpha 4 IEA KEGG rno:04620 NCBI chr 5:108,115,064...108,116,010
Ensembl chr 5:103,069,483...103,070,052 		JBrowse link
G Ifna4l1 interferon, alpha 4 like 1 IEA KEGG rno:04620 NCBI chr 5:108,640,546...108,641,115
Ensembl chr 5:103,524,733...103,525,302 		JBrowse link
G Ifna5 interferon, alpha 5 IEA KEGG rno:04620 NCBI chr 5:108,233,736...108,234,314 JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 IEA KEGG rno:04620 NCBI chr11:44,211,769...44,238,206
Ensembl chr11:30,725,790...30,749,979 		JBrowse link
G Ifnb1 interferon beta 1 IEA KEGG rno:04620 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:04620 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon IEA KEGG rno:04620 NCBI chr13:45,264,404...45,290,737
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG rno:04620 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il12a interleukin 12A IEA KEGG rno:04620 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B IEA KEGG rno:04620 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta IEA KEGG rno:04620 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 IEA KEGG rno:04620 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO RGD PMID:28954388 RGD:34888230 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:125,682,488...125,717,837 		JBrowse link
G Irf3 interferon regulatory factor 3 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Irf5 interferon regulatory factor 5 IEA KEGG rno:04620 NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:58,127,640...58,139,267 		JBrowse link
G Irf7 interferon regulatory factor 7 IEA KEGG rno:04620 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IEA KEGG rno:04620 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lbp lipopolysaccharide binding protein IEA
ISO		 KEGG
RGD		 PMID:22119168 rno:04620, RGD:7247704 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Ly96 lymphocyte antigen 96 ISO
IEA		 KEGG
RGD		 PMID:21741580 PMID:22119168 rno:04620, RGD:5685019, RGD:7247704 NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:2,582,254...2,612,386 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEA KEGG rno:04620 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 IEA KEGG rno:04620 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 IEA KEGG rno:04620 NCBI chr10:46,107,639...46,128,986
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IEA KEGG rno:04620 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 IEA KEGG rno:04620 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 IEA KEGG rno:04620 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 IEA KEGG rno:04620 NCBI chr17:58,078,175...58,098,455
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:04620 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:04620 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 IEA KEGG rno:04620 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 IEA KEGG rno:04620 NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:120,206,271...120,216,664 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 IEA KEGG rno:04620 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 IEA KEGG rno:04620 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:04620 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA KEGG rno:04620 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:04620 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEA KEGG rno:04620 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha IEA KEGG rno:04620 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:04620 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04620 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04620 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:04620 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04620 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04620 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04620 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Rac1 Rac family small GTPase 1 IEA KEGG rno:04620 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEA KEGG rno:04620 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Spp1 secreted phosphoprotein 1 IEA KEGG rno:04620 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 IEA KEGG rno:04620 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO RGD PMID:20940366 RGD:5685016 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO RGD PMID:20940366 RGD:5685016 NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:2,375,490...2,424,756 		JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:20940366 RGD:5685016 NCBI chr  X:53,923,473...53,995,777
Ensembl chr  X:49,972,330...50,042,056 		JBrowse link
G Tbk1 TANK-binding kinase 1 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:57,077,830...57,110,892 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr18:41,481,057...41,498,065
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
G Tirap TIR domain containing adaptor protein ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
G Tlr1 toll-like receptor 1 IDA
ISO		 RGD PMID:16973131 PMID:21235323 RGD:1643119, RGD:5685014 NCBI chr14:43,737,761...43,750,389
Ensembl chr14:43,384,932...43,397,125 		JBrowse link
G Tlr2 toll-like receptor 2 IDA
IEA
ISO
IMP		 KEGG
RGD		 PMID:16973131 PMID:21235323 PMID:18353287 rno:04620, RGD:1643119, RGD:5685014, RGD:5684896 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr3 toll-like receptor 3 IDA
IEA
ISO		 KEGG
RGD		 PMID:16973131 PMID:21235323 rno:04620, RGD:1643119, RGD:5685014 NCBI chr16:53,554,916...53,572,321
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 IDA
ISO
IEA		 KEGG
RGD		 PMID:16973131 PMID:22119168 PMID:21235323 rno:04620, RGD:1643119, RGD:7247704, RGD:5685014 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr5 toll-like receptor 5 IDA
IEA
ISO		 KEGG
RGD		 PMID:16973131 PMID:21235323 rno:04620, RGD:1643119, RGD:5685014 NCBI chr13:97,166,430...97,190,642
Ensembl chr13:94,634,801...94,657,738 		JBrowse link
G Tlr6 toll-like receptor 6 IDA
IEA
ISO
IMP		 KEGG
RGD		 PMID:16973131 PMID:21235323 PMID:18353287 rno:04620, RGD:1643119, RGD:5685014, RGD:5684896 NCBI chr14:43,715,809...43,727,019
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tlr7 toll-like receptor 7 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr  X:30,644,324...30,670,796
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tlr8 toll-like receptor 8 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr  X:30,708,714...30,733,104
Ensembl chr  X:27,091,778...27,116,549 		JBrowse link
G Tlr9 toll-like receptor 9 IDA
IEA
ISO		 KEGG
RGD		 PMID:16973131 PMID:21235323 rno:04620, RGD:1643119, RGD:5685014 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor IEA KEGG rno:04620 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tollip toll interacting protein IEA KEGG rno:04620 NCBI chr 1:206,391,120...206,413,809
Ensembl chr 1:196,950,771...196,983,625 		JBrowse link
G Tradd TNFRSF1A-associated via death domain ISO RGD PMID:21235323 RGD:5685014 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
G Traf6 TNF receptor associated factor 6 ISO
IEA		 KEGG
RGD		 PMID:21235323 rno:04620, RGD:5685014 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N ISO RGD PMID:21235323 RGD:5685014 NCBI chr 7:32,041,190...32,071,252
Ensembl chr 7:30,154,616...30,184,355 		JBrowse link
G Ube2v1 ubiquitin conjugating enzyme E2 V1 ISO RGD PMID:21235323 RGD:5685014 NCBI chr 3:176,736,325...176,759,174
Ensembl chr 3:156,316,781...156,340,273 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator ISO RGD PMID:21235323 RGD:5685014 NCBI chr 1:210,596,639...210,607,579
Ensembl chr 1:201,152,693...201,178,338 		JBrowse link
tumor necrosis factor mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Bag4 BAG cochaperone 4 ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr16:72,991,407...73,008,620
Ensembl chr16:66,288,678...66,308,663 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 ISO PID
RGD		 PMID:23085193 PID:200102, RGD:7800730 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ISO PID
RGD		 PMID:23085193 PID:200102, RGD:7800730 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp8 caspase 8 ISO PID PID:200102 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cav1 caveolin 1 ISO PID PID:200102 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO PID
RGD		 PMID:21119682 PMID:23312890 PID:200102, RGD:7800735, RGD:7800734 NCBI chr19:34,487,491...34,547,311
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Fadd Fas associated via death domain ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO RGD PMID:23312890 PMID:21119682 RGD:7800734, RGD:7800735 NCBI chr 3:164,102,490...164,193,932
Ensembl chr 3:143,645,637...143,733,543 		JBrowse link
G Madd MAP-kinase activating death domain ISO PID PID:200102 NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:77,114,314...77,157,701 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 ISO PID PID:200102 NCBI chr10:46,107,639...46,128,986
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO PID PID:200102 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200102 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO PID PID:200102 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO PID PID:200102 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID
RGD		 PMID:21135871 PID:200102, RGD:5490225 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 ISO PID PID:200102 NCBI chr 1:213,074,360...213,090,042
Ensembl chr 1:203,645,153...203,660,331 		JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 ISO PID PID:200102 NCBI chr 6:20,029,246...20,198,583
Ensembl chr 6:14,277,121...14,446,334 		JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 ISO PID PID:200102 NCBI chr 9:49,696,573...49,822,353
Ensembl chr 9:42,200,278...42,326,698 		JBrowse link
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 ISO PID PID:200102 NCBI chr 6:94,020,079...94,112,943
Ensembl chr 6:88,284,094...88,376,799 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO PID PID:200102 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nrk Nik related kinase ISO PID PID:200102 NCBI chr  X:102,365,765...102,462,957
Ensembl chr  X:102,365,765...102,459,657 		JBrowse link
G Nsmaf neutral sphingomyelinase activation associated factor ISO PID PID:200102 NCBI chr 5:19,517,795...19,578,773
Ensembl chr 5:19,518,348...19,577,627 		JBrowse link
G Prkci protein kinase C, iota ISO PID PID:200102 NCBI chr 2:114,250,398...114,310,784
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkcz protein kinase C, zeta ISO PID PID:200102 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO PID PID:200102 NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 ISO RGD PMID:23085193 RGD:7800730 NCBI chr 3:161,249,389...161,266,321
Ensembl chr 3:140,789,080...140,806,005 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO PID PID:200102 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ISO PID PID:200102 NCBI chr10:68,238,273...68,301,225
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO PID
RGD		 PMID:12655295 PMID:23085193 PID:200102, RGD:2292150, RGD:7800730 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Rnf11 ring finger protein 11 ISO RGD PMID:21119682 PMID:23312890 RGD:7800734 RGD:7800735 NCBI chr 5:129,441,071...129,471,799
Ensembl chr 5:124,212,445...124,234,750 		JBrowse link
G Rnf31 ring finger protein 31 ISO RGD PMID:23085193 RGD:7800730 NCBI chr15:33,053,450...33,065,285
Ensembl chr15:29,083,631...29,101,915 		JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO RGD PMID:23085193 RGD:7800730 NCBI chr 7:109,951,336...109,955,552
Ensembl chr 7:108,070,687...108,074,955 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200102 NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 ISO PID PID:200102 NCBI chr20:46,568,627...46,571,741
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Sqstm1 sequestosome 1 ISO PID PID:200102 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200102 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID
RGD		 PMID:21135871 PID:200102, RGD:5490225 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID
RGD		 PMID:21135871 PID:200102, RGD:5490225 NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:2,375,490...2,424,756 		JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:21135871 RGD:5490225 NCBI chr  X:53,923,473...53,995,777
Ensembl chr  X:49,972,330...50,042,056 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 ISO RGD PMID:23312890 PMID:21119682 RGD:7800734, RGD:7800735 NCBI chr 4:83,152,549...83,208,463
Ensembl chr 4:81,821,989...81,879,100 		JBrowse link
G Tnf tumor necrosis factor ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO RGD PMID:23312890 PMID:21119682 RGD:7800734, RGD:7800735 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO
IMP		 PID
RGD		 PMID:12655295 PMID:20967881 PID:200102, RGD:2292150, RGD:5130945 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO PID PID:200102 NCBI chr 2:113,112,937...113,511,341
Ensembl chr 2:111,184,387...111,580,750 		JBrowse link
G Tradd TNFRSF1A-associated via death domain ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf1 TNF receptor-associated factor 1 ISO PID PID:200102 NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO
IMP		 PID
RGD		 PMID:12655295 PMID:23085193 PMID:20967881 PID:200102, RGD:2292150, RGD:7800730, RGD:5130945 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Traf5 TNF receptor-associated factor 5 ISO RGD PMID:23085193 RGD:7800730 NCBI chr13:103,569,944...103,618,747
Ensembl chr13:103,572,314...103,618,709 		JBrowse link
G Txn1 thioredoxin 1 ISO PID PID:200102 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3866
      immune response pathway 539
        innate immune response pathway 296
          complement system pathway + 71
          inflammatory response pathway + 228
paths to the root