Pik3r2 (phosphoinositide-3-kinase regulatory subunit 2) - Rat Genome Database

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Gene: Pik3r2 (phosphoinositide-3-kinase regulatory subunit 2) Rattus norvegicus
Analyze
Symbol: Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
RGD ID: 68341
Description: Predicted to enable several functions, including 1-phosphatidylinositol-3-kinase regulator activity; enzyme binding activity; and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in negative regulation of cell migration involved in sprouting angiogenesis. Predicted to be located in focal adhesion and nucleus. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in pancreatic ductal adenocarcinoma. Orthologous to human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC108697; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulartory subunit polypeptide 2; phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase regulatory subunit polypeptide 2 (p85 beta); phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit 2 (beta); PI3-kinase p85 subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; ptdIns-3-kinase p85-beta; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,699,389 - 18,708,045 (+)NCBIGRCr8
mRatBN7.21618,665,517 - 18,674,067 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,665,457 - 18,674,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,707,923 - 18,716,460 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,840,602 - 19,849,140 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,760,867 - 18,769,404 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,415,109 - 20,424,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,416,432 - 20,424,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,273,500 - 20,282,051 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,171,101 - 19,179,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,171,098 - 19,179,648 (+)NCBI
Celera1618,857,756 - 18,866,282 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
N-nitrosodiethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nickel dichloride  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (EXP)
potassium dichromate  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway   (IEA)
aldosterone signaling pathway  (IEA)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway   (IEA)
endometrial cancer pathway  (IEA)
Entamoebiasis pathway   (IEA)
epidermal growth factor/neuregulin signaling pathway   (IEA,ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
hepatitis C pathway  (IEA)
influenza A pathway   (IEA)
insulin signaling pathway   (IEA)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway   (IEA)
mTOR signaling pathway  (IEA)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway   (ISO)
type 2 diabetes mellitus pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

References

References - curated
# Reference Title Reference Citation
1. p85ß phosphoinositide 3-kinase subunit regulates tumor progression. Cortés I, etal., Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11318-23. doi: 10.1073/pnas.1118138109. Epub 2012 Jun 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Guo C, etal., Genes Chromosomes Cancer. 2008 Nov;47(11):939-46. doi: 10.1002/gcc.20596.
5. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
6. Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate. Huynh H, etal., J Endocrinol 2001 Oct;171(1):109-18.
7. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. Inukai K, etal., J Biol Chem 1996 Mar 8;271(10):5317-20.
8. Upregulation of MicroRNA-126 Contributes to Endothelial Progenitor Cell Function in Deep Vein Thrombosis via Its Target PIK3R2. Meng Q, etal., J Cell Biochem. 2015 Aug;116(8):1613-23. doi: 10.1002/jcb.25115.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. MicroRNA126 inhibits proliferation and metastasis by targeting pik3r2 in prostate cancer. Song L, etal., Mol Med Rep. 2016 Feb;13(2):1204-10. doi: 10.3892/mmr.2015.4661. Epub 2015 Dec 9.
18. Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer. Stoll V, etal., Gut. 2005 Jan;54(1):109-16. doi: 10.1136/gut.2004.046706.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
Additional References at PubMed
PMID:9748281   PMID:10627473   PMID:11120660   PMID:12477932   PMID:18694566   PMID:20348926   PMID:20624904   PMID:23604317   PMID:24349482   PMID:25217619   PMID:29042193   PMID:33029740  
PMID:38063094  


Genomics

Comparative Map Data
Pik3r2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,699,389 - 18,708,045 (+)NCBIGRCr8
mRatBN7.21618,665,517 - 18,674,067 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,665,457 - 18,674,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,707,923 - 18,716,460 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,840,602 - 19,849,140 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,760,867 - 18,769,404 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,415,109 - 20,424,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,416,432 - 20,424,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,273,500 - 20,282,051 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,171,101 - 19,179,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,171,098 - 19,179,648 (+)NCBI
Celera1618,857,756 - 18,866,282 (+)NCBICelera
Cytogenetic Map16p14NCBI
PIK3R2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,153,163 - 18,170,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,153,163 - 18,170,532 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,263,973 - 18,281,342 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,125,016 - 18,142,343 (+)NCBINCBI36Build 36hg18NCBI36
Build 341918,125,015 - 18,142,343NCBI
Celera1918,165,735 - 18,183,085 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,827,466 - 17,844,856 (+)NCBIHuRef
CHM1_11918,263,528 - 18,280,901 (+)NCBICHM1_1
T2T-CHM13v2.01918,287,263 - 18,304,664 (+)NCBIT2T-CHM13v2.0
Pik3r2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,220,820 - 71,229,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,220,820 - 71,229,357 (-)EnsemblGRCm39 Ensembl
GRCm38870,768,176 - 70,776,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,768,176 - 70,776,713 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,292,080 - 73,300,611 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,697,168 - 73,705,670 (-)NCBIMGSCv36mm8
Celera873,329,482 - 73,338,028 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Pik3r2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,234,111 - 3,241,173 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,234,111 - 3,241,445 (-)NCBIChiLan1.0ChiLan1.0
PIK3R2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,013,784 - 23,031,178 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,022,130 - 22,039,523 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,632,265 - 17,649,664 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,608,470 - 18,624,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,611,179 - 18,624,177 (+)Ensemblpanpan1.1panPan2
PIK3R2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,826,037 - 44,838,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,826,339 - 44,836,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,739,520 - 44,751,946 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,311,340 - 45,323,770 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,311,351 - 45,321,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,548,506 - 44,560,928 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,958,996 - 44,971,420 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,234,496 - 45,247,145 (-)NCBIUU_Cfam_GSD_1.0
Pik3r2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,461,387 - 203,472,734 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,010,488 - 3,021,920 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,010,526 - 3,021,848 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3R2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,637,371 - 59,652,073 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,637,363 - 59,652,075 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,195,762 - 59,210,463 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,620,673 - 16,637,511 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,621,606 - 16,636,937 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,738,902 - 2,757,694 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3r2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,513,969 - 1,523,295 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,513,916 - 1,523,723 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3r2
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:304
Count of miRNA genes:191
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000026210
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
AI169383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,664,576 - 18,664,704 (+)MAPPERmRatBN7.2
Rnor_6.01620,415,492 - 20,415,619NCBIRnor6.0
Rnor_5.01620,272,560 - 20,272,687UniSTSRnor5.0
RGSC_v3.41619,170,161 - 19,170,288UniSTSRGSC3.4
Celera1618,856,816 - 18,856,943UniSTS
RH 3.4 Map16192.0UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026210   ⟹   ENSRNOP00000026210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,665,457 - 18,674,065 (+)Ensembl
Rnor_6.0 Ensembl1620,416,432 - 20,424,980 (+)Ensembl
RefSeq Acc Id: NM_022185   ⟹   NP_071521
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,699,497 - 18,708,045 (+)NCBI
mRatBN7.21618,665,517 - 18,674,065 (+)NCBI
Rnor_6.01620,416,432 - 20,424,980 (+)NCBI
Rnor_5.01620,273,500 - 20,282,051 (+)NCBI
RGSC_v3.41619,171,101 - 19,179,650 (+)RGD
Celera1618,857,756 - 18,866,282 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094436   ⟹   XP_038950364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,699,389 - 18,708,045 (+)NCBI
mRatBN7.21618,667,125 - 18,674,067 (+)NCBI
RefSeq Acc Id: XM_063275283   ⟹   XP_063131353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,699,400 - 18,708,045 (+)NCBI
RefSeq Acc Id: NP_071521   ⟸   NM_022185
- UniProtKB: Q63788 (UniProtKB/Swiss-Prot),   Q5FVS6 (UniProtKB/TrEMBL),   A6KA00 (UniProtKB/TrEMBL),   F7F9A3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026210   ⟸   ENSRNOT00000026210
RefSeq Acc Id: XP_038950364   ⟸   XM_039094436
- Peptide Label: isoform X1
- UniProtKB: Q63788 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131353   ⟸   XM_063275283
- Peptide Label: isoform X2
- UniProtKB: Q63788 (UniProtKB/Swiss-Prot),   A6KA00 (UniProtKB/TrEMBL),   F7F9A3 (UniProtKB/TrEMBL),   Q5FVS6 (UniProtKB/TrEMBL)
Protein Domains
Rho-GAP   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63788-F1-model_v2 AlphaFold Q63788 1-722 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700016
Promoter ID:EPDNEW_R10538
Type:initiation region
Name:Pik3r2_1
Description:phosphoinositide-3-kinase regulatory subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,416,374 - 20,416,434EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68341 AgrOrtholog
BioCyc Gene G2FUF-11808 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000019228 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026210.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381613 IMAGE-MGC_LOAD
InterPro PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85beta_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_cSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_nSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29741 UniProtKB/TrEMBL
MGC_CLONE MGC:108697 IMAGE-MGC_LOAD
NCBI Gene 29741 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K21B, ISOFORM B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pik3r2 PhenoGen
PRINTS PI3KINASEP85 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019228 RatGTEx
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC213981
UniProt A6K9Z9_RAT UniProtKB/TrEMBL
  A6KA00 ENTREZGENE, UniProtKB/TrEMBL
  F7F9A3 ENTREZGENE, UniProtKB/TrEMBL
  P85B_RAT UniProtKB/Swiss-Prot
  Q5FVS6 ENTREZGENE
  Q63788 ENTREZGENE
UniProt Secondary Q5FVS6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pik3r2  phosphoinositide-3-kinase regulatory subunit 2  Pik3r2  phosphoinositide-3-kinase, regulatory subunit 2 (beta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pik3r2  phosphoinositide-3-kinase, regulatory subunit 2 (beta)  Pik3r2  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Pik3r2  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)  Pik3r2  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Pik3r2  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2  Pik3r2  phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2  Name updated 629478 APPROVED
2002-06-10 Pik3r2  phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2  Pik3r2  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)  Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference