C8g (complement C8 gamma chain) - Rat Genome Database

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Gene: C8g (complement C8 gamma chain) Rattus norvegicus
Analyze
Symbol: C8g
Name: complement C8 gamma chain
RGD ID: 1309074
Description: Enables complement binding activity. Predicted to be involved in complement activation. Located in extracellular space. Orthologous to human C8G (complement C8 gamma chain); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Entamoebiasis pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: complement component 8, gamma polypeptide; complement component 8, gamma subunit; complement component C8 gamma chain; LOC296545
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,320,495 - 8,323,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,305,920 - 8,323,495 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,425,658 - 11,427,242 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,011,882 - 20,013,466 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,201,726 - 18,203,310 (-)NCBIRnor_WKY
Rnor_6.032,724,616 - 2,727,616 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,724,616 - 2,727,616 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,706,029 - 2,709,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,671,282 - 3,674,282 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,671,289 - 3,673,293 (-)NCBI
Celera33,145,600 - 3,148,600 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Biosynthesis of C8 by hepatocytes. Differential expression and intracellular association of the alpha-gamma- and beta-subunits. Ng SC and Sodetz JM, J Immunol. 1987 Nov 1;139(9):3021-7.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22516433   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
C8g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,320,495 - 8,323,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,305,920 - 8,323,495 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,425,658 - 11,427,242 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,011,882 - 20,013,466 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,201,726 - 18,203,310 (-)NCBIRnor_WKY
Rnor_6.032,724,616 - 2,727,616 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,724,616 - 2,727,616 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,706,029 - 2,709,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,671,282 - 3,674,282 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,671,289 - 3,673,293 (-)NCBI
Celera33,145,600 - 3,148,600 (-)NCBICelera
Cytogenetic Map3p13NCBI
C8G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,945,243 - 136,946,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9136,945,185 - 136,946,975 (+)EnsemblGRCh38hg38GRCh38
GRCh379139,839,695 - 139,841,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,959,534 - 138,961,240 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,115,549 - 137,117,256NCBI
Celera9110,353,929 - 110,355,658 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,299,182 - 109,300,910 (+)NCBIHuRef
CHM1_19139,988,376 - 139,990,104 (+)NCBICHM1_1
T2T-CHM13v2.09149,179,603 - 149,181,335 (+)NCBIT2T-CHM13v2.0
C8g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,388,662 - 25,391,919 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,388,663 - 25,391,731 (-)EnsemblGRCm39 Ensembl
GRCm38225,498,650 - 25,501,777 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,498,651 - 25,501,719 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,354,176 - 25,356,026 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,320,665 - 25,322,515 (-)NCBIMGSCv36mm8
Celera225,226,178 - 25,228,028 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.31NCBI
C8G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19136,974,094 - 136,976,345 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,974,556 - 136,976,152 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09108,003,376 - 108,005,648 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
C8G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,672,332 - 48,674,190 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,672,333 - 48,673,854 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,885,832 - 47,887,709 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,550,271 - 49,552,153 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,550,272 - 49,551,799 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,326,480 - 48,328,360 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,625,192 - 48,627,072 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,672,358 - 48,674,238 (-)NCBIUU_Cfam_GSD_1.0
C8g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,386,461 - 202,394,047 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669981,085 - 983,791 (-)EnsemblSpeTri2.0
SpeTri2.0 EnsemblNW_004936669985,295 - 988,726 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936669985,318 - 988,600 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C8G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21313,757,727 - 313,759,296 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103239599
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,233,119 - 1,246,410 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,240,152 - 1,246,392 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,054,794 - 4,067,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C8g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760937,871 - 939,466 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760937,871 - 939,655 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C8g
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000061904
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 35 3 35 3 13 16 1
Low 3 43 20 6 16 6 8 11 71 22 25 10 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020997   ⟹   ENSRNOP00000020997
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,312,413 - 8,315,392 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000061904   ⟹   ENSRNOP00000058619
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,320,495 - 8,323,495 (-)Ensembl
Rnor_6.0 Ensembl32,724,616 - 2,727,616 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080257   ⟹   ENSRNOP00000070671
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,312,426 - 8,315,014 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094611   ⟹   ENSRNOP00000088027
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,312,422 - 8,322,492 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095335   ⟹   ENSRNOP00000078212
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,305,920 - 8,322,492 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100264   ⟹   ENSRNOP00000079763
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,320,505 - 8,322,492 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107231   ⟹   ENSRNOP00000085280
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,319,713 - 8,322,492 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119757   ⟹   ENSRNOP00000078443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,309,076 - 8,322,492 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120022   ⟹   ENSRNOP00000092118
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,312,409 - 8,322,492 (-)Ensembl
RefSeq Acc Id: NM_001106555   ⟹   NP_001100025
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,320,495 - 8,323,495 (-)NCBI
Rnor_6.032,724,616 - 2,727,616 (-)NCBI
Rnor_5.032,706,029 - 2,709,029 (-)NCBI
RGSC_v3.433,671,282 - 3,674,282 (-)RGD
Celera33,145,600 - 3,148,600 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233581   ⟹   XP_006233643
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,320,503 - 8,322,504 (-)NCBI
Rnor_6.032,724,624 - 2,726,615 (-)NCBI
Rnor_5.032,706,029 - 2,709,029 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104709   ⟹   XP_038960637
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,320,503 - 8,322,356 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100025   ⟸   NM_001106555
- Sequence:
RefSeq Acc Id: XP_006233643   ⟸   XM_006233581
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000058619   ⟸   ENSRNOT00000061904
RefSeq Acc Id: XP_038960637   ⟸   XM_039104709
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000020997   ⟸   ENSRNOT00000020997
RefSeq Acc Id: ENSRNOP00000088027   ⟸   ENSRNOT00000094611
RefSeq Acc Id: ENSRNOP00000092118   ⟸   ENSRNOT00000120022
RefSeq Acc Id: ENSRNOP00000078443   ⟸   ENSRNOT00000119757
RefSeq Acc Id: ENSRNOP00000070671   ⟸   ENSRNOT00000080257
RefSeq Acc Id: ENSRNOP00000079763   ⟸   ENSRNOT00000100264
RefSeq Acc Id: ENSRNOP00000078212   ⟸   ENSRNOT00000095335
RefSeq Acc Id: ENSRNOP00000085280   ⟸   ENSRNOT00000107231
Protein Domains
Lipocln_cytosolic_FA-bd_dom

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPI8-F1-model_v2 AlphaFold D3ZPI8 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309074 AgrOrtholog
BioCyc Gene G2FUF-50444 BioCyc
Ensembl Genes ENSRNOG00000028701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000058619.2 UniProtKB/TrEMBL
  ENSRNOP00000078212.1 UniProtKB/TrEMBL
  ENSRNOP00000078443.1 UniProtKB/TrEMBL
  ENSRNOP00000079763 ENTREZGENE
  ENSRNOP00000079763.1 UniProtKB/TrEMBL
  ENSRNOP00000085280.1 UniProtKB/TrEMBL
  ENSRNOP00000088027.1 UniProtKB/TrEMBL
  ENSRNOP00000092118.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061904.5 UniProtKB/TrEMBL
  ENSRNOT00000094611.1 UniProtKB/TrEMBL
  ENSRNOT00000095335.1 UniProtKB/TrEMBL
  ENSRNOT00000100264 ENTREZGENE
  ENSRNOT00000100264.1 UniProtKB/TrEMBL
  ENSRNOT00000107231.1 UniProtKB/TrEMBL
  ENSRNOT00000119757.1 UniProtKB/TrEMBL
  ENSRNOT00000120022.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
InterPro A1-microglobln UniProtKB/TrEMBL
  C8G UniProtKB/TrEMBL
  Calycin UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd UniProtKB/TrEMBL
KEGG Report rno:296545 UniProtKB/TrEMBL
NCBI Gene 296545 ENTREZGENE
PANTHER PTHR47304 UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PhenoGen C8g PhenoGen
PRINTS A1MCGLOBULIN UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/TrEMBL
Superfamily-SCOP Calycin UniProtKB/TrEMBL
UniProt A0A8I5YC83_RAT UniProtKB/TrEMBL
  A0A8I5ZKU8_RAT UniProtKB/TrEMBL
  A0A8I5ZP72_RAT UniProtKB/TrEMBL
  A0A8I6A1Y6_RAT UniProtKB/TrEMBL
  A0A8I6A491_RAT UniProtKB/TrEMBL
  A0A8I6AEX7_RAT UniProtKB/TrEMBL
  D3ZPI8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 C8g  complement C8 gamma chain  C8g  complement component 8, gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 C8g  complement component 8, gamma polypeptide  C8g  complement component 8, gamma subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 C8g  complement component 8, gamma subunit  C8g_predicted  complement component 8, gamma polypeptide (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 C8g_predicted  complement component 8, gamma polypeptide (predicted)      Symbol and Name status set to approved 70820 APPROVED