Naip5 (NLR family, apoptosis inhibitory protein 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Naip5 (NLR family, apoptosis inhibitory protein 5) Rattus norvegicus
Analyze
Symbol: Naip5
Name: NLR family, apoptosis inhibitory protein 5
RGD ID: 1559914
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Predicted to be involved in innate immune response and negative regulation of apoptotic process. Predicted to be part of canonical inflammasome complex; PARTICIPATES IN NOD-like receptor signaling pathway; .
Type: protein-coding
RefSeq Status: MODEL
Previously known as: baculoviral IAP repeat-containing protein 1e; baculoviral IAP repeat-containing protein 1e-like; baculoviral IAP repeat-containing protein 1f; LOC294691; RGD1559914; similar to neuronal apoptosis inhibitory protein
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,289,785 - 33,342,807 (-)NCBIGRCr8
mRatBN7.2231,557,706 - 31,608,722 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,557,817 - 31,608,634 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0230,427,827 - 30,478,894 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0249,574,815 - 49,638,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,218,520 - 31,248,405 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera227,580,082 - 27,622,442 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Naip5
533 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:57
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000024485
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat

Markers in Region
D13Die25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2231,526,544 - 31,526,711 (+)MAPPERmRatBN7.2
mRatBN7.2231,575,356 - 31,575,523 (+)MAPPERmRatBN7.2
Rnor_6.0230,445,478 - 30,445,644NCBIRnor6.0
Rnor_6.0230,396,626 - 30,396,792NCBIRnor6.0
Rnor_5.0249,604,702 - 49,604,868UniSTSRnor5.0
Rnor_5.0249,555,793 - 49,555,959UniSTSRnor5.0
RGSC_v3.4231,185,417 - 31,185,583UniSTSRGSC3.4
RGSC_v3.4231,235,344 - 31,235,510UniSTSRGSC3.4
Celera227,597,693 - 27,597,859UniSTS
Celera227,548,743 - 27,548,909UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map2q14-q16UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000104486   ⟹   ENSRNOP00000095624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,557,817 - 31,608,634 (-)Ensembl
RefSeq Acc Id: XM_039103486   ⟹   XP_038959414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,293,181 - 33,322,517 (-)NCBI
mRatBN7.2231,559,096 - 31,588,101 (-)NCBI
RefSeq Acc Id: XM_039103487   ⟹   XP_038959415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,293,181 - 33,321,961 (-)NCBI
mRatBN7.2231,559,096 - 31,587,871 (-)NCBI
RefSeq Acc Id: XM_226743   ⟹   XP_226743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,289,785 - 33,342,807 (-)NCBI
mRatBN7.2231,557,706 - 31,608,722 (-)NCBI
Rnor_6.0230,427,827 - 30,478,893 (-)NCBI
Rnor_5.0249,574,815 - 49,638,298 (-)NCBI
RGSC_v3.4231,218,520 - 31,248,405 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_038959414 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959415 (Get FASTA)   NCBI Sequence Viewer  
  XP_226743 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095624
  ENSRNOP00000095624.1
RefSeq Acc Id: XP_226743   ⟸   XM_226743
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038959414   ⟸   XM_039103486
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038959415   ⟸   XM_039103487
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000095624   ⟸   ENSRNOT00000104486
Protein Domains
NACHT

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-54671 BioCyc
Ensembl Genes ENSRNOG00000065128 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000104486.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro BIR_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  Naip UniProtKB/TrEMBL
  NLRC4_HD UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:294691 UniProtKB/TrEMBL
NCBI Gene 294691 ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  PTHR46914 UniProtKB/TrEMBL
Pfam BIR UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
PhenoGen Naip5 PhenoGen
PRINTS DISEASERSIST UniProtKB/TrEMBL
PROSITE BIR_REPEAT_1 UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000065128 RatGTEx
SMART BIR UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6GLQ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Naip5  NLR family, apoptosis inhibitory protein 5  Naip5  NLR family, apoptosis inhibitory protein 5  Data merged from RGD:149736129 737654 PROVISIONAL
2021-08-09 Naip5  NLR family, apoptosis inhibitory protein 5      Symbol and Name status set to provisional 45752 PROVISIONAL
2010-04-23 Naip5  NLR family, apoptosis inhibitory protein 5  RGD1559914  similar to neuronal apoptosis inhibitory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1559914  similar to neuronal apoptosis inhibitory protein   RGD1559914_predicted  similar to neuronal apoptosis inhibitory protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559914_predicted  similar to neuronal apoptosis inhibitory protein (predicted)  LOC294691  similar to neuronal apoptosis inhibitory protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC294691  similar to neuronal apoptosis inhibitory protein      Symbol and Name status set to provisional 70820 PROVISIONAL