Mefv (MEFV innate immunity regulator, pyrin)

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Gene: Mefv (MEFV innate immunity regulator, pyrin) Rattus norvegicus

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Symbol:

Mefv

Name:

MEFV innate immunity regulator, pyrin

RGD ID:

61889

Description:

Predicted to enable actin binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in response to lipopolysaccharide and response to silicon dioxide. Predicted to be located in nucleus. Predicted to be part of canonical inflammasome complex and microtubule associated complex. Predicted to be active in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial mediterranean fever; and hematologic cancer (multiple). Orthologous to human MEFV (MEFV innate immunity regulator, pyrin); PARTICIPATES IN NOD-like receptor signaling pathway; INTERACTS WITH 2,4,6-trinitrotoluene; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC102552366; marenostrin; Mediterranean fever; MEFV innate immuity regulator, pyrin; MEFV, pyrin innate immunity regulator; pyrin; uncharacterized LOC102552366

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MEFV (MEFV innate immunity regulator, pyrin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Mefv (Mediterranean fever)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mefv (MEFV innate immunity regulator, pyrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MEFV (MEFV innate immunity regulator, pyrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MEFV (MEFV innate immunity regulator, pyrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mefv (MEFV innate immunity regulator, pyrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MEFV (MEFV innate immunity regulator, pyrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MEFV (MEFV innate immunity regulator, pyrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mefv (MEFV innate immunity regulator, pyrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Mefv (Mediterranean fever)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MEFV (MEFV innate immunity regulator, pyrin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:194990	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkey-219e21.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkey-18p12.4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch211-114c12.5	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch73-364h19.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch211-120g10.1	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	12,288,514 - 12,303,337 (+)	NCBI		GRCr8
mRatBN7.2	10	11,786,948 - 11,796,977 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	11,787,422 - 11,796,973 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	16,489,920 - 16,499,472 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	15,978,752 - 15,988,304 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	11,650,621 - 11,660,170 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	12,045,813 - 12,056,229 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	12,046,541 - 12,056,311 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	10,804,440 - 10,813,964 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	12,059,821 - 12,069,345 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	12,059,820 - 12,069,345 (+)	NCBI
Celera	10	10,738,861 - 10,748,385 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acne (ISO)

acute lymphoblastic leukemia (ISO)

acute myeloid leukemia (ISO)

asthma (ISO)

autistic disorder (ISO)

Behcet's disease (ISO)

brachydactyly (ISO)

Cachexia (ISO)

Cardiovascular Abnormalities (ISO)

Chediak-Higashi syndrome (ISO)

congenital heart disease (ISO)

congenital myopathy 1A (ISO)

cryptorchidism (ISO)

Developmental Disabilities (ISO)

epilepsy (ISO)

familial Mediterranean fever (ISO,ISS)

Familial Mediterranean Fever, Autosomal Dominant (ISO)

Fever (ISO)

genetic disease (ISO)

Hematologic Neoplasms (ISO)

Henoch-Schoenlein purpura (ISO)

hidradenitis suppurativa (ISO)

Hyperpigmentation (ISO)

idiopathic generalized epilepsy (ISO)

kidney failure (ISO)

lung disease (ISO)

Macrocephaly (ISO)

microcephaly (ISO)

multiple myeloma (ISO)

Muscle Hypotonia (ISO)

myelodysplastic syndrome (ISO)

neuronal ceroid lipofuscinosis (ISO)

neuropathy (ISO)

peripheral nervous system disease (ISO)

psoriatic arthritis (ISO)

pyoderma gangrenosum (ISO)

Rubinstein-Taybi syndrome (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

stereotypic movement disorder (ISO)

Sweet syndrome (ISO)

Syncope (ISO)

urticaria (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

antimycin A (ISO)

beclomethasone (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

buta-1,3-diene (ISO)

carbon nanotube (ISO)

Cuprizon (EXP)

Dibutyl phosphate (ISO)

furan (EXP)

gold atom (ISO)

gold(0) (ISO)

lipopolysaccharide (ISO)

nickel atom (ISO)

ochratoxin A (EXP)

ozone (ISO)

paracetamol (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

streptozocin (ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

inflammatory response (ISO,ISS)

innate immune response (IBA)

negative regulation of cytokine production involved in inflammatory response (ISO,ISS)

negative regulation of inflammatory response (ISO)

negative regulation of interleukin-1 beta production (ISO)

negative regulation of interleukin-12 production (ISO)

negative regulation of macrophage inflammatory protein 1 alpha production (ISO)

negative regulation of NLRP3 inflammasome complex assembly (ISO,ISS)

positive regulation of autophagy (ISO,ISS)

positive regulation of cysteine-type endopeptidase activity (ISO)

positive regulation of inflammatory response (ISO)

positive regulation of interleukin-1 beta production (ISO)

pyroptosome complex assembly (ISO,ISS)

regulation of gene expression (IBA)

regulation of interleukin-1 beta production (ISO,ISS)

response to lipopolysaccharide (IEP)

response to silicon dioxide (IEP)

response to type II interferon (ISO,ISS)

Cellular Component

autophagosome (IEA)

canonical inflammasome complex (ISO)

cytoplasm (IBA,ISO,ISS)

cytoplasmic vesicle (IEA)

cytosol (IBA,ISO)

lamellipodium (IEA)

microtubule (IEA)

microtubule associated complex (ISO,ISS)

nucleoplasm (IBA,ISO)

nucleus (ISO)

ruffle (IEA)

Molecular Function

actin binding (ISO,ISS)

identical protein binding (ISO)

protein binding (ISO)

ubiquitin protein ligase activity (IBA)

zinc ion binding (IEA,NAS)

Molecular Pathway Annotations Click to see Annotation Detail View

NOD-like receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Pulmonary manifestations and function tests in children genetically diagnosed with FMF.	Brik R, etal., Pediatr Pulmonol. 2003 Jun;35(6):452-5.
2.	Frequency of inherited variants in the MEFV gene in myelodysplastic syndrome and acute myeloid leukemia.	Celik S, etal., Int J Hematol. 2012 Mar;95(3):285-90. doi: 10.1007/s12185-012-1022-0. Epub 2012 Feb 18.
3.	The rate of MEFV gene mutations in hematolymphoid neoplasms.	Celik S, etal., Int J Immunogenet. 2010 Oct;37(5):387-91. doi: 10.1111/j.1744-313X.2010.00938.x. Epub 2010 May 27.
4.	Increased frequency of Mediterranean fever gene variants in multiple myeloma.	Celik S, etal., Oncol Lett. 2014 Oct;8(4):1735-1738. Epub 2014 Aug 4.
5.	Isolation, genomic organization, and expression analysis of the mouse and rat homologs of MEFV, the gene for familial mediterranean fever.	Chae JJ, etal., Mamm Genome 2000 Jun;11(6):428-35.
6.	Prevalence and significance of the MEFV gene mutations in childhood Henoch-Schonlein purpura without FMF symptoms.	Dogan CS, etal., Rheumatol Int. 2013 Feb;33(2):377-80. doi: 10.1007/s00296-012-2400-x. Epub 2012 Mar 27.
7.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
9.	MEFV E148Q polymorphism is associated with Henoch-Schonlein purpura in Chinese children.	He X, etal., Pediatr Nephrol. 2010 Oct;25(10):2077-82. doi: 10.1007/s00467-010-1582-2. Epub 2010 Jul 3.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Mediterranean Fever gene analysis in the azeri turk population with familial mediterranean Fever: evidence for new mutations associated with disease.	Mohammadnejad L and Farajnia S, Cell J. 2013 Summer;15(2):152-9. Epub 2013 Jul 2.
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	The M694V mutation in Armenian-Americans: a 10-year retrospective study of MEFV mutation testing for familial Mediterranean fever at UCLA.	Ong FS, etal., Clin Genet. 2013 Jul;84(1):55-9. doi: 10.1111/cge.12029. Epub 2012 Nov 7.
15.	Familial Mediterranean fever gene mutation frequencies and genotype-phenotype correlations in the Aegean region of Turkey.	Ozalkaya E, etal., Rheumatol Int. 2010 Mar 9.
16.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
17.	Familial Mediterranean fever gene and protection against asthma.	Rabinovitch E, etal., Ann Allergy Asthma Immunol. 2007 Dec;99(6):517-21.
18.	Exposure in vivo to silica or lipopolysaccharide produces transient or sustained upregulation, respectively, of PYPAF7 and MEFV genes in bronchoalveolar lavage cells in rats.	Rao KM and Meighan T, J Toxicol Environ Health A. 2006 Mar;69(6):481-90.
19.	GOA pipeline	RGD automated data pipeline
20.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
22.	Comprehensive gene review and curation	RGD comprehensive gene curation
23.	MEFV gene mutations in Egyptian children with Henoch-Schonlein purpura.	Salah S, etal., Pediatr Rheumatol Online J. 2014 Sep 9;12:41. doi: 10.1186/1546-0096-12-41. eCollection 2014.
24.	High Frequency of Inherited Variants in the MEFV Gene in Acute Lymphocytic Leukemia.	Sayan O, etal., Indian J Hematol Blood Transfus. 2011 Sep;27(3):164-8. doi: 10.1007/s12288-011-0095-x. Epub 2011 Jul 21.
25.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:11115844	PMID:11468188	PMID:16403826	PMID:17964261	PMID:19158676	PMID:20041150	PMID:22829933	PMID:25006247	PMID:26347139

Genomics

Comparative Map Data

Mefv
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	12,288,514 - 12,303,337 (+)	NCBI		GRCr8
mRatBN7.2	10	11,786,948 - 11,796,977 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	11,787,422 - 11,796,973 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	16,489,920 - 16,499,472 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	15,978,752 - 15,988,304 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	11,650,621 - 11,660,170 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	12,045,813 - 12,056,229 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	12,046,541 - 12,056,311 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	10,804,440 - 10,813,964 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	12,059,821 - 12,069,345 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	12,059,820 - 12,069,345 (+)	NCBI
Celera	10	10,738,861 - 10,748,385 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

MEFV
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	3,242,027 - 3,256,633 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	3,242,027 - 3,256,633 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	3,292,027 - 3,306,633 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	3,232,029 - 3,246,628 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	3,232,028 - 3,246,628	NCBI
Celera	16	3,497,690 - 3,512,281 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	3,261,626 - 3,276,174 (-)	NCBI		HuRef
CHM1_1	16	3,291,965 - 3,306,560 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	3,269,087 - 3,283,689 (-)	NCBI		T2T-CHM13v2.0

Mefv
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	3,524,838 - 3,536,073 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	3,525,082 - 3,535,961 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	3,706,974 - 3,718,211 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	3,707,218 - 3,718,097 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	3,707,215 - 3,718,124 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	3,622,443 - 3,633,325 (-)	NCBI		MGSCv36	mm8
Celera	16	4,345,682 - 4,356,386 (-)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI
cM Map	16	2.18	NCBI

Mefv
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	14,068,348 - 14,094,016 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	14,068,436 - 14,093,889 (+)	NCBI	ChiLan1.0	ChiLan1.0

MEFV
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	3,774,439 - 3,794,189 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	7,559,278 - 7,578,952 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	2,175,858 - 2,191,056 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	3,354,981 - 3,368,970 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	3,353,666 - 3,368,970 (-)	Ensembl	panpan1.1		panPan2

MEFV
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	37,964,776 - 37,984,830 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	37,970,608 - 37,983,737 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	6	38,276,711 - 38,296,162 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	38,282,480 - 38,295,669 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	37,962,758 - 37,982,210 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	37,935,294 - 37,954,719 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	38,410,844 - 38,430,317 (+)	NCBI		UU_Cfam_GSD_1.0

Mefv
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	105,728,858 - 105,739,439 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936694	970,706 - 980,605 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MEFV
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	38,934,573 - 38,948,609 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	40,322,567 - 40,336,494 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MEFV
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	2,971,323 - 2,991,501 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666068	27,841,180 - 27,856,544 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mefv
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624824	1,035,094 - 1,047,678 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624824	1,035,172 - 1,047,632 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mefv
45 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	403
Count of miRNA genes:	221
Interacting mature miRNAs:	249
Transcripts:	ENSRNOT00000011073
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
7387235	Uae41	Urinary albumin excretion QTL 41	5.26	0.1874	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	1	29497586	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6154182	15990232	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat

Markers in Region

AI177426

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	11,796,662 - 11,796,880 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	12,055,915 - 12,056,132	NCBI	Rnor6.0
Rnor_5.0	10	10,813,654 - 10,813,871	UniSTS	Rnor5.0
RGSC_v3.4	10	12,069,035 - 12,069,252	UniSTS	RGSC3.4
Celera	10	10,748,075 - 10,748,292	UniSTS
Cytogenetic Map	10	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	33	94	91	90	59	25	59	6	198	81	74	41	52	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597488	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597489	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086716	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF143410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011073 ⟹ ENSRNOP00000011073

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	12,046,701 - 12,056,222 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081191 ⟹ ENSRNOP00000070256

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	11,787,422 - 11,796,973 (+)	Ensembl
Rnor_6.0 Ensembl	10	12,046,541 - 12,056,311 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084004 ⟹ ENSRNOP00000070644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	12,046,736 - 12,055,314 (+)	Ensembl

RefSeq Acc Id:

NM_031634 ⟹ NP_113822

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	12,293,782 - 12,303,333 (+)	NCBI
mRatBN7.2	10	11,787,422 - 11,796,973 (+)	NCBI
Rnor_6.0	10	12,046,701 - 12,056,225 (+)	NCBI
Rnor_5.0	10	10,804,440 - 10,813,964 (+)	NCBI
RGSC_v3.4	10	12,059,821 - 12,069,345 (+)	RGD
Celera	10	10,738,861 - 10,748,385 (+)	RGD

Sequence:

show sequence

CACGTAGCTGGCTGTAGTCCTTCCTGGCCTGCATCATGGCCAATACCCGTGTTGACCATCTGCT
AAACACCCTGGAGGAGCTGCTGCCCTATGAACTAGAGAAATTCAAGTTTAAGTTGCACACCACC
AGCCTGGAGAAGGGCCACTCTAGGATCCCCCTGAGCCTCGTGAAGATGGCCAGGCCAATAAAGC
TGACCAGACTCCTGCTAACCTACTATGGGGAAGAATATGCTGTAAGGCTGACCCTGCAGATCCT
GCGGGCCACCAACCAGCGCCAACTAGCAGAGGAGCTTCACAAGGCCACAGGCCCAGAACATTTG
ACTGAAGAAAATGGAGTTGGCGGTTCTGTGCAGTCTTCTGCAGAGAATAAGGACAAGGGTGTGA
AGGGATCAGATGTCCTTGGAGAGGATGAGGCACAGCAGAACGATGATGAATCAGACATCCTGCC
ACCCATCCAGGCAGAAGTGGGGAAGGGGCCCCAGAAGAAATCACTGGCCAAAAGGAAGGATCAG
AGGGGCCCTGAGAGCCTGGACTCACAGACCAAGCCAGGGGCCAGGAGTGCAGCACCACTCTATA
GGAGAACCCTGGTGACCCAGTCCCCAGGGGACAAGGAGAACAGAGCGGGTGCTCAGACTCCGCA
GAATGCCCAGCTCTGCAGGGAGGCTGCAAGGAACTCTACAGCAATGTCCCAGGGAGGAGAGAGA
TCAAGAAGGCTGAAGTGTATTTGCCTTCAGGAAAGAAGCGACCCAGGAGTCTTGAAATTACCAC
TTACTCAAAAGAAGGAGAACCCCCAAATTCAGAAGCTCTTCCGACTCAAGAGGAAACAAGAAAT
GGCAGTCTCATTCGTACGAGAAACAGCCACCCTGAATGGAAGGACTACGGGGACTCTGGAAAAG
GGTGTAGGGATTCCAGAACATTCCATGATGCTGGATGAAGAAACATCCAGAAACATGTCTTCCA
AAATATCGTTGACTAGGGAGAAGAGATGCACTGCGTCATGGACAGAAAATGGAAACGGGGGTCC
AGAAACCCCAGAGACCTTGGGAGAGACAGTCAGCAGCATACTCTGTGACTCCTGCAGTCCAAAA
GTGCTGCTGTCATTAGGTGAAAAACTGGCCCAGACTCCAGAAGACCCAGCATCTTTAGGACAGG
CAGCTTCTAAAGGAAGGTCACGGGACAAGGTTGCATGCCCTCTTTGCCACACCCAAGGAGAACT
GCCTGCTAAGGCCTGTGTGCAAAGTTCCTGTAGCTGCTCGGTTGCTCCTGGGGACCCCAAGGCC
TCAGGCAGATGCTCCATATGCTTCCAGTGCCAAAGCTCGCGTGCAGGAAAGAGCTGTGAAGCCC
AGAGCCCCCAGTTCCTACCACAGTGCCCACGTCACATGAAGCAGGTGCAGCTGCTTTTCTGTGA
GGACCACAGGGAGCCCATCTGCCTCATCTGCAGGCTGAGCCAGGAGCATCAAGGACATCGAGTG
CGCCCCATAGAGGAGGCTGCACTACAGTACAAGGAGCAGATCCGGAAGCAGTTGGAGCGCCTGC
GNGAGATGAGGGGATATGTGGAGGAGCACAAGCTTCCGGCAGACAAGAAAGCAGAGGACTTCCT
GAAACAAACAGAAACTCAGAAACAGAGGATATCATGTCCGCTTGAGAAGCTATTCCAATTCCTG
GAGCAGCAAGAGCAACTCTTTGTGACCTGGCTGCAGGAGCTAGTCCAGACCATCGGCAAGGTCC
GAGAGACATACTACACCCAGGTTTCCCTACTGGATAAGCTGATTGGAGAACTAGAGGCCAAGCA
AGACCAGCCAGAGTGGGAGCTCATGCAGGACATTGGAGCCACCTTGCACAGGGCTGAGACGATG
ACTGCCTCTGAGCTGTTGGGCATTCCTCCAGGCGTTAAAGAAAAACTGCACCTGCTCTACCAGA
AATCAAAGTCCGCCGAGAAGAATATGCAGCGTTTCTCAGAAATGCTGGGCTCCGAAATGGCATT
CAGCGCTTCAGATGTAGCAACACGGGAAGGGTGCAGGCCTAGCACAACCAAGGCCCAGGCCTTG
ATCCCCACCGTTCACCTAAAGTGTGATGGTGCACACACACAGGATTTCGATGTAATACTTTGCG
CAGAGCTGGAAGCTGGAGGATCAGAACCTCAAGATTACCTTCATCCATCGTCAGCTCAAGACAC
ACCTGAGCTACACGAGATCCATTCTCAGAACAACAAAAGAAAATTTAAATCTTTCCTGAAGTGG
AAACCTTCCTTCTCCAGAACCGACAGGTGCTTAAGAACATGCTGGTAAATGCCTAAATCAAGGC
AAGTACTGGCTTTGGTACACCGGGTCCCTGTATGTTCCTGTCCCCTACCGCAATCTCAGTAAAC
TCCCTCTTCCTTAGATTGGGAGCACCTTGGGAGAAGCCCACACATCCCCATCCCAGCTAGGTCT
TCTTCTTCCTGCAGTTGTCGTGACTGGGACCTAGCAGCTGTTCACCCCAGCCTCATCTTCTGTG
GTGATACGAAGAGTGCACGGACCTGCTGCCTGACACTCTCCAGAGGTTCTAAAGTTACATCACC
ATGCTGGGGACTACTCCTGTCTTGGACTTCCAGCGGCTGTCACTGGGARGTGGAGTATGGAGAC
AAGACAGTTCAGAGTCCCAGGAACTTGCAAGCGCTCTGGCGAGCAGGAAGGGGACTATAACTCA
GTGGAGAATGGCTCCTGGTGGTAATAATAGCAACGCAACAGGAAGGCACATTTCTCCAGCCTGT
GAATGAGGGTGGCCCCAAGCAGGCGGGCAGCTTTCTAGACTACACAGCTAGGAGCAACATGACA
TGTACCTGGCCTCTGGCTTCTCCCCTCCAGTTCCTGTCAACCTGCCTTTAACCCTGGGGACATG
AAGAACAACATAGCTCTTTGGACCCTCAGTCCTGCCAGTGACCAGATACTTCACCGAGCGCCCA
ACACTGTGCCAACATTCTGGCTTATGCCTCACATTCATGCACTCGGAAGTCATTAAAAAGGTGT
CAGCTGGTGCAAGGAATGGAATGAATAGGAAGATAATAAACTGAGAGGCTGAGGCAGGATGGTA
CCCGTGAGTTTGAGTCTAACTGGATGGATTCGGGTTACTCTGACTGGGGTCCAGCCGTCAAAAA
GAAAAAACAATATTGTACTTGTATTATTTAGTACTATTATTGCTGTAATAAAATATTCTGACAA
AACAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017597488 ⟹ XP_017452977

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	12,288,514 - 12,303,337 (+)	NCBI
mRatBN7.2	10	11,786,949 - 11,796,977 (+)	NCBI
Rnor_6.0	10	12,045,813 - 12,056,229 (+)	NCBI

Sequence:

show sequence

TTTTTCAGTTATGCCTACAGGCCAATCTGATGGAGGCGGTTTTTCAGTTCAGGTTCCTCTTCCG
GAACATGTCAGGTTGGCCGCTAACATCAGTTACCACAGATATCTAGGATGTTTAGAAAGGTAGA
TAATAACACTTTCCATTTATTATCAAATGATTGAGAAAAAAGTAAAGAAGGCTGCAGAAACTGT
ACCACAGAAGCATCTCAAGCACCCTAGGGAGAGCCTAGAGAATATGTGTCAAAGGGCACAGGGA
AGAGCACCCTGACTCCCAGGGAGCAAGGGTCAAGTCAGCCGTGGGAACAGATGCATAAGAATTC
TGGTGACAACCGTGGCCCTCACGTCCCCGTTTGAAGACTTTACGCTGCTGGATAGACCGGACAT
GAACCGGGCAGACTGGAAAGGTGTTGCAGTGCCTTTCTGGCTTCTGCTTTCTTGAGAAGGCCTG
GGCAAAGCAGACAGTGTTCATTGCTGTCTGTTCCTTCACCTGCCATTGGCCCTGGAGGTGTATA
AACCCCAAGAGTTGAAAGAGAGCCAACTCCACGAAAGATCATCGTTCTCCCTCTCTTCCACAGC
CCAGGGTCCTGAGAGCAAGCAAGAGCACAAGAGCAGCAGGAGGGTCTGGCTCTCAATCCCAGAA
CCTCCCTAGAGTCTGTCCTGCCTTTTGTTCGACCAGGACTTAGGCTGGCACAGTGGAGATCTCC
TCATTGGAAAAGGCTGGATCCTCAAAGAAAGCATGCAGCGGGCCAGACCTTGGACACGCCCTCA
TCGCTACTCTCAGTTCCCACCAAAGCCTATGTGCTTCCTGTGCCTTGTCCGTTATTTCACAAGC
TGTTTCTTGCTTGTTCTGAAGTTGCAGGAGAGAAGTCTTCATTTTCTGTCAGAAGCCACGTAGC
TGGCTGTAGTCCTTCCTGGCCTGCATCATGGCCAATACCCGTGTTGACCATCTGCTAAACACCC
TGGAGGAGCTGCTGCCCTATGAACTAGAGAAATTCAAGTTTAAGTTGCACACCACCAGCCTGGA
GAAGGGCCACTCTAGGATCCCCCTGAGCCTCGTGAAGATGGCCAGGCCAATAAAGCTGACCAGA
CTCCTGCTAACCTACTATGGGGAAGAATATGCTGTAAGGCTGACCCTGCAGATCCTGCGGGCCA
CCAACCAGCGCCAACTAGCAGAGGAGCTTCACAAGGCCACAGGCCCAGAACATTTGACTGAAGA
AAATGGAGTTGGCGGTTCTGTGCAGTCTTCTGCAGAGAATAAGGACAAGGGTGTGAAGGGATCA
GATGTCCCTGGAGAGGATGAGGCACAGCAGAACGATGATGAATCAGACATCCTGCCACCCATCC
AGGCAGAAGTGGGGAAGGGGCCCCAGAAGAAATCACTGGCCAAAAGGAAGGATCAGAGGGGCCC
TGAGAGCCTGGACTCACAGACCAAGCCAGGGGCCAGGAGTGCAGCACCACTCTATAGGAGAACC
CTGGTGACCCAGTCCCCAGGGGACAAGGAGAACAGAGCGGGTGCTCAGCTCCGCAGGAATGCCA
GCTCTGCAGGGAGGCTGCAAGGACTCTACAGCAATGTCCCAGGGAGGAGAGAGATCAAGAAGGC
TGAAGTGTATTTGCCTTCAGGAAAGAAGCGACCCAGGAGTCTTGAAATTACCACTTACTCAAAA
GAAGGAGAACCCCCAAATTCAGAAGCTCTTCCGACTCAAGAGGAAACAAGAAATGGCAGTCTCA
TTCGTACGAGAACAGCCACCCTGAATGGAAGGACTACGGGGACTCTGGAAAAGGGTGTAGGGAT
TCCAGAACATTCCATGATGCTGGATGAAGAAACATCCAGAAACATGTCTTCCAAAATATCGTTG
ACTAGGGAGAAGAGATGCACTGCGTCATGGACAGAAAATGGAAACGGGGGTCCAGAAACCCCAG
AGACCTTGGGAGAGACAGTCAGCAGCATACTCTGTGACTCCTGCAGTCCAAAAGTGCTGCTGTC
ATTAGGTGAAAAACTGGCCCAGACTCCAGAAGACCCAGCATCTTTAGGACAGGCAGCTTCTAAA
GGTATCCTCCCCCAGCGCTCCAGAAAACGCGATGCAGGCCCAGAAAAATGCACATTTACACATC
TTGCACAACAAGTTGCATCAAACTTCGGAAGGTCACGGGACAAGGTTGCATGCCCTCTTTGCCA
CACCCAAGGAGAACTGCCTGCTAAGGCCTGTGTGCAAAGTTCCTGTAGCTGCTCGGTTGCTCCT
GGGGACCCCAAGGCCTCAGGCAGACACTCCATATGCTTCCAGTGCCAAAGCTCGCGTGCAGGAA
AGAGCTGTGAAGCCCAGAGCCCCCAGTTCCTACCACAGTGCCCACGTCACATGAAGCAGGTGCA
GCTGCTCTTCTGTGAGGACCACAGGGAGCCCATCTGCCTCATCTGCAGGCTGAGCCAGGAGCAT
CAAGGACATCGAGTGCGCCCCATAGAGGAGGCTGCACTACAGTACAAGGAGCAGATCCGGAAGC
AGTTGGAGCGCCTGCGGGAGATGAGGGGATATGTGGAGGAGCACAAGCTTCCGGCAGACAAGAA
AGCAGAGGACTTCCTGAAACAAACAGAAACTCAGAAACAGAGGATATCATGTCCGCTTGAGAAG
CTATTCCAATTCCTGGAGCAGCAAGAGCAACTCTTTGTGACCTGGCTGCAGGAGCTAGTCCAGA
CCATCGGCAAGGTCCGAGAGACATACTACACCCAGGTTTCCCTACTGGATAAGCTGATTGGAGA
ACTAGAGGCCAAGCAAGACCAGCCAGAGTGGGAGCTCATGCAGGACATTGGAGCCACCTTGCAC
AGGGCTGAGACGATGACTGCCTCTGAGCTGTTGGGCATTCCTCCAGGCGTTAAAGAAAAACTGC
ACCTGCTCTACCAGAAATCAAAGTCCGCCGAGAAGAATATGCAGCGTTTCTCAGAAATGCTGGG
CTCCGAAATGGCATTCAGCGCTTCAGATGTAGCAACACGGGAAGGGTGCAGGCCTAGCACAACC
AAGGCCCAGGCCTTGATCCCCACCGTTCACCTAAAGTGTGATGGTGCACACACACAGGATTTCG
ATGTAATACTTTGCGCAGAGCTGGAAGCTGGAGGATCAGAACCTCAAGATTACCTTCATCCGTC
GTCAGCTCAAGACACACCTGAGCTACACGAGATCCATTCTCAGAACAACAAAAGAAAATTTAAA
TCTTTCCTGAAGTGGAAACCTTCCTTCTTGTCGTGACTGGGACCTAGCAGCTGTTCACCCCAGC
CTCATCTTCTGTGGTGATACGAAGAGTGCACGGACCTGCTGCCTGACACTCTCCAGAGGTTCTA
AAGTTACATCACCATGCTGGGGACTACTCCTGTCTTGGACTCCAGCGGCTGTCACTGGGAGGTG
GAGTATGGAGACAAGACAGTTCAGAGTCCCAGGAACTTGCAACGCTCTGGCGAGCAGGAAGGGG
ACTATAACTCAGTGGAGAATGGCTCCTGGTGGTAATAATAGCAACGCAACAGGAAGGCACATTT
CTCCAGCCTGTGAATGAGGGTGGCCCCAAGCAGGCGGGCAGCTTTCTAGACTACACAGCTAGGA
GCAACATGACATGTACCTGGCCTCTGGCTTCTCCCCTCCAGTTCCTGTCAACCTGCCTTTAACC
CTGGGGACATGAAGAACAACATAGCTCTTTGGACCCTCAGTCCTGCCAGTGACCAGATACTTCA
CCGAGCGCCCAACACTGTGCCAACATTCTGGCTTATGCCTCACATTCATGCACTCGGAAGTCAT
TAAAAAGGTGTCAGCTGGTGCAAGGAATGGAATGAATAGGAAGATAATAAACTGAGAGGCTGAG
GCAGGATGGTACCCGTGAGTTTGAGTCTAACTGGATGGATTCGGGTTACTCTGACTGGGGTCCA
GCCGTCAAAAAGAAAAAACAATATTGTACTTGTATTATTTAGTACTATTATTGCTGTAATAAAA
TATTCTGACAAAGCAA

hide sequence

RefSeq Acc Id:

XM_039086716 ⟹ XP_038942644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	12,288,514 - 12,303,337 (+)	NCBI
mRatBN7.2	10	11,786,948 - 11,796,977 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_113822	(Get FASTA)	NCBI Sequence Viewer
	XP_017452977	(Get FASTA)	NCBI Sequence Viewer
	XP_038942644	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF03767	(Get FASTA)	NCBI Sequence Viewer
	EDL96326	(Get FASTA)	NCBI Sequence Viewer
	EDL96327	(Get FASTA)	NCBI Sequence Viewer
	EDL96328	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070256.2
GenBank Protein	Q9JJ25	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113822 ⟸ NM_031634

- UniProtKB:

Q9JJ25 (UniProtKB/Swiss-Prot), A0A0G2JYG3 (UniProtKB/Swiss-Prot), A6K4V5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MANTRVDHLLNTLEELLPYELEKFKFKLHTTSLEKGHSRIPLSLVKMARPIKLTRLLLTYYGEE
YAVRLTLQILRATNQRQLAEELHKATGPEHLTEENGVGGSVQSSAENKDKGVKGSDVLGEDEAQ
QNDDESDILPPIQAEVGKGPQKKSLAKRKDQRGPESLDSQTKPGARSAAPLYRRTLVTQSPGDK
ENRAGAQTPQNAQLCREAARNSTAMSQGGERSRRLKCICLQERSDPGVLKLPLTQKKENPQIQK
LFRLKRKQEMAVSFVRETATLNGRTTGTLEKGVGIPEHSMMLDEETSRNMSSKISLTREKRCTA
SWTENGNGGPETPETLGETVSSILCDSCSPKVLLSLGEKLAQTPEDPASLGQAASKGRSRDKVA
CPLCHTQGELPAKACVQSSCSCSVAPGDPKASGRCSICFQCQSSRAGKSCEAQSPQFLPQCPRH
MKQVQLLFCEDHREPICLICRLSQEHQGHRVRPIEEAALQYKEQIRKQLERLREMRGYVEEHKL
PADKKAEDFLKQTETQKQRISCPLEKLFQFLEQQEQLFVTWLQELVQTIGKVRETYYTQVSLLD
KLIGELEAKQDQPEWELMQDIGATLHRAETMTASELLGIPPGVKEKLHLLYQKSKSAEKNMQRF
SEMLGSEMAFSASDVATREGCRPSTTKAQALIPTVHLKCDGAHTQDFDVILCAELEAGGSEPQD
YLHPSSAQDTPELHEIHSQNNKRKFKSFLKWKPSFSRTDRCLRTCW

hide sequence

RefSeq Acc Id:	XP_017452977 ⟸ XM_017597488
- Peptide Label:	isoform X2
- UniProtKB:	Q9JJ25 (UniProtKB/Swiss-Prot), A0A0G2JYG3 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MANTRVDHLLNTLEELLPYELEKFKFKLHTTSLEKGHSRIPLSLVKMARPIKLTRLLLTYYGEE YAVRLTLQILRATNQRQLAEELHKATGPEHLTEENGVGGSVQSSAENKDKGVKGSDVPGEDEAQ QNDDESDILPPIQAEVGKGPQKKSLAKRKDQRGPESLDSQTKPGARSAAPLYRRTLVTQSPGDK ENRAGAQLRRNASSAGRLQGLYSNVPGRREIKKAEVYLPSGKKRPRSLEITTYSKEGEPPNSEA LPTQEETRNGSLIRTRTATLNGRTTGTLEKGVGIPEHSMMLDEETSRNMSSKISLTREKRCTAS WTENGNGGPETPETLGETVSSILCDSCSPKVLLSLGEKLAQTPEDPASLGQAASKGILPQRSRK RDAGPEKCTFTHLAQQVASNFGRSRDKVACPLCHTQGELPAKACVQSSCSCSVAPGDPKASGRH SICFQCQSSRAGKSCEAQSPQFLPQCPRHMKQVQLLFCEDHREPICLICRLSQEHQGHRVRPIE EAALQYKEQIRKQLERLREMRGYVEEHKLPADKKAEDFLKQTETQKQRISCPLEKLFQFLEQQE QLFVTWLQELVQTIGKVRETYYTQVSLLDKLIGELEAKQDQPEWELMQDIGATLHRAETMTASE LLGIPPGVKEKLHLLYQKSKSAEKNMQRFSEMLGSEMAFSASDVATREGCRPSTTKAQALIPTV HLKCDGAHTQDFDVILCAELEAGGSEPQDYLHPSSAQDTPELHEIHSQNNKRKFKSFLKWKPSF LS hide sequence

Ensembl Acc Id:

ENSRNOP00000070256 ⟸ ENSRNOT00000081191

Ensembl Acc Id:

ENSRNOP00000070644 ⟸ ENSRNOT00000084004

Ensembl Acc Id:

ENSRNOP00000011073 ⟸ ENSRNOT00000011073

RefSeq Acc Id:	XP_038942644 ⟸ XM_039086716
- Peptide Label:	isoform X1
- UniProtKB:	Q9JJ25 (UniProtKB/Swiss-Prot), A0A0G2JYG3 (UniProtKB/Swiss-Prot), A0A0G2JXG0 (UniProtKB/TrEMBL)

Protein Domains

B box-type Pyrin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JJ25-F1-model_v2	AlphaFold	Q9JJ25	1-747	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61889	AgrOrtholog
BioCyc Gene	G2FUF-25986	BioCyc
Ensembl Genes	ENSRNOG00000008134	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000081191.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	DAPIN	UniProtKB/TrEMBL
	DEATH-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pyrin	UniProtKB/Swiss-Prot
	TRIM/RBCC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_B-box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:58923	UniProtKB/Swiss-Prot
NCBI Gene	58923	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE TRIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR24103:SF606	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PAAD_DAPIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-B_box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mefv	PhenoGen
PROSITE	DAPIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_BBOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008134	RatGTEx
SMART	BBOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PYRIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	B-box zinc-binding domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DEATH_like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC233290
UniProt	A0A0G2JXG0	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2JYG3	ENTREZGENE
	A6K4V4_RAT	UniProtKB/TrEMBL
	A6K4V5	ENTREZGENE, UniProtKB/TrEMBL
	A6K4V6_RAT	UniProtKB/TrEMBL
	MEFV_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A0A0G2JYG3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-10-27	Mefv	MEFV innate immunity regulator, pyrin	Mefv	MEFV innate immuity regulator, pyrin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2019-04-10	Mefv	MEFV innate immuity regulator, pyrin	Mefv	MEFV, pyrin innate immunity regulator	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2017-01-17	Mefv	MEFV, pyrin innate immunity regulator	Mefv	Mediterranean fever	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-07-29	Mefv	Mediterranean fever	LOC102552366	uncharacterized LOC102552366	Data merged from RGD:7667673	737654	PROVISIONAL
2013-12-18	LOC102552366	uncharacterized LOC102552366			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-09-10	Mefv	Mediterranean fever		Mediterranean fever	Name updated	1299863	APPROVED
2002-06-10	Mefv	Mediterranean fever			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains a bZIP basic domain, a B-box zinc finger domain, an a-helical or potential coiled-coil domain, and two nuclear localization signals; lacks the B30.2 (rfp) domain of human homolog	61661

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)