Symbol:
Mefv
Name:
MEFV innate immunity regulator, pyrin
RGD ID:
61889
Description:
Predicted to enable actin binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in response to lipopolysaccharide and response to silicon dioxide. Predicted to be located in nucleus and plasma membrane. Predicted to be part of canonical inflammasome complex and microtubule associated complex. Predicted to be active in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in several diseases, including IgA vasculitis; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to human MEFV (MEFV innate immunity regulator, pyrin); PARTICIPATES IN NOD-like receptor signaling pathway; INTERACTS WITH 2,4,6-trinitrotoluene; 6-propyl-2-thiouracil; acetamide.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC102552366; marenostrin; Mediterranean fever; MEFV innate immuity regulator, pyrin; MEFV, pyrin innate immunity regulator; pyrin; uncharacterized LOC102552366
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
MEFV (MEFV innate immunity regulator, pyrin) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):
Mefv (Mediterranean fever) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Mefv (MEFV innate immunity regulator, pyrin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
MEFV (MEFV innate immunity regulator, pyrin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
MEFV (MEFV innate immunity regulator, pyrin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Mefv (MEFV innate immunity regulator, pyrin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
MEFV (MEFV innate immunity regulator, pyrin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
MEFV (MEFV innate immunity regulator, pyrin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Mefv (MEFV innate immunity regulator, pyrin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Mefv (Mediterranean fever)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
MEFV (MEFV innate immunity regulator, pyrin)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
zgc:194990
Alliance
DIOPT (Ensembl Compara|PANTHER)
Danio rerio (zebrafish):
si:dkey-219e21.2
Alliance
DIOPT (Ensembl Compara|PANTHER)
Danio rerio (zebrafish):
si:dkey-18p12.4
Alliance
DIOPT (Ensembl Compara|PANTHER)
Danio rerio (zebrafish):
si:ch211-114c12.5
Alliance
DIOPT (Ensembl Compara|PANTHER)
Danio rerio (zebrafish):
si:ch73-364h19.2
Alliance
DIOPT (Ensembl Compara|PANTHER)
Danio rerio (zebrafish):
si:ch211-120g10.1
Alliance
DIOPT (Ensembl Compara|PANTHER)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 10 12,288,514 - 12,303,337 (+) NCBI GRCr8 mRatBN7.2 10 11,786,948 - 11,796,977 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 10 11,787,422 - 11,796,973 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 10 16,489,920 - 16,499,472 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 10 15,978,752 - 15,988,304 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 10 11,650,621 - 11,660,170 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 10 12,045,813 - 12,056,229 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 10 12,046,541 - 12,056,311 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 10 10,804,440 - 10,813,964 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 10 12,059,821 - 12,069,345 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 10 12,059,820 - 12,069,345 (+) NCBI Celera 10 10,738,861 - 10,748,385 (+) NCBI Celera Cytogenetic Map 10 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - KEGG (archival)
1.
Pulmonary manifestations and function tests in children genetically diagnosed with FMF.
Brik R, etal., Pediatr Pulmonol. 2003 Jun;35(6):452-5.
2.
Frequency of inherited variants in the MEFV gene in myelodysplastic syndrome and acute myeloid leukemia.
Celik S, etal., Int J Hematol. 2012 Mar;95(3):285-90. doi: 10.1007/s12185-012-1022-0. Epub 2012 Feb 18.
3.
The rate of MEFV gene mutations in hematolymphoid neoplasms.
Celik S, etal., Int J Immunogenet. 2010 Oct;37(5):387-91. doi: 10.1111/j.1744-313X.2010.00938.x. Epub 2010 May 27.
4.
Increased frequency of Mediterranean fever gene variants in multiple myeloma.
Celik S, etal., Oncol Lett. 2014 Oct;8(4):1735-1738. Epub 2014 Aug 4.
5.
Isolation, genomic organization, and expression analysis of the mouse and rat homologs of MEFV, the gene for familial mediterranean fever.
Chae JJ, etal., Mamm Genome 2000 Jun;11(6):428-35.
6.
Prevalence and significance of the MEFV gene mutations in childhood Henoch-Schonlein purpura without FMF symptoms.
Dogan CS, etal., Rheumatol Int. 2013 Feb;33(2):377-80. doi: 10.1007/s00296-012-2400-x. Epub 2012 Mar 27.
7.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.
Rat ISS GO annotations from GOA human gene data--August 2006
GOA data from the GO Consortium
9.
MEFV E148Q polymorphism is associated with Henoch-Schonlein purpura in Chinese children.
He X, etal., Pediatr Nephrol. 2010 Oct;25(10):2077-82. doi: 10.1007/s00467-010-1582-2. Epub 2010 Jul 3.
10.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
11.
Mediterranean Fever gene analysis in the azeri turk population with familial mediterranean Fever: evidence for new mutations associated with disease.
Mohammadnejad L and Farajnia S, Cell J. 2013 Summer;15(2):152-9. Epub 2013 Jul 2.
12.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
14.
The M694V mutation in Armenian-Americans: a 10-year retrospective study of MEFV mutation testing for familial Mediterranean fever at UCLA.
Ong FS, etal., Clin Genet. 2013 Jul;84(1):55-9. doi: 10.1111/cge.12029. Epub 2012 Nov 7.
15.
Familial Mediterranean fever gene mutation frequencies and genotype-phenotype correlations in the Aegean region of Turkey.
Ozalkaya E, etal., Rheumatol Int. 2010 Mar 9.
16.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
17.
Familial Mediterranean fever gene and protection against asthma.
Rabinovitch E, etal., Ann Allergy Asthma Immunol. 2007 Dec;99(6):517-21.
18.
Exposure in vivo to silica or lipopolysaccharide produces transient or sustained upregulation, respectively, of PYPAF7 and MEFV genes in bronchoalveolar lavage cells in rats.
Rao KM and Meighan T, J Toxicol Environ Health A. 2006 Mar;69(6):481-90.
19.
GOA pipeline
RGD automated data pipeline
20.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
22.
Comprehensive gene review and curation
RGD comprehensive gene curation
23.
MEFV gene mutations in Egyptian children with Henoch-Schonlein purpura.
Salah S, etal., Pediatr Rheumatol Online J. 2014 Sep 9;12:41. doi: 10.1186/1546-0096-12-41. eCollection 2014.
24.
High Frequency of Inherited Variants in the MEFV Gene in Acute Lymphocytic Leukemia.
Sayan O, etal., Indian J Hematol Blood Transfus. 2011 Sep;27(3):164-8. doi: 10.1007/s12288-011-0095-x. Epub 2011 Jul 21.
25.
Tentative Sequence Identification Numbers
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Mefv Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 10 12,288,514 - 12,303,337 (+) NCBI GRCr8 mRatBN7.2 10 11,786,948 - 11,796,977 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 10 11,787,422 - 11,796,973 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 10 16,489,920 - 16,499,472 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 10 15,978,752 - 15,988,304 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 10 11,650,621 - 11,660,170 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 10 12,045,813 - 12,056,229 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 10 12,046,541 - 12,056,311 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 10 10,804,440 - 10,813,964 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 10 12,059,821 - 12,069,345 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 10 12,059,820 - 12,069,345 (+) NCBI Celera 10 10,738,861 - 10,748,385 (+) NCBI Celera Cytogenetic Map 10 q12 NCBI
MEFV Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 16 3,242,027 - 3,256,633 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 16 3,242,027 - 3,256,633 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 16 3,292,027 - 3,306,633 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 16 3,232,029 - 3,246,628 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 16 3,232,028 - 3,246,628 NCBI Celera 16 3,497,690 - 3,512,281 (-) NCBI Celera Cytogenetic Map 16 p13.3 NCBI HuRef 16 3,261,626 - 3,276,174 (-) NCBI HuRef CHM1_1 16 3,291,965 - 3,306,560 (-) NCBI CHM1_1 T2T-CHM13v2.0 16 3,269,087 - 3,283,689 (-) NCBI T2T-CHM13v2.0
Mefv Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 16 3,524,838 - 3,536,073 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 16 3,525,082 - 3,535,961 (-) Ensembl GRCm39 Ensembl GRCm38 16 3,706,974 - 3,718,211 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 16 3,707,218 - 3,718,097 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 16 3,707,215 - 3,718,124 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 16 3,622,443 - 3,633,325 (-) NCBI MGSCv36 mm8 Celera 16 4,345,682 - 4,356,386 (-) NCBI Celera Cytogenetic Map 16 A1 NCBI cM Map 16 2.18 NCBI
Mefv Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955442 14,068,348 - 14,094,016 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955442 14,068,436 - 14,093,889 (+) NCBI ChiLan1.0 ChiLan1.0
MEFV Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 18 3,774,439 - 3,794,189 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 16 7,559,278 - 7,578,952 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 16 2,175,858 - 2,191,056 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 16 3,354,981 - 3,368,970 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 16 3,353,666 - 3,368,970 (-) Ensembl panpan1.1 panPan2
MEFV Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 6 37,964,776 - 37,984,830 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 6 37,970,608 - 37,983,737 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 ROS_Cfam_1.0 6 38,276,711 - 38,296,162 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 6 38,282,480 - 38,295,669 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 6 37,962,758 - 37,982,210 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 6 37,935,294 - 37,954,719 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 6 38,410,844 - 38,430,317 (+) NCBI UU_Cfam_GSD_1.0
Mefv
MEFV
MEFV
Mefv
.
Predicted Target Of
Count of predictions: 403 Count of miRNA genes: 221 Interacting mature miRNAs: 249 Transcripts: ENSRNOT00000011073 Prediction methods: Microtar, Miranda, Rnahybrid Result types: miRGate_prediction
9589136 Insul27 Insulin level QTL 27 10.46 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 10 11474010 56474010 Rat 8662860 Vetf10 Vascular elastic tissue fragility QTL 10 artery integrity trait (VT:0010639) number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562) 10 6154182 73453136 Rat 2313066 Bss63 Bone structure and strength QTL 63 1.4 0.0001 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) 10 5387014 50387014 Rat 631554 Bp133 Blood pressure QTL 133 0.005 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 10 743364 63851208 Rat 2313064 Bmd71 Bone mineral density QTL 71 0.9 0.0001 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) 10 5387014 50387014 Rat 70223 Bp57 Blood pressure QTL 57 5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 10 1 80676123 Rat 634329 Pia15 Pristane induced arthritis QTL 15 3.1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 1 24158324 Rat 1578761 Stresp21 Stress response QTL 21 3.3 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 10 6375746 51375746 Rat 2293680 Bss40 Bone structure and strength QTL 40 5.66 0.0001 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) 10 1 35225947 Rat 7387235 Uae41 Urinary albumin excretion QTL 41 5.26 0.1874 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 10 1 29497586 Rat 2298544 Neuinf9 Neuroinflammation QTL 9 4.6 nervous system integrity trait (VT:0010566) spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126) 10 5801990 62146030 Rat 10401803 Kidm50 Kidney mass QTL 50 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 10 418344 45418344 Rat 737820 Alc9 Alcohol consumption QTL 9 2.2 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) 10 5144027 19233348 Rat 2313081 Bss64 Bone structure and strength QTL 64 1.3 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 10 5387014 50387014 Rat 631828 Alc5 Alcohol consumption QTL 5 2.4 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) 10 5144027 17245662 Rat 634327 Hc4 Hypercalciuria QTL 4 2.4 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) 10 1 38328221 Rat 2313095 Bss62 Bone structure and strength QTL 62 1.5 0.0001 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) 10 5387014 50387014 Rat 631660 Hcar1 Hepatocarcinoma resistance QTL 1 3.4 0.0001 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) 10 6154182 15990232 Rat 1576304 Schws7 Schwannoma susceptibility QTL 7 0.0115 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 10 4765527 19816042 Rat 7411611 Foco17 Food consumption QTL 17 18.7 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 10 1 42315980 Rat 2303118 Mamtr7 Mammary tumor resistance QTL 7 0.003 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) 10 9658275 104670812 Rat 9590268 Scort13 Serum corticosterone level QTL 13 3.26 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 10 11474010 56474010 Rat 2313104 Bss61 Bone structure and strength QTL 61 0.9 0.0001 tibia area (VT:1000281) tibia midshaft cross-sectional area (CMO:0001717) 10 5387014 50387014 Rat 61427 Cia16 Collagen induced arthritis QTL 16 3.2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 6357896 96121100 Rat 9590310 Scort19 Serum corticosterone level QTL 19 6.3 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 10 11474010 56474010 Rat
AI177426
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 10 11,796,662 - 11,796,880 (+) MAPPER mRatBN7.2 Rnor_6.0 10 12,055,915 - 12,056,132 NCBI Rnor6.0 Rnor_5.0 10 10,813,654 - 10,813,871 UniSTS Rnor5.0 RGSC_v3.4 10 12,069,035 - 12,069,252 UniSTS RGSC3.4 Celera 10 10,748,075 - 10,748,292 UniSTS Cytogenetic Map 10 q12 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
33
94
91
90
59
25
59
6
198
81
74
41
52
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000011073 ⟹ ENSRNOP00000011073
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source Rnor_6.0 Ensembl 10 12,046,701 - 12,056,222 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000081191 ⟹ ENSRNOP00000070256
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 10 11,787,422 - 11,796,973 (+) Ensembl Rnor_6.0 Ensembl 10 12,046,541 - 12,056,311 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000084004 ⟹ ENSRNOP00000070644
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source Rnor_6.0 Ensembl 10 12,046,736 - 12,055,314 (+) Ensembl
RefSeq Acc Id:
NM_031634 ⟹ NP_113822
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 12,293,782 - 12,303,333 (+) NCBI mRatBN7.2 10 11,787,422 - 11,796,973 (+) NCBI Rnor_6.0 10 12,046,701 - 12,056,225 (+) NCBI Rnor_5.0 10 10,804,440 - 10,813,964 (+) NCBI RGSC_v3.4 10 12,059,821 - 12,069,345 (+) RGD Celera 10 10,738,861 - 10,748,385 (+) RGD
Sequence:
CACGTAGCTGGCTGTAGTCCTTCCTGGCCTGCATCATGGCCAATACCCGTGTTGACCATCTGCTAAACACCCTGGAGGAGCTGCTGCCCTATGAACTAGAGAAATTCAAGTTTAAGTTGCACACCACC
hide sequence
RefSeq Acc Id:
XM_017597488 ⟹ XP_017452977
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 12,288,514 - 12,303,337 (+) NCBI mRatBN7.2 10 11,786,949 - 11,796,977 (+) NCBI Rnor_6.0 10 12,045,813 - 12,056,229 (+) NCBI
Sequence:
TTTTTCAGTTATGCCTACAGGCCAATCTGATGGAGGCGGTTTTTCAGTTCAGGTTCCTCTTCCG
hide sequence
RefSeq Acc Id:
XM_039086716 ⟹ XP_038942644
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 12,288,514 - 12,303,337 (+) NCBI mRatBN7.2 10 11,786,948 - 11,796,977 (+) NCBI
RefSeq Acc Id:
NP_113822 ⟸ NM_031634
- UniProtKB:
Q9JJ25 (UniProtKB/Swiss-Prot), A0A0G2JYG3 (UniProtKB/Swiss-Prot), A6K4V5 (UniProtKB/TrEMBL)
- Sequence:
MANTRVDHLLNTLEELLPYELEKFKFKLHTTSLEKGHSRIPLSLVKMARPIKLTRLLLTYYGEEYAVRLTLQILRATNQRQLAEELHKATGPEHLTEENGVGGSVQSSAENKDKGVKGSDVLGEDEAQ
hide sequence
RefSeq Acc Id:
XP_017452977 ⟸ XM_017597488
- Peptide Label:
isoform X2
- UniProtKB:
Q9JJ25 (UniProtKB/Swiss-Prot), A0A0G2JYG3 (UniProtKB/Swiss-Prot)
- Sequence:
MANTRVDHLLNTLEELLPYELEKFKFKLHTTSLEKGHSRIPLSLVKMARPIKLTRLLLTYYGEEYAVRLTLQILRATNQRQLAEELHKATGPEHLTEENGVGGSVQSSAENKDKGVKGSDVPGEDEAQ
hide sequence
Ensembl Acc Id:
ENSRNOP00000070256 ⟸ ENSRNOT00000081191
Ensembl Acc Id:
ENSRNOP00000070644 ⟸ ENSRNOT00000084004
Ensembl Acc Id:
ENSRNOP00000011073 ⟸ ENSRNOT00000011073
RefSeq Acc Id:
XP_038942644 ⟸ XM_039086716
- Peptide Label:
isoform X1
- UniProtKB:
Q9JJ25 (UniProtKB/Swiss-Prot), A0A0G2JYG3 (UniProtKB/Swiss-Prot), A0A0G2JXG0 (UniProtKB/TrEMBL)
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2022-10-27
Mefv
MEFV innate immunity regulator, pyrin
Mefv
MEFV innate immuity regulator, pyrin
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2019-04-10
Mefv
MEFV innate immuity regulator, pyrin
Mefv
MEFV, pyrin innate immunity regulator
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2017-01-17
Mefv
MEFV, pyrin innate immunity regulator
Mefv
Mediterranean fever
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2015-07-29
Mefv
Mediterranean fever
LOC102552366
uncharacterized LOC102552366
Data merged from RGD:7667673
737654 PROVISIONAL
2013-12-18
LOC102552366
uncharacterized LOC102552366
Symbol and Name status set to provisional
70820 PROVISIONAL
2004-09-10
Mefv
Mediterranean fever
Mediterranean fever
Name updated
1299863 APPROVED
2002-06-10
Mefv
Mediterranean fever
Name updated
70584 APPROVED
Note Type
Note
Reference
gene_domains
contains a bZIP basic domain, a B-box zinc finger domain, an a-helical or potential coiled-coil domain, and two nuclear localization signals; lacks the B30.2 (rfp) domain of human homolog
61661
