Mefv (MEFV innate immunity regulator, pyrin) - Rat Genome Database

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Gene: Mefv (MEFV innate immunity regulator, pyrin) Rattus norvegicus
Analyze
Symbol: Mefv
Name: MEFV innate immunity regulator, pyrin
RGD ID: 61889
Description: Predicted to enable actin binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in response to lipopolysaccharide and response to silicon dioxide. Predicted to be located in nucleus. Predicted to be part of canonical inflammasome complex and microtubule associated complex. Predicted to be active in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial mediterranean fever; and hematologic cancer (multiple). Orthologous to human MEFV (MEFV innate immunity regulator, pyrin); PARTICIPATES IN NOD-like receptor signaling pathway; INTERACTS WITH 2,4,6-trinitrotoluene; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102552366; marenostrin; Mediterranean fever; MEFV innate immuity regulator, pyrin; MEFV, pyrin innate immunity regulator; pyrin; uncharacterized LOC102552366
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21011,786,948 - 11,796,977 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,787,422 - 11,796,973 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1016,489,920 - 16,499,472 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,978,752 - 15,988,304 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01011,650,621 - 11,660,170 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01012,045,813 - 12,056,229 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1012,046,541 - 12,056,311 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,804,440 - 10,813,964 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41012,059,821 - 12,069,345 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11012,059,820 - 12,069,345 (+)NCBI
Celera1010,738,861 - 10,748,385 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pulmonary manifestations and function tests in children genetically diagnosed with FMF. Brik R, etal., Pediatr Pulmonol. 2003 Jun;35(6):452-5.
2. Frequency of inherited variants in the MEFV gene in myelodysplastic syndrome and acute myeloid leukemia. Celik S, etal., Int J Hematol. 2012 Mar;95(3):285-90. doi: 10.1007/s12185-012-1022-0. Epub 2012 Feb 18.
3. The rate of MEFV gene mutations in hematolymphoid neoplasms. Celik S, etal., Int J Immunogenet. 2010 Oct;37(5):387-91. doi: 10.1111/j.1744-313X.2010.00938.x. Epub 2010 May 27.
4. Increased frequency of Mediterranean fever gene variants in multiple myeloma. Celik S, etal., Oncol Lett. 2014 Oct;8(4):1735-1738. Epub 2014 Aug 4.
5. Isolation, genomic organization, and expression analysis of the mouse and rat homologs of MEFV, the gene for familial mediterranean fever. Chae JJ, etal., Mamm Genome 2000 Jun;11(6):428-35.
6. Prevalence and significance of the MEFV gene mutations in childhood Henoch-Schonlein purpura without FMF symptoms. Dogan CS, etal., Rheumatol Int. 2013 Feb;33(2):377-80. doi: 10.1007/s00296-012-2400-x. Epub 2012 Mar 27.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. MEFV E148Q polymorphism is associated with Henoch-Schonlein purpura in Chinese children. He X, etal., Pediatr Nephrol. 2010 Oct;25(10):2077-82. doi: 10.1007/s00467-010-1582-2. Epub 2010 Jul 3.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Mediterranean Fever gene analysis in the azeri turk population with familial mediterranean Fever: evidence for new mutations associated with disease. Mohammadnejad L and Farajnia S, Cell J. 2013 Summer;15(2):152-9. Epub 2013 Jul 2.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. The M694V mutation in Armenian-Americans: a 10-year retrospective study of MEFV mutation testing for familial Mediterranean fever at UCLA. Ong FS, etal., Clin Genet. 2013 Jul;84(1):55-9. doi: 10.1111/cge.12029. Epub 2012 Nov 7.
15. Familial Mediterranean fever gene mutation frequencies and genotype-phenotype correlations in the Aegean region of Turkey. Ozalkaya E, etal., Rheumatol Int. 2010 Mar 9.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Familial Mediterranean fever gene and protection against asthma. Rabinovitch E, etal., Ann Allergy Asthma Immunol. 2007 Dec;99(6):517-21.
18. Exposure in vivo to silica or lipopolysaccharide produces transient or sustained upregulation, respectively, of PYPAF7 and MEFV genes in bronchoalveolar lavage cells in rats. Rao KM and Meighan T, J Toxicol Environ Health A. 2006 Mar;69(6):481-90.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. MEFV gene mutations in Egyptian children with Henoch-Schonlein purpura. Salah S, etal., Pediatr Rheumatol Online J. 2014 Sep 9;12:41. doi: 10.1186/1546-0096-12-41. eCollection 2014.
24. High Frequency of Inherited Variants in the MEFV Gene in Acute Lymphocytic Leukemia. Sayan O, etal., Indian J Hematol Blood Transfus. 2011 Sep;27(3):164-8. doi: 10.1007/s12288-011-0095-x. Epub 2011 Jul 21.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:11115844   PMID:11468188   PMID:16403826   PMID:17964261   PMID:19158676   PMID:20041150   PMID:22829933   PMID:25006247   PMID:26347139  


Genomics

Comparative Map Data
Mefv
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21011,786,948 - 11,796,977 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,787,422 - 11,796,973 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1016,489,920 - 16,499,472 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,978,752 - 15,988,304 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01011,650,621 - 11,660,170 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01012,045,813 - 12,056,229 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1012,046,541 - 12,056,311 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,804,440 - 10,813,964 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41012,059,821 - 12,069,345 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11012,059,820 - 12,069,345 (+)NCBI
Celera1010,738,861 - 10,748,385 (+)NCBICelera
Cytogenetic Map10q12NCBI
MEFV
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38163,242,027 - 3,256,633 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl163,242,027 - 3,256,633 (-)EnsemblGRCh38hg38GRCh38
GRCh37163,292,027 - 3,306,633 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,232,029 - 3,246,628 (-)NCBINCBI36Build 36hg18NCBI36
Build 34163,232,028 - 3,246,628NCBI
Celera163,497,690 - 3,512,281 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef163,261,626 - 3,276,174 (-)NCBIHuRef
CHM1_1163,291,965 - 3,306,560 (-)NCBICHM1_1
T2T-CHM13v2.0163,269,087 - 3,283,689 (-)NCBIT2T-CHM13v2.0
Mefv
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,524,838 - 3,536,073 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,525,082 - 3,535,961 (-)EnsemblGRCm39 Ensembl
GRCm38163,706,974 - 3,718,211 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl163,707,218 - 3,718,097 (-)EnsemblGRCm38mm10GRCm38
MGSCv37163,707,215 - 3,718,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36163,622,443 - 3,633,325 (-)NCBIMGSCv36mm8
Celera164,345,682 - 4,356,386 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.18NCBI
Mefv
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,068,348 - 14,094,016 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,068,436 - 14,093,889 (+)NCBIChiLan1.0ChiLan1.0
MEFV
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1167,559,278 - 7,578,952 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0162,175,858 - 2,191,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,354,981 - 3,368,970 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,353,666 - 3,368,970 (-)Ensemblpanpan1.1panPan2
MEFV
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1637,964,776 - 37,984,830 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl637,970,608 - 37,983,737 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0638,276,711 - 38,296,162 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,282,480 - 38,295,669 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1637,962,758 - 37,982,210 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0637,935,294 - 37,954,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,410,844 - 38,430,317 (+)NCBIUU_Cfam_GSD_1.0
Mefv
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,728,858 - 105,739,439 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936694970,706 - 980,605 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEFV
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1338,934,573 - 38,948,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,322,567 - 40,336,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEFV
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,971,323 - 2,991,501 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606827,841,180 - 27,856,544 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mefv
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248241,035,094 - 1,047,678 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248241,035,172 - 1,047,632 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mefv
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:403
Count of miRNA genes:221
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000011073
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat

Markers in Region
AI177426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,796,662 - 11,796,880 (+)MAPPERmRatBN7.2
Rnor_6.01012,055,915 - 12,056,132NCBIRnor6.0
Rnor_5.01010,813,654 - 10,813,871UniSTSRnor5.0
RGSC_v3.41012,069,035 - 12,069,252UniSTSRGSC3.4
Celera1010,748,075 - 10,748,292UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11
Low 3 13 30 17 8 17 3 17 14 11
Below cutoff 14 27 24 24 8 11 53 14 19 8

Sequence


RefSeq Acc Id: ENSRNOT00000011073   ⟹   ENSRNOP00000011073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1012,046,701 - 12,056,222 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081191   ⟹   ENSRNOP00000070256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1011,787,422 - 11,796,973 (+)Ensembl
Rnor_6.0 Ensembl1012,046,541 - 12,056,311 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084004   ⟹   ENSRNOP00000070644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1012,046,736 - 12,055,314 (+)Ensembl
RefSeq Acc Id: NM_031634   ⟹   NP_113822
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21011,787,422 - 11,796,973 (+)NCBI
Rnor_6.01012,046,701 - 12,056,225 (+)NCBI
Rnor_5.01010,804,440 - 10,813,964 (+)NCBI
RGSC_v3.41012,059,821 - 12,069,345 (+)RGD
Celera1010,738,861 - 10,748,385 (+)RGD
Sequence:
RefSeq Acc Id: XM_017597486   ⟹   XP_017452975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21011,786,948 - 11,796,977 (+)NCBI
Rnor_6.01012,045,813 - 12,056,229 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597488   ⟹   XP_017452977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21011,786,949 - 11,796,977 (+)NCBI
Rnor_6.01012,045,813 - 12,056,229 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086716   ⟹   XP_038942644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21011,786,948 - 11,796,977 (+)NCBI
RefSeq Acc Id: NP_113822   ⟸   NM_031634
- UniProtKB: Q9JJ25 (UniProtKB/Swiss-Prot),   A0A0G2JYG3 (UniProtKB/Swiss-Prot),   A6K4V5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452975   ⟸   XM_017597486
- Peptide Label: isoform X1
- UniProtKB: Q9JJ25 (UniProtKB/Swiss-Prot),   A0A0G2JYG3 (UniProtKB/Swiss-Prot),   A0A0G2JXG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452977   ⟸   XM_017597488
- Peptide Label: isoform X2
- UniProtKB: Q9JJ25 (UniProtKB/Swiss-Prot),   A0A0G2JYG3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070256   ⟸   ENSRNOT00000081191
RefSeq Acc Id: ENSRNOP00000070644   ⟸   ENSRNOT00000084004
RefSeq Acc Id: ENSRNOP00000011073   ⟸   ENSRNOT00000011073
RefSeq Acc Id: XP_038942644   ⟸   XM_039086716
- Peptide Label: isoform X1
- UniProtKB: Q9JJ25 (UniProtKB/Swiss-Prot),   A0A0G2JYG3 (UniProtKB/Swiss-Prot),   A0A0G2JXG0 (UniProtKB/TrEMBL)
Protein Domains
B box-type   Pyrin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ25-F1-model_v2 AlphaFold Q9JJ25 1-747 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61889 AgrOrtholog
BioCyc Gene G2FUF-25986 BioCyc
Ensembl Genes ENSRNOG00000008134 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081191 ENTREZGENE
  ENSRNOT00000081191.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DAPIN UniProtKB/TrEMBL
  DEATH-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrin UniProtKB/Swiss-Prot
  Znf_B-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 58923 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24103:SF606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAAD_DAPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-B_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mefv PhenoGen
PROSITE DAPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008134 RatGTEx
SMART BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233290
UniProt A0A0G2JXG0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JYG3 ENTREZGENE
  A6K4V4_RAT UniProtKB/TrEMBL
  A6K4V5 ENTREZGENE, UniProtKB/TrEMBL
  A6K4V6_RAT UniProtKB/TrEMBL
  MEFV_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0G2JYG3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-27 Mefv  MEFV innate immunity regulator, pyrin  Mefv  MEFV innate immuity regulator, pyrin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-10 Mefv  MEFV innate immuity regulator, pyrin  Mefv  MEFV, pyrin innate immunity regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-01-17 Mefv  MEFV, pyrin innate immunity regulator  Mefv  Mediterranean fever  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Mefv  Mediterranean fever  LOC102552366  uncharacterized LOC102552366  Data merged from RGD:7667673 737654 PROVISIONAL
2013-12-18 LOC102552366  uncharacterized LOC102552366      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Mefv  Mediterranean fever    Mediterranean fever   Name updated 1299863 APPROVED
2002-06-10 Mefv  Mediterranean fever       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a bZIP basic domain, a B-box zinc finger domain, an a-helical or potential coiled-coil domain, and two nuclear localization signals; lacks the B30.2 (rfp) domain of human homolog 61661