Mefv (MEFV innate immunity regulator, pyrin) - Rat Genome Database

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Gene: Mefv (MEFV innate immunity regulator, pyrin) Heterocephalus glaber
Analyze
Symbol: Mefv
Name: MEFV innate immunity regulator, pyrin (Ensembl:MEFV innate immuity regulator, pyrin)
RGD ID: 18919478
Description: ENCODES a protein that exhibits actin binding (inferred); identical protein binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN positive regulation of inflammatory response (ortholog); response to lipopolysaccharide (ortholog); response to silicon dioxide (ortholog); ASSOCIATED WITH acne (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN canonical inflammasome complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Mediterranean fever; MEFV innate immuity regulator, pyrin; MEFV, pyrin innate immunity regulator; pyrin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248241,035,094 - 1,047,678 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248241,035,172 - 1,047,632 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Mefv
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248241,035,094 - 1,047,678 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248241,035,172 - 1,047,632 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MEFV
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38163,242,027 - 3,256,633 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl163,242,027 - 3,256,633 (-)EnsemblGRCh38hg38GRCh38
GRCh37163,292,027 - 3,306,633 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,232,029 - 3,246,628 (-)NCBINCBI36Build 36hg18NCBI36
Build 34163,232,028 - 3,246,628NCBI
Celera163,497,690 - 3,512,281 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef163,261,626 - 3,276,174 (-)NCBIHuRef
CHM1_1163,291,965 - 3,306,560 (-)NCBICHM1_1
T2T-CHM13v2.0163,269,087 - 3,283,689 (-)NCBIT2T-CHM13v2.0
Mefv
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,524,838 - 3,536,073 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,525,082 - 3,535,961 (-)EnsemblGRCm39 Ensembl
GRCm38163,706,974 - 3,718,211 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl163,707,218 - 3,718,097 (-)EnsemblGRCm38mm10GRCm38
MGSCv37163,707,215 - 3,718,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36163,622,443 - 3,633,325 (-)NCBIMGSCv36mm8
Celera164,345,682 - 4,356,386 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.18NCBI
Mefv
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81012,288,514 - 12,303,337 (+)NCBIGRCr8
mRatBN7.21011,786,948 - 11,796,977 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,787,422 - 11,796,973 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1016,489,920 - 16,499,472 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,978,752 - 15,988,304 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01011,650,621 - 11,660,170 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01012,045,813 - 12,056,229 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1012,046,541 - 12,056,311 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,804,440 - 10,813,964 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41012,059,821 - 12,069,345 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11012,059,820 - 12,069,345 (+)NCBI
Celera1010,738,861 - 10,748,385 (+)NCBICelera
Cytogenetic Map10q12NCBI
Mefv
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,068,348 - 14,094,016 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,068,436 - 14,093,889 (+)NCBIChiLan1.0ChiLan1.0
MEFV
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,774,439 - 3,794,189 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1167,559,278 - 7,578,952 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0162,175,858 - 2,191,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,354,981 - 3,368,970 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,353,666 - 3,368,970 (-)Ensemblpanpan1.1panPan2
MEFV
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1637,964,776 - 37,984,830 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl637,970,608 - 37,983,737 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0638,276,711 - 38,296,162 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,282,480 - 38,295,669 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1637,962,758 - 37,982,210 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0637,935,294 - 37,954,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,410,844 - 38,430,317 (+)NCBIUU_Cfam_GSD_1.0
Mefv
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,728,858 - 105,739,439 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936694970,706 - 980,605 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEFV
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1338,934,573 - 38,948,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,322,567 - 40,336,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEFV
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,971,323 - 2,991,501 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606827,841,180 - 27,856,544 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000015130   ⟹   ENSHGLP00000014980
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248241,035,094 - 1,047,678 (-)Ensembl
RefSeq Acc Id: XM_013065547   ⟹   XP_012921001
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248241,035,172 - 1,047,632 (-)NCBI
Protein Sequences
Protein RefSeqs XP_012921001 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014980
  ENSHGLP00100021540
GenBank Protein JAO03628 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_012921001   ⟸   XM_013065547
- UniProtKB: A0A0P6JGA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000014980   ⟸   ENSHGLT00000015130


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010721 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100015852 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000015130 ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLT00100021766 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  2.60.120.920 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  DAPIN UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  SPRY_dom UniProtKB/TrEMBL
  Znf_B-box UniProtKB/TrEMBL
NCBI Gene Mefv ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/TrEMBL
  PTHR24103:SF606 UniProtKB/TrEMBL
Pfam PRY UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  zf-B_box UniProtKB/TrEMBL
PRINTS BUTYPHLNCDUF UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  DAPIN UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/TrEMBL
SMART BBOX UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/TrEMBL
  SSF47986 UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A0P6JGA7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-18 Mefv  MEFV innate immunity regulator, pyrin  Mefv  MEFV innate immuity regulator, pyrin  Symbol and/or name change 5135510 APPROVED