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Ontology Browser

tumor necrosis factor mediated signaling pathway (PW:0000233)
Annotations: Rat: (52) Mouse: (54) Human: (54) Chinchilla: (53) Bonobo: (53) Dog: (54) Squirrel: (54) Pig: (52)     Pathway Diagram Browser
Parent Terms Term With Siblings Child Terms
altered extrinsic apoptotic pathway +  
altered tumor necrosis factor superfamily mediated signaling pathway +  
FasL mediated signaling pathway +    
interleukin-1 signaling pathway   
interleukin-6 signaling pathway   
Trail mediated signaling pathway +    
tumor necrosis factor mediated signaling pathway +    
Tumor necrosis factor (Tnf) signaling plays pivotal roles in immunity, cell proliferation, differentiation and apoptosis by activating several pathways. NF-kB is a major pathway activated by Tnf; others include JNK and P38 MAPK. Through receptor associated adapters Tnf elicits apoptosis via the extrinsic pathway. Deregulation of Tnf signaling has been implicated in a great number of human diseases - cerebral malaria, cancer, multiple sclerosis, are a few examples.

View Interactive Diagram
tumor necrosis factor member 13 signaling pathway 
tumor necrosis factor member 13b signaling pathway 
tumor necrosis factor member 14 signaling pathway 

Related Synonyms: PID:200102 ;   TNF signaling pathway ;   TNFalpha signaling pathway
Definition Sources: GO:0033209, PMID:12040173, PMID:12655295, PMID:20303867, Reactome:REACT_1432.1

paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.