Prkci (protein kinase C, iota) - Rat Genome Database

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Gene: Prkci (protein kinase C, iota) Rattus norvegicus
Analyze
Symbol: Prkci
Name: protein kinase C, iota
RGD ID: 620961
Description: Predicted to enable diacylglycerol-dependent serine/threonine kinase activity and phospholipid binding activity. Involved in several processes, including Golgi vesicle budding; cellular response to insulin stimulus; and response to interleukin-1. Located in bicellular tight junction and cell leading edge. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Orthologous to human PRKCI (protein kinase C iota); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aPKC-lambda/iota; atypical protein kinase C-lambda/iota; nPKC-iota; Pkcl; protein kinase C iota type; protein kinase C, lambda
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,250,398 - 114,310,784 (-)NCBIGRCr8
mRatBN7.22112,321,919 - 112,382,305 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,321,929 - 112,382,352 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2118,969,610 - 119,036,697 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02117,082,171 - 117,149,259 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02111,791,942 - 111,852,081 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02115,941,998 - 116,002,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2115,941,993 - 116,002,561 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02135,636,956 - 135,697,732 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42116,739,625 - 116,801,084 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12116,686,636 - 116,699,453 (-)NCBI
Celera2107,508,914 - 107,569,241 (-)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
fenvalerate  (EXP)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
glafenine  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
methidathion  (ISO)
nefazodone  (EXP)
oxybenzone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
Ro 31-8220  (ISO)
selenium atom  (ISO)
sulforaphane  (EXP)
sulindac  (EXP)
tamibarotene  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Albert CJ and Ford DA, Am J Physiol. 1999 Feb;276(2 Pt 2):H642-50.
2. Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11.
3. Corticotropin-releasing hormone activates protein kinase C in an isoenzyme-specific manner. Dermitzaki E, etal., Biochem Biophys Res Commun. 2005 Feb 18;327(3):828-36.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. Izumi Y, etal., J Cell Biol 1998 Oct 5;143(1):95-106.
7. Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3. Kim YB, etal., J Biol Chem 2002 Sep 6;277(36):32915-22.
8. The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. Kojima Y, etal., Hum Pathol. 2008 Jun;39(6):824-31.
9. PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. Matsumoto M, etal., J Clin Invest. 2003 Sep;112(6):935-44.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. PKC¿ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP. Ren SQ, etal., EMBO J. 2013 May 15;32(10):1365-80. doi: 10.1038/emboj.2013.60. Epub 2013 Mar 19.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. Rosse C, etal., PLoS Biol. 2009 Nov;7(11):e1000235. Epub 2009 Nov 3.
20. Differential contributions of protein kinase C isoforms in the regulation of group IIA secreted phospholipase A(2) expression in cytokine-stimulated rat fibroblasts. Sugita M, etal., Biochim Biophys Acta. 2010 Jan;1801(1):70-6. Epub 2009 Sep 24.
21. The PAR-aPKC system: lessons in polarity. Suzuki A and Ohno S, J Cell Sci. 2006 Mar 15;119(Pt 6):979-87.
22. Atypical protein kinase C plays a critical role in protein transport from pre-Golgi intermediates. Tisdale EJ, etal., J Biol Chem 2003 Sep 26;278(39):38015-21.
23. Protein kinase C modulation of the regulation of sarcoplasmic reticular function by protein kinase A-mediated phospholamban phosphorylation in diabetic rats. Watanuki S, etal., Br J Pharmacol. 2004 Jan;141(2):347-59. Epub 2003 Dec 22.
24. Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis. Weichert W, etal., Int J Oncol. 2003 Sep;23(3):633-9.
Additional References at PubMed
PMID:8226978   PMID:9819385   PMID:10467349   PMID:10882525   PMID:11257119   PMID:11260256   PMID:11463795   PMID:11500922   PMID:11724794   PMID:14570876   PMID:14685273   PMID:14758363  
PMID:15322187   PMID:15723051   PMID:15802290   PMID:16267237   PMID:16892058   PMID:18815554   PMID:19056867   PMID:19090727   PMID:19327373   PMID:19819945   PMID:20237282   PMID:20817751  
PMID:21419810   PMID:21983565   PMID:23152633   PMID:23305840   PMID:26199377   PMID:27498875   PMID:28073831   PMID:28432079  


Genomics

Comparative Map Data
Prkci
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,250,398 - 114,310,784 (-)NCBIGRCr8
mRatBN7.22112,321,919 - 112,382,305 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,321,929 - 112,382,352 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2118,969,610 - 119,036,697 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02117,082,171 - 117,149,259 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02111,791,942 - 111,852,081 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02115,941,998 - 116,002,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2115,941,993 - 116,002,561 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02135,636,956 - 135,697,732 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42116,739,625 - 116,801,084 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12116,686,636 - 116,699,453 (-)NCBI
Celera2107,508,914 - 107,569,241 (-)NCBICelera
Cytogenetic Map2q24NCBI
PRKCI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383170,222,424 - 170,305,977 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3170,222,424 - 170,305,977 (+)EnsemblGRCh38hg38GRCh38
GRCh373169,940,212 - 170,023,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363171,422,914 - 171,506,464 (+)NCBINCBI36Build 36hg18NCBI36
Build 343171,422,926 - 171,506,466NCBI
Celera3168,339,909 - 168,423,454 (+)NCBICelera
Cytogenetic Map3q26.2NCBI
HuRef3167,310,436 - 167,393,660 (+)NCBIHuRef
CHM1_13169,903,696 - 169,987,264 (+)NCBICHM1_1
T2T-CHM13v2.03173,007,078 - 173,090,623 (+)NCBIT2T-CHM13v2.0
Prkci
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39331,049,893 - 31,106,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl331,049,896 - 31,107,108 (+)EnsemblGRCm39 Ensembl
GRCm38330,995,742 - 31,052,740 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl330,995,747 - 31,052,959 (+)EnsemblGRCm38mm10GRCm38
MGSCv37330,894,693 - 30,951,662 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36331,186,790 - 31,243,616 (+)NCBIMGSCv36mm8
Celera330,907,826 - 30,963,884 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map314.65NCBI
Prkci
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955420423,140 - 489,592 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955420423,406 - 486,676 (+)NCBIChiLan1.0ChiLan1.0
PRKCI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,117,174 - 168,201,113 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13168,122,382 - 168,205,837 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03167,237,093 - 167,320,522 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13175,426,774 - 175,510,072 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3175,426,774 - 175,510,072 (+)Ensemblpanpan1.1panPan2
PRKCI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13434,767,066 - 34,839,823 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3434,766,801 - 34,837,605 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3443,779,787 - 43,851,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03434,847,084 - 34,921,270 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3434,846,775 - 34,923,810 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13434,792,870 - 34,864,800 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03434,760,842 - 34,834,497 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03435,025,008 - 35,098,029 (+)NCBIUU_Cfam_GSD_1.0
Prkci
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602101,385,061 - 101,451,426 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365932,170,808 - 2,236,673 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365932,170,539 - 2,236,904 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13108,913,173 - 108,997,931 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113108,913,018 - 108,997,934 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213117,694,977 - 117,742,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11519,103,682 - 19,180,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606327,884,831 - 27,966,994 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkci
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473048,258,524 - 48,340,217 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkci
456 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:203
Interacting mature miRNAs:261
Transcripts:ENSRNOT00000012924
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
RH143812  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,322,042 - 112,322,150 (+)MAPPERmRatBN7.2
Rnor_6.02115,942,122 - 115,942,229NCBIRnor6.0
Rnor_5.02135,637,080 - 135,637,187UniSTSRnor5.0
RGSC_v3.42116,739,749 - 116,739,856UniSTSRGSC3.4
Celera2107,509,038 - 107,509,145UniSTS
RH 3.4 Map2719.4UniSTS
Cytogenetic Map2q24UniSTS
AI406627  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,322,077 - 112,322,223 (+)MAPPERmRatBN7.2
Rnor_6.02115,942,157 - 115,942,302NCBIRnor6.0
Rnor_5.02135,637,115 - 135,637,260UniSTSRnor5.0
RGSC_v3.42116,739,784 - 116,739,929UniSTSRGSC3.4
Celera2107,509,073 - 107,509,218UniSTS
RH 3.4 Map2721.5UniSTS
Cytogenetic Map2q24UniSTS
AI007955  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,377,692 - 112,377,852 (+)MAPPERmRatBN7.2
Rnor_6.02115,997,940 - 115,998,099NCBIRnor6.0
Rnor_5.02135,693,122 - 135,693,281UniSTSRnor5.0
RGSC_v3.42116,796,473 - 116,796,632UniSTSRGSC3.4
Celera2107,564,634 - 107,564,793UniSTS
RH 3.4 Map2722.3UniSTS
Cytogenetic Map2q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000012924   ⟹   ENSRNOP00000012924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2112,321,929 - 112,382,352 (-)Ensembl
Rnor_6.0 Ensembl2115,941,993 - 116,002,561 (-)Ensembl
RefSeq Acc Id: NM_032059   ⟹   NP_114448
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,250,398 - 114,310,784 (-)NCBI
mRatBN7.22112,321,919 - 112,382,305 (-)NCBI
Rnor_6.02115,941,998 - 116,002,550 (-)NCBI
Rnor_5.02135,636,956 - 135,697,732 (-)NCBI
RGSC_v3.42116,739,625 - 116,801,084 (-)RGD
Celera2107,508,914 - 107,569,241 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114448 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB41799 (Get FASTA)   NCBI Sequence Viewer  
  ACA66272 (Get FASTA)   NCBI Sequence Viewer  
  BAA78372 (Get FASTA)   NCBI Sequence Viewer  
  EDM01152 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012924.4
  ENSRNOP00055013108
  ENSRNOP00060002411
  ENSRNOP00065033924
GenBank Protein F1M7Y5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114448   ⟸   NM_032059
- UniProtKB: B1PZT8 (UniProtKB/Swiss-Prot),   F1M7Y5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012924   ⟸   ENSRNOT00000012924
Protein Domains
AGC-kinase C-terminal   PB1   Phorbol-ester/DAG-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7Y5-F1-model_v2 AlphaFold F1M7Y5 1-596 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691273
Promoter ID:EPDNEW_R1798
Type:initiation region
Name:Prkci_1
Description:protein kinase C, iota
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02116,002,588 - 116,002,648EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620961 AgrOrtholog
BioCyc Gene G2FUF-53470 BioCyc
Ensembl Genes ENSRNOG00000009652 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055009646 UniProtKB/Swiss-Prot
  ENSRNOG00060002248 UniProtKB/Swiss-Prot
  ENSRNOG00065024212 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012924.6 UniProtKB/Swiss-Prot
  ENSRNOT00055016309 UniProtKB/Swiss-Prot
  ENSRNOT00060003519 UniProtKB/Swiss-Prot
  ENSRNOT00065041525 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  aPKC_iota UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PB1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PB1_aPKC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PB1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKC UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84006 UniProtKB/Swiss-Prot
NCBI Gene 84006 ENTREZGENE
PANTHER PROTEIN KINASE C IOTA TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot
PhenoGen Prkci PhenoGen
PIRSF PKC_zeta UniProtKB/Swiss-Prot
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009652 RatGTEx
  ENSRNOG00055009646 RatGTEx
  ENSRNOG00060002248 RatGTEx
  ENSRNOG00065024212 RatGTEx
SMART PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cysteine-rich domain UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot
UniProt A6IHK4_RAT UniProtKB/TrEMBL
  B1PZT8 ENTREZGENE
  F1M7Y5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B1PZT8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Prkci  protein kinase C, iota  Pkcl  protein kinase C, lambda  Symbol and Name updated 1299863 APPROVED
2002-08-07 Pkcl  protein kinase C, lambda      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process mediates protein transport in the early secretory pathway 724652
gene_regulation activated by phosphatidylinositol 3,4,5-triphosphate and phosphatidic acid 724652