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Gene: PRKCI (protein kinase C iota) Homo sapiens
Symbol: PRKCI
Name: protein kinase C iota
Description: Exhibits phospholipid binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of neurogenesis; and regulation of apoptotic process. Localizes to several cellular components, including cytosol; intercellular bridge; and microtubule cytoskeleton. Biomarker of invasive ductal carcinoma and ovarian carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aPKC-lambda/iota; atypical protein kinase C-lambda/iota; DXS1179E; MGC26534; nPKC-iota; PKCI; PRKC-lambda/iota; protein kinase C iota type; protein kinase c, lambda
Mus musculus (house mouse) : Prkci (protein kinase C, iota)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prkci (protein kinase C, iota)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkci (protein kinase C iota)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCI (protein kinase C iota)
Canis lupus familiaris (dog) : PRKCI (protein kinase C iota)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkci (protein kinase C iota)
Sus scrofa (pig) : PRKCI (protein kinase C iota)
Chlorocebus sabaeus (African green monkey) : PRKCI (protein kinase C iota)
Heterocephalus glaber (naked mole-rat) : Prkci (protein kinase C iota)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl3170,222,424 - 170,305,977 (+)EnsemblGRCh38hg38GRCh38
GRCh383170,222,424 - 170,305,981 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373169,940,220 - 170,023,770 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363171,422,914 - 171,506,464 (+)NCBINCBI36hg18NCBI36
Build 343171,422,926 - 171,506,466NCBI
Celera3168,339,909 - 168,423,454 (+)NCBI
Cytogenetic Map3q26.2NCBI
HuRef3167,310,436 - 167,393,660 (+)NCBIHuRef
CHM1_13169,903,696 - 169,987,264 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRKCI
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732937
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.