Prkci (protein kinase C iota) - Rat Genome Database

Name: Prkci
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Prkci (protein kinase C iota) Ictidomys tridecemlineatus

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Symbol:

Prkci

Name:

protein kinase C iota

RGD ID:

12625511

Description:

ENCODES a protein that exhibits ATP binding (inferred); calcium,diacylglycerol-dependent serine/threonine kinase activity (inferred); diacylglycerol-dependent serine/threonine kinase activity (inferred); INVOLVED IN actin filament organization (ortholog); cell migration (ortholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); autistic disorder (ortholog); autosomal dominant dyskeratosis congenita 1 (ortholog); FOUND IN bicellular tight junction (ortholog); cell leading edge (ortholog); glutamatergic synapse (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRKCI (protein kinase C iota)	NCBI	Ortholog
Mus musculus (house mouse):	Prkci (protein kinase C, iota)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Prkci (protein kinase C, iota)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prkci (protein kinase C iota)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRKCI (protein kinase C iota)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRKCI (protein kinase C iota)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRKCI (protein kinase C iota)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRKCI (protein kinase C iota)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prkci (protein kinase C iota)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	101,385,061 - 101,451,426 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936593	2,170,808 - 2,236,673 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936593	2,170,539 - 2,236,904 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

abdominal obesity-metabolic syndrome (ISO)

autistic disorder (ISO)

autosomal dominant dyskeratosis congenita 1 (ISO)

Experimental Diabetes Mellitus (ISO)

Fanconi-Bickel syndrome (ISO)

invasive ductal carcinoma (ISO)

obesity (ISO)

ovarian carcinoma (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (IEA,ISO)

cell migration (ISO)

cell-cell junction organization (IEA)

cellular response to insulin stimulus (IEA,ISO)

establishment of apical/basal cell polarity (IEA,ISO)

establishment or maintenance of epithelial cell apical/basal polarity (IEA)

eye photoreceptor cell development (IEA,ISO)

Golgi vesicle budding (ISO)

negative regulation of glial cell apoptotic process (IEA)

negative regulation of neuron apoptotic process (IEA)

positive regulation of D-glucose import (IEA)

positive regulation of endothelial cell apoptotic process (IEA)

positive regulation of glial cell proliferation (IEA)

positive regulation of neuron projection development (IEA)

positive regulation of NF-kappaB transcription factor activity (ISO)

positive regulation of protein localization to plasma membrane (IEA)

protein phosphorylation (ISO)

regulation of postsynaptic membrane neurotransmitter receptor levels (ISO)

response to interleukin-1 (ISO)

response to peptide hormone (ISO)

Cellular Component

apical part of cell (IEA)

apical plasma membrane (IEA)

bicellular tight junction (ISO)

brush border (IEA)

cell leading edge (ISO)

cytoplasm (IEA)

cytosol (IEA)

glutamatergic synapse (ISO)

intercellular bridge (IEA)

microtubule cytoskeleton (IEA)

nucleus (IEA)

PAR polarity complex (IEA)

Schaffer collateral - CA1 synapse (ISO)

Schmidt-Lanterman incisure (IEA)

Molecular Function

ATP binding (IEA)

calcium,diacylglycerol-dependent serine/threonine kinase activity (IEA)

diacylglycerol-dependent serine/threonine kinase activity (IEA)

diacylglycerol-dependent, calcium-independent serine/threonine kinase activity (IEA)

metal ion binding (IEA)

phospholipid binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

insulin signaling pathway (ISO)

interleukin-1 signaling pathway (ISO)

protein kinase C (PKC) signaling pathway (ISO)

tumor necrosis factor mediated signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Prkci
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	101,385,061 - 101,451,426 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936593	2,170,808 - 2,236,673 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936593	2,170,539 - 2,236,904 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRKCI
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	170,222,424 - 170,305,977 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	170,222,424 - 170,305,977 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	169,940,212 - 170,023,765 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	171,422,914 - 171,506,464 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	171,422,926 - 171,506,466	NCBI
Celera	3	168,339,909 - 168,423,454 (+)	NCBI		Celera
Cytogenetic Map	3	q26.2	NCBI
HuRef	3	167,310,436 - 167,393,660 (+)	NCBI		HuRef
CHM1_1	3	169,903,696 - 169,987,264 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	173,007,078 - 173,090,623 (+)	NCBI		T2T-CHM13v2.0

Prkci
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	31,049,893 - 31,106,889 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	31,049,896 - 31,107,108 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	30,995,742 - 31,052,740 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	30,995,747 - 31,052,959 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	30,894,693 - 30,951,662 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	31,186,790 - 31,243,616 (+)	NCBI		MGSCv36	mm8
Celera	3	30,907,826 - 30,963,884 (+)	NCBI		Celera
Cytogenetic Map	3	A3	NCBI
cM Map	3	14.65	NCBI

Prkci
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	114,250,398 - 114,310,784 (-)	NCBI		GRCr8
mRatBN7.2	2	112,321,919 - 112,382,305 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	112,321,929 - 112,382,352 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	118,969,610 - 119,036,697 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	117,082,171 - 117,149,259 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	111,791,942 - 111,852,081 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	115,941,998 - 116,002,550 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	115,941,993 - 116,002,561 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	135,636,956 - 135,697,732 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	116,739,625 - 116,801,084 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	116,686,636 - 116,699,453 (-)	NCBI
Celera	2	107,508,914 - 107,569,241 (-)	NCBI		Celera
Cytogenetic Map	2	q24	NCBI

Prkci
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	423,140 - 489,592 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	423,406 - 486,676 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRKCI
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	168,117,174 - 168,201,113 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	168,122,382 - 168,205,837 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	167,237,093 - 167,320,522 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	175,426,774 - 175,510,072 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	175,426,774 - 175,510,072 (+)	Ensembl	panpan1.1		panPan2

PRKCI
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	34,767,066 - 34,839,823 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	34,766,801 - 34,837,605 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	43,779,787 - 43,851,893 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	34,847,084 - 34,921,270 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	34,846,775 - 34,923,810 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	34,792,870 - 34,864,800 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	34,760,842 - 34,834,497 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	35,025,008 - 35,098,029 (+)	NCBI		UU_Cfam_GSD_1.0

PRKCI
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	108,913,173 - 108,997,931 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	108,913,018 - 108,997,934 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	117,694,977 - 117,742,789 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRKCI
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	19,103,682 - 19,180,689 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666063	27,884,831 - 27,966,994 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prkci
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	48,258,524 - 48,340,217 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040270080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040270081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000002795 ⟹ ENSSTOP00000002501

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936593	2,170,808 - 2,236,673 (-)	Ensembl

Ensembl Acc Id:

ENSSTOT00000031681 ⟹ ENSSTOP00000032149

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936593	2,186,137 - 2,193,674 (-)	Ensembl

Ensembl Acc Id:

ENSSTOT00000032396 ⟹ ENSSTOP00000031830

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936593	2,170,808 - 2,236,673 (-)	Ensembl

RefSeq Acc Id:

XM_005332486 ⟹ XP_005332543

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	101,385,061 - 101,451,426 (+)	NCBI
SpeTri2.0	NW_004936593	2,170,539 - 2,236,904 (-)	NCBI

Sequence:

show sequence

GCTGGGCCCGGGTGGCGGTGGAGGCGGCTGCGGCCGCGGGCGGTGGGAGGAGCCGCGAGGTTCC
GGCTGCCCGGGCTAGGCGACCCTTGGGTCGGCGCCGTGGGCGAGGTACGCAGGTAGGCGGGCGA
GCGGCCGCCGCTCAGGGATCGGCTCCGGCGGCGGAGTGCAGAGCGGCGCCTGGCGCGCCCCCCG
CACCCTCGGCCGCCGGCGTCCAGGCGGGGCTGTGAGGAGATGCCGACCCAGAGGGACAGCAGTA
CCATGTCCCATACGGTCGGGGGCGGCGGCAGCGGGGACCACTCTCATCAGGTCCGAGTGAAAGC
CTACTACCGCGGGGATATCATGATAACACACTTTGAGCCTTCCATCTCCTTTGAGGGTCTTTGC
AATGAGGTTCGAGACATGTGTTCTTTTGACAATGAACAGCTTTTTACCATGAAATGGATAGATG
AGGAAGGAGACCCGTGTACAGTATCATCTCAGTTGGAGTTAGAAGAAGCCTTTAGGCTTTATGA
GCTAAATAAGGATTCAGAACTCTTGATTCATGTGTTCCCTTGTGTGCCAGAACGTCCTGGGATG
CCTTGTCCAGGAGAAGATAAATCCATCTACCGCAGAGGTGCCCGTCGCTGGAGAAAGCTTTATT
GTGCAAATGGCCACACTTTTCAAGCCAAACGTTTCAACAGGCGTGCTCATTGTGCCATCTGCAC
AGACCGAATATGGGGACTTGGACGCCAAGGATATAAGTGCATCAACTGCAAACTCTTGGTTCAT
AAGAAGTGCCACAAGCTAGTCACAATTGAATGTGGGCGACATTCTTTGCCACCGGAACCAATGA
TGCCAATGGACCAGTCCTCCATGCATTCAGACCATCCACAGACAGTAATTCCATATAATCCTTC
AAGTCATGAGAGTTTGGACCAAGTTGGTGAGGAAAAGGAGGCAATGAACACCAGGGAAAGTGGC
AAAGCTTCATCCAGTTTAGGTCTTCAGGATTTTGATTTGCTTCGGGTAATAGGAAGAGGAAGTT
ATGCCAAAGTACTGTTGGTTAGATTAAAAAAAACAGATCGTATTTATGCAATGAAAGTTGTGAA
AAAAGAGCTCGTCAATGATGATGAGGATATTGATTGGGTACAGACAGAAAAGCATGTTTTTGAG
CAGGCTTCAAATCATCCTTTTCTTGTTGGGCTGCATTCATGCTTTCAGACAGAAAGCAGATTGT
TCTTTGTTATAGAGTATGTAAATGGAGGAGATCTGATGTTTCATATGCAGCGACAAAGAAAACT
TCCTGAAGAACATGCCAGGTTTTATTCTGCGGAAATTAGTCTAGCCTTAAATTATCTTCATGAG
CGAGGGATAATTTATAGAGATTTGAAATTAGACAATGTATTATTGGATTCAGAAGGACACATTA
AACTCACTGACTATGGCATGTGTAAGGAAGGATTACGGCCAGGAGATACAACTAGCACTTTCTG
TGGTACTCCTAATTACATTGCTCCTGAAATTTTAAGAGGAGAAGATTATGGTTTCAGCGTCGAC
TGGTGGGCTCTTGGTGTACTAATGTTTGAGATGATGGCAGGAAGGTCTCCGTTTGATATTGTTG
GGAGTTCTGATAACCCTGATCAAAACACAGAGGATTATCTCTTCCAAGTTATTTTGGAAAAACA
AATTCGCATTCCACGTTCTCTGTCTGTAAAAGCTGCAAGTGTCCTAAAGAGTTTTCTGAACAAG
GACCCAAAGGAACGATTGGGTTGTCATCCTCAAACAGGATTTGCTGATATACAGGGGCATCCAT
TCTTTCGAAATGTTGATTGGGATATGATGGAACAAAAGCAGGTGGTACCTCCCTTTAAACCAAA
TATTTCTGGAGAATTTGGCTTGGACAACTTTGATTCTCAGTTTACTAATGAACCTGTACAACTC
ACTCCAGATGATGATGACATTGTGAGGAAGATTGATCAGTCTGAATTTGAAGGTTTTGAGTATA
TCAATCCTCTTTTGATGTCTGCAGAAGAATGTGTCTGATCCTCATTTTTCAACTGTGCATTCTC
TTTATGTTGCCATTTAATGCATGGATAAGCTTGTTACCAGCCTGAATACAATTAACCATTTTAT
ATTTGCCACTCCTCCCCCCAAAAAAACACAACAATATCTTATAGACTATAAGAATAAATTATTA
CATTTAAATATAACTGAAAAAAATTAAAACTAGCTTTCAGACAATCATGTCAAAATTTAGTTGG
ATTGAATCTTCAGAGGCCGGATGAGTAATGGAATTACCTTTTTAATTTAAA

hide sequence

RefSeq Acc Id:

XM_040270080 ⟹ XP_040126014

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	101,385,073 - 101,443,956 (+)	NCBI

RefSeq Acc Id:

XM_040270081 ⟹ XP_040126015

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	101,385,073 - 101,439,507 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005332543	(Get FASTA)	NCBI Sequence Viewer
	XP_040126014	(Get FASTA)	NCBI Sequence Viewer
	XP_040126015	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000002501.3
	ENSSTOP00000031830.1
	ENSSTOP00000032149.1
GenBank Protein	KAG3270989	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005332543 ⟸ XM_005332486
- Peptide Label:	isoform X1
- UniProtKB:	I3M147 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPTQRDSSTMSHTVGGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQ LFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRG ARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGR HSLPPEPMMPMDQSSMHSDHPQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDL LRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNV LLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMA GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTG FADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQ SEFEGFEYINPLLMSAEECV hide sequence

RefSeq Acc Id:	XP_040126014 ⟸ XM_040270080
- Peptide Label:	isoform X2
- UniProtKB:	I3M147 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_040126015 ⟸ XM_040270081
- Peptide Label:	isoform X3
- UniProtKB:	A0A287DE40 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000032149 ⟸ ENSSTOT00000031681

Ensembl Acc Id:

ENSSTOP00000031830 ⟸ ENSSTOT00000032396

Ensembl Acc Id:

ENSSTOP00000002501 ⟸ ENSSTOT00000002795

Protein Domains

AGC-kinase C-terminal PB1 Phorbol-ester/DAG-type Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000002794	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000002795.3	UniProtKB/TrEMBL
	ENSSTOT00000031681.1	UniProtKB/TrEMBL
	ENSSTOT00000032396.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.60.20	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	AGC-kinase_C	UniProtKB/TrEMBL
	aPKC_iota	UniProtKB/TrEMBL
	C1-like_sf	UniProtKB/TrEMBL
	DAG/PE-bd	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	PB1-like	UniProtKB/TrEMBL
	PB1_aPKC	UniProtKB/TrEMBL
	PB1_dom	UniProtKB/TrEMBL
	PE/DAG-bd	UniProtKB/TrEMBL
	PKC	UniProtKB/TrEMBL
	Pkinase_C	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
	Ser_Thr_kinase_AGC	UniProtKB/TrEMBL
NCBI Gene	Prkci	ENTREZGENE
PANTHER	PROTEIN KINASE C IOTA TYPE	UniProtKB/TrEMBL
	PROTEIN KINASE C IOTA TYPE	UniProtKB/TrEMBL
	RIBOSOMAL PROTEIN S6 KINASE	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	C1_1	UniProtKB/TrEMBL
	PB1	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
	Pkinase_C	UniProtKB/TrEMBL
PIRSF	PKC_zeta	UniProtKB/TrEMBL
PRINTS	DAGPEDOMAIN	UniProtKB/TrEMBL
PROSITE	AGC_KINASE_CTER	UniProtKB/TrEMBL
	PB1	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
	ZF_DAG_PE_1	UniProtKB/TrEMBL
	ZF_DAG_PE_2	UniProtKB/TrEMBL
SMART	PB1	UniProtKB/TrEMBL
	S_TK_X	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
	SM00109	UniProtKB/TrEMBL
Superfamily-SCOP	CAD & PB1 domains	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
	SSF57889	UniProtKB/TrEMBL
UniProt	A0A287DE40	ENTREZGENE, UniProtKB/TrEMBL
	A0A287DF27_ICTTR	UniProtKB/TrEMBL
	I3M147	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - PID (archival)