Gene: Sugt1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone) Rattus norvegicus
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Symbol:
Sugt1
Name:
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
Description:
Predicted to be involved in positive regulation by host of symbiont catalytic activity and protein stabilization. Predicted to localize to the protein-containing complex. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone); PARTICIPATES IN NOD-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Aa1114; LOC290408; SGT1, suppressor of G2 allele of SKP1; SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae); Suppressor of G2 allele of SKP1 homolog
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Sugt1 (SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Sugt1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Sugt1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Sugt1 (SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae))
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
D1054.3
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
SGT1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Sgt1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
sugt1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 15 61,873,158 - 61,913,983 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 15 61,873,056 - 61,914,072 (+) Ensembl Rnor_5.0 15 65,536,894 - 65,577,747 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 15 60,840,998 - 60,881,860 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 15 60,856,682 - 60,897,528 (+) NCBI Celera 15 54,571,908 - 54,612,569 (+) NCBI Celera Cytogenetic Map 15 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol increases expression ISO RGD:1316811 6480464 Ethinyl Estradiol results in increased expression of SUGT1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SUGT1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1316811 6480464 Tetrachlorodibenzodioxin affects the expression of SUGT1 mRNA CTD PMID:21570461 , PMID:24680724 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SUGT1 mRNA CTD PMID:21724226 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of SUGT1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of SUGT1 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:1316810 6480464 Lactic Acid results in decreased expression of SUGT1 mRNA CTD PMID:30851411 2-methylcholine affects expression ISO RGD:1316810 6480464 beta-methylcholine affects the expression of SUGT1 mRNA CTD PMID:21179406 4,4'-diaminodiphenylmethane affects expression ISO RGD:1316811 6480464 4, 4'-diaminodiphenylmethane affects the expression of SUGT1 mRNA CTD PMID:18648102 all-trans-retinoic acid decreases expression ISO RGD:1316811 6480464 Tretinoin results in decreased expression of SUGT1 mRNA CTD PMID:16604517 Aroclor 1254 decreases expression ISO RGD:1316811 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of SUGT1 mRNA CTD PMID:23650126 arsenous acid decreases expression ISO RGD:1316810 6480464 Arsenic Trioxide results in decreased expression of SUGT1 mRNA CTD PMID:20458559 ATP multiple interactions ISO RGD:1316810 6480464 Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein] more ... CTD PMID:23184943 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SUGT1 mRNA CTD PMID:25181051 calcium atom multiple interactions ISO RGD:1316810 6480464 Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]] CTD PMID:23184943 calcium(0) multiple interactions ISO RGD:1316810 6480464 Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]] CTD PMID:23184943 cisplatin increases phosphorylation ISO RGD:1316811 6480464 Cisplatin results in increased phosphorylation of SUGT1 protein CTD PMID:22006019 cobalt dichloride decreases expression ISO RGD:1316810 6480464 cobaltous chloride results in decreased expression of SUGT1 protein CTD PMID:16622835 crocidolite asbestos decreases expression ISO RGD:1316810 6480464 Asbestos, Crocidolite results in decreased expression of SUGT1 mRNA CTD PMID:29523930 cyclosporin A increases expression ISO RGD:1316811 6480464 Cyclosporine results in increased expression of SUGT1 mRNA CTD PMID:19770486 cyclosporin A increases expression ISO RGD:1316810 6480464 Cyclosporine results in increased expression of SUGT1 mRNA CTD PMID:20106945 , PMID:25562108 diarsenic trioxide decreases expression ISO RGD:1316810 6480464 Arsenic Trioxide results in decreased expression of SUGT1 mRNA CTD PMID:20458559 dicrotophos decreases expression ISO RGD:1316810 6480464 dicrotophos results in decreased expression of SUGT1 mRNA CTD PMID:28302478 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of SUGT1 mRNA CTD PMID:22546817 doxorubicin increases oxidation EXP 6480464 Doxorubicin results in increased oxidation of SUGT1 protein CTD PMID:28818578 enzyme inhibitor multiple interactions ISO RGD:1316810 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SUGT1 protein CTD PMID:23301498 erythromycin estolate increases expression EXP 6480464 Erythromycin Estolate results in increased expression of SUGT1 mRNA CTD PMID:24412560 ethanol affects splicing ISO RGD:1316811 6480464 Ethanol affects the splicing of SUGT1 mRNA CTD PMID:30319688 flutamide increases expression EXP 6480464 Flutamide results in increased expression of SUGT1 mRNA CTD PMID:24136188 hexadecanoic acid decreases phosphorylation ISO RGD:1316810 6480464 Palmitic Acid results in decreased phosphorylation of SUGT1 protein CTD PMID:28073184 methyl methanesulfonate decreases expression ISO RGD:1316810 6480464 Methyl Methanesulfonate results in decreased expression of SUGT1 mRNA CTD PMID:23649840 N-methyl-4-phenylpyridinium decreases expression ISO RGD:1316810 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SUGT1 mRNA CTD PMID:24810058 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of SUGT1 mRNA CTD PMID:22546817 nickel sulfate decreases expression ISO RGD:1316810 6480464 nickel sulfate results in decreased expression of SUGT1 mRNA CTD PMID:16780908 nickel sulfate increases expression ISO RGD:1316810 6480464 nickel sulfate results in increased expression of SUGT1 mRNA CTD PMID:16780908 paracetamol affects expression ISO RGD:1316811 6480464 Acetaminophen affects the expression of SUGT1 mRNA CTD PMID:17562736 phlorizin decreases expression ISO RGD:1316811 6480464 Phlorhizin results in decreased expression of SUGT1 mRNA CTD PMID:22538082 rac-lactic acid decreases expression ISO RGD:1316810 6480464 Lactic Acid results in decreased expression of SUGT1 mRNA CTD PMID:30851411 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SUGT1 mRNA CTD PMID:31150632 urethane increases expression ISO RGD:1316810 6480464 Urethane results in increased expression of SUGT1 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1316811 6480464 Valproic Acid affects the expression of SUGT1 mRNA CTD PMID:17292431 valproic acid affects expression ISO RGD:1316810 6480464 Valproic Acid affects the expression of SUGT1 mRNA CTD PMID:25979313 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of SUGT1 mRNA CTD PMID:19015723 zinc atom multiple interactions ISO RGD:1316810 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of SUGT1 mRNA CTD PMID:18593933 zinc(0) multiple interactions ISO RGD:1316810 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of SUGT1 mRNA CTD PMID:18593933
Gene Ontology Annotations
Molecular Pathway Annotations
Imported Annotations - KEGG (archival)
NOD-like receptor signaling pathway IEA 6907045 KEGG rno:04621
2298549 Neuinf12 Neuroinflammation QTL 12 3.5 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) 15 1 62301382 Rat 2317750 Glom26 Glomerulus QTL 26 4.3 urine protein amount (VT:0005160) urine protein level (CMO:0000591) 15 15492360 72568189 Rat 9590272 Scort14 Serum corticosterone level QTL 14 2.78 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 15 16980907 61980907 Rat 8694427 Bw163 Body weight QTL 163 4.82 0.001 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) 15 16980907 61980907 Rat 2300167 Bmd63 Bone mineral density QTL 63 5.9 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 15 17249641 62249641 Rat 2300173 Bmd62 Bone mineral density QTL 62 12.8 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 15 17249641 62249641 Rat 2293688 Bss29 Bone structure and strength QTL 29 5.31 0.0001 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 15 17249641 62249641 Rat 1331729 Rf42 Renal function QTL 42 3.071 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) 15 18093208 81255430 Rat 61424 Scl1 Serum cholesterol level QTL 1 7.7 0.001 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 15 18513913 88036354 Rat 1578646 Bmd18 Bone mineral density QTL 18 5.2 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) 15 26381041 106550657 Rat 1578647 Bmd17 Bone mineral density QTL 17 4 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 15 26381041 106550657 Rat 1578660 Bss19 Bone structure and strength QTL 19 4.3 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) 15 26381041 106550657 Rat 10054130 Srcrt8 Stress Responsive Cort QTL 8 2.18 0.0085 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 15 28709741 73709741 Rat 1582214 Stl21 Serum triglyceride level QTL 21 3.1 0.022 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 15 33219101 89640841 Rat 1582227 Gluco30 Glucose level QTL 30 3.6 0.0003 blood glucose amount (VT:0000188) absolute change in blood glucose level area under curve (CMO:0002034) 15 33219101 89640841 Rat 1582228 Epfw3 Epididymal fat weight QTL 3 4.1 0.0002 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 15 33219101 89640841 Rat 1582242 Gluco28 Glucose level QTL 28 3.3 0.0008 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 15 33219101 89640841 Rat 1582244 Bw79 Body weight QTL 79 4 0.0002 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 15 33219101 89640841 Rat 631273 Lecl2 Lens clarity QTL 2 0.001 lens clarity trait (VT:0001304) age of onset/diagnosis of cataract (CMO:0001584) 15 39480797 62596410 Rat 2293686 Bmd36 Bone mineral density QTL 36 7.4 0.0001 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) 15 39749557 79033707 Rat 2293691 Bmd37 Bone mineral density QTL 37 6.6 0.0001 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) 15 39749557 79033707 Rat 1598828 Glom14 Glomerulus QTL 14 2.5 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) 15 41068094 86068094 Rat 1300144 Rf23 Renal function QTL 23 3.61 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) 15 43097470 106550657 Rat 724545 Niddm54 Non-insulin dependent diabetes mellitus QTL 54 0.02 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 15 57528970 81263988 Rat 2317050 Aia24 Adjuvant induced arthritis QTL 24 2.06 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 15 59651151 81255430 Rat 1576315 Schws6 Schwannoma susceptibility QTL 6 0.0069 nervous system integrity trait (VT:0010566) post-insult time of death (CMO:0002005) 15 61447766 106447766 Rat
Predicted Target Of
Count of predictions: 156 Count of miRNA genes: 108 Interacting mature miRNAs: 112 Transcripts: ENSRNOT00000017086, ENSRNOT00000042606 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
