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Gene: Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2) Rattus norvegicus
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Symbol: Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Description: Predicted to have Ras guanyl-nucleotide exchange factor activity. Involved in positive regulation of small GTPase mediated signal transduction. Predicted to localize to the nucleosome. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2); PARTICIPATES IN insulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: son of sevenless 1; son of sevenless homolog 2; son of sevenless homolog 2 (Drosophila); Sos1
Orthologs:
Homo sapiens (human) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Canis lupus familiaris (dog) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Sus scrofa (pig) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Chlorocebus sabaeus (African green monkey) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Heterocephalus glaber (naked mole-rat) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0691,885,292 - 92,008,059 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,883,425 - 92,007,957 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06101,337,035 - 101,457,580 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,609,463 - 91,722,481 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1691,671,060 - 91,684,551 (-)NCBI
Celera686,538,138 - 86,650,990 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Sos2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620435
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.