RGD Reference Report - Regulation of NF-kappaB by ubiquitination. - Rat Genome Database

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Regulation of NF-kappaB by ubiquitination.

Authors: Chen, J  Chen, ZJ 
Citation: Chen J and Chen ZJ, Curr Opin Immunol. 2013 Feb;25(1):4-12. doi: 10.1016/j.coi.2012.12.005. Epub 2013 Jan 8.
RGD ID: 7800734
Pubmed: PMID:23312890   (View Abstract at PubMed)
PMCID: PMC3594545   (View Article at PubMed Central)
DOI: DOI:10.1016/j.coi.2012.12.005   (Journal Full-text)

The nuclear factor kappa enhancer binding protein (NF-kappaB) family of transcription factors regulates the expression of a large array of genes involved in diverse cellular processes including inflammation, immunity and cell survival. Activation of NF-kappaB requires ubiquitination, a highly conserved and versatile modification that can regulate cell signaling through both proteasome dependent and independent mechanisms. Studies in the past few years have provided new insights into the mechanisms underlying regulation of NF-kappaB by ubiquitination, including the involvement of multiple linkages of ubiquitin, the essential role of ubiquitin binding, and the function of unanchored polyubiquitin chains. In this review, we will focus on recent advances in understanding the role of ubiquitination in NF-kappaB regulation in various pathways.

Objects Annotated

Genes (Rattus norvegicus)
Cyld  (CYLD lysine 63 deubiquitinase)
Itch  (itchy E3 ubiquitin protein ligase)
Tax1bp1  (Tax1 binding protein 1)
Tnfaip3  (TNF alpha induced protein 3)

Genes (Mus musculus)
Cyld  (CYLD lysine 63 deubiquitinase)
Itch  (itchy, E3 ubiquitin protein ligase)
Rnf11  (ring finger protein 11)
Tax1bp1  (Tax1 (human T cell leukemia virus type I) binding protein 1)
Tnfaip3  (tumor necrosis factor, alpha-induced protein 3)

Genes (Homo sapiens)
CYLD  (CYLD lysine 63 deubiquitinase)
ITCH  (itchy E3 ubiquitin protein ligase)
RNF11  (ring finger protein 11)
TAX1BP1  (Tax1 binding protein 1)
TNFAIP3  (TNF alpha induced protein 3)


Additional Information