calcium ion - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	calcium ion	go back to main search page
Accession:	CHEBI:39124	browse the term
Synonyms:	related_synonym:	Formula=Ca; calcium ions

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Genes (358)

calcium ion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxymethylbilane synthase

decreases activity

Calcium ion decreases activity of purified Hmbs protein

RGD

NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525

atorvastatin calcium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family A member 1

increases expression
decreases expression
multiple interactions

Atorvastatin results in increased expression of ABCA1 mRNA
Atorvastatin results in decreased expression of ABCA1 mRNA; Atorvastatin results in decreased expression of ABCA1 protein
[Rosiglitazone co-treated with Atorvastatin] results in increased expression of ABCA1 protein

PMID:15183127 PMID:16386711 PMID:25278499

NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895

G

ATP-binding cassette, sub-family B member 11

multiple interactions
decreases activity

Atorvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]; Atorvastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atorvastatin results in decreased activity of ABCB11 protein

PMID:15901796 PMID:23956101 PMID:24014644

NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958

G

ATP-binding cassette, sub-family B member 1A

multiple interactions
decreases expression
decreases activity
increases transport

ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Atorvastatin]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
Atorvastatin results in decreased expression of ABCB1A mRNA
Atorvastatin analog results in decreased activity of ABCB1 protein
ABCB1 protein results in increased transport of Atorvastatin; ABCB1 protein results in increased transport of Atorvastatin analog

PMID:10751037 PMID:15616150 PMID:19802823 PMID:24502637

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ATP-binding cassette, sub-family B member 4

increases expression

Atorvastatin results in increased expression of ABCB4 mRNA; Atorvastatin results in increased expression of ABCB4 protein

PMID:15986414 PMID:25278499

NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231

G

ATP-binding cassette, sub-family member 2

decreases activity
multiple interactions
increases expression

Atorvastatin analog results in decreased activity of ABCC2 protein
ABCC2 protein binds to and results in increased uptake of Atorvastatin analog; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
Atorvastatin results in increased expression of ABCC2 mRNA

PMID:15616150 PMID:23562342 PMID:25278499

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

ATP-binding cassette, sub-family C member 3

increases expression

Atorvastatin results in increased expression of ABCC3 mRNA; Atorvastatin results in increased expression of ABCC3 protein

NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823

G

ATP binding cassette subfamily G member 2 (Junior blood group)

increases expression

Atorvastatin results in increased expression of ABCG2 mRNA

NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661

G

ATP binding cassette subfamily G member 5

increases expression

Atorvastatin results in increased expression of ABCG5 mRNA

NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439

G

ATP binding cassette subfamily G member 8

increases expression

Atorvastatin results in increased expression of ABCG8 mRNA

NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761

G

acetyl-Coenzyme A carboxylase beta

increases expression
multiple interactions

Atorvastatin results in increased expression of ACACB mRNA
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of ACACB mRNA]

NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822

G

angiotensin I converting enzyme

decreases expression

Atorvastatin results in decreased expression of ACE mRNA

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

angiotensin converting enzyme 2

increases expression

Atorvastatin results in increased expression of ACE2 mRNA

NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416

G

acyl-Coenzyme A oxidase 1, palmitoyl

multiple interactions

Atorvastatin inhibits the reaction [Fructose results in decreased expression of ACOX1 mRNA]

NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871

G

actin alpha 2, smooth muscle, aorta

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of ACTA2 protein]

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

ADAM metallopeptidase domain 12

decreases expression

Atorvastatin results in decreased expression of ADAM12 protein

NCBI chr 7:133,484,928...133,826,859
Ensembl chr 7:133,484,928...133,833,875

G

a disintegrin and metallopeptidase domain 17

decreases expression

Atorvastatin results in decreased expression of ADAM17 protein

NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633

G

adhesion G protein-coupled receptor E1

multiple interactions

Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]

NCBI chr17:57,665,650...57,790,527
Ensembl chr17:57,665,691...57,790,527

G

adiponectin, C1Q and collagen domain containing

decreases expression
increases expression

Atorvastatin results in decreased expression of ADIPOQ protein
Atorvastatin results in increased expression of ADIPOQ protein

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

angiotensinogen

multiple interactions

Atorvastatin inhibits the reaction [AGT protein results in decreased expression of SOD1 protein]; Atorvastatin inhibits the reaction [AGT protein results in increased abundance of Malondialdehyde]; Atorvastatin inhibits the reaction [AGT protein results in increased activity of MAPK1 protein]; Atorvastatin inhibits the reaction [AGT protein results in increased activity of MAPK3 protein]; Atorvastatin inhibits the reaction [AGT protein results in increased expression of NOX1 protein]

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

aldo-keto reductase family 7, member A5

increases expression

Atorvastatin results in increased expression of AKR7A2 mRNA; Atorvastatin results in increased expression of AKR7A2 protein

NCBI chr 4:139,038,005...139,046,097
Ensembl chr 4:139,038,055...139,045,737

G

thymoma viral proto-oncogene 1

multiple interactions
increases phosphorylation
decreases phosphorylation

Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of AKT1 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]
Atorvastatin results in increased phosphorylation of AKT1 protein
[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of AKT1 protein; Atorvastatin results in decreased expression of and results in decreased phosphorylation of AKT1 protein

PMID:18172863 PMID:19526287 PMID:20305681 PMID:27345130 PMID:27815113 More...

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

angiopoietin 2

increases expression

Atorvastatin results in increased expression of ANGPT2 mRNA

NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578

G

apolipoprotein B

multiple interactions
decreases secretion
decreases expression

Atorvastatin results in decreased expression of and results in decreased secretion of APOB protein
Atorvastatin inhibits the reaction [Fructose results in increased expression of APOB protein]
Atorvastatin results in decreased secretion of APOB protein
Atorvastatin results in decreased expression of APOB protein

PMID:9512650 PMID:10357840 PMID:11728391 PMID:12065722 PMID:12172771 More...

NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835

G

apolipoprotein E

decreases expression
multiple interactions

Atorvastatin results in decreased expression of APOE mRNA; Atorvastatin results in decreased expression of APOE protein
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BAX protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CASP3 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of RELA protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TRP53 protein]
[Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein

PMID:16386711 PMID:19603250 PMID:32976958 PMID:37121058

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

amyloid beta precursor protein

multiple interactions

Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A2 protein]; Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A3 protein]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

activating transcription factor 6

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

autophagy related 5

multiple interactions
increases response to substance

ATG5 mutant form promotes the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; ATG5 mutant form promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein]
ATG5 results in increased susceptibility to Atorvastatin

NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287

G

BCL2-antagonist/killer 1

increases expression

Atorvastatin results in increased expression of BAK1 protein

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

BCL2-associated X protein

increases expression
multiple interactions

Atorvastatin results in increased expression of BAX protein
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BAX protein]

PMID:19935899 PMID:37121058

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression
multiple interactions

Atorvastatin results in decreased expression of BCL2 mRNA; Atorvastatin results in decreased expression of BCL2 protein
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of BCL2 protein]
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in decreased expression of BCL2 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased expression of BCL2 protein]

PMID:16470222 PMID:31423616 PMID:32259528 PMID:37121058

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

beclin 1, autophagy related

increases expression

Atorvastatin results in increased expression of BECN1 protein

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

bone gamma carboxyglutamate protein

increases expression

Atorvastatin results in increased expression of BGLAP mRNA

NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771

G

BH3 interacting domain death agonist

multiple interactions

Atorvastatin results in decreased expression of and results in increased cleavage of BID protein; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of and results in increased cleavage of BID protein]; U 0126 inhibits the reaction [Atorvastatin results in decreased expression of and results in increased cleavage of BID protein]

NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814

G

baculoviral IAP repeat-containing 5

decreases expression

Atorvastatin results in decreased expression of BIRC5 mRNA; Atorvastatin results in decreased expression of BIRC5 protein

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

G

bone morphogenetic protein 2

increases expression
increases secretion

Atorvastatin results in increased expression of BMP2 mRNA
Atorvastatin results in increased secretion of BMP2 protein

PMID:16470222 PMID:17252541

NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805

G

complement component 3

multiple interactions

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of C3 protein modified form]

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

caspase 1

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CASP1 protein]

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 3

increases activity
decreases activity
multiple interactions
increases cleavage

Atorvastatin results in increased activity of CASP3 protein
Atorvastatin results in decreased activity of CASP3 protein
[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]
Atorvastatin results in increased cleavage of CASP3 protein
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the cleavage of CASP3 protein; ATG5 mutant form promotes the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CASP3 protein]; Atorvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of and results in increased activity of CASP3 protein; bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; RHOA protein inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]

PMID:16470222 PMID:18172863 PMID:18339080 PMID:19429019 PMID:20305681 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

multiple interactions
increases activity

[Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP8 protein
[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein]; [Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased expression of CASP8 protein]
Atorvastatin results in increased activity of CASP8 protein

PMID:15705602 PMID:18172863 PMID:20946910

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions
increases activity

[Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP9 protein
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of CASP9 protein]; U 0126 inhibits the reaction [Atorvastatin results in increased activity of CASP9 protein]

PMID:15705602 PMID:16470222 PMID:18172863 PMID:18339080 PMID:29630879

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions
increases activity

Atorvastatin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
Atorvastatin results in increased activity of CAT protein

PMID:17479860 PMID:25218292

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression

Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Atorvastatin results in decreased expression of and results in decreased secretion of CCL2 protein; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of CCL2 mRNA]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of CCL2 protein]

PMID:12117737 PMID:25058445 PMID:34939712

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

CD14 antigen

decreases expression

Atorvastatin results in decreased expression of CD14 protein

NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851

G

CD36 molecule

multiple interactions

Atorvastatin inhibits the reaction [Rosiglitazone results in increased expression of CD36 mRNA]; Atorvastatin inhibits the reaction [Rosiglitazone results in increased expression of CD36 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CD36 protein]

PMID:15183127 PMID:16386711 PMID:32259528

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD40 antigen

decreases expression

Atorvastatin results in decreased expression of CD40 protein

NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868

G

CD40 ligand

decreases expression

Atorvastatin results in decreased expression of CD40LG protein

PMID:16368305 PMID:19171469

NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402

G

CD83 antigen

decreases expression

Atorvastatin results in decreased expression of CD83 protein

NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608

G

CD86 antigen

decreases expression

Atorvastatin results in decreased expression of CD86 protein

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

cell division cycle 42

multiple interactions

[Poly I-C co-treated with Atorvastatin] results in decreased expression of CDC42 mRNA

NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031

G

cadherin 1

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of CDH1 protein]

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression

[Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1A protein; CDKN1A protein mutant form inhibits the reaction [Atorvastatin results in increased cleavage of PARP1 protein]
Atorvastatin results in increased expression of CDKN1A protein

PMID:18172863 PMID:20876807

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

multiple interactions
increases expression

[Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1B protein
Atorvastatin results in increased expression of CDKN1B protein

PMID:16470222 PMID:18172863

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

conserved helix-loop-helix ubiquitous kinase

multiple interactions

Atorvastatin inhibits the reaction [Sodium Glutamate results in increased phosphorylation of CHUK protein]

NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919

G

chloride channel, voltage-sensitive 1

decreases expression

Atorvastatin results in decreased expression of CLCN1 protein

NCBI chr 6:42,263,552...42,292,693
Ensembl chr 6:42,263,619...42,292,690

G

collagen, type I, alpha 1

increases expression

Atorvastatin results in increased expression of COL1A1 mRNA

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

carnitine palmitoyltransferase 1a, liver

increases expression
multiple interactions

Atorvastatin results in increased expression of CPT1A mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin results in increased expression of CPT1A mRNA]

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

C-reactive protein, pentraxin-related

multiple interactions
decreases expression

[Atorvastatin co-treated with Amlodipine] results in decreased expression of CRP protein; Atorvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP mRNA]; Atorvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein]
Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of CRP protein]
Atorvastatin results in decreased expression of CRP protein

PMID:16025360 PMID:16360360 PMID:17673219 PMID:18389332 PMID:21584495 More...

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

citrate synthase

increases expression
multiple interactions

Atorvastatin results in increased expression of CS mRNA
Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of CS mRNA]

NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348

G

colony stimulating factor 2 (granulocyte-macrophage)

multiple interactions

Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of CSF2 mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of CSF2 protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of CSF2 mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of CSF2 protein]

NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493

G

C-X-C motif chemokine ligand 10

decreases expression

Atorvastatin results in decreased expression of CXCL10

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 15

multiple interactions
increases expression
decreases secretion
decreases expression

Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of CXCL8 mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of CXCL8 protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of CXCL8 mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of CXCL8 protein]; Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Atorvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; Atorvastatin results in decreased expression of and results in decreased secretion of CXCL8 protein; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of CXCL8 mRNA]
Atorvastatin results in increased expression of CXCL8 protein
Atorvastatin results in decreased secretion of CXCL8 protein
Atorvastatin results in decreased expression of CXCL8 mRNA; Atorvastatin results in decreased expression of CXCL8 protein

PMID:12117737 PMID:16387846 PMID:16410222 PMID:19171469 PMID:19482827

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome b-245, alpha polypeptide

multiple interactions

Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of CYBA mRNA]

NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669

G

cytochrome c, somatic

multiple interactions
affects localization

[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of CYCS protein]
Atorvastatin affects the localization of CYCS protein
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin affects the localization of CYCS protein]

PMID:31423616 PMID:32259528

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 11, subfamily a, polypeptide 1

affects expression

Atorvastatin affects the expression of CYP11A1 mRNA

NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

Atorvastatin results in increased expression of CYP17A1 mRNA

NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

Atorvastatin results in increased expression of CYP19A1 mRNA

NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression
increases expression

Atorvastatin results in decreased expression of CYP27A1 mRNA; Atorvastatin results in decreased expression of CYP27A1 protein
Atorvastatin results in increased expression of CYP27A1 mRNA

PMID:16386711 PMID:25278499

NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051

G

cytochrome P450, family 2, subfamily b, polypeptide 10

increases expression

Atorvastatin results in increased expression of CYP2B6 mRNA
Atorvastatin results in increased expression of CYP2B10 mRNA; Atorvastatin results in increased expression of CYP2B10 protein

PMID:15802384 PMID:15986414

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 39, subfamily a, polypeptide 1

increases expression

Atorvastatin results in increased expression of CYP39A1 mRNA

NCBI chr17:43,978,263...44,062,322
Ensembl chr17:43,978,316...44,062,322

G

cytochrome P450, family 3, subfamily a, polypeptide 11

increases expression

Atorvastatin results in increased expression of CYP3A11 mRNA; Atorvastatin results in increased expression of CYP3A11 protein

NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774

G

cytochrome P450, family 7, subfamily a, polypeptide 1

increases expression
multiple interactions

Atorvastatin results in increased expression of CYP7A1 mRNA
Atorvastatin inhibits the reaction [Dietary Fats results in decreased expression of CYP7A1 mRNA]

PMID:25278499 PMID:32048413

NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633

G

cytochrome P450, family 7, subfamily b, polypeptide 1

decreases expression

Atorvastatin results in decreased expression of CYP7B1 mRNA

NCBI chr 3:18,126,108...18,298,054
Ensembl chr 3:18,126,114...18,297,502

G

doublecortin

increases expression

Atorvastatin results in increased expression of DCX protein

NCBI chr X:142,638,838...142,716,392
Ensembl chr X:142,638,838...142,716,307

G

diacylglycerol O-acyltransferase 1

increases expression
multiple interactions
increases activity

Atorvastatin results in increased expression of DGAT1 mRNA
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of DGAT1 protein]

NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153

G

DNA replication and sister chromatid cohesion 1

affects response to substance

DSCC1 protein affects the susceptibility to Atorvastatin

NCBI chr15:54,939,497...54,953,887
Ensembl chr15:54,939,495...54,953,887

G

endothelin 1

decreases expression

Atorvastatin results in decreased expression of EDN1 protein

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

endothelin receptor type A

multiple interactions
decreases expression

Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]; Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA]

NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093

G

epidermal growth factor receptor

multiple interactions

Atorvastatin inhibits the reaction [Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein]

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases response to substance

EIF2AK3 mutant form inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]
EIF2AK3 results in increased susceptibility to Atorvastatin

NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229

G

eukaryotic translation initiation factor 2, subunit 1 alpha

multiple interactions
increases phosphorylation

4-phenylbutyric acid inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]; EIF2AK3 mutant form inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein]

NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784

G

erythrocyte membrane protein band 4.1

multiple interactions

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in decreased expression of EPB41 protein]

NCBI chr 4:131,650,724...131,802,824
Ensembl chr 4:131,650,724...131,802,632

G

coagulation factor II

decreases activity

Atorvastatin results in decreased activity of F2 protein

NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759

G

coagulation factor V

decreases activity

Atorvastatin results in decreased activity of F5 protein

NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846

G

Fas associated via death domain

multiple interactions

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased expression of FADD protein]

NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200

G

Fas cell surface death receptor

affects expression

Atorvastatin affects the expression of FAS mRNA; Atorvastatin affects the expression of FAS protein

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fas ligand

multiple interactions
increases expression

[Atorvastatin co-treated with Acetylcysteine] inhibits the reaction [sodium arsenite results in increased expression of FASLG protein]
Atorvastatin results in increased expression of FASLG protein modified form
Atorvastatin inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of FASLG protein modified form]

PMID:15063428 PMID:20946910

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

fatty acid synthase

increases expression
multiple interactions

Atorvastatin results in increased expression of FASN mRNA
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of FASN mRNA]

PMID:11728391 PMID:12056585 PMID:32259528

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

F-box protein 32

increases expression

Atorvastatin results in increased expression of FBXO32 mRNA

NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328

G

fibroblast growth factor 15

decreases expression

Atorvastatin results in decreased expression of FGF15 mRNA

NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690

G

forkhead box O1

decreases phosphorylation

Atorvastatin results in decreased phosphorylation of FOXO1 protein

NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642

G

ferritin heavy polypeptide 1

multiple interactions

Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]

NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[Atorvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA

NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729

G

glucokinase

decreases expression
multiple interactions

Atorvastatin results in decreased expression of GCK protein
NR1I2 protein promotes the reaction [Atorvastatin results in decreased expression of GCK protein]

NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081

G

gap junction protein, alpha 1

multiple interactions

Atorvastatin promotes the reaction [dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of GJA1 protein]]

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

guanine nucleotide binding protein (G protein), gamma 3

multiple interactions
affects localization

[Isoproterenol co-treated with Atorvastatin] affects the localization of GNG3 protein
Atorvastatin affects the localization of GNG3 protein

NCBI chr19:8,814,293...8,816,610
Ensembl chr19:8,814,297...8,816,558

G

glutamic-oxaloacetic transaminase 1, soluble

multiple interactions

Atorvastatin inhibits the reaction [Streptozocin results in increased secretion of GOT1 protein]

NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044

G

glycerol-3-phosphate acyltransferase, mitochondrial

multiple interactions

Atorvastatin inhibits the reaction [Fructose results in increased expression of GPAM mRNA]

NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670

G

glutamic pyruvic transaminase, soluble

multiple interactions

[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]; Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; Buthionine Sulfoximine promotes the reaction [[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein]
[Atorvastatin co-treated with triptolide] results in increased expression of GPT protein; [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of GPT protein]; Atorvastatin inhibits the reaction [Streptozocin results in increased secretion of GPT protein]

PMID:29679711 PMID:30657622 PMID:32259528 PMID:32976958 PMID:33600922 More...

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 4

multiple interactions

Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein]

NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273

G

heparin-binding EGF-like growth factor

decreases expression

Atorvastatin results in decreased expression of HBEGF protein

NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

multiple interactions
affects binding
increases expression
increases activity

Atorvastatin results in increased expression of and results in increased activity of HMGCR protein
Atorvastatin binds to HMGCR protein
Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA]; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]; Atorvastatin results in increased expression of and results in increased activity of HMGCR protein; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of HMGCR mRNA]

PMID:9512650 PMID:10357840 PMID:12056585 PMID:12065722 PMID:12612140 More...

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

heme oxygenase 1

increases expression
multiple interactions

Atorvastatin results in increased expression of HMOX1 mRNA
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein]
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]

PMID:16410222 PMID:32259528 PMID:32976958 PMID:38484826

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

hepatic nuclear factor 4, alpha

multiple interactions

Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HNF4A mRNA]

NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830

G

5-hydroxytryptamine (serotonin) receptor 7

multiple interactions

Atorvastatin inhibits the reaction [Dietary Fats promotes the reaction [Isoproterenol results in increased expression of HTR7 mRNA]]; Atorvastatin inhibits the reaction [Isoproterenol promotes the reaction [Dietary Fats results in increased expression of HTR7 mRNA]]

NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907

G

intercellular adhesion molecule 1

multiple interactions
increases expression

Atorvastatin inhibits the reaction [TNF results in increased expression of ICAM1]
Atorvastatin results in increased expression of ICAM1 protein
Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of ICAM1 protein]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]

PMID:12615677 PMID:17589825 PMID:19171469 PMID:25058445

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

inhibitor of kappaB kinase beta

multiple interactions

Atorvastatin inhibits the reaction [Sodium Glutamate results in increased phosphorylation of IKBKB protein]

NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605

G

interleukin 12a

decreases expression

Atorvastatin results in decreased expression of IL12A mRNA

NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880

G

interleukin 18

multiple interactions

Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 1 beta

multiple interactions

Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of IL1B mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]
Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]

PMID:17589825 PMID:19482827 PMID:25058445 PMID:32048413 PMID:34939712 More...

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 2 receptor, alpha chain

affects expression

Atorvastatin affects the expression of IL2RA protein

NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004

G

interleukin 6

multiple interactions
decreases expression
decreases secretion

Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of IL6 mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of IL6 protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; Atorvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Atorvastatin results in decreased expression of and results in decreased secretion of IL6 protein; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of IL6 mRNA]
Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of IL6 mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of IL6 protein]
Atorvastatin results in decreased expression of IL6 mRNA; Atorvastatin results in decreased expression of IL6 protein
Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of IL6 protein]; Atorvastatin inhibits the reaction [Dietary Fats promotes the reaction [Isoproterenol results in increased expression of IL6 mRNA]]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; Atorvastatin inhibits the reaction [Isoproterenol promotes the reaction [Dietary Fats results in increased expression of IL6 mRNA]]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
Atorvastatin results in decreased secretion of IL6 protein

PMID:12117737 PMID:16387846 PMID:17521631 PMID:19171469 PMID:19482827 More...

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

insulin I

multiple interactions

Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of INS1 protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]

PMID:19800637 PMID:34939712

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

insulin II

increases expression

Atorvastatin results in increased expression of INS protein

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

interleukin-1 receptor-associated kinase 1

multiple interactions

[Atorvastatin co-treated with Enalapril] results in decreased expression of IRAK1 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of IRAK1 mRNA

NCBI chr X:73,057,520...73,067,527
Ensembl chr X:73,057,520...73,067,524

G

interferon regulatory factor 4

decreases expression

Atorvastatin results in decreased expression of IRF4 protein

NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959

G

integrin alpha 2

multiple interactions

Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]; geranylgeraniol inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]

NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636

G

integrin alpha L

multiple interactions

Atorvastatin inhibits the reaction [TNF results in increased expression of ITGAL]

NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310

G

integrin alpha M

decreases expression

Atorvastatin results in decreased expression of ITGAM protein

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

integrin alpha X

decreases expression

Atorvastatin results in decreased expression of ITGAX protein

NCBI chr 7:127,728,697...127,749,829
Ensembl chr 7:127,728,719...127,749,829

G

integrin beta 1 (fibronectin receptor beta)

increases expression
multiple interactions

Atorvastatin results in increased expression of ITGB1 mRNA
Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]; geranylgeraniol inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of ITGB1 mRNA]

NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681

G

integrin beta 2

multiple interactions

Atorvastatin inhibits the reaction [TNF results in increased expression of ITGB2]

NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542

G

jun proto-oncogene

multiple interactions

[Atorvastatin co-treated with Celecoxib] results in increased expression of JUN protein; Atorvastatin results in increased phosphorylation of and results in increased activity of JUN protein; Celecoxib promotes the reaction [Atorvastatin results in increased phosphorylation of and results in increased activity of JUN protein]

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

potassium voltage-gated channel, subfamily H (eag-related), member 2

decreases activity
multiple interactions

Atorvastatin results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]

NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602

G

ketohexokinase

multiple interactions

Atorvastatin inhibits the reaction [Fructose results in increased expression of KHK protein]

NCBI chr 5:31,078,780...31,088,592
Ensembl chr 5:31,078,775...31,088,592

G

kinesin family member 6

increases response to substance

KIF6 polymorphism results in increased susceptibility to Atorvastatin

NCBI chr17:49,922,121...50,216,875
Ensembl chr17:49,922,164...50,216,875

G

karyopherin subunit alpha 2

multiple interactions
affects localization

[Ivermectin co-treated with Atorvastatin] affects the localization of KPNA2 protein
Atorvastatin affects the localization of KPNA2 protein

NCBI chr11:106,879,455...106,890,351
Ensembl chr11:106,879,455...106,890,367

G

karyopherin subunit alpha 7

multiple interactions

Atorvastatin inhibits the reaction [Poly I-C results in increased expression of KPNA7 mRNA]

NCBI chr 5:144,920,537...144,946,446
Ensembl chr 5:144,920,329...145,020,840

G

lecithin cholesterol acyltransferase

multiple interactions

Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LCAT protein]

NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014

G

lipocalin 2

multiple interactions

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of LCN2 mRNA
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of LCN2 protein]

PMID:29679711 PMID:32259528

NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264

G

low density lipoprotein receptor

increases activity
multiple interactions
increases expression

Atorvastatin results in increased activity of LDLR protein
Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA]; Atorvastatin inhibits the reaction [Dietary Fats results in decreased expression of LDLR mRNA]
Atorvastatin results in increased expression of LDLR mRNA

PMID:10357840 PMID:11728391 PMID:12612140 PMID:24502637 PMID:30273964 More...

NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215

G

leptin

multiple interactions

Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein]

NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876

G

lipoprotein lipase

multiple interactions

Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein]

NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased lipidation of MAP1LC3B protein]

NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation
decreases phosphorylation

geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]
Atorvastatin inhibits the reaction [AGT protein results in increased activity of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK1 protein]
Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:16470222 PMID:18339080 PMID:18360054 PMID:19451411

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 14

multiple interactions

Atorvastatin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]
Atorvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK14 protein]

PMID:17589825 PMID:19767766 PMID:20018284 PMID:20305681

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]
Atorvastatin inhibits the reaction [AGT protein results in increased activity of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Atorvastatin results in increased phosphorylation of MAPK3 protein]
Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:16470222 PMID:18339080 PMID:18360054 PMID:19451411

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

myoglobin

increases expression
multiple interactions

Atorvastatin results in increased expression of MB protein
[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased secretion of MB protein

PMID:27815113 PMID:29679711

NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870

G

myeloid cell leukemia sequence 1

decreases expression

Atorvastatin results in decreased expression of MCL1 protein

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

transformed mouse 3T3 cell double minute 2

increases expression

Atorvastatin results in increased expression of MDM2 protein

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

myocyte enhancer factor 2D

increases expression

Atorvastatin results in increased expression of MEF2D mRNA

NCBI chr 3:88,049,248...88,079,398
Ensembl chr 3:88,049,679...88,079,393

G

mitofusin 2

multiple interactions

Atorvastatin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of MFN2 protein]

NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161

G

microRNA 133b

multiple interactions

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR133B mRNA

NCBI chr 1:20,752,993...20,753,111
Ensembl chr 1:20,752,993...20,753,111

G

microRNA 145a

increases expression

Atorvastatin results in increased expression of MIR145 mRNA

NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965

G

microRNA 146

multiple interactions

[Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146A; [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146A

NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288

G

microRNA 146b

multiple interactions

[Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146B; [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146B

NCBI chr19:46,331,201...46,331,309
Ensembl chr19:46,331,201...46,331,309

G

microRNA 206

multiple interactions

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR206 mRNA

NCBI chr 1:20,749,234...20,749,306
Ensembl chr 1:20,749,234...20,749,306

G

microRNA 221

decreases expression

Atorvastatin results in decreased expression of MIR221

NCBI chr X:19,012,533...19,012,627
Ensembl chr X:19,012,533...19,012,627

G

microRNA 222

decreases expression

Atorvastatin results in decreased expression of MIR222

NCBI chr X:19,013,132...19,013,210
Ensembl chr X:19,013,132...19,013,210

G

MLX interacting protein-like

multiple interactions

Atorvastatin inhibits the reaction [Fructose affects the localization of and results in increased activity of MLXIPL protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of MLXIPL protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin inhibits the reaction [Fructose results in increased activity of MLXIPL protein]]

PMID:19053045 PMID:21122807

NCBI chr 5:135,118,744...135,168,622
Ensembl chr 5:135,118,744...135,167,236

G

matrix metallopeptidase 2

decreases expression
increases activity

Atorvastatin results in decreased expression of MMP2 protein
Atorvastatin results in increased activity of MMP2 protein

PMID:18360054 PMID:23831763

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

multiple interactions
increases activity

Atorvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Atorvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Sildenafil Citrate promotes the reaction [Atorvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]]
Atorvastatin results in increased activity of MMP9 protein

PMID:15728660 PMID:23831763 PMID:26614570

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

myeloperoxidase

multiple interactions

Atorvastatin inhibits the reaction [Paraquat results in increased activity of MPO protein]

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

macrophage scavenger receptor 1

multiple interactions

[Rosiglitazone co-treated with Atorvastatin] results in increased expression of MSR1 mRNA

NCBI chr 8:39,996,284...40,095,790
Ensembl chr 8:40,034,726...40,095,714

G

myostatin

increases expression

Atorvastatin results in increased expression of MSTN protein

NCBI chr 1:53,100,799...53,107,238
Ensembl chr 1:53,100,799...53,107,238

G

cytochrome c oxidase I, mitochondrial

affects expression
multiple interactions

Atorvastatin affects the expression of COX1 mRNA
Quercetin inhibits the reaction [Atorvastatin affects the expression of COX1 mRNA]

NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872

G

metallothionein 2

multiple interactions

Atorvastatin inhibits the reaction [Fructose results in increased expression of MT2A mRNA]

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

G

mechanistic target of rapamycin kinase

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of and results in increased phosphorylation of MTOR protein]

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

microsomal triglyceride transfer protein

increases expression
multiple interactions
decreases expression

Atorvastatin results in increased expression of MTTP mRNA
Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of MTTP mRNA]
Atorvastatin results in decreased expression of MTTP mRNA

PMID:10357840 PMID:12056585

NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729

G

myelocytomatosis oncogene

decreases expression

Atorvastatin results in decreased expression of MYC mRNA

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

G

myeloid differentiation primary response gene 88

multiple interactions

Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of MYD88 mRNA]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of MYD88 protein]

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

G

myosin, heavy polypeptide 2, skeletal muscle, adult

affects expression
multiple interactions

Atorvastatin affects the expression of MYH2 protein
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of MYH2 protein

NCBI chr11:67,061,853...67,088,343
Ensembl chr11:67,061,853...67,088,343

G

nuclear factor, erythroid derived 2,-like 1

increases expression

Atorvastatin results in increased expression of NFE2L1 mRNA

NCBI chr11:96,708,239...96,720,810
Ensembl chr11:96,708,240...96,720,794

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
increases expression
decreases expression

[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of NFE2L2 mRNA; Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein]
Atorvastatin results in increased expression of NFE2L2 mRNA
Atorvastatin results in decreased expression of NFE2L2 protein
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in decreased expression of NFE2L2 protein]; Atorvastatin results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of NFE2L2 protein]

PMID:30511338 PMID:31423616 PMID:32259528 PMID:32976958 PMID:38484826

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

multiple interactions

[Ivermectin co-treated with Atorvastatin] inhibits the reaction [Poly I-C results in increased expression of NFKB1 mRNA]; Atorvastatin inhibits the reaction [Poly I-C results in increased expression of NFKB1 mRNA]
Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]

PMID:34696514 PMID:37023836

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

NLR family, pyrin domain containing 3

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NLRP3 protein]
Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]

PMID:34939712 PMID:37023836

NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782

G

nicotinamide N-methyltransferase

increases expression

Atorvastatin results in increased expression of NNMT protein

NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453

G

nitric oxide synthase 2, inducible

multiple interactions
decreases expression

Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOS2 mRNA]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
Atorvastatin results in decreased expression of NOS2 mRNA; Atorvastatin results in decreased expression of NOS2 protein

PMID:15166393 PMID:25058445 PMID:25218292

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

multiple interactions
increases expression
affects response to substance

Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]; Melatonin promotes the reaction [Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]]
Atorvastatin results in increased expression of NOS3 mRNA; Atorvastatin results in increased expression of NOS3 protein
[Dexamethasone co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; [Losartan co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [sodium arsenite results in decreased expression of and results in decreased phosphorylation of NOS3 protein]; Atorvastatin inhibits the reaction [sodium arsenite results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOS3 protein]; Atorvastatin inhibits the reaction [Streptozocin results in decreased expression of NOS3 protein]
Atorvastatin inhibits the reaction [Homocysteine results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of NOS3 protein]
NOS3 promoter SNP affects the susceptibility to Atorvastatin

PMID:12490971 PMID:15166393 PMID:16410222 PMID:16962929 PMID:17042910 More...

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

NADPH oxidase 1

multiple interactions

Atorvastatin inhibits the reaction [AGT protein results in increased expression of NOX1 protein]

NCBI chr X:132,987,170...133,038,455
Ensembl chr X:132,987,170...133,122,705

G

NADPH oxidase 4

multiple interactions

Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOX4 mRNA]
Atorvastatin inhibits the reaction [Homocysteine results in increased expression of NOX4 mRNA]

PMID:20018284 PMID:25218292

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

natriuretic peptide type A

multiple interactions

Atorvastatin inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

natriuretic peptide type B

decreases expression

Atorvastatin results in decreased expression of NPPB protein

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

Atorvastatin results in decreased expression of NR0B2 mRNA

NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases expression

[Atorvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA; [Atorvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA; NR1I2 protein promotes the reaction [Atorvastatin results in decreased expression of GCK protein]; NR1I2 protein promotes the reaction [Atorvastatin results in decreased expression of SLC2A2 protein]
Atorvastatin promotes the reaction [Dietary Fats results in increased expression of NR1I2 protein]
Atorvastatin binds to and results in increased activity of NR1I2 protein
Atorvastatin results in increased expression of NR1I2 protein

PMID:15986414 PMID:24204015 PMID:26616219

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

nuclear receptor subfamily 1, group I, member 3

increases activity

Atorvastatin results in increased activity of NR1I3 protein

NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270

G

nuclear respiratory factor 1

multiple interactions
affects expression
increases expression

Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of NRF1 mRNA]; Quercetin inhibits the reaction [Atorvastatin affects the expression of NRF1 mRNA]

NCBI chr 6:30,047,984...30,153,462
Ensembl chr 6:30,047,987...30,153,457

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions
increases cleavage

2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in increased cleavage of PARP1 protein]; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of PARP1 protein; bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein]; CDKN1A protein mutant form inhibits the reaction [Atorvastatin results in increased cleavage of PARP1 protein]
ATG5 mutant form promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein]

PMID:16470222 PMID:18172863 PMID:20876807 PMID:31423616

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

phosphate cytidylyltransferase 1, choline, alpha isoform

increases activity

Atorvastatin results in increased activity of PCYT1A protein

NCBI chr16:32,249,739...32,293,883
Ensembl chr16:32,249,739...32,293,888

G

pyruvate dehydrogenase kinase, isoenzyme 4

multiple interactions

Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]]

NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309

G

3-phosphoinositide dependent protein kinase 1

multiple interactions

[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of and results in decreased expression of PDPK1 protein

NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

decreases expression

Atorvastatin results in decreased expression of PIK3CA mRNA

NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635

G

pyruvate kinase liver and red blood cell

multiple interactions

Atorvastatin inhibits the reaction [Fructose results in increased expression of PKLR mRNA]

PMID:19053045 PMID:21122807

NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091

G

pyruvate kinase, muscle

increases expression

Atorvastatin results in increased expression of PKM mRNA

NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658

G

plasminogen activator, urokinase

decreases expression

Atorvastatin results in decreased expression of PLAU protein

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

perilipin 2

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of PLIN2 protein]

NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297

G

pro-opiomelanocortin-alpha

increases expression

Atorvastatin results in increased expression of POMC protein

NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642

G

paraoxonase 1

increases activity
multiple interactions
increases expression

Atorvastatin results in increased activity of PON1 protein
Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein]
PON1 gene polymorphism affects the reaction [Atorvastatin results in increased abundance of Cholesterol, HDL]; PON1 gene SNP affects the reaction [Atorvastatin results in increased abundance of Cholesterol, HDL]; PON1 protein affects the reaction [Atorvastatin results in increased abundance of Cholesterol, HDL]
Atorvastatin results in increased expression of PON1 mRNA

PMID:15324535 PMID:15690306 PMID:15969877 PMID:16238680 PMID:30273964

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

paraoxonase 2

increases activity
increases expression

Atorvastatin results in increased activity of PON2 protein
Atorvastatin results in increased expression of PON2 mRNA

NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455

G

peroxisome proliferator activated receptor alpha

decreases expression
multiple interactions

Atorvastatin results in decreased expression of PPARA mRNA
Atorvastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of PPARA protein]

PMID:12065722 PMID:18812576 PMID:21554872 PMID:32259528

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

peroxisome proliferator activated receptor gamma

multiple interactions

Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

decreases expression
affects expression
multiple interactions
increases expression

Atorvastatin results in decreased expression of PPARGC1A mRNA
Atorvastatin affects the expression of PPARGC1A mRNA
Atorvastatin results in decreased expression of PPARGC1A protein
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of PPARGC1A mRNA
Atorvastatin results in increased expression of PPARGC1A mRNA
[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of PPARGC1A mRNA]; Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]; Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]

PMID:21775390 PMID:22343369 PMID:30511338 PMID:32259528

NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068

G

peroxisome proliferative activated receptor, gamma, coactivator 1 beta

affects expression
affects response to substance
decreases expression
multiple interactions

Atorvastatin affects the expression of PPARGC1B mRNA
PPARGC1B protein affects the susceptibility to Atorvastatin
Atorvastatin affects the expression of PPARGC1B protein
Atorvastatin results in decreased expression of PPARGC1B mRNA
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the cleavage of CASP3 protein; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of MYH2 protein; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of NFE2L2 mRNA; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of PPARGC1A mRNA; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of PPARGC1B mRNA; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of SOD2 protein; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of TFAM mRNA; [PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of TOMM20 protein
Quercetin inhibits the reaction [Atorvastatin affects the expression of PPARGC1B mRNA]

PMID:21775390 PMID:30511338

NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502

G

protein phosphatase 3, catalytic subunit, alpha isoform

increases expression

Atorvastatin results in increased expression of PPP3CA mRNA

NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488

G

protein kinase, AMP-activated, alpha 1 catalytic subunit

increases activity

Atorvastatin results in increased activity of PRKAA1 protein

NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380

G

protein kinase, cAMP dependent, catalytic, alpha

multiple interactions

Atorvastatin results in increased phosphorylation of and results in increased activity of PRKACA protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin results in increased phosphorylation of and results in increased activity of PRKACA protein]

NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072

G

protein kinase C, alpha

multiple interactions

[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of PRKCA protein]

NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754

G

protein kinase C, theta

increases expression

Atorvastatin results in increased expression of PRKCQ mRNA; Atorvastatin results in increased expression of PRKCQ protein

NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033

G

protein kinase C, zeta

multiple interactions

[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PRKCZ protein]

NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818

G

phosphatase and tensin homolog

increases expression

Atorvastatin results in increased expression of PTEN protein

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

[Atorvastatin co-treated with Pioglitazone] results in increased expression of PTGS2 protein; [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of PTGS2 protein]
Atorvastatin results in increased expression of PTGS2 protein

PMID:16908763 PMID:34939712

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

Rac family small GTPase 1

multiple interactions

[Poly I-C co-treated with Atorvastatin] results in decreased expression of RAC1 mRNA; Atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]]
Atorvastatin inhibits the reaction [Streptozocin results in increased activity of RAC1 protein]
Atorvastatin inhibits the reaction [Streptozocin results in increased activity of and results in increased localization of RAC1 protein]

PMID:17279352 PMID:17589825 PMID:34696514

NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791

G

RB transcriptional corepressor 1

multiple interactions

[Atorvastatin co-treated with Celecoxib] results in decreased expression of RB1 protein modified form; [Atorvastatin co-treated with Celecoxib] results in increased expression of RB1 protein

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of RELA protein]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of RELA mRNA]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of RELA protein]; Atorvastatin inhibits the reaction [Nitroglycerin results in increased localization of RELA protein]
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of RELA protein]

PMID:19733216 PMID:34939712 PMID:37121058 PMID:38213245

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

ras homolog family member A

increases expression
decreases activity
multiple interactions
decreases localization

Atorvastatin results in increased expression of RHOA protein
Atorvastatin results in decreased activity of RHOA protein
Atorvastatin inhibits the reaction [Streptozocin results in increased activity of RHOA protein]
[Poly I-C co-treated with Atorvastatin co-treated with Ivermectin] results in increased expression of RHOA mRNA; [Poly I-C co-treated with Atorvastatin] results in increased expression of RHOA mRNA; Atorvastatin results in increased localization of and results in decreased prenylation of RHOA protein; Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOA protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased expression of BCL2 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]; RHOA mutant form inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]; RHOA protein inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]

PMID:16470222 PMID:17589825 PMID:18172863 PMID:34696514

NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133

G

ras homolog family member B

increases localization
increases expression
multiple interactions

Atorvastatin results in increased localization of RHOB protein
Atorvastatin results in increased expression of RHOB protein
[Atorvastatin co-treated with Celecoxib] results in increased localization of RHOB protein; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOB protein]

NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009

G

ras homolog family member C

decreases localization
multiple interactions
increases expression

Atorvastatin results in decreased localization of RHOC protein
Celecoxib promotes the reaction [Atorvastatin results in decreased localization of RHOC protein]; Celecoxib promotes the reaction [Atorvastatin results in increased expression of RHOC protein]

NCBI chr 3:104,696,350...104,701,775
Ensembl chr 3:104,695,691...104,701,775

G

scavenger receptor class B, member 1

multiple interactions

[Rosiglitazone co-treated with Atorvastatin] results in increased expression of SCARB1 protein

NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158

G

stearoyl-Coenzyme A desaturase 1

multiple interactions

Atorvastatin inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]

NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318

G

selectin, endothelial cell

increases expression

Atorvastatin results in increased expression of SELE protein

NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

multiple interactions

Atorvastatin inhibits the reaction [Fructose results in increased expression of SERPINE1 mRNA]

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

serum/glucocorticoid regulated kinase 2

multiple interactions

[Atorvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA

NCBI chr 2:162,829,249...162,856,059
Ensembl chr 2:162,829,250...162,856,047

G

sirtuin 1

multiple interactions
increases phosphorylation

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SIRT1 protein]
Atorvastatin results in increased phosphorylation of SIRT1 protein

PMID:33073877 PMID:34939712

NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483

G

solute carrier family 10 (sodium/bile acid cotransporter family), member 1

increases expression

Atorvastatin results in increased expression of SLC10A1 mRNA

NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479

G

solute carrier family 10, member 2

increases expression

Atorvastatin results in increased expression of SLC10A2 mRNA; Atorvastatin results in increased expression of SLC10A2 protein

NCBI chr 8:5,133,219...5,155,287
Ensembl chr 8:5,133,219...5,155,351

G

solute carrier family 1 (glial high affinity glutamate transporter), member 2

multiple interactions

Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A2 protein]

NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129

G

solute carrier family 1 (glial high affinity glutamate transporter), member 3

multiple interactions

Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A3 protein]

NCBI chr15:8,663,608...8,742,648
Ensembl chr15:8,663,608...8,740,248

G

solute carrier family 22 (organic cation transporter), member 1

multiple interactions
increases expression

Atorvastatin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Atorvastatin results in increased expression of SLC22A1 mRNA

PMID:21641380 PMID:25278499

NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716

G

solute carrier family 22 (organic cation transporter), member 3

multiple interactions

Atorvastatin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591

G

solute carrier family 22 (organic cation transporter), member 5

multiple interactions

Atorvastatin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486

G

solute carrier family 29 (nucleoside transporters), member 1

increases expression

Atorvastatin results in increased expression of SLC29A1 mRNA

NCBI chr17:45,896,126...45,910,544
Ensembl chr17:45,896,126...45,910,532

G

solute carrier family 2 (facilitated glucose transporter), member 2

decreases expression
multiple interactions

Atorvastatin results in decreased expression of SLC2A2 protein
NR1I2 protein promotes the reaction [Atorvastatin results in decreased expression of SLC2A2 protein]

NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508

G

solute carrier family 2 (facilitated glucose transporter), member 4

multiple interactions

Atorvastatin inhibits the reaction [Sodium Glutamate results in decreased expression of SLC2A4 mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in decreased expression of SLC2A4 protein]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of SLC2A4 mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of SLC2A4 protein]

PMID:19800637 PMID:25834641

NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014

G

solute carrier family 4 (anion exchanger), member 1

multiple interactions

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite affects the localization of SLC4A1 protein]

NCBI chr11:102,239,646...102,256,107
Ensembl chr11:102,239,650...102,257,029

G

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

multiple interactions

Atorvastatin inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 protein]

NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166

G

solute carrier organic anion transporter family, member 1a1

decreases expression

Atorvastatin results in decreased expression of SLCO1A1 mRNA

NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688

G

solute carrier organic anion transporter family, member 1a4

increases expression
decreases expression

Atorvastatin results in increased expression of SLCO1A4 mRNA; Atorvastatin results in increased expression of SLCO1A4 protein
Atorvastatin results in decreased expression of SLCO1A4 protein

PMID:15986414 PMID:24909372 PMID:25278499

NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925

G

solute carrier organic anion transporter family, member 1b2

increases expression
increases uptake
multiple interactions

Atorvastatin results in increased expression of SLCO1B2 mRNA
SLCO1B3 protein results in increased uptake of Atorvastatin
glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Glyburide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; repaglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Rosiglitazone inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]

PMID:23121773 PMID:25106415 PMID:25278499

NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372

G

solute carrier organic anion transporter family, member 2b1

multiple interactions
increases uptake

glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Glyburide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; repaglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Rosiglitazone inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]

PMID:23121773 PMID:25106415

NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547

G

superoxide dismutase 1, soluble

multiple interactions

Atorvastatin inhibits the reaction [AGT protein results in decreased expression of SOD1 protein]

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

multiple interactions
affects expression
decreases expression
increases expression

Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of SOD2 mRNA]; Quercetin affects the reaction [Atorvastatin affects the expression of SOD2 mRNA]
Atorvastatin affects the expression of SOD2 protein
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin affects the expression of SOD2 protein]
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of SOD2 protein
Atorvastatin results in decreased expression of SOD2 protein

PMID:21775390 PMID:30511338 PMID:31423616

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

superoxide dismutase 3, extracellular

increases expression

Atorvastatin results in increased expression of SOD3 protein

NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760

G

sequestosome 1

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of SQSTM1 protein]

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

sterol regulatory element binding transcription factor 1

multiple interactions

[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; Atorvastatin inhibits the reaction [Fructose results in increased activity of SREBF1 protein]

PMID:19053045 PMID:32259528

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

sterol regulatory element binding factor 2

multiple interactions
increases expression
increases localization

Atorvastatin results in increased activity of and results in increased localization of SREBF2 protein; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of SREBF2 mRNA]
Atorvastatin results in increased localization of SREBF2 protein

PMID:11728391 PMID:12056585 PMID:12065722

NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580

G

steroidogenic acute regulatory protein

affects expression

Atorvastatin affects the expression of STAR mRNA

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

G

synaptophysin

increases expression

Atorvastatin results in increased expression of SYP protein

NCBI chr X:7,504,819...7,519,495
Ensembl chr X:7,504,710...7,519,495

G

transcription factor A, mitochondrial

increases expression
decreases expression
multiple interactions

Atorvastatin results in increased expression of TFAM mRNA
Atorvastatin results in decreased expression of TFAM protein
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of TFAM mRNA
Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of TFAM mRNA]

PMID:21775390 PMID:30511338

NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110

G

transferrin receptor

affects expression
multiple interactions

Atorvastatin affects the expression of TFRC protein
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein]

PMID:16387846 PMID:32976958

NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612

G

transforming growth factor, beta 1

multiple interactions

2-chloro-5-nitrobenzanilide inhibits the reaction [Atorvastatin inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]]; Atorvastatin inhibits the reaction [Dietary Fats promotes the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]]; Atorvastatin inhibits the reaction [Isoproterenol promotes the reaction [Dietary Fats results in increased expression of TGFB1 mRNA]]; Atorvastatin inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]

PMID:24161914 PMID:32329363

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

thrombospondin 1

decreases expression

Atorvastatin results in decreased expression of THBS1 mRNA

NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614

G

toll-like receptor 2

increases expression

Atorvastatin results in increased expression of TLR2 protein

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

G

toll-like receptor 4

multiple interactions
decreases expression
increases expression

[Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 protein
Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of TLR4 mRNA]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of TLR4 protein]; Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 mRNA]; Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 protein]
Atorvastatin results in decreased expression of TLR4 mRNA; Atorvastatin results in decreased expression of TLR4 protein
Atorvastatin results in increased expression of TLR4 protein

PMID:16387846 PMID:20524934 PMID:27883937 PMID:38213245

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor

multiple interactions
decreases expression
decreases secretion

Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of FASLG protein modified form]; Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Atorvastatin inhibits the reaction [TNF results in increased expression of ICAM1]; Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; Atorvastatin inhibits the reaction [TNF results in increased expression of ITGAL]; Atorvastatin inhibits the reaction [TNF results in increased expression of ITGB2]; Atorvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]
Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of TNF mRNA]; Atorvastatin inhibits the reaction [Sodium Glutamate results in increased expression of TNF protein]
[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [Dietary Fats promotes the reaction [Isoproterenol results in increased expression of TNF mRNA]]; Atorvastatin inhibits the reaction [Isoproterenol promotes the reaction [Dietary Fats results in increased expression of TNF mRNA]]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]; Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]; Atorvastatin inhibits the reaction [TNF protein results in increased oxidation of Glucose]; Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PDK4 protein]]
Atorvastatin results in decreased expression of TNF mRNA
Atorvastatin results in decreased secretion of TNF protein
Atorvastatin results in decreased expression of TNF protein

PMID:12117737 PMID:12615677 PMID:15063428 PMID:16387846 PMID:17521631 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 1a

decreases expression

Atorvastatin results in decreased expression of TNFRSF1A protein

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

tumor necrosis factor (ligand) superfamily, member 10

increases response to substance

TNFSF10 protein results in increased susceptibility to Atorvastatin

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

G

translocase of outer mitochondrial membrane 20

increases expression
multiple interactions

Atorvastatin results in increased expression of TOMM20 protein
[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of TOMM20 protein

NCBI chr 8:127,657,414...127,672,671
Ensembl chr 8:127,657,417...127,672,594

G

TNF receptor-associated factor 6

multiple interactions

[Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TRAF6 mRNA

NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014

G

transformation related protein 53

increases expression
multiple interactions

Atorvastatin results in increased expression of TP53 protein
Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TRP53 protein]

PMID:29630879 PMID:37121058

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

tubulin, beta 3 class III

increases expression

Atorvastatin results in increased expression of TUBB3 protein

NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754

G

vascular cell adhesion molecule 1

decreases expression
multiple interactions

Atorvastatin results in decreased expression of VCAM1 mRNA; Atorvastatin results in decreased expression of VCAM1 protein
Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of VCAM1 protein]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]

PMID:17589825 PMID:17673219 PMID:22245985 PMID:25058445

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

G

vascular endothelial growth factor D

affects expression

Atorvastatin affects the expression of VEGFD mRNA

NCBI chr X:163,156,282...163,185,643
Ensembl chr X:163,156,374...163,185,646

G

vimentin

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of VIM protein]

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

Von Willebrand factor

increases expression

Atorvastatin results in increased expression of VWF protein

NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642

G

WT1 transcription factor

multiple interactions

[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of WT1 protein]

NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961

G

xin actin-binding repeat containing 1

multiple interactions

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA

NCBI chr 9:119,842,821...119,852,660
Ensembl chr 9:119,842,821...119,852,664

calcium carbonate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone gamma carboxyglutamate protein

decreases expression

Calcium Carbonate results in decreased expression of BGLAP protein

NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771

G

calpain 1

increases activity

Calcium Carbonate analog results in increased activity of CAPN1 protein

NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927

G

caspase 3

increases activity

Calcium Carbonate analog results in increased activity of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

DNA-damage inducible transcript 3

increases expression

Calcium Carbonate analog results in increased expression of DDIT3

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

parathyroid hormone

affects expression
decreases expression

Calcium Carbonate affects the expression of PTH protein
Calcium Carbonate results in decreased expression of PTH protein

PMID:1752077 PMID:2027271 PMID:3826069 PMID:7891547 PMID:8481062 More...

NCBI chr 7:112,984,783...112,987,879
Ensembl chr 7:112,984,787...112,987,777

G

parathyroid hormone-like peptide

decreases expression

Calcium Carbonate results in decreased expression of PTHLH protein

NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681

G

secreted phosphoprotein 1

decreases expression

Calcium Carbonate results in decreased expression of SPP1 protein

NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916

calcium dichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

a disintegrin and metallopeptidase domain 10

increases expression

Calcium Chloride results in increased expression of ADAM10 mRNA; Calcium Chloride results in increased expression of ADAM10 protein

NCBI chr 9:70,586,133...70,687,511
Ensembl chr 9:70,586,279...70,687,511

G

a disintegrin and metallopeptidase domain 17

increases expression

Calcium Chloride results in increased expression of ADAM17 mRNA; Calcium Chloride results in increased expression of ADAM17 protein

NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633

G

alkaline phosphatase, liver/bone/kidney

increases expression

Calcium Chloride results in increased expression of ALPL mRNA

NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695

G

apolipoprotein C-III

increases expression

Calcium Chloride results in increased expression of APOC3 protein

NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934

G

ATP synthase peripheral stalk subunit F6

increases expression

Calcium Chloride results in increased expression of ATP5PF protein

NCBI chr16:84,624,754...84,632,495
Ensembl chr16:84,624,754...84,632,513

G

BCL2-associated athanogene 4

increases expression

Calcium Chloride results in increased expression of BAG4 protein

NCBI chr 8:26,254,566...26,275,237
Ensembl chr 8:26,254,566...26,275,315

G

bone gamma carboxyglutamate protein

increases expression

Calcium Chloride results in increased expression of BGLAP mRNA

NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771

G

BICD cargo adaptor 2

increases expression

Calcium Chloride results in increased expression of BICD2 protein

NCBI chr13:49,495,025...49,540,502
Ensembl chr13:49,495,061...49,540,502

G

calmodulin 3

multiple interactions

Calcium Chloride inhibits the reaction [CALM3 protein binds to and results in decreased activity of UBE3B protein]

NCBI chr 7:16,649,304...16,657,957
Ensembl chr 7:16,649,304...16,658,039

G

caspase 3

multiple interactions
increases cleavage

cordycepin inhibits the reaction [Calcium Chloride results in increased cleavage of CASP3 protein]

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 9

increases cleavage
multiple interactions

Calcium Chloride results in increased cleavage of CASP9 protein
cordycepin inhibits the reaction [Calcium Chloride results in increased cleavage of CASP9 protein]

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

calcium-sensing receptor

multiple interactions
increases activity

Calcium Chloride promotes the reaction [Calcium results in increased phosphorylation of CASR protein]
Calcium Chloride results in increased activity of CASR protein

PMID:16316325 PMID:17376781

NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503

G

C-C motif chemokine ligand 2

increases phosphorylation
increases expression
multiple interactions

Calcium Chloride results in increased phosphorylation of CCL2 protein
Calcium Chloride results in increased expression of CCL2 mRNA; Calcium Chloride results in increased expression of CCL2 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of CCL2 protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of CCL2 mRNA]; resveratrol inhibits the reaction [Calcium Chloride results in increased phosphorylation of CCL2 protein]

PMID:21530968 PMID:22728078

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

chaperonin containing TCP1 subunit 6A

decreases expression

Calcium Chloride results in decreased expression of CCT6A protein

NCBI chr 5:129,864,420...129,875,284
Ensembl chr 5:129,864,062...129,875,212

G

CD68 antigen

multiple interactions
increases expression

resveratrol inhibits the reaction [Calcium Chloride results in increased expression of CD68 mRNA]

NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979

G

cyclin dependent kinase inhibitor 1B

multiple interactions

Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein]

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

cyclin dependent kinase inhibitor 2A

multiple interactions

Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A mRNA]; Calcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A protein]

NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890

G

CCAAT/enhancer binding protein alpha

increases activity

Calcium Chloride results in increased activity of CEBPA protein

NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353

G

C-type lectin domain family 3, member b

increases expression

Calcium Chloride results in increased expression of CLEC3B protein

NCBI chr 9:122,980,011...122,986,497
Ensembl chr 9:122,980,011...122,986,497

G

chloride intracellular channel 3

decreases expression

Calcium Chloride results in decreased expression of CLIC3 protein

NCBI chr 2:25,346,855...25,348,789
Ensembl chr 2:25,346,850...25,348,788

G

CKLF-like MARVEL transmembrane domain containing 6

increases expression

Calcium Chloride results in increased expression of CMTM6 protein

NCBI chr 9:114,560,184...114,578,412
Ensembl chr 9:114,560,184...114,578,412

G

collagen, type I, alpha 1

increases expression

Calcium Chloride results in increased expression of COL1A1 mRNA

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type VIII, alpha 1

increases expression

Calcium Chloride results in increased expression of COL8A1 protein

NCBI chr16:57,444,619...57,575,100
Ensembl chr16:57,444,621...57,575,100

G

COP9 signalosome subunit 3

increases expression

Calcium Chloride results in increased expression of COPS3 protein

NCBI chr11:59,708,621...59,739,080
Ensembl chr11:59,708,621...59,730,664

G

cystatin C

increases expression

Calcium Chloride results in increased expression of CST3 protein

NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612

G

collagen triple helix repeat containing 1

decreases expression

Calcium Chloride results in decreased expression of CTHRC1 protein

NCBI chr15:38,940,327...38,950,516
Ensembl chr15:38,940,327...38,950,516

G

cathepsin B

increases expression
multiple interactions

Calcium Chloride results in increased expression of CTSB protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of CTSB protein]

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cathepsin K

increases expression
multiple interactions

Calcium Chloride results in increased expression of CTSK protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of CTSK protein]

NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673

G

decorin

decreases expression

Calcium Chloride results in decreased expression of DCN protein

NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005

G

DEAD box helicase 39b

increases expression

Calcium Chloride results in increased expression of DDX39B protein

NCBI chr17:35,460,722...35,472,683
Ensembl chr17:35,460,722...35,472,683

G

EH-domain containing 2

increases expression

Calcium Chloride results in increased expression of EHD2 protein

NCBI chr 7:15,680,883...15,701,402
Ensembl chr 7:15,680,883...15,701,492

G

coagulation factor X

multiple interactions

[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein; aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; nothofagin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]

NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676

G

coagulation factor XI

multiple interactions

[F11 protein co-treated with Calcium Chloride] results in increased activity of F9 protein

NCBI chr 8:45,693,696...45,715,092
Ensembl chr 8:45,694,211...45,715,068

G

coagulation factor II

multiple interactions

[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein; aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; nothofagin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]

NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759

G

coagulation factor V

multiple interactions

[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein; aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; nothofagin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]

NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846

G

coagulation factor IX

multiple interactions

[F11 protein co-treated with Calcium Chloride] results in increased activity of F9 protein

NCBI chr X:59,044,675...59,076,120
Ensembl chr X:59,044,824...59,076,119

G

Fyn proto-oncogene

increases expression

Calcium Chloride results in increased expression of FYN protein

NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377

G

GIT ArfGAP 1

increases expression

Calcium Chloride results in increased expression of GIT1 protein

NCBI chr11:77,384,114...77,398,600
Ensembl chr11:77,384,388...77,398,612

G

gonadotropin releasing hormone 1

multiple interactions

[manganese chloride co-treated with Calcium Chloride] results in increased secretion of GNRH1 protein

NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888

G

glutathione peroxidase 1

multiple interactions
increases expression

Quercetin inhibits the reaction [Calcium Chloride results in increased expression of GPX1 mRNA]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of GPX1 mRNA]

PMID:21530968 PMID:24337353

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione peroxidase 3

multiple interactions
increases expression

Quercetin inhibits the reaction [Calcium Chloride results in increased expression of GPX3 mRNA]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of GPX3 mRNA]

PMID:21530968 PMID:24337353

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

heme oxygenase 1

multiple interactions

Calcium Chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

HtrA serine peptidase 1

decreases expression

Calcium Chloride results in decreased expression of HTRA1 protein

NCBI chr 7:130,537,933...130,587,388
Ensembl chr 7:130,537,841...130,587,390

G

intercellular adhesion molecule 1

increases expression
multiple interactions

Calcium Chloride results in increased expression of ICAM1 mRNA
resveratrol inhibits the reaction [Calcium Chloride results in increased expression of ICAM1 mRNA]

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

intraflagellar transport 27

increases expression

Calcium Chloride results in increased expression of IFT27 protein

NCBI chr15:78,043,660...78,058,281
Ensembl chr15:78,043,663...78,058,307

G

interleukin 1 beta

increases expression
multiple interactions

Calcium Chloride results in increased expression of IL1B protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of IL1B protein]

PMID:22728078 PMID:36731150

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

inter-alpha trypsin inhibitor, heavy chain 1

multiple interactions

Calcium Chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]

NCBI chr14:30,651,137...30,665,246
Ensembl chr14:30,651,137...30,665,246

G

inter-alpha trypsin inhibitor, heavy chain 2

multiple interactions

Calcium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]

NCBI chr 2:10,099,408...10,135,492
Ensembl chr 2:10,099,404...10,136,207

G

kallikrein related-peptidase 8

increases activity

Calcium Chloride results in increased activity of KLK8 protein

NCBI chr 7:43,447,001...43,453,250
Ensembl chr 7:43,447,001...43,453,250

G

LIM and SH3 protein 1

increases expression

Calcium Chloride results in increased expression of LASP1 protein

NCBI chr11:97,689,748...97,729,591
Ensembl chr11:97,689,826...97,729,590

G

leucine rich repeat (in FLII) interacting protein 1

decreases expression

Calcium Chloride results in decreased expression of LRRFIP1 protein

NCBI chr 1:90,924,652...91,056,666
Ensembl chr 1:90,926,459...91,056,666

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

Calcium Chloride results in increased phosphorylation of MAPK1 protein
[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK1 protein; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK1 protein]

PMID:21215118 PMID:33621091

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

increases expression
multiple interactions
increases phosphorylation

Calcium Chloride results in increased expression of MAPK3 protein
[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK3 protein; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK3 protein]
Calcium Chloride results in increased phosphorylation of MAPK3 protein

PMID:21215118 PMID:25824407 PMID:33621091

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

matrix metallopeptidase 2

increases expression
increases activity
multiple interactions

Calcium Chloride results in increased expression of MMP2 mRNA; Calcium Chloride results in increased expression of MMP2 protein
Calcium Chloride results in increased activity of MMP2 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased activity of MMP2 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP2 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP2 protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased activity of MMP2 protein]
Calcium Chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [Deferoxamine results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]

PMID:10086886 PMID:16159824 PMID:20621845 PMID:21530968 PMID:22728078 More...

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

increases expression
increases activity
multiple interactions

Calcium Chloride results in increased expression of MMP9 mRNA; Calcium Chloride results in increased expression of MMP9 protein
Calcium Chloride results in increased activity of MMP9 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased activity of MMP9 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP9 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP9 protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased activity of MMP9 protein]

PMID:20621845 PMID:21530968 PMID:22728078 PMID:24337353

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

myelocytomatosis oncogene

multiple interactions

Calcium Chloride inhibits the reaction [Azoxymethane results in increased expression of MYC mRNA]; Calcium Chloride inhibits the reaction [Azoxymethane results in increased expression of MYC protein]

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

G

neutrophil cytosolic factor 1

increases expression
multiple interactions

Calcium Chloride results in increased expression of NCF1 mRNA; Calcium Chloride results in increased expression of NCF1 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of NCF1 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of NCF1 protein]

NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479

G

nitric oxide synthase 1, neuronal

multiple interactions

Calcium Chloride promotes the reaction [NOS1 protein results in increased reduction of Trinitrotoluene]

NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905

G

nitric oxide synthase 2, inducible

increases expression
multiple interactions

Calcium Chloride results in increased expression of NOS2 mRNA
Quercetin inhibits the reaction [Calcium Chloride results in increased expression of NOS2 mRNA]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

5',3'-nucleotidase, cytosolic

increases expression

Calcium Chloride results in increased expression of NT5C protein

NCBI chr11:115,381,251...115,382,659
Ensembl chr11:115,381,246...115,382,688

G

nucleoredoxin

increases expression

Calcium Chloride results in increased expression of NXN protein

NCBI chr11:76,148,052...76,289,967
Ensembl chr11:76,148,024...76,289,966

G

paraoxonase 1

multiple interactions

Calcium Chloride promotes the reaction [PON1 protein results in increased hydrolysis of Paraoxon]

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

periostin, osteoblast specific factor

decreases expression

Calcium Chloride results in decreased expression of POSTN protein

NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458

G

peptidylprolyl isomerase D (cyclophilin D)

increases expression

Calcium Chloride results in increased expression of PPID mRNA; Calcium Chloride results in increased expression of PPID protein

NCBI chr 3:79,498,644...79,511,117
Ensembl chr 3:79,498,649...79,510,957

G

presenilin 2

increases expression

Calcium Chloride results in increased expression of PSEN2 protein

NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003

G

RAD50 double strand break repair protein

decreases expression

Calcium Chloride results in decreased expression of RAD50 protein

NCBI chr11:53,540,346...53,598,146
Ensembl chr11:53,540,346...53,598,146

G

reversion-inducing-cysteine-rich protein with kazal motifs

increases expression

Calcium Chloride results in increased expression of RECK protein

NCBI chr 4:43,875,521...43,944,806
Ensembl chr 4:43,875,530...43,944,806

G

S100 calcium binding protein A13

multiple interactions

[Calcium Chloride co-treated with cuprous chloride] binds to and affects the folding of S100A13 protein; Calcium Chloride binds to and affects the folding of S100A13 protein

NCBI chr 3:90,421,542...90,431,888
Ensembl chr 3:90,421,659...90,431,890

G

S100 calcium binding protein A8 (calgranulin A)

increases expression

Calcium Chloride results in increased expression of S100A8 mRNA; Calcium Chloride results in increased expression of S100A8 protein

NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342

G

S100 calcium binding protein A9 (calgranulin B)

increases expression

Calcium Chloride results in increased expression of S100A9 mRNA; Calcium Chloride results in increased expression of S100A9 protein

NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028

G

src homology 2 domain-containing transforming protein C1

increases expression

Calcium Chloride results in increased expression of SHC1 protein

NCBI chr 3:89,325,858...89,337,336
Ensembl chr 3:89,325,750...89,337,334

G

superoxide dismutase 2, mitochondrial

increases activity
multiple interactions

Calcium Chloride results in increased activity of SOD2 protein
Quercetin inhibits the reaction [Calcium Chloride results in increased activity of SOD2 protein]

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

signal transducer and activator of transcription 6

decreases expression

Calcium Chloride results in decreased expression of STAT6 protein

NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826

G

synapsin I

multiple interactions

[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein]

NCBI chr X:20,726,750...20,787,157
Ensembl chr X:20,726,750...20,787,243

G

transforming growth factor, beta 1

decreases expression

Calcium Chloride results in decreased expression of TGFB1 protein

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tissue inhibitor of metalloproteinase 1

decreases expression
multiple interactions

Calcium Chloride results in decreased expression of TIMP1 mRNA
Quercetin inhibits the reaction [Calcium Chloride results in decreased expression of TIMP1 mRNA]

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tumor necrosis factor

multiple interactions
increases expression

Quercetin inhibits the reaction [Calcium Chloride results in increased expression of TNF protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased expression of TNF mRNA]
cordycepin inhibits the reaction [Calcium Chloride results in increased expression of TNF protein]
Calcium Chloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]
Calcium Chloride results in increased expression of TNF mRNA; Calcium Chloride results in increased expression of TNF protein

PMID:21530968 PMID:22728078 PMID:36416909 PMID:36731150

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor alpha induced protein 6

multiple interactions

Calcium Chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]; Calcium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]

NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions
increases activity

Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Ionomycin promotes the reaction [Calcium Chloride inhibits the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]]
Ionomycin inhibits the reaction [Calcium Chloride results in increased activity of TRPV1 protein]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [Calcium Chloride results in increased activity of TRPV1 protein]; resiniferatoxin promotes the reaction [Calcium Chloride results in increased activity of TRPV1 protein]

NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068

G

ubiquitin protein ligase E3B

multiple interactions

Calcium Chloride inhibits the reaction [CALM3 protein binds to and results in decreased activity of UBE3B protein]

NCBI chr 5:114,518,578...114,559,226
Ensembl chr 5:114,518,668...114,559,230

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

decreases phosphorylation
multiple interactions

Calcium Chloride results in decreased phosphorylation of UQCRFS1 protein
[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; [tert-Butylhydroperoxide co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; Cyclosporine inhibits the reaction [[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein]; Cyclosporine inhibits the reaction [[tert-Butylhydroperoxide co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein]

NCBI chr13:30,724,295...30,729,299
Ensembl chr13:30,724,291...30,729,345

G

vascular endothelial growth factor A

increases expression
multiple interactions

Calcium Chloride results in increased expression of VEGFA mRNA
resveratrol inhibits the reaction [Calcium Chloride results in increased expression of VEGFA mRNA]

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

calcium oxalate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2-associated X protein

increases expression
multiple interactions

Calcium Oxalate results in increased expression of BAX protein
SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased expression of BAX protein]

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions
decreases expression

SIRT1 protein inhibits the reaction [Calcium Oxalate results in decreased expression of BCL2 protein]

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

caspase 3

multiple interactions
increases cleavage

SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased cleavage of CASP3 protein]

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

decreases expression
multiple interactions

Calcium Oxalate results in decreased expression of CAT protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CAT protein]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions

Calcium Oxalate results in decreased expression of CCL2 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CCL2 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein]

PMID:37414240 PMID:37454925

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

CD44 antigen

decreases expression
multiple interactions

Calcium Oxalate results in decreased expression of CD44 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CD44 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein]

PMID:37414240 PMID:37454925

NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010

G

cytochrome b-245, beta polypeptide

increases expression
multiple interactions

Calcium Oxalate results in increased expression of NOX2 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in increased expression of NOX2 protein]

NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010

G

histone deacetylase 1

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA]

NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506

G

histone deacetylase 2

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA]

NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885

G

histone deacetylase 3

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA]

NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069

G

histone deacetylase 8

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA]

NCBI chr X:101,328,244...101,549,005
Ensembl chr X:101,328,245...101,548,965

G

heme oxygenase 1

increases expression
multiple interactions

Calcium Oxalate results in increased expression of HMOX1 protein
phenyl-N-tert-butylnitrone inhibits the reaction [Calcium Oxalate results in increased expression of HMOX1 protein]

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

inositol 1,4,5-trisphosphate receptor 1

increases expression
multiple interactions

Calcium Oxalate results in increased expression of ITPR1 protein
Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR1 protein]

NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070

G

inositol 1,4,5-triphosphate receptor 2

increases expression
multiple interactions

Calcium Oxalate results in increased expression of ITPR2 protein
Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR2 protein]

NCBI chr 6:146,009,797...146,403,757
Ensembl chr 6:146,009,797...146,403,721

G

inositol 1,4,5-triphosphate receptor 3

increases expression

Calcium Oxalate results in increased expression of ITPR3 protein

NCBI chr17:27,275,976...27,341,197
Ensembl chr17:27,276,278...27,341,197

G

NADPH oxidase 4

increases expression
multiple interactions

Calcium Oxalate results in increased expression of NOX4 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in increased expression of NOX4 protein]

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

sirtuin 1

multiple interactions
decreases expression

phenyl-N-tert-butylnitrone inhibits the reaction [Calcium Oxalate results in decreased expression of SIRT1 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in decreased expression of BCL2 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased cleavage of CASP3 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased expression of BAX protein]

NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483

G

superoxide dismutase 1, soluble

decreases expression
multiple interactions

Calcium Oxalate results in decreased expression of SOD1 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of SOD1 protein]

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

secreted phosphoprotein 1

multiple interactions
decreases expression

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of SPP1 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein]

PMID:37414240 PMID:37454925

NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916

calcium phosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 10

increases expression

calcium phosphate results in increased expression of CXCL10 protein

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 12

increases expression

calcium phosphate results in increased expression of CXCL12 protein

NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328

rosuvastatin calcium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family A member 1

decreases expression
multiple interactions

Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]

NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895

G

ATP-binding cassette, sub-family B member 11

multiple interactions

Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium

PMID:15901796 PMID:19853032

NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958

G

ATP-binding cassette, sub-family member 2

multiple interactions
affects secretion
increases expression

ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the secretion of Rosuvastatin Calcium
[Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
Rosuvastatin Calcium results in increased expression of ABCC2 protein

PMID:19853032 PMID:23562342 PMID:24909372

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

ATP-binding cassette, sub-family C member 3

increases expression

Rosuvastatin Calcium results in increased expression of ABCC3 protein

NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823

G

ATP binding cassette subfamily G member 1

decreases expression

Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA

NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962

G

ATP binding cassette subfamily G member 2 (Junior blood group)

multiple interactions
increases activity

[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Rosuvastatin Calcium results in increased activity of ABCG2 protein

PMID:19853032 PMID:30083819

NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661

G

acetylcholinesterase

multiple interactions

[Piracetam co-treated with Rosuvastatin Calcium] inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]; Rosuvastatin Calcium inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

thymoma viral proto-oncogene 1

affects phosphorylation

Rosuvastatin Calcium affects the phosphorylation of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

apolipoprotein A-I

multiple interactions
increases expression

Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein]

PMID:12767421 PMID:15539964

NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764

G

apolipoprotein B

decreases expression

Rosuvastatin Calcium results in decreased expression of APOB protein

PMID:15539964 PMID:18702965

NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835

G

BCL2-associated X protein

multiple interactions

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA]

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression

Rosuvastatin Calcium results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

complement component 3

decreases expression

Rosuvastatin Calcium results in decreased expression of C3 mRNA

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

caspase 3

increases activity
increases expression

Rosuvastatin Calcium results in increased activity of CASP3 protein
Rosuvastatin Calcium results in increased expression of CASP3 protein

PMID:21478229 PMID:32771489

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

increases activity
multiple interactions

Rosuvastatin Calcium results in increased activity of CAT protein
[Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]

PMID:20146376 PMID:32007421 PMID:35130744

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

decreases expression

Rosuvastatin Calcium results in decreased expression of CCL2 mRNA

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cAMP responsive element binding protein 5

decreases expression

Rosuvastatin Calcium results in decreased expression of CREB5 mRNA

NCBI chr 6:53,264,154...53,677,349
Ensembl chr 6:53,264,255...53,677,361

G

C-reactive protein, pentraxin-related

multiple interactions

Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

cytochrome b-245, alpha polypeptide

multiple interactions
decreases expression

[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669

G

cytochrome b-245, beta polypeptide

multiple interactions
decreases expression

Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

PMID:16633368 PMID:21562509

NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010

G

estrogen receptor 1 (alpha)

decreases expression

Rosuvastatin Calcium results in decreased expression of ESR1 protein

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

Rosuvastatin Calcium results in increased expression of GCLC mRNA
[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

G protein-coupled receptor 183

increases expression
multiple interactions

Rosuvastatin Calcium results in increased expression of GPR183 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA]

NCBI chr14:122,189,743...122,202,605
Ensembl chr14:122,189,963...122,202,607

G

granzyme K

multiple interactions
increases expression

Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA]

NCBI chr13:113,308,164...113,317,499
Ensembl chr13:113,308,142...113,362,442

G

hepatic nuclear factor 4, alpha

increases secretion

HNF4A protein results in increased secretion of Rosuvastatin Calcium

NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830

G

interleukin 18 receptor accessory protein

decreases expression
multiple interactions

Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]

NCBI chr 1:40,554,548...40,590,867
Ensembl chr 1:40,554,522...40,590,865

G

interleukin 1 beta

decreases expression

Rosuvastatin Calcium results in decreased expression of IL1B mRNA

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

potassium voltage-gated channel, subfamily H (eag-related), member 2

decreases activity

Rosuvastatin Calcium results in decreased activity of KCNH2 protein

NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602

G

potassium inwardly-rectifying channel, subfamily J, member 15

decreases expression

Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA

NCBI chr16:95,058,417...95,101,119
Ensembl chr16:95,058,417...95,101,119

G

kinase insert domain protein receptor

multiple interactions

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

myoglobin

affects expression

Rosuvastatin Calcium affects the expression of MB protein

NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870

G

myostatin

increases expression

Rosuvastatin Calcium results in increased expression of MSTN protein

NCBI chr 1:53,100,799...53,107,238
Ensembl chr 1:53,100,799...53,107,238

G

nuclear factor, erythroid derived 2, like 2

multiple interactions

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA]

PMID:32007421 PMID:35130744

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nitric oxide synthase 2, inducible

increases expression
multiple interactions

Rosuvastatin Calcium results in increased expression of NOS2 mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]

PMID:21443142 PMID:32007421 PMID:35130744

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

multiple interactions
increases expression
affects response to substance

Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein
Rosuvastatin Calcium results in increased expression of NOS3 mRNA
NOS3 protein affects the susceptibility to Rosuvastatin Calcium

PMID:12354446 PMID:15681303 PMID:18162361 PMID:21562509

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

orosomucoid 1

multiple interactions
decreases expression

Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA]

NCBI chr 4:63,262,793...63,266,400
Ensembl chr 4:63,262,797...63,266,400

G

platelet/endothelial cell adhesion molecule 1

multiple interactions

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein]

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

selectin, platelet

decreases expression

Rosuvastatin Calcium results in decreased expression of SELP mRNA

NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595

G

serine (or cysteine) peptidase inhibitor, clade E, member 2

multiple interactions

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]

NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897

G

solute carrier organic anion transporter family, member 1a4

multiple interactions
increases uptake
decreases expression
affects transport

Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein
SLCO1A4 protein affects the transport of Rosuvastatin Calcium

PMID:19833843 PMID:24909372 PMID:26888941

NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925

G

solute carrier organic anion transporter family, member 1a5

multiple interactions
increases uptake

diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]

NCBI chr 6:142,179,953...142,268,707
Ensembl chr 6:142,179,953...142,268,707

G

solute carrier organic anion transporter family, member 1b2

multiple interactions
increases uptake

Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]

PMID:26888941 PMID:31299240

NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372

G

solute carrier organic anion transporter family, member 2b1

multiple interactions
increases uptake

Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]

NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547

G

superoxide dismutase 1, soluble

multiple interactions
increases expression

[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

trefoil factor 1

decreases expression

Rosuvastatin Calcium results in decreased expression of TFF1 mRNA

NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251

G

transforming growth factor, beta 1

multiple interactions
decreases expression

Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA

PMID:15681303 PMID:27097221

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tumor necrosis factor

decreases expression
multiple interactions

Rosuvastatin Calcium results in decreased expression of TNF mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]

PMID:15681303 PMID:32007421 PMID:35130744

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

troponin I, cardiac 3

multiple interactions

Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]

PMID:32007421 PMID:35130744

NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228

G

vanin 3

decreases expression

Rosuvastatin Calcium results in decreased expression of VNN3P mRNA

NCBI chr10:23,727,360...23,745,741
Ensembl chr10:23,727,360...23,745,741

G

WT1 transcription factor

increases expression

Rosuvastatin Calcium results in increased expression of WT1 mRNA

NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961

tricalcium bis(phosphate)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dynamin 1-like

increases expression

tricalcium phosphate results in increased expression of DNM1L protein

NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823

G

heme oxygenase 1

decreases expression

tricalcium phosphate results in decreased expression of HMOX1 protein

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

microtubule-associated protein 1 light chain 3 beta

affects localization
multiple interactions

tricalcium phosphate affects the localization of MAP1LC3B protein
Acetylcysteine inhibits the reaction [tricalcium phosphate affects the localization of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [tricalcium phosphate results in increased expression of MAP1LC3B protein]

NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499

G

mitofusin 2

decreases expression

tricalcium phosphate results in decreased expression of MFN2 protein

NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161

G

mixed lineage kinase domain-like

increases phosphorylation
multiple interactions

tricalcium phosphate results in increased phosphorylation of MLKL protein
Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased phosphorylation of MLKL protein]; N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide inhibits the reaction [tricalcium phosphate results in increased phosphorylation of MLKL protein]; necrostatin-1 inhibits the reaction [tricalcium phosphate results in increased phosphorylation of MLKL protein]

NCBI chr 8:112,037,879...112,065,081
Ensembl chr 8:112,038,429...112,064,809

G

nuclear factor, erythroid derived 2, like 2

decreases expression

tricalcium phosphate results in decreased expression of NFE2L2 protein

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

NAD(P)H dehydrogenase, quinone 1

decreases expression

tricalcium phosphate results in decreased expression of NQO1 protein

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

PTEN induced putative kinase 1

multiple interactions

Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased expression of PINK1 protein]; tricalcium phosphate results in increased expression of and results in increased localization of PINK1 protein

NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618

G

receptor (TNFRSF)-interacting serine-threonine kinase 1

increases phosphorylation
multiple interactions

tricalcium phosphate results in increased phosphorylation of RIPK1 protein
Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK1 protein]; N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK1 protein]; necrostatin-1 inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK1 protein]

NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130

G

receptor-interacting serine-threonine kinase 3

increases phosphorylation
multiple interactions

tricalcium phosphate results in increased phosphorylation of RIPK3 protein
Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK3 protein]; N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK3 protein]; necrostatin-1 inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK3 protein]

NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322

G

sequestosome 1

decreases expression
multiple interactions

tricalcium phosphate results in decreased expression of SQSTM1 protein
Acetylcysteine inhibits the reaction [tricalcium phosphate results in decreased expression of SQSTM1 protein]

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

thioredoxin 1

decreases expression

tricalcium phosphate results in decreased expression of TXN1 protein

NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411

G

thioredoxin interacting protein

increases expression

tricalcium phosphate results in increased expression of TXNIP protein

NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22307
chemical entity	22306
molecular entity	22302
ion	18100
monoatomic ion	17326
monoatomic cation	16465
metal cation	16465
calcium ion	358
calcium cation +	357
Path 2
Term	Annotations
CHEBI ontology	22307
subatomic particle	22302
composite particle	22302
hadron	22302
baryon	22302
nucleon	22302
atomic nucleus	22302
atom	22302
main group element atom	22182
main group molecular entity	22182
s-block molecular entity	21770
alkaline earth molecular entity	898
calcium molecular entity	761
elemental calcium	759
calcium ion	358
calcium cation +	357

paths to the root