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Gene: F2 (coagulation factor II) Mus musculus
Symbol: F2
Name: coagulation factor II
Description: Exhibits enzyme activator activity and serine-type endopeptidase activity. Involved in several processes, including platelet activation; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of cell shape. Localizes to the collagen-containing extracellular matrix. Predicted to colocalize with the external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune hypersensitivity disease (multiple); and thrombophilia (multiple). Is expressed in embryo; liver; liver lobe; skeletal muscle; and testis. Orthologous to human F2 (coagulation factor II, thrombin).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Cf-2; Cf2; FII; prothrombin; thrombin
Homo sapiens (human) : F2 (coagulation factor II, thrombin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : F2 (coagulation factor II)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2 (coagulation factor II, thrombin)
Pan paniscus (bonobo/pygmy chimpanzee) : F2 (coagulation factor II, thrombin)
Canis lupus familiaris (dog) : F2 (coagulation factor II, thrombin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2 (coagulation factor II, thrombin)
Sus scrofa (pig) : F2 (coagulation factor II, thrombin)
Heterocephalus glaber (naked mole-rat) : F2 (coagulation factor II, thrombin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl291,625,320 - 91,636,414 (-)Ensembl
GRCm38291,612,397 - 91,636,457 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37291,465,477 - 91,476,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv36291,426,159 - 91,437,253 (-)NCBImm8
Celera293,014,831 - 93,025,920 (-)NCBICelera
Cytogenetic Map2 E1NCBI
cM Map250.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on F2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62288
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.