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Gene: F2 (coagulation factor II) Mus musculus
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Symbol: F2
Name: coagulation factor II
Description: Exhibits enzyme activator activity and serine-type endopeptidase activity. Involved in several processes, including platelet activation; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of cell shape. Localizes to the collagen-containing extracellular matrix. Predicted to colocalize with the external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune hypersensitivity disease (multiple); and thrombophilia (multiple). Is expressed in embryo; liver; liver lobe; skeletal muscle; and testis. Orthologous to human F2 (coagulation factor II, thrombin).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Cf-2; Cf2; FII; prothrombin; thrombin
Orthologs:
Homo sapiens (human) : F2 (coagulation factor II, thrombin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : F2 (coagulation factor II)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2 (coagulation factor II, thrombin)
Pan paniscus (bonobo/pygmy chimpanzee) : F2 (coagulation factor II, thrombin)
Canis lupus familiaris (dog) : F2 (coagulation factor II, thrombin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2 (coagulation factor II, thrombin)
Sus scrofa (pig) : F2 (coagulation factor II, thrombin)
Heterocephalus glaber (naked mole-rat) : F2 (coagulation factor II, thrombin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl291,625,320 - 91,636,414 (-)Ensembl
GRCm38291,612,397 - 91,636,457 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37291,465,477 - 91,476,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv36291,426,159 - 91,437,253 (-)NCBImm8
Celera293,014,831 - 93,025,920 (-)NCBICelera
Cytogenetic Map2 E1NCBI
cM Map250.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on F2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62288
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.