F2 (coagulation factor II) - Rat Genome Database

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Gene: F2 (coagulation factor II) Mus musculus
Analyze
Symbol: F2
Name: coagulation factor II
RGD ID: 62288
MGI Page MGI
Description: Exhibits enzyme activator activity and serine-type endopeptidase activity. Involved in several processes, including platelet activation; positive regulation of cell growth; and positive regulation of phosphatidylinositol 3-kinase signaling. Localizes to collagen-containing extracellular matrix. Predicted to colocalize with external side of plasma membrane. Is expressed in several structures, including liver; musculoskeletal system; and testis. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Cf-2; Cf2; F; FII; prot; prothrombin; thro; thrombin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,442,742 - 91,466,802 (-)NCBIGRCm39mm39
GRCm39 Ensembl291,455,665 - 91,466,759 (-)Ensembl
GRCm38291,612,397 - 91,636,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,625,320 - 91,636,414 (-)EnsemblGRCm38mm10GRCm38
MGSCv37291,465,477 - 91,476,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv36291,426,159 - 91,437,253 (-)NCBImm8
Celera293,014,831 - 93,025,920 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired angioedema  (ISO)
Acute Coronary Syndrome  (ISO)
Acute Lung Injury  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
appendicitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
bacterial pneumonia  (ISO)
blood coagulation disease  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
bullous pemphigoid  (ISO)
calcium oxalate nephrolithiasis  (ISO)
carotid stenosis  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chagas disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital disorder of glycosylation type IIc  (ISO)
Congenital Prothrombin Deficiency  (ISO)
Contusions  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
dengue disease  (ISO)
Diabetic Nephropathies  (ISO)
disseminated intravascular coagulation  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (IMP)
Experimental Diabetes Mellitus  (IEP)
eye disease  (ISO)
factor VIII deficiency  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Femur Head Necrosis  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
hemolytic-uremic syndrome  (ISO)
hemophilia B  (ISO)
Hemorrhage  (IMP,ISO)
Hemorrhagic Shock  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
hereditary angioedema  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Human Viral Hepatitis  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (IMP)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hypertrophy  (ISO)
intellectual disability  (ISO)
intracranial sinus thrombosis  (ISO)
Kidney Calculi  (ISO)
Knee Osteoarthritis  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Mesenteric Ischemia  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (ISO)
Nerve Degeneration  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (IDA,ISO)
ovarian cancer  (ISO)
Paratuberculosis  (ISO)
Pediatric Crohn's Disease  (ISO)
portal vein thrombosis  (ISO)
pre-eclampsia  (ISO)
prostate cancer  (ISO)
prothrombin deficiency  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (IMP)
Reperfusion Injury  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
Septic Peritonitis  (IMP)
sickle cell anemia  (IMP,ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
Thromboembolism  (ISO)
thrombophilia  (ISO)
thrombophilia due to thrombin defect  (ISO)
thrombosis  (IMP,ISO)
toxic shock syndrome  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urinary Calculi  (ISO)
urticaria  (ISO)
vascular skin disease  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Fibrillation  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,3-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,3-diphenyl-N-(1-phenylethyl)-1-propanamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acenocoumarol  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amidotrizoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
argatroban  (EXP,ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
aspalathin  (ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
ATP  (EXP,ISO)
atropine  (EXP)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bivalirudin  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium(0)  (ISO)
calmidazolium  (ISO)
capsaicin  (ISO)
cerivastatin  (ISO)
chlorogenic acid  (ISO)
chlorpromazine  (ISO)
clobazam  (ISO)
clopidogrel  (EXP)
clothianidin  (ISO)
cobalt atom  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
dabigatran  (EXP,ISO)
dermatan sulfate  (ISO)
dexamethasone  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (EXP)
dienogest  (ISO)
Difethialone  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
eptifibatide  (ISO)
Ethyl icosapentate  (ISO)
etonogestrel  (ISO)
fenofibrate  (ISO)
flutamide  (ISO)
furan  (ISO)
genistein  (ISO)
gestodene  (ISO)
heparin  (EXP,ISO)
hydrocortisone succinate  (ISO)
indometacin  (ISO)
ioxaglic acid  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) citrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lepirudin  (ISO)
lipopolysaccharide  (EXP)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
medroxyprogesterone acetate  (ISO)
melagatran  (ISO)
methotrexate  (ISO)
ML-7  (ISO)
morphine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
olanzapine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
paraquat  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenprocoumon  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylinositol 4-phosphate  (ISO)
phylloquinone  (ISO)
pirinixic acid  (EXP)
potassium chloride  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
quinapril hydrochloride  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
splitomicin  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thromboxane A2  (ISO)
thromboxane B2  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (EXP)
U-73122  (ISO)
valproic acid  (ISO)
venom  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
warfarin  (ISO)
ximelagatran  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
blood coagulation  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to mechanical stimulus  (ISO)
cytolysis by host of symbiont cells  (ISO)
fibrinolysis  (ISO)
hemostasis  (IEA)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of proteolysis  (ISO)
neutrophil-mediated killing of gram-negative bacterium  (ISO)
platelet activation  (IBA,IDA,ISO)
positive regulation of blood coagulation  (IBA,ISO)
positive regulation of cell growth  (IGI)
positive regulation of cell population proliferation  (IGI)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of lipid kinase activity  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IGI)
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
proteolysis  (IEA)
regulation of cell shape  (IGI)
regulation of cytosolic calcium ion concentration  (ISO)
regulation of gene expression  (IDA)
response to inactivity  (ISO)
response to Thyroglobulin triiodothyronine  (ISO)
response to thyrotropin-releasing hormone  (ISO)
response to thyroxine  (ISO)
response to wounding  (ISO)
thrombin-activated receptor signaling pathway  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood coagulation  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal heart morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
cardiac fibrosis  (IAGP)
cerebellum hemorrhage  (IAGP)
decreased bone mineral content  (IEA)
decreased embryo size  (IAGP)
decreased exploration in new environment  (IEA)
decreased lean body mass  (IEA)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to induced thrombosis  (IAGP)
distended pericardium  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
gastrointestinal hemorrhage  (IAGP)
heart hemorrhage  (IAGP)
hemopericardium  (IAGP)
hemorrhage  (IAGP)
hemothorax  (IAGP)
impaired blood coagulation  (IAGP)
increased bleeding time  (IAGP)
increased circulating fructosamine level  (IEA)
increased circulating serum albumin level  (IEA)
increased susceptibility to bacterial infection  (IAGP)
internal hemorrhage  (IAGP)
intestinal hemorrhage  (IAGP)
intracranial hemorrhage  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
muscle hemorrhage  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
petechiae  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
purpura  (IAGP)
skin hemorrhage  (IAGP)
spinal hemorrhage  (IAGP)
subcutaneous hemorrhage  (IAGP)
testicular hemorrhage  (IAGP)
tremors  (IEA)
References

References - curated
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Additional References at PubMed
PMID:2222810   PMID:7608171   PMID:8291612   PMID:8707309   PMID:8903359   PMID:9263397   PMID:9565620   PMID:9636196   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11776313   PMID:12477932   PMID:14610273   PMID:15265791   PMID:15452111   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16428384   PMID:16602821   PMID:16720835   PMID:16824188  
PMID:17021183   PMID:17330941   PMID:17380206   PMID:17428793   PMID:17606903   PMID:18224415   PMID:18305483   PMID:18398001   PMID:18772359   PMID:18990707   PMID:19351827   PMID:19592578  
PMID:19794141   PMID:20519511   PMID:21191574   PMID:21267068   PMID:21339289   PMID:21531712   PMID:21724997   PMID:21840881   PMID:21873635   PMID:22235124   PMID:23239877   PMID:23299312  
PMID:23409043   PMID:23982175   PMID:24025335   PMID:24194600   PMID:24311376   PMID:24652285   PMID:24665136   PMID:24710407   PMID:24740693   PMID:24790104   PMID:25112870   PMID:25604482  
PMID:25967238   PMID:26045608   PMID:26238780   PMID:26350460   PMID:26370502   PMID:26457757   PMID:26475502   PMID:26748875   PMID:26769047   PMID:27034473   PMID:27252233   PMID:27626380  
PMID:28071719   PMID:28409836   PMID:28489922   PMID:29321368   PMID:29438518   PMID:30066835   PMID:30606478   PMID:30870413   PMID:31040226   PMID:31461896   PMID:31910739   PMID:32000579  
PMID:32325033  


Genomics

Comparative Map Data
F2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,442,742 - 91,466,802 (-)NCBIGRCm39mm39
GRCm39 Ensembl291,455,665 - 91,466,759 (-)Ensembl
GRCm38291,612,397 - 91,636,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,625,320 - 91,636,414 (-)EnsemblGRCm38mm10GRCm38
MGSCv37291,465,477 - 91,476,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv36291,426,159 - 91,437,253 (-)NCBImm8
Celera293,014,831 - 93,025,920 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
F2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1146,719,196 - 46,739,506 (+)EnsemblGRCh38hg38GRCh38
GRCh381146,719,213 - 46,739,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371146,740,763 - 46,761,056 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,697,331 - 46,717,631 (+)NCBINCBI36hg18NCBI36
Build 341146,697,330 - 46,717,631NCBI
Celera1146,888,702 - 46,909,014 (+)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1146,446,660 - 46,466,973 (+)NCBIHuRef
CHM1_11146,739,149 - 46,759,462 (+)NCBICHM1_1
F2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,596,196 - 77,609,486 (-)NCBI
Rnor_6.0 Ensembl380,529,428 - 80,543,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0380,529,468 - 80,542,993 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0387,228,703 - 87,242,228 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,005,318 - 76,018,603 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,901,694 - 75,914,982 (-)NCBI
Celera376,801,000 - 76,814,280 (-)NCBICelera
Cytogenetic Map3q24NCBI
F2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,356,769 - 1,367,517 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,356,675 - 1,367,788 (-)NCBIChiLan1.0ChiLan1.0
F2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11147,227,891 - 47,249,157 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,227,891 - 47,249,157 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01146,669,925 - 46,690,391 (+)NCBIMhudiblu_PPA_v0panPan3
F2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,782,744 - 42,799,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,782,751 - 42,799,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,511,662 - 41,528,485 (-)NCBI
ROS_Cfam_1.01843,438,760 - 43,455,850 (-)NCBI
UMICH_Zoey_3.11842,924,063 - 42,940,888 (-)NCBI
UNSW_CanFamBas_1.01842,479,219 - 42,496,510 (-)NCBI
UU_Cfam_GSD_1.01843,208,980 - 43,225,802 (-)NCBI
F2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,260,330 - 20,277,033 (-)NCBI
SpeTri2.0NW_0049365622,371,725 - 2,388,617 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,791,451 - 15,819,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,793,257 - 15,819,151 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,145,002 - 17,170,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,876,974 - 1,887,720 (-)NCBI

Position Markers
F2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1UniSTS
cM Map247.5UniSTS
PMC22695P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38291,635,070 - 91,635,661UniSTSGRCm38
MGSCv37291,475,227 - 91,475,818UniSTSGRCm37
Celera293,024,576 - 93,025,167UniSTS
Cytogenetic Map2E1UniSTS
cM Map247.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31324555105313225Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240995481115079684Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25769377391693944Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25808964792089647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260690268119525037Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26317561097175769Mouse
1301405Etohr_methanol response acute (mouse)Not determined26317561097175769Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26317561097175769Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26317561097175769Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26317561097175769Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26317561097175769Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26373981097739957Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267817543101817798Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267817543101817798Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268893925102894063Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268893925102894063Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74693773114293051Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274693773129371085Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276591138110591306Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276848414103265478Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined281064989115064989Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284178143118178248Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286265371120265478Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286265371120265478Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286265371120265478Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286265371120265478Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287610298121610433Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288184658122184825Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88313078122313225Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291259629125259759Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:264
Count of miRNA genes:165
Interacting mature miRNAs:188
Transcripts:ENSMUST00000028681, ENSMUST00000111335, ENSMUST00000153182
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000028681   ⟹   ENSMUSP00000028681
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl291,625,320 - 91,636,414 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111335   ⟹   ENSMUSP00000106967
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl291,625,329 - 91,636,407 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153182
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl291,631,173 - 91,636,395 (-)Ensembl
RefSeq Acc Id: NM_010168   ⟹   NP_034298
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,455,665 - 91,466,802 (-)NCBI
GRCm38291,625,320 - 91,636,457 (-)NCBI
MGSCv37291,465,477 - 91,476,571 (-)RGD
Celera293,014,831 - 93,025,920 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011239288   ⟹   XP_011237590
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,444,331 - 91,466,799 (-)NCBI
GRCm38291,613,986 - 91,636,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030247399   ⟹   XP_030103259
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39291,442,742 - 91,466,799 (-)NCBI
GRCm38291,612,397 - 91,636,454 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034298   ⟸   NM_010168
- Peptide Label: preproprotein
- UniProtKB: P19221 (UniProtKB/Swiss-Prot),   Q3TJ94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011237590   ⟸   XM_011239288
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030103259   ⟸   XM_030247399
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000106967   ⟸   ENSMUST00000111335
RefSeq Acc Id: ENSMUSP00000028681   ⟸   ENSMUST00000028681
Protein Domains
Gla   Kringle   Peptidase S1

Promoters
RGD ID:6831322
Promoter ID:MM_KWN:30488
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Liver
Transcripts:ENSMUST00000111335,   NM_010168,   OTTMUST00000033634
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36291,476,086 - 91,476,587 (-)MPROMDB
RGD ID:6877926
Promoter ID:EPDNEW_M2414
Type:initiation region
Name:F2_1
Description:Mus musculus coagulation factor II , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38291,636,401 - 91,636,461EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88380 AgrOrtholog
Ensembl Genes ENSMUSG00000027249 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000028681 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000106967 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028681 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000111335 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.140.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prothrombin/thrombin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombin_light_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombin_light_chain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14061 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88380 ENTREZGENE
NCBI Gene 14061 ENTREZGENE
PANTHER PTHR24254:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombin_light UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB F2 RGD
PhenoGen F2 PhenoGen
PIRSF Thrombin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTHROMBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H7BX99_MOUSE UniProtKB/TrEMBL
  P19221 ENTREZGENE
  Q3TJ94 ENTREZGENE, UniProtKB/TrEMBL
  THRB_MOUSE UniProtKB/Swiss-Prot