Tlr2 (toll-like receptor 2) - Rat Genome Database

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Gene: Tlr2 (toll-like receptor 2) Mus musculus
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Symbol: Tlr2
Name: toll-like receptor 2
RGD ID: 1551003
MGI Page MGI
Description: Enables lipoteichoic acid binding activity and peptide binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of cytokine production; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including pattern recognition receptor signaling pathway; regulation of cytokine production; and response to bacterium. Located in external side of plasma membrane. Part of Toll-like receptor 2-Toll-like receptor 6 protein complex. Is expressed in several structures, including brain; early embryo; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ly10; Ly105
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,743,579 - 83,749,045 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,743,579 - 83,749,074 (-)EnsemblGRCm39 Ensembl
GRCm38383,836,272 - 83,841,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,836,272 - 83,841,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv37383,640,194 - 83,645,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,922,199 - 83,927,694 (-)NCBIMGSCv36mm8
Celera383,852,064 - 83,857,400 (-)NCBICelera
Cytogenetic Map3E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (IMP)
acne  (ISO)
acute kidney failure  (IMP,ISO)
acute necrotizing pancreatitis  (ISO)
Acute Tubulointerstitial Nephritis  (IMP)
allergic conjunctivitis  (IMP)
allergic rhinitis  (IDA,ISO)
alveolar echinococcosis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (IDA)
aspergillosis  (IEP)
asthma  (IEP,IMP,ISO)
atherosclerosis  (IMP)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
Bacterial Eye Infections  (ISO)
Bacterial Keratitis  (IMP)
bacterial pneumonia  (IMP,ISO)
Behcet's disease  (ISO)
Brain Abscess  (IMP)
Brain Injuries  (ISO)
breast cancer  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
carotid artery thrombosis  (IMP)
carotid stenosis  (ISO)
cholangitis  (IMP)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IMP)
Chronic Hepatitis B  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
clonorchiasis  (IMP)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Cough  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (IMP)
diffuse scleroderma  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (IEP,ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
endophthalmitis  (IDA,IMP)
Endotoxemia  (ISO)
Eosinophilia  (ISO)
eumycotic mycetoma  (IEP)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (IAGP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
eye disease  (ISO)
Fever  (IMP)
Fungal Eye Infections  (ISO)
gastroesophageal reflux disease  (ISO)
glomerulonephritis  (IMP)
Gram-Positive Bacterial Infections  (IMP)
Hearing Loss  (ISO)
hepatitis B  (IDA)
hepatocellular carcinoma  (IMP,ISO)
Herpes Simplex Encephalitis  (IMP,ISO)
herpes simplex virus keratitis  (IMP)
Human Influenza  (ISO)
Hyperalgesia  (IMP,ISO)
Hypoxia-Ischemia, Brain  (IMP)
ileitis  (ISO)
Inflammation  (IDA,IMP,ISO)
invasive aspergillosis  (IMP)
keratitis  (IMP,ISO)
keratoconjunctivitis  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (IDA,IEP,IMP,ISO)
Kuhnt-Junius degeneration  (ISO)
leprosy  (ISO)
leptospirosis  (IMP)
liver cirrhosis  (IMP)
Liver Reperfusion Injury  (IEP,ISO)
lung disease  (ISO)
mastoiditis  (ISO)
membranoproliferative glomerulonephritis  (IEP)
Meningitis, Escherichia Coli  (IEP)
meningococcal meningitis  (ISO)
mite infestation  (ISO)
molluscum contagiosum  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
non-alcoholic steatohepatitis  (IEP)
obesity  (IMP)
obstructive jaundice  (IEP)
Oral Lichen Planus  (ISO)
otitis media  (IMP,ISO)
Otitis Media with Effusion  (IMP)
Pain  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
Plaque, Atherosclerotic  (ISO)
Pneumococcal Meningitis  (IEP)
Pneumococcal Pneumonia  (IMP)
pneumocystosis  (IMP)
pneumonia  (IMP)
prostate cancer  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (IEP)
pulmonary fibrosis  (IMP)
pulmonary sarcoidosis  (IMP,ISO)
pulmonary tuberculosis  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (IMP)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IEP,IMP)
seborrheic dermatitis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
sinusitis  (ISO)
skin papilloma  (ISO)
Staphylococcal Infections  (ISO)
Streptococcal Infections  (IMP)
suppurative otitis media  (ISO)
Transplant Rejection  (IMP,ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (IAGP,ISO)
typhoid fever  (IMP)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
visceral leishmaniasis  (IMP)
vitiligo  (ISO)
Wallerian Degeneration  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-mercaptopropanoic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
acetamide  (ISO)
adapalene  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
Aflatoxin G1  (EXP)
aldehydo-D-glucose  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (ISO)
ammonium hexachloroplatinate  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
astaxanthin  (EXP)
astemizole  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (EXP,ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP)
carbon atom  (ISO)
carbon nanotube  (EXP,ISO)
cefaloridine  (ISO)
cerium trichloride  (EXP)
CGP 52608  (ISO)
chitosan  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
deoxynivalenol  (EXP)
diarsenic trioxide  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (EXP,ISO)
dioxygen  (ISO)
disodium selenite  (EXP)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
elemental carbon  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
fenoldopam  (ISO)
ferric oxide  (EXP)
ferulic acid  (EXP)
fipronil  (ISO)
folic acid  (EXP)
fonofos  (ISO)
furan  (ISO)
galactose  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (EXP)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
hyaluronic acid  (EXP)
hydroxycitronellal  (ISO)
icosanoid  (EXP)
indometacin  (ISO)
indoprofen  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoeugenol  (ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
L-ascorbic acid  (EXP)
levamisole  (EXP)
lipophosphoglycan  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lycopene  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methylseleninic acid  (ISO)
muramyl dipeptide  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nitrites  (EXP)
nitroprusside  (EXP)
o-anisidine  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (EXP)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
peptidoglycan  (EXP,ISO)
phenobarbital  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
poly(I:C)  (ISO)
prednisolone  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propiconazole  (EXP)
prostaglandin E2  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (EXP)
SCH 23390  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sulfasalazine  (EXP)
sulfur dioxide  (ISO)
sulindac  (ISO)
tacrolimus hydrate  (EXP)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trans-isoeugenol  (ISO)
tributyrin  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
Tungsten carbide  (ISO)
vinclozolin  (ISO)
vitamin D  (EXP,ISO)
vorinostat  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell activation  (ISO)
cell surface pattern recognition receptor signaling pathway  (IMP)
cellular response to bacterial lipopeptide  (IMP,TAS)
cellular response to diacyl bacterial lipopeptide  (ISO)
cellular response to lipoteichoic acid  (IMP,ISO)
cellular response to peptidoglycan  (IMP)
cellular response to triacyl bacterial lipopeptide  (ISO)
cellular response to type II interferon  (ISO)
central nervous system myelin formation  (ISO)
defense response  (IMP)
defense response to Gram-positive bacterium  (IMP,ISO)
defense response to virus  (ISO)
detection of diacyl bacterial lipopeptide  (ISO)
detection of triacyl bacterial lipopeptide  (ISO)
ERK1 and ERK2 cascade  (IMP)
I-kappaB phosphorylation  (ISO)
immune response  (IEA)
immune system process  (IEA)
inflammatory response  (IBA,ISO)
innate immune response  (TAS)
learning  (IGI)
leukocyte migration  (IMP)
leukotriene metabolic process  (ISO)
microglia development  (IGI)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (IGI)
negative regulation of actin filament polymerization  (IGI)
negative regulation of cell population proliferation  (ISO)
negative regulation of interleukin-12 production  (IMP)
negative regulation of interleukin-17 production  (IMP)
negative regulation of phagocytosis  (IGI,IMP)
negative regulation of synapse assembly  (IGI)
neutrophil migration  (IMP)
NIK/NF-kappaB signaling  (IMP)
nitric oxide biosynthetic process  (IMP)
nitric oxide metabolic process  (ISO)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (ISO)
positive regulation of chemokine production  (IMP,ISO)
positive regulation of cytokine production  (IGI)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (IGI,ISO)
positive regulation of interferon-beta production  (IDA)
positive regulation of interleukin-1 beta production  (IGI)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (IDA)
positive regulation of interleukin-18 production  (IDA)
positive regulation of interleukin-6 production  (IDA,IMP,ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of leukocyte migration  (IMP)
positive regulation of macrophage cytokine production  (IDA,IMP)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of neutrophil migration  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (IMP,ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of nitric-oxide synthase biosynthetic process  (IDA)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of toll-like receptor signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of tumor necrosis factor production  (IDA,IGI,IMP)
positive regulation of Wnt signaling pathway  (ISO)
positive regulation of xenophagy  (IMP)
regulation of cytokine production  (IEA)
regulation of dendritic cell cytokine production  (IDA)
response to bacterial lipoprotein  (ISO)
response to bacterium  (IMP)
response to fatty acid  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to molecule of bacterial origin  (IEA)
response to molecule of fungal origin  (IMP)
response to peptidoglycan  (IMP)
response to progesterone  (ISO)
response to toxic substance  (ISO)
signal transduction  (IEA)
toll-like receptor 2 signaling pathway  (IEA)
toll-like receptor signaling pathway  (IBA,ISO)
toll-like receptor TLR6:TLR2 signaling pathway  (ISO)
xenophagy  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal cortex morphology  (IAGP)
abnormal adrenal gland morphology  (IAGP)
abnormal adrenal gland secretion  (IAGP)
abnormal airway responsiveness  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal astrocyte physiology  (IAGP)
abnormal body fat mass  (IAGP)
abnormal cellular extravasation  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal circadian behavior  (IAGP)
abnormal circulating cholesterol level  (IAGP)
abnormal circulating corticosterone level  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal circulating LDL cholesterol level  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal circulating pituitary hormone level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal endoplasmic reticulum morphology  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal glial cell physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal innate immunity  (IAGP)
abnormal interleukin level  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal locomotor circadian rhythm  (IAGP)
abnormal long term spatial reference memory  (IAGP)
abnormal lung interstitium morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal mitochondrial shape  (IAGP)
abnormal myelination  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal white fat cell size  (IAGP)
amyloid beta deposits  (IAGP)
atherosclerotic lesions  (IAGP)
brain ischemia  (IAGP)
cardiac interstitial fibrosis  (IAGP)
colonic necrosis  (IAGP)
decreased angiogenesis  (IAGP)
decreased body weight  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-1 beta level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased circulating VLDL cholesterol level  (IAGP)
decreased fat cell size  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased heart left ventricle weight  (IAGP)
decreased heart weight  (IAGP)
decreased IgG3 level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased inflammatory response  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-1 secretion  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-12b secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased liver tumor incidence  (IAGP)
decreased lung tumor incidence  (IAGP)
decreased lung weight  (IAGP)
decreased macrophage cytokine production  (IAGP)
decreased macrophage nitric oxide production  (IAGP)
decreased microglial cell activation  (IAGP)
decreased mitochondrial number  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased splenocyte proliferation  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to hepatic steatosis  (IAGP)
decreased susceptibility to Herpesvirales infection  (IAGP)
decreased susceptibility to Herpesvirales infection induced morbidity/mortality  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased thermal nociceptive threshold  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
enlarged adrenal glands  (IAGP)
hepatic steatosis  (IAGP)
hyperoxia  (IAGP)
hyperresponsive to tactile stimuli  (IAGP)
impaired passive avoidance behavior  (IAGP)
improved glucose tolerance  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased apoptosis  (IAGP)
increased B cell apoptosis  (IAGP)
increased body weight  (IAGP)
increased carcinoma incidence  (IAGP)
increased circulating adrenocorticotropin level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased colon adenoma incidence  (IAGP)
increased energy expenditure  (IAGP)
increased food intake  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased T cell number  (IAGP)
insulitis  (IAGP)
no abnormal phenotype detected  (IEA)
premature death  (IAGP)
rectal hemorrhage  (IAGP)
small pancreatic islets  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. [Changes of Toll-like Receptor mRNA and Related Cytokines in Patients with Hepatic Alveolar Echinococcosis]. Abudusalamu A, etal., Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2016 Dec;34(6):542-6.
2. Serum Toll-Like Receptor-2, Toll-Like Receptor-4 Levels in Patients with HBeAg-Negative Chronic Viral Hepatitis B. Akbal E, etal., Viral Immunol. 2017 May;30(4):278-282. doi: 10.1089/vim.2016.0131. Epub 2017 Apr 17.
3. Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion. Amura CR, etal., Mol Immunol. 2012 Oct;52(3-4):249-57. doi: 10.1016/j.molimm.2012.05.020. Epub 2012 Jun 27.
4. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. Andersson A, etal., J Leukoc Biol. 2008 Nov;84(5):1248-55. Epub 2008 Jul 21.
5. Immunolocalization of toll-like receptor 2 in viral warts and molluscum contagiosum. Bakry OA, etal., Anal Quant Cytol Histol. 2013 Dec;35(6):316-23.
6. Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Balloy V, etal., Infect Immun. 2005 Sep;73(9):5420-5.
7. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
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9. Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis. Bereczky-Veress B, etal., PLoS One. 2010 Aug 27;5(8):e12350.
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129. Mouse MP Annotation Import Pipeline RGD automated import pipeline
130. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
131. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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137. Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis. Sarangi PP, etal., J Virol. 2007 Oct;81(20):11128-38. Epub 2007 Aug 8.
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PMID:31954829   PMID:31964813   PMID:31978265   PMID:31993047   PMID:32007503   PMID:32030804   PMID:32058931   PMID:32068020   PMID:32075760   PMID:32080167   PMID:32094297   PMID:32098158  
PMID:32125695   PMID:32133407   PMID:32144270   PMID:32150572   PMID:32170671   PMID:32172666   PMID:32209688   PMID:32234538   PMID:32268093   PMID:32290861   PMID:32330088   PMID:32341377  
PMID:32404866   PMID:32424099   PMID:32459842   PMID:32466296   PMID:32479995   PMID:32503644   PMID:32504758   PMID:32554809   PMID:32576672   PMID:32610084   PMID:32632165   PMID:32651433  
PMID:32652111   PMID:32661363   PMID:32696994   PMID:32698010   PMID:32726802   PMID:32745117   PMID:32788720   PMID:32813318   PMID:32874003   PMID:32889432   PMID:32912327   PMID:32912852  
PMID:32958053   PMID:32970964   PMID:33011801   PMID:33027646   PMID:33077627   PMID:33148715   PMID:33168941   PMID:33189487   PMID:33193308   PMID:33202847   PMID:33214151   PMID:33303547  
PMID:33318302   PMID:33390812   PMID:33412104   PMID:33542719   PMID:33567279   PMID:33596932   PMID:33652137   PMID:33723368   PMID:33746957   PMID:33798196   PMID:33963333   PMID:33986920  
PMID:34014921   PMID:34021910   PMID:34087422   PMID:34107067   PMID:34111601   PMID:34127487   PMID:34166614   PMID:34192530   PMID:34194428   PMID:34206257   PMID:34215822   PMID:34222495  
PMID:34360582   PMID:34372877   PMID:34395439   PMID:34398403   PMID:34424458   PMID:34508096   PMID:34512626   PMID:34576099   PMID:34591792   PMID:34601054   PMID:34622466   PMID:34742442  
PMID:34755600   PMID:34760891   PMID:34769252   PMID:34819929   PMID:34867973   PMID:34877502   PMID:35031299   PMID:35035808   PMID:35131445   PMID:35153674   PMID:35314006   PMID:35332963  
PMID:35362478   PMID:35372108   PMID:35493479   PMID:35493520   PMID:35584674   PMID:35586249   PMID:35681486  


Genomics

Comparative Map Data
Tlr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,743,579 - 83,749,045 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,743,579 - 83,749,074 (-)EnsemblGRCm39 Ensembl
GRCm38383,836,272 - 83,841,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,836,272 - 83,841,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv37383,640,194 - 83,645,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,922,199 - 83,927,694 (-)NCBIMGSCv36mm8
Celera383,852,064 - 83,857,400 (-)NCBICelera
Cytogenetic Map3E3NCBI
TLR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384153,684,280 - 153,710,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4153,684,070 - 153,706,260 (+)EnsemblGRCh38hg38GRCh38
GRCh374154,605,432 - 154,627,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,824,891 - 154,846,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 344154,966,670 - 154,984,135NCBI
Celera4151,929,928 - 151,951,730 (+)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4150,336,457 - 150,358,268 (+)NCBIHuRef
CHM1_14154,583,811 - 154,605,614 (+)NCBICHM1_1
T2T-CHM13v2.04157,008,777 - 157,030,716 (+)NCBIT2T-CHM13v2.0
Tlr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22169,200,620 - 169,206,819 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,197,419 - 169,206,630 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,379,970 - 176,385,353 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02174,399,903 - 174,405,286 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02169,001,363 - 169,006,752 (-)NCBIRnor_WKY
Rnor_6.02182,840,171 - 182,846,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,840,727 - 182,846,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,252,701 - 202,258,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,607,990 - 175,613,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,558,096 - 175,564,098 (-)NCBI