Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Tlr2 (toll-like receptor 2) Mus musculus
Symbol: Tlr2
Name: toll-like receptor 2
Description: Exhibits lipoteichoic acid binding activity and peptide binding activity. Involved in several processes, including positive regulation of defense response; regulation of cytokine production; and response to bacterium. Localizes to Toll-like receptor 2-Toll-like receptor 6 protein complex and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in several diseases, including dermatitis (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2); PARTICIPATES IN Toll-like receptor signaling pathway; Chagas disease pathway; Entamoebiasis pathway; INTERACTS WITH (+)-pilocarpine; (-)-citrinin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ly105
Homo sapiens (human) : TLR2 (toll like receptor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tlr2 (toll-like receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr2 (toll like receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR2 (toll like receptor 2)
Canis lupus familiaris (dog) : TLR2 (toll like receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr2 (toll like receptor 2)
Sus scrofa (pig) : TLR2 (toll like receptor 2)
Heterocephalus glaber (naked mole-rat) : Tlr2 (toll like receptor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl383,836,272 - 83,841,767 (-)EnsemblGRCm38mm10GRCm38
GRCm38383,836,272 - 83,841,824 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37383,640,194 - 83,645,530 (-)NCBIGRCm37mm9NCBIm37
MGSCv36383,922,199 - 83,927,694 (-)NCBImm8
Celera383,852,064 - 83,857,400 (-)NCBICelera
Cytogenetic Map3E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tlr2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1551003
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.