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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732638
Species: Mus musculus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparamultiple interactionsEXP 6480464CTDAtorvastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]PMID:18812576
Pparadecreases expressionISOPPARA (Homo sapiens)6480464CTDAtorvastatin results in decreased expression of PPARA mRNAPMID:21554872
Pparamultiple interactionsISOPpara (Rattus norvegicus)6480464CTD[dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARA protein]; Atorvastatin inhibits the reaction [Fructose results in increased expression of PPARA protein]PMID:12065722 PMID:32259528
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