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Gene: Gpx4 (glutathione peroxidase 4) Mus musculus
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Symbol: Gpx4
Name: glutathione peroxidase 4
Description: Exhibits glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in several processes, including negative regulation of ferroptosis; response to oxidative stress; and spermatogenesis. Localizes to the cytosol; mitochondrion; and nuclear envelope. Is expressed in several structures, including alimentary system; embryo ectoderm; extraembryonic component; nervous system; and sensory organ. Orthologous to human GPX4 (glutathione peroxidase 4).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1700027O09Rik; GPx-4; GSHPx-4; MGC103187; MGC118087; mtPHGPx; PHGPx; phospholipid hydroperoxide glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; snGPx; sperm nuclei glutathione peroxidase
Orthologs:
Homo sapiens (human) : GPX4 (glutathione peroxidase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gpx4 (glutathione peroxidase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpx4 (glutathione peroxidase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : GPX4 (glutathione peroxidase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpx4 (glutathione peroxidase 4)
Sus scrofa (pig) : GPX4 (glutathione peroxidase 4)
more info ...
Related Pseudogenes: Gpx4-ps1   Gpx4-ps2  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381080,047,166 - 80,056,439 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371079,516,255 - 79,519,184 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,456,617 - 79,459,567 (+)NCBImm8
Celera1081,061,975 - 81,071,248 (+)NCBICelera
Cytogenetic Map10 C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Gpx4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736050
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.