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Gene: Gpx4 (glutathione peroxidase 4) Mus musculus
Symbol: Gpx4
Name: glutathione peroxidase 4
Description: Exhibits glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in several processes, including negative regulation of ferroptosis; response to oxidative stress; and spermatogenesis. Localizes to the cytosol; mitochondrion; and nuclear envelope. Is expressed in several structures, including alimentary system; embryo ectoderm; extraembryonic component; nervous system; and sensory organ. Orthologous to human GPX4 (glutathione peroxidase 4).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1700027O09Rik; GPx-4; GSHPx-4; MGC103187; MGC118087; mtPHGPx; PHGPx; phospholipid hydroperoxide glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; snGPx; sperm nuclei glutathione peroxidase
Homo sapiens (human) : GPX4 (glutathione peroxidase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gpx4 (glutathione peroxidase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpx4 (glutathione peroxidase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : GPX4 (glutathione peroxidase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpx4 (glutathione peroxidase 4)
Sus scrofa (pig) : GPX4 (glutathione peroxidase 4)
more info ...
Related Pseudogenes: Gpx4-ps1   Gpx4-ps2  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381080,047,166 - 80,056,439 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371079,516,255 - 79,519,184 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,456,617 - 79,459,567 (+)NCBImm8
Celera1081,061,975 - 81,071,248 (+)NCBICelera
Cytogenetic Map10 C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gpx4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736050
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.