Prkaa1 (protein kinase, AMP-activated, alpha 1 catalytic subunit) - Rat Genome Database

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Gene: Prkaa1 (protein kinase, AMP-activated, alpha 1 catalytic subunit) Mus musculus
Symbol: Prkaa1
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
RGD ID: 1550489
Description: Enables AMP-activated protein kinase activity; chromatin binding activity; and histone kinase activity (H2B-S36 specific). Involved in several processes, including regulation of gene expression; regulation of organelle organization; and regulation of protein modification process. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; positive regulation of skeletal muscle tissue development; and regulation of peptidyl-serine phosphorylation. Located in several cellular components, including axon; dendrite; and neuronal cell body. Is active in chromatin. Is expressed in several structures, including brain; connective tissue; early conceptus; future brain; and spinal cord. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5'-AMP-activated protein kinase catalytic subunit alpha-1; ACACA kinase; acetyl-CoA carboxylase kinase; AI194361; AI450832; AL024255; AMP-activated protein kinase, alpha 1 catalytic subunit; AMPK; AMPK subunit alpha-1; AMPKalpha1; C130083N04Rik; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; tau-protein kinase PRKAA1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39155,172,641 - 5,211,380 (+)NCBIGRCm39mm39
GRCm39 Ensembl155,173,343 - 5,211,380 (+)Ensembl
GRCm38155,143,861 - 5,181,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,143,861 - 5,181,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37155,093,861 - 5,131,899 (+)NCBIGRCm37mm9NCBIm37
MGSCv36155,091,090 - 5,129,114 (+)NCBImm8
Celera154,993,697 - 5,031,451 (+)NCBICelera
Cytogenetic Map15A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (ISO)
(R,R)-tramadol  (ISO)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (ISO)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (EXP)
4-nitrophenol  (EXP)
4-nonylphenol  (ISO)
5-aminolevulinic acid  (ISO)
acadesine  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
amiodarone  (ISO)
amlexanox  (EXP)
ammonium chloride  (ISO)
apigenin  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
Calcimycin  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
celecoxib  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cylindrospermopsin  (ISO)
D-glucopyranose 6-phosphate  (EXP)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deguelin  (EXP)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dihydroxyacetone  (EXP)
dioscin  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
econazole  (EXP)
enalapril  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
flavonoids  (ISO)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
lipopolysaccharide  (EXP)
mangiferin  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
naproxen  (ISO)
nickel atom  (ISO)
nicotinamide  (ISO)
nitric oxide  (ISO)
Nonylphenol  (ISO)
O-palmitoylcarnitine  (ISO)
oleic acid  (ISO)
orlistat  (EXP,ISO)
orotic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phorone  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
progesterone  (ISO)
pterostilbene  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
SB 203580  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium azide  (EXP)
sodium dichromate  (ISO)
steviol  (EXP)
sumatriptan  (ISO)
tebuconazole  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
tramadol  (ISO)
triacsin C  (EXP)
Tributyltin oxide  (EXP,ISO)
Triptolide  (ISO)
tunicamycin  (EXP)
U0126  (ISO)
WIN 55212-2  (ISO)
xylazine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
bile acid and bile salt transport  (ISO)
bile acid signaling pathway  (ISO)
CAMKK-AMPK signaling cascade  (ISO)
cellular response to calcium ion  (IGI,ISO)
cellular response to ethanol  (ISO)
cellular response to glucose starvation  (IDA,ISO)
cellular response to glucose stimulus  (IGI,ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to nutrient levels  (IDA,ISO)
cellular response to organonitrogen compound  (ISO)
cellular response to oxidative stress  (IGI)
cellular response to prostaglandin E stimulus  (IGI)
cellular response to xenobiotic stimulus  (ISO)
cholesterol biosynthetic process  (IEA)
cholesterol metabolic process  (IEA)
chromatin organization  (IEA)
cold acclimation  (ISO)
energy homeostasis  (ISO)
fatty acid biosynthetic process  (IEA)
fatty acid homeostasis  (ISO)
fatty acid metabolic process  (IEA)
fatty acid oxidation  (IMP)
glucose homeostasis  (IMP)
glucose metabolic process  (IMP)
intracellular signal transduction  (IBA)
lipid biosynthetic process  (IDA)
lipid droplet disassembly  (ISO)
lipid metabolic process  (IEA)
motor behavior  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of gene expression  (IGI)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of lipid catabolic process  (IDA)
negative regulation of TOR signaling  (IMP)
negative regulation of tubulin deacetylation  (IGI)
neuron cellular homeostasis  (ISO)
phosphorylation  (IEA)
positive regulation of adipose tissue development  (IDA)
positive regulation of autophagy  (IMP,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of gene expression  (IMP,ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of mitochondrial transcription  (IMP)
positive regulation of peptidyl-lysine acetylation  (IGI)
positive regulation of protein localization  (IGI)
positive regulation of protein targeting to mitochondrion  (IMP)
positive regulation of skeletal muscle tissue development  (IMP)
protein localization to lipid droplet  (IDA,ISO)
protein phosphorylation  (IBA,ISO)
regulation of bile acid secretion  (ISO)
regulation of circadian rhythm  (IMP)
regulation of gene expression  (ISO)
regulation of microtubule cytoskeleton organization  (IGI)
regulation of peptidyl-serine phosphorylation  (IMP)
regulation of stress granule assembly  (IGI)
regulation of vesicle-mediated transport  (ISO)
response to 17alpha-ethynylestradiol  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to camptothecin  (IMP)
response to gamma radiation  (IMP)
response to hydrogen peroxide  (IMP)
response to UV  (IMP)
response to xenobiotic stimulus  (ISO)
rhythmic process  (IEA)
steroid biosynthetic process  (IEA)
steroid metabolic process  (IEA)
sterol biosynthetic process  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Expression and significance of lipin1 and AMPKalpha in hepatic insulin resistance in diet-induced insulin resistance rats. Chen SH, etal., Exp Clin Endocrinol Diabetes. 2012 Feb;120(2):84-8. Epub 2012 Jan 9.
2. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
3. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, etal., FEBS Lett. 2003 Jul 3;546(1):113-20.
4. AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice. Hulo S, etal., Respir Res. 2011 May 19;12:64.
5. Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. Ishii H, etal., J Hepatol. 2009 Mar;50(3):562-71. Epub 2008 Dec 27.
6. Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. Ju TC, etal., J Cell Biol. 2011 Jul 25;194(2):209-27. Epub 2011 Jul 18.
7. Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat. Lakshmanan AP, etal., Free Radic Res. 2011 Jul;45(7):788-95. Epub 2011 May 9.
8. Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats. Li X, etal., Arch Toxicol. 2017 Jan;91(1):481-494. doi: 10.1007/s00204-016-1697-8. Epub 2016 Apr 18.
9. MGDs mouse GO annotations MGD data from the GO Consortium
11. Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity. Nath N, etal., Biochem Biophys Res Commun. 2009 Aug 14;386(1):16-20. Epub 2009 May 30.
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Overexpression of AMPKalpha1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats. Seo E, etal., Korean J Physiol Pharmacol. 2009 Dec;13(6):449-54. Epub 2009 Dec 31.
18. Genetic variation in genes involved in hormones, inflammation, and energetic factors and breast cancer risk in an admixed population. Slattery M, etal., Carcinogenesis. 2012 May 4.
19. Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. Slattery ML, etal., Carcinogenesis. 2010 Sep;31(9):1604-11. Epub 2010 Jul 9.
20. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Storozhuk Y, etal., Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.
21. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Yamauchi T, etal., Nature 2003 Jun 12;423(6941):762-9.
22. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. Yang Z, etal., J Biol Chem. 2010 Jun 18;285(25):19051-9. Epub 2010 Apr 26.
23. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
Additional References at PubMed
PMID:7671812   PMID:10098881   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:11903059   PMID:12044627   PMID:12477932   PMID:12520002   PMID:12546688  
PMID:12904583   PMID:14532293   PMID:14573616   PMID:14610273   PMID:14985505   PMID:15314686   PMID:15753079   PMID:15878856   PMID:15878932   PMID:16054095   PMID:16141072   PMID:16141073  
PMID:16186119   PMID:16308421   PMID:16567505   PMID:16809770   PMID:17023420   PMID:17244624   PMID:17324122   PMID:17438283   PMID:17446219   PMID:17525164   PMID:17619104   PMID:17671657  
PMID:17724029   PMID:17767908   PMID:17855357   PMID:17967808   PMID:18036344   PMID:18040027   PMID:18227155   PMID:18328803   PMID:18350549   PMID:18381066   PMID:18381428   PMID:18390901  
PMID:18439900   PMID:18480843   PMID:18556591   PMID:18562309   PMID:18639556   PMID:18674809   PMID:18701654   PMID:18703865   PMID:18721796   PMID:18752001   PMID:18799693   PMID:18809807  
PMID:18818284   PMID:18840652   PMID:18927084   PMID:19050047   PMID:19050283   PMID:19158325   PMID:19176354   PMID:19176702   PMID:19208854   PMID:19217427   PMID:19236843   PMID:19237506  
PMID:19262508   PMID:19268526   PMID:19274086   PMID:19657063   PMID:19700529   PMID:19830459   PMID:19833968   PMID:19844161   PMID:19934007   PMID:19940131   PMID:19942859   PMID:20036235  
PMID:20108250   PMID:20123786   PMID:20124121   PMID:20126541   PMID:20197054   PMID:20206634   PMID:20221584   PMID:20361929   PMID:20363874   PMID:20368287   PMID:20392689   PMID:20399150  
PMID:20399918   PMID:20422711   PMID:20450902   PMID:20460104   PMID:20460585   PMID:20465544   PMID:20477759   PMID:20558612   PMID:20573496   PMID:20577053   PMID:20615388   PMID:20647423  
PMID:20650315   PMID:20660302   PMID:20664053   PMID:20670625   PMID:20685962   PMID:20696287   PMID:20708602   PMID:20830737   PMID:20934448   PMID:21099273   PMID:21099309   PMID:21106494  
PMID:21119216   PMID:21124450   PMID:21135058   PMID:21135130   PMID:21187071   PMID:21195347   PMID:21205641   PMID:21205985   PMID:21209912   PMID:21212267   PMID:21232561   PMID:21239628  
PMID:21258367   PMID:21262463   PMID:21297178   PMID:21359855   PMID:21363937   PMID:21402702   PMID:21414288   PMID:21436046   PMID:21459323   PMID:21470048   PMID:21483791   PMID:21506122  
PMID:21536037   PMID:21593427   PMID:21597006   PMID:21606593   PMID:21673972   PMID:21685727   PMID:21750268   PMID:21799304   PMID:21803294   PMID:21810931   PMID:21819956   PMID:21849631  
PMID:21852563   PMID:21873433   PMID:21873635   PMID:21876756   PMID:21885655   PMID:21906645   PMID:21941369   PMID:21947382   PMID:21993711   PMID:21994947   PMID:22002056   PMID:22007913  
PMID:22119190   PMID:22129093   PMID:22209521   PMID:22233421   PMID:22253816   PMID:22260947   PMID:22293193   PMID:22451268   PMID:22454291   PMID:22474243   PMID:22539595   PMID:22560875  
PMID:22564979   PMID:22581459   PMID:22610379   PMID:22645311   PMID:22683340   PMID:22700192   PMID:22763120   PMID:22767231   PMID:22791749   PMID:22815809   PMID:22815934   PMID:22815988  
PMID:22846606   PMID:22851545   PMID:22872236   PMID:22932492   PMID:22952059   PMID:22995402   PMID:23024365   PMID:23041647   PMID:23064268   PMID:23142078   PMID:23159612   PMID:23180823  
PMID:23184942   PMID:23201261   PMID:23238131   PMID:23283301   PMID:23288166   PMID:23303186   PMID:23306156   PMID:23307809   PMID:23310952   PMID:23322781   PMID:23382195   PMID:23390161  
PMID:23412344   PMID:23463002   PMID:23476055   PMID:23479225   PMID:23486478   PMID:23515442   PMID:23518923   PMID:23527250   PMID:23583109   PMID:23589839   PMID:23592382   PMID:23625915  
PMID:23658008   PMID:23686584   PMID:23705032   PMID:23716691   PMID:23748787   PMID:23785098   PMID:23796563   PMID:23835445   PMID:23875776   PMID:23883517   PMID:23905686   PMID:23906616  
PMID:23926128   PMID:23931756   PMID:23943624   PMID:23958300   PMID:23983188   PMID:24012615   PMID:24043309   PMID:24072697   PMID:24080823   PMID:24093678   PMID:24095280   PMID:24104879  
PMID:24115035   PMID:24209762   PMID:24228806   PMID:24295634   PMID:24315994   PMID:24337047   PMID:24347059   PMID:24385485   PMID:24403081   PMID:24420540   PMID:24457600   PMID:24465016  
PMID:24595038   PMID:24652947   PMID:24665903   PMID:24727412   PMID:24771016   PMID:24793415   PMID:24805196   PMID:24855056   PMID:24858404   PMID:24874076   PMID:24946181   PMID:24965601  
PMID:24988326   PMID:24993069   PMID:25003940   PMID:25013763   PMID:25018087   PMID:25051362   PMID:25070369   PMID:25086610   PMID:25088745   PMID:25090113   PMID:25195104   PMID:25225331  
PMID:25229693   PMID:25256353   PMID:25307521   PMID:25315694   PMID:25348630   PMID:25366347   PMID:25428125   PMID:25472042   PMID:25483961   PMID:25484082   PMID:25497570   PMID:25505152  
PMID:25512602   PMID:25536376   PMID:25552597   PMID:25588837   PMID:25591781   PMID:25607458   PMID:25609422   PMID:25616953   PMID:25683712   PMID:25711403   PMID:25751139   PMID:25767884  
PMID:25788287   PMID:25799226   PMID:25830091   PMID:25833220   PMID:25835326   PMID:25858560   PMID:25861159   PMID:25902870   PMID:25937278   PMID:25975226   PMID:26020972   PMID:26034200  
PMID:26091038   PMID:26105792   PMID:26244519   PMID:26268732   PMID:26322680   PMID:26365580   PMID:26367078   PMID:26370082   PMID:26384382   PMID:26419588   PMID:26496200   PMID:26496610  
PMID:26518685   PMID:26556533   PMID:26595272   PMID:26625127   PMID:26687997   PMID:26741062   PMID:26772142   PMID:26799633   PMID:26822081   PMID:26856538   PMID:26890602   PMID:26902588  
PMID:26926143   PMID:26944679   PMID:26952277   PMID:26975583   PMID:27010458   PMID:27013659   PMID:27035650   PMID:27052588   PMID:27058143   PMID:27103069   PMID:27103439   PMID:27106803  
PMID:27177226   PMID:27183598   PMID:27185873   PMID:27215380   PMID:27230958   PMID:27242197   PMID:27256105   PMID:27264993   PMID:27283242   PMID:27304906   PMID:27305174   PMID:27307439  
PMID:27381369   PMID:27411013   PMID:27430620   PMID:27444205   PMID:27449088   PMID:27500459   PMID:27506764   PMID:27517519   PMID:27524625   PMID:27598258   PMID:27600021   PMID:27641099  
PMID:27650555   PMID:27668984   PMID:27733575   PMID:27758862   PMID:27777247   PMID:27793977   PMID:27797909   PMID:27826658   PMID:27840174   PMID:27879319   PMID:27909079   PMID:27914812  
PMID:27919027   PMID:27941154   PMID:27965101   PMID:27966786   PMID:27978459   PMID:28009285   PMID:28060740   PMID:28065882   PMID:28085510   PMID:28085543   PMID:28089566   PMID:28107516  
PMID:28121062   PMID:28162974   PMID:28179232   PMID:28181410   PMID:28225087   PMID:28234358   PMID:28235712   PMID:28290498   PMID:28300563   PMID:28315332   PMID:28330873   PMID:28335680  
PMID:28449683   PMID:28459206   PMID:28467931   PMID:28496133   PMID:28500773   PMID:28502587   PMID:28515121   PMID:28542142   PMID:28621313   PMID:28628912   PMID:28668388   PMID:28684424  
PMID:28739141   PMID:28766983   PMID:28847007   PMID:28884830   PMID:28915221   PMID:28973855   PMID:28974562   PMID:28978464   PMID:28978947   PMID:28988114   PMID:29030114   PMID:29038293  
PMID:29053957   PMID:29126229   PMID:29202476   PMID:29268850   PMID:29269398   PMID:29279848   PMID:29288408   PMID:29316805   PMID:29343420   PMID:29351847   PMID:29442133   PMID:29466728  
PMID:29479319   PMID:29502204   PMID:29512400   PMID:29515462   PMID:29563610   PMID:29580989   PMID:29610348   PMID:29858246   PMID:29861059   PMID:29909009   PMID:29915361   PMID:29929979  
PMID:29982418   PMID:29982462   PMID:30018077   PMID:30049881   PMID:30053525   PMID:30072101   PMID:30104247   PMID:30171880   PMID:30201950   PMID:30213948   PMID:30249643   PMID:30279167  
PMID:30328345   PMID:30341325   PMID:30348767   PMID:30405100   PMID:30413706   PMID:30415923   PMID:30463013   PMID:30467274   PMID:30527811   PMID:30550785   PMID:30606143   PMID:30643968  
PMID:30733434   PMID:30804206   PMID:30807229   PMID:30818059   PMID:30842418   PMID:30917323   PMID:30946604   PMID:30946605   PMID:30982734   PMID:30995468   PMID:31010958   PMID:31016544  
PMID:31053472   PMID:31160601   PMID:31167140   PMID:31409640   PMID:31413360   PMID:31526569   PMID:31540695   PMID:31560952   PMID:31614179   PMID:31676673   PMID:31693892   PMID:31697807  
PMID:31868590   PMID:32029897   PMID:32048347   PMID:32117320   PMID:32184359   PMID:32191914   PMID:32213711   PMID:32243780   PMID:32293932   PMID:32316320   PMID:32324591   PMID:32375022  
PMID:32378514   PMID:32414840   PMID:32439824   PMID:32504885   PMID:32554528   PMID:32650778   PMID:32662486   PMID:32663458   PMID:32820462   PMID:32822587   PMID:32839348   PMID:32934963  
PMID:32965675   PMID:32978273   PMID:32987623   PMID:33022274   PMID:33059001   PMID:33148712   PMID:33202149   PMID:33219380   PMID:33251722   PMID:33261140   PMID:33262120   PMID:33372189  
PMID:33461007   PMID:33492732   PMID:33511118   PMID:33535040   PMID:33564961   PMID:33790902   PMID:33798773   PMID:33904622   PMID:33913477   PMID:33951438   PMID:33968022   PMID:34002012  
PMID:34077757   PMID:34157307   PMID:34268656   PMID:34291733   PMID:34380027   PMID:34496874   PMID:34576076   PMID:34668531   PMID:34767944   PMID:35004133   PMID:35008461   PMID:35019933  
PMID:35081489   PMID:35099001   PMID:35237793   PMID:35459945   PMID:35538889  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39155,172,641 - 5,211,380 (+)NCBIGRCm39mm39
GRCm39 Ensembl155,173,343 - 5,211,380 (+)Ensembl
GRCm38155,143,861 - 5,181,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,143,861 - 5,181,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37155,093,861 - 5,131,899 (+)NCBIGRCm37mm9NCBIm37
MGSCv36155,091,090 - 5,129,114 (+)NCBImm8
Celera154,993,697 - 5,031,451 (+)NCBICelera
Cytogenetic Map15A1NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38540,759,389 - 40,798,374 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl540,759,389 - 40,798,374 (-)EnsemblGRCh38hg38GRCh38
GRCh37540,759,491 - 40,798,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,795,238 - 40,834,054 (-)NCBINCBI36hg18NCBI36
Build 34540,795,238 - 40,834,046NCBI
Celera540,648,066 - 40,686,889 (-)NCBI
Cytogenetic Map5p13.1NCBI
HuRef540,711,304 - 40,750,184 (-)NCBIHuRef
CHM1_1540,761,376 - 40,800,178 (-)NCBICHM1_1
T2T-CHM13v2.0541,015,789 - 41,054,877 (-)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2254,240,298 - 54,275,978 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl254,240,137 - 54,275,978 (+)Ensembl
Rnor_6.0254,857,688 - 54,893,404 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,857,688 - 54,893,404 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0273,882,080 - 73,917,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,327,821 - 54,360,462 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1254,256,055 - 54,288,695 (+)NCBI
Celera249,888,577 - 49,923,847 (+)NCBICelera
Cytogenetic Map2q16NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542625,079,718 - 25,102,090 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542625,079,718 - 25,102,090 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1574,627,844 - 74,666,505 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,627,830 - 74,666,505 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0569,581,748 - 69,620,721 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1468,579,061 - 68,614,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,579,037 - 68,611,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,255,490 - 68,291,515 (+)NCBI
ROS_Cfam_1.0469,085,598 - 69,121,628 (+)NCBI
ROS_Cfam_1.0 Ensembl469,085,149 - 69,121,622 (+)Ensembl
UMICH_Zoey_3.1468,844,836 - 68,880,871 (+)NCBI
UNSW_CanFamBas_1.0468,957,934 - 68,993,962 (+)NCBI
UU_Cfam_GSD_1.0469,496,965 - 69,533,038 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213229,528,457 - 229,554,782 (-)NCBI
SpeTri2.0NW_0049365181,817,051 - 1,843,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1625,745,324 - 25,783,707 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,745,902 - 25,783,524 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1439,516,307 - 39,553,627 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607129,939,348 - 29,980,047 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475914,142,956 - 14,171,718 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475914,143,439 - 14,174,971 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38155,180,602 - 5,180,800UniSTSGRCm38
MGSCv37155,130,602 - 5,130,800UniSTSGRCm37
Celera155,030,154 - 5,030,352UniSTS
Cytogenetic Map15A1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38155,181,748 - 5,181,850UniSTSGRCm38
MGSCv37155,131,748 - 5,131,850UniSTSGRCm37
Celera155,031,300 - 5,031,402UniSTS
Cytogenetic Map15A1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38155,181,444 - 5,181,776UniSTSGRCm38
MGSCv37155,131,444 - 5,131,776UniSTSGRCm37
Celera155,030,996 - 5,031,328UniSTS
Cytogenetic Map15A1UniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357459Nhdlq7_mnon-HDL QTL 7 (mouse)Not determined15120489829Mouse
1302121Cliff_mcliff drop aversion (mouse)Not determined15120489829Mouse
1300953Bdt5_mbone density traits 5 (mouse)Not determined15120489829Mouse
5491193Mobq4_mmultigenic obesity QTL 4 (mouse)Not determined15120489829Mouse
1301662Faq8_mfluctuating asymmetry QTL 8 (mouse)Not determined15120489829Mouse
1301023Sluc24_msusceptibility to lung cancer 24 (mouse)Not determined15120489829Mouse
4141541Tglq3_mtriglyceride QTL 3 (mouse)Not determined15120489829Mouse
11062069Bpq31_mblood pressure QTL 31 (mouse)15126273195Mouse
4141446Ffaq4_mfree fatty acid QTL 4 (mouse)Not determined127101390Mouse
1300594Eae2_msusceptibility to experimental allergic encephalomyelitis 2 (mouse)Not determined15131218736Mouse
1301136Pgia8_mproteoglycan induced arthritis 8 (mouse)Not determined15324016724388176Mouse
4141358Ath22_matherosclerosis 22 (mouse)Not determined346465237464652Mouse
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15347438971197538Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1932
Count of miRNA genes:640
Interacting mature miRNAs:835
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000051186   ⟹   ENSMUSP00000063166
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl155,173,343 - 5,211,380 (+)Ensembl
GRCm38.p6 Ensembl155,143,861 - 5,181,899 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228218   ⟹   ENSMUSP00000154562
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl155,173,373 - 5,211,373 (+)Ensembl
GRCm38.p6 Ensembl155,143,891 - 5,181,892 (+)Ensembl
RefSeq Acc Id: NM_001013367   ⟹   NP_001013385
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39155,173,343 - 5,211,380 (+)NCBI
GRCm38155,143,861 - 5,181,899 (+)ENTREZGENE
MGSCv37155,093,861 - 5,131,899 (+)RGD
Celera154,993,697 - 5,031,451 (+)RGD
RefSeq Acc Id: NM_001355640   ⟹   NP_001342569
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39155,173,343 - 5,211,380 (+)NCBI
GRCm38155,143,861 - 5,181,899 (+)NCBI
RefSeq Acc Id: XM_036159053   ⟹   XP_036014946
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39155,172,641 - 5,211,380 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001013385   ⟸   NM_001013367
- Peptide Label: isoform 1
- UniProtKB: Q5EG47 (UniProtKB/Swiss-Prot),   Q3TUQ7 (UniProtKB/TrEMBL),   Q8BUX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001342569   ⟸   NM_001355640
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000063166   ⟸   ENSMUST00000051186
RefSeq Acc Id: ENSMUSP00000154562   ⟸   ENSMUST00000228218
RefSeq Acc Id: XP_036014946   ⟸   XM_036159053
- Peptide Label: isoform X1
Protein Domains
AdenylateSensor   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5EG47-F1-model_v2 AlphaFold Q5EG47 1-559 view protein structure

RGD ID:6826372
Promoter ID:MM_KWN:17935
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000051186,   NM_001013367
Mouse AssemblyChrPosition (strand)Source
MGSCv36155,093,586 - 5,094,102 (+)MPROMDB
RGD ID:8683330
Promoter ID:EPDNEW_M19695
Type:multiple initiation site
Description:Mus musculus protein kinase, AMP-activated, alpha 1 catalyticsubunit , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38155,143,881 - 5,143,941EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2145955 AgrOrtholog
Ensembl Genes ENSMUSG00000050697 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000063166 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000154562.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000051186 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000228218.2 UniProtKB/TrEMBL
InterPro AMPK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMPKA1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KA1/Ssp2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRKAA1_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:105787 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AdenylateSensor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkaa1 PhenoGen
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AAPK1_MOUSE UniProtKB/Swiss-Prot