Xirp1 (xin actin-binding repeat containing 1) - Rat Genome Database
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Gene: Xirp1 (xin actin-binding repeat containing 1) Mus musculus
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Symbol: Xirp1
Name: xin actin-binding repeat containing 1
RGD ID: 1312414
MGI Page MGI
Description: Predicted to have actin filament binding activity and filamin binding activity. Involved in several processes, including Notch signaling pathway; negative regulation of cell population proliferation; and striated muscle cell development. Localizes to adherens junction and fascia adherens. Predicted to colocalize with focal adhesion and stress fiber. Is expressed in several structures, including heart; musculature; and tail somite. Used to study hypertrophic cardiomyopathy. Orthologous to human XIRP1 (xin actin binding repeat containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; atorvastatin calcium.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI415219; cardiomyopathy associated 1; cardiomyopathy-associated protein 1; Cmya; Cmya1; MGC144145; MGC144146; mXin alpha; X; xin actin-binding repeat-containing protein 1; Xin alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,842,821 - 119,852,664 (-)NCBIGRCm39mm39
GRCm389120,013,755 - 120,023,598 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,013,755 - 120,023,598 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,922,873 - 119,932,716 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,862,453 - 119,872,296 (-)NCBImm8
Celera9120,481,114 - 120,490,957 (-)NCBICelera
Cytogenetic Map9F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:9159189   PMID:10021346   PMID:12203715   PMID:12477932   PMID:12819125   PMID:16708114   PMID:17766470   PMID:17855775   PMID:17925400   PMID:18682726   PMID:19843512   PMID:23117660  
PMID:23261932   PMID:23296090   PMID:23485711   PMID:24963132   PMID:25582411   PMID:26403541   PMID:27206985   PMID:27639425  


Genomics

Comparative Map Data
Xirp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,842,821 - 119,852,664 (-)NCBIGRCm39mm39
GRCm389120,013,755 - 120,023,598 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,013,755 - 120,023,598 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,922,873 - 119,932,716 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,862,453 - 119,872,296 (-)NCBImm8
Celera9120,481,114 - 120,490,957 (-)NCBICelera
Cytogenetic Map9F4NCBI
XIRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl339,183,210 - 39,192,596 (-)EnsemblGRCh38hg38GRCh38
GRCh38339,183,214 - 39,192,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37339,224,706 - 39,234,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,199,711 - 39,209,081 (-)NCBINCBI36hg18NCBI36
Celera339,166,370 - 39,175,740 (-)NCBI
Cytogenetic Map3p22.2NCBI
HuRef339,267,117 - 39,276,496 (-)NCBIHuRef
CHM1_1339,175,713 - 39,185,094 (-)NCBICHM1_1
Xirp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08128,694,809 - 128,712,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,702,133 - 128,711,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,903,077 - 127,912,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,995,308 - 125,001,397 (-)NCBIRGSC3.4rn4RGSC3.4
Celera8118,886,557 - 118,903,852 (-)NCBICelera
Cytogenetic Map8q32NCBI
Xirp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,781,194 - 24,786,728 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,778,157 - 24,787,691 (+)NCBIChiLan1.0ChiLan1.0
XIRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1339,360,422 - 39,369,807 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0339,079,712 - 39,089,098 (-)NCBIMhudiblu_PPA_v0panPan3
XIRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl238,851,832 - 8,855,862 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1238,849,713 - 8,859,515 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Xirp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647328,434,910 - 28,444,146 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XIRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,867,478 - 23,873,589 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,867,476 - 23,876,850 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,127,756 - 26,137,310 (-)NCBISscrofa10.2Sscrofa10.2susScr3
XIRP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115221,365 - 232,284 (+)NCBI
Xirp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247311,779,004 - 1,788,668 (+)NCBI

Position Markers
AF051945  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389120,014,034 - 120,014,142UniSTSGRCm38
MGSCv379119,923,152 - 119,923,260UniSTSGRCm37
Celera9120,481,393 - 120,481,501UniSTS
Cytogenetic Map9F4UniSTS
Whitehead/MRC_RH91196.63UniSTS
AI415219  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389120,013,966 - 120,014,053UniSTSGRCm38
MGSCv379119,923,084 - 119,923,171UniSTSGRCm37
Celera9120,481,325 - 120,481,412UniSTS
Cytogenetic Map9F4UniSTS
Whitehead/MRC_RH91180.93UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:934
Count of miRNA genes:497
Interacting mature miRNAs:564
Transcripts:ENSMUST00000111635
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000111635   ⟹   ENSMUSP00000107262
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9120,013,755 - 120,023,598 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213113   ⟹   ENSMUSP00000149083
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9120,013,757 - 120,018,498 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238557   ⟹   ENSMUSP00000158836
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9120,014,374 - 120,019,815 (-)Ensembl
RefSeq Acc Id: NM_011724   ⟹   NP_035854
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,842,821 - 119,852,664 (-)NCBI
GRCm389120,013,755 - 120,023,598 (-)ENTREZGENE
MGSCv379119,922,873 - 119,932,716 (-)RGD
Celera9120,481,114 - 120,490,957 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030244248   ⟹   XP_030100108
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,842,821 - 119,852,660 (-)NCBI
GRCm389120,013,755 - 120,023,593 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244249   ⟹   XP_030100109
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,842,821 - 119,852,660 (-)NCBI
GRCm389120,013,755 - 120,023,585 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154843   ⟹   XP_036010736
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,842,821 - 119,852,661 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_035854   ⟸   NM_011724
- Sequence:
RefSeq Acc Id: XP_030100108   ⟸   XM_030244248
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030100109   ⟸   XM_030244249
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000107262   ⟸   ENSMUST00000111635
RefSeq Acc Id: ENSMUSP00000158836   ⟸   ENSMUST00000238557
RefSeq Acc Id: ENSMUSP00000149083   ⟸   ENSMUST00000213113
RefSeq Acc Id: XP_036010736   ⟸   XM_036154843
- Peptide Label: isoform X2

Promoters
RGD ID:6845337
Promoter ID:MM_KWN:59156
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_001081339_XIRP1,   UC009SBW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,926,181 - 119,926,681 (-)MPROMDB
RGD ID:8671214
Promoter ID:EPDNEW_M13638
Type:initiation region
Name:Xirp1_1
Description:Mus musculus xin actin-binding repeat containing 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389120,023,566 - 120,023,626EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333878 AgrOrtholog
Ensembl Genes ENSMUSG00000079243 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000107262 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000149083 UniProtKB/TrEMBL
  ENSMUSP00000158836 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000111635 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000213113 UniProtKB/TrEMBL
  ENSMUST00000238557 UniProtKB/TrEMBL
InterPro Actin-binding_Xin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XIRP1/XIRP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22437 UniProtKB/TrEMBL
MGD MGI:1333878 ENTREZGENE
NCBI Gene 22437 ENTREZGENE
PANTHER PTHR22591 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Xin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Xirp1 PhenoGen
PROSITE XIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.10117 ENTREZGENE
UniProt A0A1L1SQJ8_MOUSE UniProtKB/TrEMBL
  A0A571BDS0_MOUSE UniProtKB/TrEMBL
  E9QQ93_MOUSE UniProtKB/TrEMBL
  O70373 ENTREZGENE, UniProtKB/Swiss-Prot