Gene: Xirp1 (xin actin-binding repeat containing 1) Mus musculus
Analyze
Symbol:
Xirp1
Name:
xin actin-binding repeat containing 1
Description:
ENCODES a protein that exhibits actin filament binding (ortholog); filamin binding (ortholog); INVOLVED IN cardiac muscle cell development; negative regulation of cell population proliferation; Notch signaling pathway; ASSOCIATED WITH abnormal A band morphology; abnormal cardiac muscle contractility; abnormal cardiovascular system morphology; ASSOCIATED WITH microcephaly (ortholog); Poisoning (ortholog); FOUND IN cell-cell adherens junction; fascia adherens; intercalated disc; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atorvastatin calcium; benzo[a]pyrene
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AI415219; cardiomyopathy associated 1; cardiomyopathy-associated protein 1; Cmya1; MGC144145; MGC144146; mXin alpha; xin actin-binding repeat-containing protein 1; Xin alpha
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
XIRP1 (xin actin binding repeat containing 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Xirp1 (xin actin-binding repeat containing 1) HGNC
EggNOG, OrthoMCL, NCBI, HomoloGene, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Xirp1 (xin actin binding repeat containing 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
XIRP1 (xin actin binding repeat containing 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
XIRP1 (xin actin binding repeat containing 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Xirp1 (xin actin binding repeat containing 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
XIRP1 (xin actin binding repeat containing 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Xirp1 (xin actin-binding repeat containing 1)
Alliance
DIOPT (OrthoFinder, PANTHER)
Homo sapiens (human):
XIRP1 (xin actin binding repeat containing 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
xirp1 (xin actin binding repeat containing 1)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 120,013,755 - 120,023,598 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 119,922,873 - 119,932,716 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 119,862,453 - 119,872,296 (-) NCBI mm8 Celera 9 120,481,114 - 120,490,957 (-) NCBI Celera Cytogenetic Map 9 F4 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
Poisoning ISO RGD:1312413 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21964422
Imported Annotations - MGI
hypertrophic cardiomyopathy IEA 13592920 MouseDO
Gene-Chemical Interaction Annotations
1,3-dinitrobenzene affects expression ISO RGD:1304776 6480464 3-dinitrobenzene affects the expression of XIRP1 mRNA CTD PMID:24140754 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of XIRP1 mRNA CTD PMID:21570461 6-propyl-2-thiouracil decreases expression ISO RGD:1304776 6480464 Propylthiouracil results in decreased expression of XIRP1 mRNA CTD PMID:24780913 aflatoxin B1 increases methylation ISO RGD:1312413 6480464 Aflatoxin B1 results in increased methylation of XIRP1 gene CTD PMID:27153756 atorvastatin calcium multiple interactions EXP 6480464 [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA CTD PMID:29679711 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of XIRP1 mRNA CTD PMID:22228805 bisphenol A decreases expression ISO RGD:1304776 6480464 bisphenol A results in decreased expression of XIRP1 mRNA CTD PMID:25181051 bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of XIRP1 promoter CTD PMID:27312807 ciprofloxacin multiple interactions EXP 6480464 [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA CTD PMID:29679711 cobalt dichloride increases expression ISO RGD:1312413 6480464 cobaltous chloride results in increased expression of XIRP1 mRNA CTD PMID:22941251 dichloroacetic acid decreases expression EXP 6480464 Dichloroacetic Acid results in decreased expression of XIRP1 mRNA CTD PMID:28962523 doxorubicin decreases expression ISO RGD:1312413 6480464 Doxorubicin results in decreased expression of XIRP1 mRNA CTD PMID:29803840 ethanol multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of XIRP1 mRNA CTD PMID:30517762 ethanol increases expression EXP 6480464 Ethanol results in increased expression of XIRP1 mRNA CTD PMID:30319688 lutein increases expression EXP 6480464 Lutein results in increased expression of XIRP1 mRNA CTD PMID:24865317 methylmercury chloride affects expression ISO RGD:1304776 6480464 methylmercuric chloride affects the expression of XIRP1 mRNA CTD PMID:20864626 paraquat increases expression EXP 6480464 Paraquat results in increased expression of XIRP1 mRNA CTD PMID:12595580 pioglitazone multiple interactions EXP 6480464 [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of XIRP1 mRNA CTD PMID:27935865 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA CTD PMID:29679711 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of XIRP1 mRNA CTD PMID:29203145 Soman increases expression ISO RGD:1304776 6480464 Soman results in increased expression of XIRP1 mRNA CTD PMID:19281266 spermine increases expression EXP 6480464 Spermine results in increased expression of XIRP1 mRNA CTD PMID:18673383 Tesaglitazar decreases expression ISO RGD:1304776 6480464 tesaglitazar results in decreased expression of XIRP1 mRNA CTD PMID:21515302 tetrachloromethane multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of XIRP1 mRNA CTD PMID:30517762 triclosan decreases expression ISO RGD:1312413 6480464 Triclosan results in decreased expression of XIRP1 mRNA CTD PMID:30510588 troglitazone decreases expression ISO RGD:1304776 6480464 troglitazone results in decreased expression of XIRP1 mRNA CTD PMID:21515302 valproic acid increases methylation ISO RGD:1312413 6480464 Valproic Acid results in increased methylation of XIRP1 gene CTD PMID:29154799
Gene Ontology Annotations
Biological Process actin cytoskeleton organization IEA InterPro:IPR012510 , InterPro:IPR030072 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 actin filament organization ISO UniProtKB:Q702N8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cardiac muscle cell development IMP MGI:MGI:3521795 2290270 (MGI:MGI:3775114, PMID:17766470) MGI MGI:MGI:3775114 , PMID:17766470 cardiac muscle cell differentiation IC GO:0055013 2290270 (MGI:MGI:3775114, PMID:17766470) GOC MGI:MGI:3775114 , PMID:17766470 heart development IEA InterPro:IPR030072 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 heart morphogenesis ISA EMBL:AF051944 2290270 (MGI:MGI:1329802, PMID:10021346) MGI MGI:MGI:1329802 , PMID:10021346 negative regulation of cell population proliferation IMP 2290270 (MGI:MGI:3767901, PMID:17855775) MGI MGI:MGI:3767901 , PMID:17855775 negative regulation of protein binding ISO UniProtKB:Q702N8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Notch signaling pathway IDA 2290270 (MGI:MGI:5609934, PMID:23117660) MGI MGI:MGI:5609934 , PMID:23117660 regulation of membrane potential IMP MGI:MGI:3521795 2290270 (MGI:MGI:3775114, PMID:17766470) MGI MGI:MGI:3775114 , PMID:17766470 sarcomere organization IMP MGI:MGI:3521795 2290270 (MGI:MGI:3775114, PMID:17766470) MGI MGI:MGI:3775114 , PMID:17766470 Cellular Component cell junction IEA UniProtKB-KW:KW-0965 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cell junction IEA InterPro:IPR012510 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 cell-cell adherens junction IDA 2290270 (MGI:MGI:2386380, PMID:12203715) MGI MGI:MGI:2386380 , PMID:12203715 fascia adherens IDA 2290270 (MGI:MGI:1329802 more ... MGI MGI:MGI:1329802 more ... focal adhesion colocalizes_with ISO UniProtKB:Q702N8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 intercalated disc IDA 2290270 (MGI:MGI:3775114, PMID:17766470) MGI MGI:MGI:3775114 , PMID:17766470 stress fiber colocalizes_with ISO UniProtKB:Q702N8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Molecular Function actin binding IEA InterPro:IPR012510 , InterPro:IPR030072 2290270 UniProt GO_REF:0000002, MGI:MGI:2152098 actin binding IEA UniProtKB-KW:KW-0009 2290270 UniProt GO_REF:0000004, MGI:MGI:1354194 actin filament binding ISO UniProtKB:Q702N8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 filamin binding ISO RefSeq:NM_194293 2290270 MGI GO_REF:0000008, MGI:MGI:2154458
Phenotype Annotations
4141833 W10q13_m weight 10 weeks QTL 13 (mouse) Not determined 63332429 120362868 Mouse 4141545 Tailaq2_m tail length adjusted QTL 2 (mouse) Not determined 63332429 120362868 Mouse 1357635 Splq4_m spleen weight QTL 4 (mouse) Not determined 9 63332429 120362868 Mouse 1300549 Bbaa17_m B. burgdorferi-associated arthritis 17 (mouse) Not determined 9 86230401 120230530 Mouse 1302103 Dob2_m dietary obesity 2 (mouse) Not determined 9 86239845 120289624 Mouse 11251716 Siim2_m stress induced immobility 2 (mouse) 9 86748483 120748483 Mouse 12880422 V25Dq6_m vitamin D inactive form serum level QTL 6 (mouse) 9 87800000 121800000 Mouse 10412242 Alpq8_m alcohol preference QTL 8 (mouse) Not determined 9 89284925 123284925 Mouse 1301649 Psl1_m promotion susceptibility QTL 1 (mouse) Not determined 9 89412277 123412396 Mouse 12910770 Splic1_m spleen iron content 1 (mouse) 9 91413879 124595110 Mouse 12910772 Lvic6_m liver iron content 6 (mouse) 9 91413879 124595110 Mouse 12910773 Splic3_m spleen iron content 3 (mouse) 9 91413879 124595110 Mouse 1558767 Skmw11_m skeletal muscle weight 11 (mouse) Not determined 9 91641084 124595110 Mouse 13463474 Hbbcq5_m hemoglobin concentration QTL 5 (mouse) 9 91641084 124595110 Mouse 13463475 Hctq7_m hematocrit QTL 7 (mouse) 9 91641084 124595110 Mouse 13463477 Rbc9_m red blood cell count 9 (mouse) 9 91641084 124595110 Mouse 13463478 Mchq18_m mean corpuscular hemoglobin QTL 18 (mouse) 9 91641084 124595110 Mouse 13463480 Mchcq2_m mean corpuscular hemoglobin concentration QTL 2 (mouse) 9 91641084 124595110 Mouse 12904937 Edlmmq9_m extensor digitorum longus muscle mass QTL 9 (mouse) 9 91683173 124595110 Mouse 12904947 Tammq7_m tibialis anterior muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 12904961 Gmmq7_m gastrocnemius muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 1302001 Bdln5_m body length 5 (mouse) Not determined 9 93762590 124595110 Mouse 1301484 Bwq6_m body weight (mouse) Not determined 9 93762590 124595110 Mouse 14746992 Manh67_m mandible shape 67 (mouse) 9 94036768 124595110 Mouse 11537364 Cnes5_m C. neoformans susceptibility locus 5 (mouse) 9 96917590 124595110 Mouse 1301297 Lcho1_m liver cholesterol 1 (mouse) Not determined 9 101060861 124595110 Mouse 1357627 Tgq2_m triglyceride QTL 2 (mouse) Not determined 9 102000187 124595110 Mouse 1357648 Obq18_m obesity QTL 18 (mouse) Not determined 9 102000187 124595110 Mouse 1301789 Pbwg4_m postnatal body weight growth 4 (mouse) Not determined 9 103289445 124595110 Mouse 10412290 Pvacm1l_m plasma vascular cell adhesion molecule 1 levels (mouse) Not determined 9 103289445 124595110 Mouse 12879896 Berr3_m berghei resistance locus 3 (mouse) 9 103289445 124595110 Mouse
Predicted Target Of
Count of predictions: 934 Count of miRNA genes: 497 Interacting mature miRNAs: 564 Transcripts: ENSMUST00000111635 Prediction methods: Miranda, Rnahybrid Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
