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Gene: Tfam (transcription factor A, mitochondrial) Mus musculus
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Symbol: Tfam
Name: transcription factor A, mitochondrial
Description: Exhibits mitochondrial promoter sequence-specific DNA binding activity. Involved in mitochondrial respiratory chain complex assembly and mitochondrial transcription. Localizes to mitochondrial nucleoid. Is expressed in several structures, including brain; branchial arch; early conceptus; genitourinary system; and hemolymphoid system. Used to study Kearns-Sayre syndrome and Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AI661103; Hmgts; mtTFA; testis-specific high mobility group protein; testis-specific HMG-box protein m-tsHMG; TS-HMG; tsHMG
Orthologs:
Homo sapiens (human) : TFAM (transcription factor A, mitochondrial)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tfam (transcription factor A, mitochondrial)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tfam (transcription factor A, mitochondrial)
Pan paniscus (bonobo/pygmy chimpanzee) : TFAM (transcription factor A, mitochondrial)
Canis lupus familiaris (dog) : TFAM (transcription factor A, mitochondrial)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tfam (transcription factor A, mitochondrial)
Sus scrofa (pig) : TFAM (transcription factor A, mitochondrial)
Chlorocebus sabaeus (African green monkey) : TFAM (transcription factor A, mitochondrial)
Heterocephalus glaber (naked mole-rat) : Tfam (transcription factor A, mitochondrial)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1071,225,464 - 71,238,280 (-)EnsemblGRCm38mm10GRCm38
GRCm381071,225,468 - 71,238,328 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371070,688,225 - 70,700,792 (-)NCBIGRCm37mm9NCBIm37
MGSCv361070,620,777 - 70,633,344 (-)NCBImm8
Celera1072,300,895 - 72,313,462 (-)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tfam
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733567
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.