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Gene: Tfam (transcription factor A, mitochondrial) Mus musculus
Symbol: Tfam
Name: transcription factor A, mitochondrial
Description: Exhibits mitochondrial promoter sequence-specific DNA binding activity. Involved in mitochondrial respiratory chain complex assembly and mitochondrial transcription. Localizes to mitochondrial nucleoid. Is expressed in several structures, including brain; branchial arch; early conceptus; genitourinary system; and hemolymphoid system. Used to study Kearns-Sayre syndrome and Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
Also known as: AI661103; Hmgts; mtTFA; testis-specific high mobility group protein; testis-specific HMG-box protein m-tsHMG; TS-HMG; tsHMG
Homo sapiens (human) : TFAM (transcription factor A, mitochondrial)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tfam (transcription factor A, mitochondrial)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tfam (transcription factor A, mitochondrial)
Pan paniscus (bonobo/pygmy chimpanzee) : TFAM (transcription factor A, mitochondrial)
Canis lupus familiaris (dog) : TFAM (transcription factor A, mitochondrial)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tfam (transcription factor A, mitochondrial)
Sus scrofa (pig) : TFAM (transcription factor A, mitochondrial)
Chlorocebus sabaeus (African green monkey) : TFAM (transcription factor A, mitochondrial)
Heterocephalus glaber (naked mole-rat) : Tfam (transcription factor A, mitochondrial)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1071,225,464 - 71,238,280 (-)EnsemblGRCm38mm10GRCm38
GRCm381071,225,468 - 71,238,328 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371070,688,225 - 70,700,792 (-)NCBIGRCm37mm9NCBIm37
MGSCv361070,620,777 - 70,633,344 (-)NCBImm8
Celera1072,300,895 - 72,313,462 (-)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tfam
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733567
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.