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Gene: TFAM (transcription factor A, mitochondrial) Homo sapiens
Symbol: TFAM
Name: transcription factor A, mitochondrial
Description: Exhibits DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in positive regulation of transcription, DNA-templated and transcription initiation from mitochondrial promoter. Localizes to mitochondrial nucleoid and protein-containing complex. Implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Biomarker of obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: mitochondrial transcription factor 1; mitochondrial transcription factor A; MTDPS15; MtTF1; mtTFA; TCF-6; TCF6; TCF6L1; TCF6L2; TCF6L3; transcription factor 6; transcription factor 6-like 1; Transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3
Mus musculus (house mouse) : Tfam (transcription factor A, mitochondrial)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tfam (transcription factor A, mitochondrial)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tfam (transcription factor A, mitochondrial)
Pan paniscus (bonobo/pygmy chimpanzee) : TFAM (transcription factor A, mitochondrial)
Canis lupus familiaris (dog) : TFAM (transcription factor A, mitochondrial)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tfam (transcription factor A, mitochondrial)
Sus scrofa (pig) : TFAM (transcription factor A, mitochondrial)
Chlorocebus sabaeus (African green monkey) : TFAM (transcription factor A, mitochondrial)
Heterocephalus glaber (naked mole-rat) : Tfam (transcription factor A, mitochondrial)
more info ...
Related Pseudogenes: TFAMP1   TFAMP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1058,385,345 - 58,399,220 (+)EnsemblGRCh38hg38GRCh38
GRCh381058,385,143 - 58,399,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371060,144,903 - 60,158,990 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361059,815,182 - 59,825,903 (+)NCBINCBI36hg18NCBI36
Celera1053,410,112 - 53,420,833 (+)NCBI
Cytogenetic Map10q21.1NCBI
HuRef1054,133,767 - 54,148,729 (+)NCBIHuRef
CHM1_11060,426,687 - 60,440,776 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TFAM
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605718
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.