Traf6 (TNF receptor-associated factor 6) - Rat Genome Database

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Gene: Traf6 (TNF receptor-associated factor 6) Mus musculus
Analyze
Symbol: Traf6
Name: TNF receptor-associated factor 6
RGD ID: 1315707
MGI Page MGI
Description: Enables ubiquitin protein ligase activity. Involved in several processes, including bone resorption; cytokine-mediated signaling pathway; and positive regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; lipopolysaccharide-mediated signaling pathway; and regulation of gene expression. Located in cytoplasmic side of plasma membrane; cytosol; and lipid droplet. Part of CD40 receptor complex. Is expressed in several structures, including aorta-gonad-mesonephros; future brain; lower jaw; mandibular process; and sensory organ. Used to study hypohidrotic ectodermal dysplasia. Orthologous to human TRAF6 (TNF receptor associated factor 6).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2310003F17Rik; AI851288; C630032O20Rik; E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392101,508,765 - 101,532,013 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2101,508,774 - 101,532,014 (+)EnsemblGRCm39 Ensembl
GRCm382101,678,420 - 101,701,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2101,678,429 - 101,701,669 (+)EnsemblGRCm38mm10GRCm38
MGSCv372101,518,597 - 101,541,133 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362101,479,279 - 101,501,815 (+)NCBIMGSCv36mm8
Celera2102,903,294 - 102,925,894 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map253.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (ISO)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ampicillin  (EXP)
angiotensin II  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (EXP,ISO)
apocynin  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
Bergenin  (EXP)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
boldenone  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (EXP)
cadmium selenide  (ISO)
camptothecin  (ISO)
cefoxitin  (EXP)
clofibrate  (EXP)
clothianidin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
crocin-1  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
DAPT  (EXP,ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
enalapril  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ferric oxide  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furosemide  (ISO)
Fusarenone X  (EXP)
Fusaric acid  (ISO)
gentamycin  (EXP)
glyburide  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (EXP)
kaempferol  (ISO)
ketoconazole  (ISO)
lactulose  (ISO)
lipoarabinomannan  (EXP)
lipopolysaccharide  (EXP,ISO)
lycopene  (EXP)
maneb  (EXP)
mangiferin  (EXP)
melittin  (EXP)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (ISO)
metronidazole  (EXP)
N-acetyl-L-cysteine  (ISO)
neomycin  (EXP)
nickel dichloride  (ISO)
niclosamide  (EXP)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorooctanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (ISO)
procyanidin B1  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
resveratrol  (EXP)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (ISO)
sulfasalazine  (EXP)
telmisartan  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
tropisetron  (ISO)
urethane  (ISO)
vancomycin  (EXP)
xanthohumol  (EXP)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IMP)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (IMP)
antiviral innate immune response  (ISO)
autophagosome assembly  (ISO)
bone remodeling  (IMP)
bone resorption  (IMP)
canonical NF-kappaB signal transduction  (IMP,ISO)
cell development  (IMP)
cellular response to angiotensin  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to lipopolysaccharide  (ISO)
cytokine-mediated signaling pathway  (ISO)
cytoplasmic pattern recognition receptor signaling pathway  (ISO)
DNA damage response  (IEA)
immune response  (IMP)
immune system process  (IEA)
in utero embryonic development  (IMP)
innate immune response  (IBA)
interleukin-1-mediated signaling pathway  (IMP,ISO)
interleukin-17-mediated signaling pathway  (IDA,IMP)
interleukin-17A-mediated signaling pathway  (ISO)
interleukin-33-mediated signaling pathway  (ISO)
JNK cascade  (ISO)
lipopolysaccharide-mediated signaling pathway  (IBA,IGI,IMP)
myeloid dendritic cell differentiation  (IMP)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural tube closure  (IMP)
non-canonical NF-kappaB signal transduction  (ISO)
odontogenesis of dentin-containing tooth  (IMP)
ossification  (IMP)
osteoclast differentiation  (IMP)
positive regulation of canonical NF-kappaB signal transduction  (IGI,IMP,ISO)
positive regulation of interleukin-12 production  (IMP)
positive regulation of interleukin-2 production  (ISO)
positive regulation of interleukin-6 production  (IMP)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of lipopolysaccharide-mediated signaling pathway  (IMP)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell cytokine production  (ISO)
positive regulation of T cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of type I interferon production  (IDA)
protein autoubiquitination  (ISO,TAS)
protein K63-linked ubiquitination  (IBA,IDA,ISO)
protein polyubiquitination  (IMP,ISO)
protein ubiquitination  (IDA,IGI)
regulation of apoptotic process  (IEA)
regulation of canonical NF-kappaB signal transduction  (IBA)
regulation of immunoglobulin production  (IDA)
response to interleukin-1  (ISO)
response to ischemia  (ISO)
signal transduction  (IDA)
T cell receptor signaling pathway  (ISO)
T-helper 1 type immune response  (IMP)
toll-like receptor 4 signaling pathway  (ISO)
tumor necrosis factor-mediated signaling pathway  (IBA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal brain commissure morphology  (IEA)
abnormal brain morphology  (IEA)
abnormal coat/ hair morphology  (IAGP)
abnormal coronary sinus connection  (IEA)
abnormal dendritic cell differentiation  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal ductus venosus valve topology  (IEA)
abnormal endolymphatic sac topology  (IEA)
abnormal eye muscle morphology  (IEA)
abnormal forebrain morphology  (IEA)
abnormal hair follicle development  (IAGP)
abnormal kidney morphology  (IEA)
abnormal long bone metaphysis morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lymphocyte anergy  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal male preputial gland morphology  (IAGP)
abnormal Meibomian gland development  (IAGP)
abnormal Mullerian duct morphology  (IEA)
abnormal myocardium compact layer morphology  (IEA)
abnormal olfactory bulb morphology  (IEA)
abnormal optic cup morphology  (IEA)
abnormal optic stalk morphology  (IEA)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal sebaceous gland morphology  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal stapes morphology  (IEA)
abnormal vertebral artery topology  (IEA)
abnormal vitelline vein topology  (IEA)
abnormal Wolffian duct morphology  (IEA)
absent ductus venosus valve  (IEA)
absent eccrine glands  (IAGP)
absent guard hair  (IAGP)
absent incisors  (IAGP)
absent molars  (IAGP)
absent spleen white pulp  (IAGP)
absent stapedial artery  (IEA)
alopecia  (IAGP)
bifid ureter  (IEA)
blood in lymph vessels  (IEA)
decreased B cell proliferation  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone resorption  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased dendritic cell number  (IAGP)
decreased immature B cell number  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased length of long bones  (IAGP)
decreased lymph node number  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased T cell proliferation  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
dilated bile duct  (IEA)
ductus venosus stenosis  (IEA)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged spleen  (IAGP)
exencephaly  (IEA)
failure of tooth eruption  (IAGP)
herniated liver  (IEA)
hypochromic anemia  (IAGP)
increased activated T cell number  (IAGP)
increased bone mineral density  (IAGP)
increased grip strength  (IEA)
increased interleukin-2 secretion  (IAGP)
increased memory T cell number  (IAGP)
intestinal/bowel diverticulum  (IEA)
kinked tail  (IAGP)
multiple persisting craniopharyngeal ducts  (IEA)
muscular ventricular septal defect  (IEA)
osteopetrosis  (IAGP)
perimembraneous ventricular septal defect  (IEA)
perinatal lethality, incomplete penetrance  (IAGP)
persistent right 6th pharyngeal arch artery  (IEA)
persistent right dorsal aorta  (IEA)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
short femur  (IAGP)
small perianal sebaceous gland  (IAGP)
subcutaneous edema  (IEA)
thin hypoglossal nerve  (IEA)
thymus atrophy  (IAGP)
translucent skin  (IAGP)
umbilical vein stenosis  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. Fernandes A, etal., Glia. 2011 Jan;59(1):14-25. doi: 10.1002/glia.21072. Epub 2010 Oct 21.
3. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX, etal., Nat Commun. 2016 Jun 1;7:11267. doi: 10.1038/ncomms11267.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
6. Ischemic Preconditioning-Induced SOCS-1 Protects Rat Intestinal Ischemia Reperfusion Injury via Degradation of TRAF6. Liu SZ, etal., Dig Dis Sci. 2017 Jan;62(1):105-114. doi: 10.1007/s10620-016-4277-0. Epub 2016 Aug 18.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential biomarker for the aggressive tumor phenotype in laryngeal carcinoma. Starska K, etal., Folia Histochem Cytobiol. 2009 Jan;47(3):401-10. doi: 10.2478/v10042-009-0075-2.
16. Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice. Sugase T, etal., Int J Cancer. 2017 Jun 1;140(11):2608-2621. doi: 10.1002/ijc.30666. Epub 2017 Mar 10.
17. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
18. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
Additional References at PubMed
PMID:8889548   PMID:8910514   PMID:9610637   PMID:10097072   PMID:10215628   PMID:10349636   PMID:10421844   PMID:10465784   PMID:10747026   PMID:10748240   PMID:11007897   PMID:11042159  
PMID:11076861   PMID:11244088   PMID:11250893   PMID:11278268   PMID:11406619   PMID:11547829   PMID:11923871   PMID:11967542   PMID:11994463   PMID:12060722   PMID:12140561   PMID:12185073  
PMID:12230506   PMID:12354380   PMID:12459498   PMID:12477932   PMID:12566447   PMID:12616498   PMID:12631284   PMID:12637570   PMID:12711536   PMID:12787561   PMID:12902324   PMID:12958312  
PMID:14499111   PMID:14500659   PMID:14530355   PMID:14610273   PMID:14634083   PMID:14645259   PMID:14661019   PMID:14673102   PMID:14699584   PMID:15029200   PMID:15047173   PMID:15102471  
PMID:15125833   PMID:15147900   PMID:15305292   PMID:15308666   PMID:15322147   PMID:15361868   PMID:15385464   PMID:15492225   PMID:15548667   PMID:15618518   PMID:15665823   PMID:15678102  
PMID:15705807   PMID:15721744   PMID:15864310   PMID:15905851   PMID:16033648   PMID:16079148   PMID:16141072   PMID:16141073   PMID:16147974   PMID:16184196   PMID:16196101   PMID:16210631  
PMID:16221674   PMID:16237096   PMID:16246731   PMID:16252010   PMID:16263713   PMID:16306937   PMID:16362041   PMID:16378096   PMID:16393988   PMID:16436380   PMID:16446357   PMID:16630834  
PMID:16697380   PMID:16772369   PMID:16831874   PMID:16897814   PMID:16921377   PMID:17055451   PMID:17092936   PMID:17224624   PMID:17277780   PMID:17332487   PMID:17360955   PMID:17389358  
PMID:17462996   PMID:17507094   PMID:17562858   PMID:17572386   PMID:17633018   PMID:17703191   PMID:17709375   PMID:17878362   PMID:17947236   PMID:17974599   PMID:17982070   PMID:18079694  
PMID:18083102   PMID:18097000   PMID:18174161   PMID:18195092   PMID:18202703   PMID:18239685   PMID:18246070   PMID:18268035   PMID:18378686   PMID:18382763   PMID:18407828   PMID:18411265  
PMID:18411338   PMID:18423196   PMID:18603409   PMID:18617513   PMID:18634786   PMID:18635759   PMID:18682563   PMID:18710948   PMID:18758450   PMID:18768464   PMID:18772140   PMID:18782768  
PMID:18799149   PMID:18805969   PMID:18824541   PMID:18849341   PMID:18922473   PMID:18984593   PMID:18996842   PMID:19091594   PMID:19112497   PMID:19136968   PMID:19155515   PMID:19198591  
PMID:19201866   PMID:19224920   PMID:19270748   PMID:19346732   PMID:19365810   PMID:19385034   PMID:19412180   PMID:19479062   PMID:19483718   PMID:19494812   PMID:19500387   PMID:19576795  
PMID:19592497   PMID:19596990   PMID:19661270   PMID:19713527   PMID:19798431   PMID:19822644   PMID:19823099   PMID:19825828   PMID:19898473   PMID:19898489   PMID:20100871   PMID:20139273  
PMID:20185725   PMID:20345905   PMID:20351308   PMID:20501938   PMID:20529958   PMID:20614026   PMID:20622119   PMID:20644648   PMID:21041452   PMID:21098220   PMID:21098228   PMID:21115689  
PMID:21131124   PMID:21155952   PMID:21187332   PMID:21262968   PMID:21267068   PMID:21305609   PMID:21401811   PMID:21435586   PMID:21454471   PMID:21460221   PMID:21494550   PMID:21525932  
PMID:21527253   PMID:21566132   PMID:21677750   PMID:21703539   PMID:21725320   PMID:21743479   PMID:21765415   PMID:21822257   PMID:21873635   PMID:21949653   PMID:22011580   PMID:22059479  
PMID:22095711   PMID:22290431   PMID:22323536   PMID:22345171   PMID:22357600   PMID:22427868   PMID:22503986   PMID:22522491   PMID:22590573   PMID:22593578   PMID:22637723   PMID:22649194  
PMID:22693634   PMID:22719861   PMID:22720096   PMID:22749815   PMID:22842344   PMID:22851696   PMID:22860133   PMID:22863753   PMID:22904686   PMID:22925919   PMID:22935568   PMID:22984582  
PMID:23028045   PMID:23042151   PMID:23148225   PMID:23355738   PMID:23376919   PMID:23707529   PMID:23776175   PMID:23782702   PMID:23791643   PMID:23799152   PMID:23867620   PMID:23907468  
PMID:23909487   PMID:23911927   PMID:23914844   PMID:23918981   PMID:23942232   PMID:23951545   PMID:23960234   PMID:23962979   PMID:24058613   PMID:24114841   PMID:24163132   PMID:24170780  
PMID:24465914   PMID:24474797   PMID:24492375   PMID:24558484   PMID:24576954   PMID:24578159   PMID:24586659   PMID:24670424   PMID:24777252   PMID:24805195   PMID:24879442   PMID:24987958  
PMID:25205119   PMID:25267210   PMID:25340740   PMID:25642822   PMID:25689829   PMID:25700345   PMID:25761602   PMID:25808491   PMID:25828701   PMID:25957028   PMID:26048146   PMID:26133577  
PMID:26280119   PMID:26291555   PMID:26305951   PMID:26347470   PMID:26385923   PMID:26458771   PMID:26474655   PMID:26548852   PMID:26600673   PMID:26619121   PMID:26887372   PMID:27025258  
PMID:27233966   PMID:27257617   PMID:27330028   PMID:27401343   PMID:27473656   PMID:27501752   PMID:27507811   PMID:27586056   PMID:27637329   PMID:27695001   PMID:27768832   PMID:27813153  
PMID:27818144   PMID:27918549   PMID:27996060   PMID:28024152   PMID:28087809   PMID:28185240   PMID:28214532   PMID:28235804   PMID:28338920   PMID:28378753   PMID:28380049   PMID:28385374  
PMID:28404732   PMID:28432355   PMID:28436935   PMID:28438834   PMID:28439546   PMID:28507064   PMID:28612997   PMID:28739881   PMID:28784800   PMID:28811005   PMID:28849049   PMID:28886971  
PMID:28974699   PMID:28993672   PMID:29114077   PMID:29273889   PMID:29339448   PMID:29386112   PMID:29432170   PMID:29522531   PMID:29539633   PMID:29563609   PMID:29782494   PMID:29845194  
PMID:29894691   PMID:29975947   PMID:30037215   PMID:30044969   PMID:30089718   PMID:30103950   PMID:30108181   PMID:30190125   PMID:30392071   PMID:30755476   PMID:30793522   PMID:30806153  
PMID:30886050   PMID:30931933   PMID:30973865   PMID:31086261   PMID:31243359   PMID:31268348   PMID:31396572   PMID:31415761   PMID:31451677   PMID:31479774   PMID:31670092   PMID:31932498  
PMID:31942069   PMID:31964525   PMID:32253651   PMID:32267572   PMID:32386989   PMID:32445435   PMID:32604472   PMID:32611726   PMID:32975614   PMID:33017719   PMID:33085187   PMID:33142239  
PMID:33152432   PMID:33460643   PMID:33568397   PMID:33717204   PMID:33822016   PMID:33830019   PMID:33839577   PMID:34155681   PMID:34524943   PMID:34602057   PMID:34767456   PMID:35000151  
PMID:35045331   PMID:35157702   PMID:35235149   PMID:35255300   PMID:35526485   PMID:35724494   PMID:35733270   PMID:36049365   PMID:36172375   PMID:36194648   PMID:36194667   PMID:36309487  
PMID:36717790   PMID:36761777   PMID:37030499   PMID:37085671   PMID:37099039   PMID:37743632   PMID:37850718   PMID:37932534   PMID:37975259   PMID:37977223   PMID:38029807   PMID:38047378  
PMID:38267979   PMID:38415924  


Genomics

Comparative Map Data
Traf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392101,508,765 - 101,532,013 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2101,508,774 - 101,532,014 (+)EnsemblGRCm39 Ensembl
GRCm382101,678,420 - 101,701,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2101,678,429 - 101,701,669 (+)EnsemblGRCm38mm10GRCm38
MGSCv372101,518,597 - 101,541,133 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362101,479,279 - 101,501,815 (+)NCBIMGSCv36mm8
Celera2102,903,294 - 102,925,894 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map253.9NCBI
TRAF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381136,483,769 - 36,510,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1136,483,769 - 36,510,272 (-)EnsemblGRCh38hg38GRCh38
GRCh371136,505,319 - 36,531,822 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361136,467,302 - 36,488,398 (-)NCBINCBI36Build 36hg18NCBI36
Build 341136,467,298 - 36,488,398NCBI
Celera1136,661,891 - 36,684,256 (-)NCBICelera
Cytogenetic Map11p12NCBI
HuRef1136,207,402 - 36,234,755 (-)NCBIHuRef
CHM1_11136,504,096 - 36,530,410 (-)NCBICHM1_1
T2T-CHM13v2.01136,626,229 - 36,653,443 (-)NCBIT2T-CHM13v2.0
Traf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83108,418,537 - 108,443,330 (+)NCBIGRCr8
mRatBN7.2387,963,517 - 87,988,316 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl387,963,514 - 87,983,507 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx391,457,599 - 91,477,545 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03100,056,626 - 100,076,572 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0397,885,654 - 97,905,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0391,252,829 - 91,271,607 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl391,252,829 - 91,271,607 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0397,912,482 - 97,935,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4386,827,582 - 86,847,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1386,728,165 - 86,742,912 (+)NCBI
Celera387,069,225 - 87,089,051 (+)NCBICelera
Cytogenetic Map3q31NCBI
Traf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554229,932,680 - 9,949,100 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554229,925,765 - 9,950,354 (+)NCBIChiLan1.0ChiLan1.0
TRAF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2938,702,879 - 38,731,477 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11138,707,533 - 38,736,877 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,457,633 - 36,483,616 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11136,330,336 - 36,356,334 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1136,335,609 - 36,356,334 (-)Ensemblpanpan1.1panPan2
TRAF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11831,674,242 - 31,689,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1831,675,391 - 31,688,641 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1831,278,398 - 31,300,151 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01832,281,552 - 32,303,317 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1832,281,510 - 32,299,115 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11831,851,198 - 31,872,911 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01831,435,636 - 31,457,386 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01832,072,955 - 32,094,690 (+)NCBIUU_Cfam_GSD_1.0
Traf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494728,732,923 - 28,750,178 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365331,857,666 - 1,876,120 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365331,857,685 - 1,874,973 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl224,602,804 - 24,626,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1224,602,749 - 24,628,263 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2226,767,127 - 26,786,940 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRAF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1128,726,357 - 28,752,389 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl128,734,380 - 28,747,092 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038125,864,012 - 125,890,813 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Traf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476710,729,413 - 10,748,455 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476710,729,766 - 10,803,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Traf6
656 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1719
Count of miRNA genes:751
Interacting mature miRNAs:973
Transcripts:ENSMUST00000004949, ENSMUST00000143341, ENSMUST00000144063
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276678758103095823Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
4141448Mpaps1_mmicrophthalmia anophthalmia susceptibility 1 (mouse)Not determined97028557112115196Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
25394565Skmw50_mskeletal muscle weight 50, soleus (mouse)297783888102476127Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse

Markers in Region
D84655  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382101,697,774 - 101,697,922UniSTSGRCm38
MGSCv372101,537,931 - 101,538,079UniSTSGRCm37
Celera2102,922,692 - 102,922,840UniSTS
Cytogenetic Map2E2UniSTS
Whitehead/MRC_RH21397.91UniSTS
Traf6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382101,697,354 - 101,697,777UniSTSGRCm38
MGSCv372101,537,511 - 101,537,934UniSTSGRCm37
Celera2102,922,272 - 102,922,695UniSTS
Cytogenetic Map2E2UniSTS
cM Map2 UniSTS
D2Mit161  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382101,694,497 - 101,694,645UniSTSGRCm38
MGSCv372101,534,654 - 101,534,802UniSTSGRCm37
Celera2102,919,414 - 102,919,562UniSTS
Cytogenetic Map2E2UniSTS
cM Map250.3UniSTS
Whitehead Genetic250.3UniSTS
AI851288  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382101,701,272 - 101,701,407UniSTSGRCm38
MGSCv372101,541,429 - 101,541,564UniSTSGRCm37
Celera2102,926,190 - 102,926,325UniSTS
Cytogenetic Map2E2UniSTS
Whitehead/MRC_RH21387.2UniSTS
BE333972  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382101,699,015 - 101,699,132UniSTSGRCm38
MGSCv372101,539,172 - 101,539,289UniSTSGRCm37
Celera2102,923,933 - 102,924,050UniSTS
Cytogenetic Map2E2UniSTS
Whitehead/MRC_RH21397.91UniSTS
Traf6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E2UniSTS
cM Map2 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000004949   ⟹   ENSMUSP00000004949
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2101,508,785 - 101,532,014 (+)Ensembl
GRCm38.p6 Ensembl2101,678,440 - 101,701,669 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2101,508,774 - 101,516,580 (+)Ensembl
GRCm38.p6 Ensembl2101,678,429 - 101,686,235 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2101,514,560 - 101,520,430 (+)Ensembl
GRCm38.p6 Ensembl2101,684,215 - 101,690,085 (+)Ensembl
RefSeq Acc Id: NM_001303273   ⟹   NP_001290202
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392101,508,765 - 101,532,013 (+)NCBI
GRCm382101,678,420 - 101,701,668 (+)NCBI
Celera2102,903,274 - 102,926,586 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009424   ⟹   NP_033450
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392101,508,765 - 101,532,013 (+)NCBI
GRCm382101,678,420 - 101,701,668 (+)NCBI
MGSCv372101,518,597 - 101,541,133 (+)RGD
Celera2102,903,274 - 102,926,586 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033450   ⟸   NM_009424
- UniProtKB: Q6P9M0 (UniProtKB/Swiss-Prot),   Q8BLV2 (UniProtKB/Swiss-Prot),   P70196 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001290202   ⟸   NM_001303273
- UniProtKB: Q6P9M0 (UniProtKB/Swiss-Prot),   Q8BLV2 (UniProtKB/Swiss-Prot),   P70196 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000004949   ⟸   ENSMUST00000004949
Protein Domains
MATH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70196-F1-model_v2 AlphaFold P70196 1-530 view protein structure

Promoters
RGD ID:6832978
Promoter ID:MM_KWN:30728
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000111225,   OTTMUST00000034583,   UC008LHN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362101,518,391 - 101,518,891 (+)MPROMDB
RGD ID:6878034
Promoter ID:EPDNEW_M2468
Type:initiation region
Name:Traf6_1
Description:Mus musculus TNF receptor-associated factor 6 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382101,678,429 - 101,678,489EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108072 AgrOrtholog
Ensembl Genes ENSMUSG00000027164 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000004949 ENTREZGENE
  ENSMUST00000004949.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
InterPro MATH/TRAF_dom UniProtKB/Swiss-Prot
  TNF_rcpt--assoc_TRAF UniProtKB/Swiss-Prot
  TRAF-like UniProtKB/Swiss-Prot
  TRAF6 UniProtKB/Swiss-Prot
  TRAF6_MATH UniProtKB/Swiss-Prot
  TRAF6_Z2 UniProtKB/Swiss-Prot
  TRAF_MEP1_MATH_dom UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_RING_CS UniProtKB/Swiss-Prot
  Znf_TRAF UniProtKB/Swiss-Prot
KEGG Report mmu:22034 UniProtKB/Swiss-Prot
MGD MGI:108072 ENTREZGENE
NCBI Gene 22034 ENTREZGENE
PANTHER PTHR10131 UniProtKB/Swiss-Prot
  TNF RECEPTOR-ASSOCIATED FACTOR 6 UniProtKB/Swiss-Prot
Pfam TRAF-mep_MATH UniProtKB/Swiss-Prot
  TRAF6_Z2 UniProtKB/Swiss-Prot
  zf-C3HC4_2 UniProtKB/Swiss-Prot
  zf-TRAF UniProtKB/Swiss-Prot
PhenoGen Traf6 PhenoGen
PIRSF TRAF UniProtKB/Swiss-Prot
PROSITE MATH UniProtKB/Swiss-Prot
  ZF_RING_1 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
  ZF_TRAF UniProtKB/Swiss-Prot
SMART MATH UniProtKB/Swiss-Prot
  RING UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  TRAF domain-like UniProtKB/Swiss-Prot
UniProt P70196 ENTREZGENE
  Q6P9M0 ENTREZGENE
  Q8BLV2 ENTREZGENE
  TRAF6_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6P9M0 UniProtKB/Swiss-Prot
  Q8BLV2 UniProtKB/Swiss-Prot