Traf6 (TNF receptor-associated factor 6) - Rat Genome Database

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Gene: Traf6 (TNF receptor-associated factor 6) Mus musculus
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Symbol: Traf6
Name: TNF receptor-associated factor 6
RGD ID: 1315707
MGI Page MGI
Description: Enables ubiquitin protein ligase activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; lipopolysaccharide-mediated signaling pathway; and regulation of gene expression. Located in cytoplasmic side of plasma membrane; cytosol; and lipid droplet. Part of CD40 receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including aorta-gonad-mesonephros; future brain; lower jaw; mandibular process; and sensory organ. Used to study hypohidrotic ectodermal dysplasia. Orthologous to human TRAF6 (TNF receptor associated factor 6).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2310003F17Rik; AI851288; C630032O20Rik; E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392101,508,765 - 101,532,013 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2101,508,774 - 101,532,014 (+)EnsemblGRCm39 Ensembl
GRCm382101,678,420 - 101,701,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2101,678,429 - 101,701,669 (+)EnsemblGRCm38mm10GRCm38
MGSCv372101,518,597 - 101,541,133 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362101,479,279 - 101,501,815 (+)NCBIMGSCv36mm8
Celera2102,903,294 - 102,925,894 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map253.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Traf6Mousehypertrophic cardiomyopathy treatmentIMP 155646134 RGD 
Traf6Mousehypertrophic cardiomyopathy treatmentIEP 155646134protein:increased expression:heart (human)RGD 
Traf6MouseIntestinal Reperfusion Injury  ISOTraf6 (Rattus norvegicus)151347179 RGD 
Traf6Mouseintrinsic cardiomyopathy  ISOTRAF6 (Homo sapiens)155646134protein:increased expression:heart (human)RGD 
Traf6Mouselaryngeal carcinoma disease_progressionISOTRAF6 (Homo sapiens)150573814 RGD 
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Traf6Mouseintellectual disability  ISOTRAF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
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Traf6Mousecoronary artery disease  ISOTRAF6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20524934
Traf6Mouserheumatoid arthritis  ISOTRAF6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20453842 and PMID:23143596
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Traf6Mousehypohidrotic ectodermal dysplasia  IAGP 13592920OMIM:129490 more ...MouseDO 

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Traf6Mouse(-)-epigallocatechin 3-gallate multiple interactionsISOTRAF6 (Homo sapiens)6480464epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein]CTDPMID:27890776
Traf6Mouse(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein]CTDPMID:27890776
Traf6Mouse1,2-dichloroethane increases expressionEXP 6480464ethylene dichloride results in increased expression of TRAF6 mRNACTDPMID:28960355
Traf6Mouse1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of TRAF6 mRNACTDPMID:22206623
Traf6Mouse17beta-estradiol increases expressionISOTRAF6 (Homo sapiens)6480464Estradiol results in increased expression of TRAF6 mRNACTDPMID:16202921
Traf6Mouse17beta-estradiol multiple interactionsISOTRAF6 (Homo sapiens)6480464[Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein] and [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein]CTDPMID:29625166
Traf6Mouse17beta-estradiol multiple interactionsISOTraf6 (Rattus norvegicus)64804641 more ...CTDPMID:29625166
Traf6Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TRAF6 mRNACTDPMID:12167310 and PMID:15310856
Traf6Mouse2,6-dinitrotoluene affects expressionISOTraf6 (Rattus norvegicus)64804642 and 6-dinitrotoluene affects the expression of TRAF6 mRNACTDPMID:21346803
Traf6Mouse2-amino-2-deoxy-D-galactopyranose multiple interactionsEXP 6480464[lipopolysaccharide more ...CTDPMID:28213090
Traf6Mouse2-amino-2-deoxy-D-glucopyranose multiple interactionsISOTRAF6 (Homo sapiens)6480464Glucosamine analog inhibits the reaction [TNF results in increased expression of TRAF6 mRNA] and Glucosamine inhibits the reaction [TNF results in increased expression of TRAF6 mRNA]CTDPMID:18173918
Traf6Mouse3-phenylprop-2-enal multiple interactionsEXP 6480464cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA]CTDPMID:18306459
Traf6Mouse4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of TRAF6 mRNACTDPMID:18648102
Traf6Mouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of TRAF6 mRNACTDPMID:39298647
Traf6Mouse6-propyl-2-thiouracil decreases expressionISOTraf6 (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of TRAF6 mRNACTDPMID:30047161
Traf6Mouseacetic acid multiple interactionsEXP 6480464Melitten inhibits the reaction [Acetic Acid results in increased expression of TRAF6 protein]CTDPMID:33002459
Traf6Mouseacetic acid increases expressionEXP 6480464Acetic Acid results in increased expression of TRAF6 proteinCTDPMID:33002459
Traf6Mouseacetylsalicylic acid increases expressionISOTRAF6 (Homo sapiens)6480464Aspirin results in increased expression of TRAF6 mRNACTDPMID:11906190
Traf6Mousealdehydo-D-glucosamine multiple interactionsISOTRAF6 (Homo sapiens)6480464Glucosamine analog inhibits the reaction [TNF results in increased expression of TRAF6 mRNA] and Glucosamine inhibits the reaction [TNF results in increased expression of TRAF6 mRNA]CTDPMID:18173918
Traf6Mouseall-trans-retinoic acid increases expressionISOTRAF6 (Homo sapiens)6480464Tretinoin results in increased expression of TRAF6 mRNACTDPMID:33167477

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Biological Process
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Traf6Mouseactivation of protein kinase activity involved_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mouseanimal organ morphogenesis acts_upstream_of_or_withinIMPMGI:26754692290270 PMID:15705807MGIPMID:15705807
Traf6Mouseantigen processing and presentation of exogenous peptide antigen via MHC class II acts_upstream_of_or_withinIMPMGI:26787752290270 PMID:14499111MGIPMID:14499111
Traf6Mouseantiviral innate immune response involved_inIEAUniProtKB:Q9Y4K3 and ensembl:ENSP000004336232290270 EnsemblGO_REF:0000107
Traf6Mouseantiviral innate immune response involved_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mouseautophagosome assembly involved_inIEAUniProtKB:Q9Y4K3 and ensembl:ENSP000004336232290270 EnsemblGO_REF:0000107
Traf6Mouseautophagosome assembly involved_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mousebone remodeling involved_inIMP 2290270 PMID:10421844UniProtPMID:10421844
Traf6Mousebone resorption involved_inIMP 2290270 PMID:10215628UniProtPMID:10215628
Traf6Mousecanonical NF-kappaB signal transduction involved_inIMP 2290270 PMID:17633018UniProtPMID:17633018
Traf6Mousecanonical NF-kappaB signal transduction involved_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6MouseCD40 signaling pathway involved_inIEAUniProtKB:Q9Y4K3 and ensembl:ENSP000004336232290270 EnsemblGO_REF:0000107
Traf6Mousecell development acts_upstream_of_or_withinIMPMGI:26754692290270 PMID:15705807MGIPMID:15705807
Traf6Mousecellular response to angiotensin  ISOTraf6 (Rattus norvegicus)9068941 RGDPMID:27249171 and REF_RGD_ID:155646134
Traf6Mousecellular response to cytokine stimulus involved_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mousecellular response to hydrogen peroxide  ISOTraf6 (Rattus norvegicus)9068941 RGDPMID:27249171 and REF_RGD_ID:155646134
Traf6Mousecellular response to lipopolysaccharide acts_upstream_of_or_withinISOUniProtKB:Q9Y4K32290270 PMID:23776175MGIPMID:23776175
Traf6Mousecytokine-mediated signaling pathway  ISOTraf6 (Rattus norvegicus)9068941 RGDPMID:15890643 and REF_RGD_ID:1579817
Traf6Mousecytokine-mediated signaling pathway involved_inISOTraf6 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Traf6Mousecytoplasmic pattern recognition receptor signaling pathway involved_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
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Cellular Component
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Traf6MouseCD40 receptor complex part_ofIDA 2290270 PMID:20614026BHF-UCLPMID:20614026
Traf6Mousecell cortex located_inIEAUniProtKB-SubCell:SL-01382290270 UniProtGO_REF:0000044
Traf6Mousecytoplasm is_active_inIBAPANTHER:PTN008938480 more ...2290270 GO_CentralGO_REF:0000033
Traf6Mousecytoplasm is_active_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mousecytoplasm located_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mousecytoplasmic side of plasma membrane is_active_inIBAPANTHER:PTN008494376 and MGI:1080722290270 GO_CentralGO_REF:0000033
Traf6Mousecytoplasmic side of plasma membrane located_inIDA 2290270 PMID:20614026BHF-UCLPMID:20614026
Traf6Mousecytosol located_inIDA 2290270 PMID:16831874UniProtPMID:16831874
Traf6Mousecytosol located_inTAS 2290270 ReactomeReactome:R-MMU-205060 and Reactome:R-MMU-933534
Traf6Mouseextrinsic component of cytoplasmic side of plasma membrane is_active_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mouseglutamatergic synapse is_active_inIBAPANTHER:PTN008494376 more ...2290270 GO_CentralGO_REF:0000033
Traf6Mouseglutamatergic synapse is_active_inIMP 2290270 PMID:28973854SynGOPMID:28973854
Traf6Mouseglutamatergic synapse is_active_inIDA 2290270 PMID:28973854SynGOPMID:28973854
Traf6Mouseglutamatergic synapse is_active_inIEP 2290270 PMID:28973854SynGOPMID:28973854
Traf6Mouselipid droplet located_inIDA 2290270 PMID:21435586UniProtPMID:21435586
Traf6Mousenucleus located_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mousenucleus located_inIEAUniProtKB-SubCell:SL-01912290270 UniProtGO_REF:0000044
Traf6Mouseperinuclear region of cytoplasm located_inIEAUniProtKB:Q9Y4K3 and ensembl:ENSP000004336232290270 EnsemblGO_REF:0000107
Traf6Mouseperinuclear region of cytoplasm located_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mouseplasma membrane located_inISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
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Molecular Function
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Original Reference(s)
Traf6Mousehistone deacetylase binding enablesISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mousehistone deacetylase binding enablesIEAUniProtKB:Q9Y4K3 and ensembl:ENSP000004336232290270 EnsemblGO_REF:0000107
Traf6Mouseidentical protein binding enablesIEAUniProtKB:Q9Y4K3 and ensembl:ENSP000004336232290270 EnsemblGO_REF:0000107
Traf6Mouseidentical protein binding enablesISOUniProtKB:Q9Y4K32290270 GO_CentralGO_REF:0000119
Traf6Mouseprotein binding enablesIPIUniProtKB:Q793I82290270 PMID:12566447IntActPMID:12566447
Traf6Mouseprotein binding enablesIPIUniProtKB:Q3UKC12290270 PMID:18239685BHF-UCLPMID:18239685
Traf6Mouseprotein binding enablesIPIUniProtKB:Q610842290270 PMID:14661019 and PMID:16362041IntActPMID:14661019 and PMID:16362041
Traf6Mouseprotein binding enablesIPIUniProtKB:Q8K4B22290270 PMID:23376919IntActPMID:23376919
Traf6Mouseprotein binding enablesIPIPR:Q5DU562290270 PMID:22863753MGIPMID:22863753
Traf6Mouseprotein binding enablesIPIPR:Q8BXR62290270 PMID:23042151MGIPMID:23042151
Traf6Mouseprotein binding enablesIPIUniProtKB:Q609432290270 PMID:19825828MGIPMID:19825828
Traf6Mouseprotein binding enablesIPIUniProtKB:Q8N7N62290270 PMID:21822257IntActPMID:21822257
Traf6Mouseprotein binding enablesIPIUniProtKB:P275122290270 PMID:8910514IntActPMID:8910514
Traf6Mouseprotein binding enablesIPIUniProtKB:Q9QZH62290270 PMID:10465784 and PMID:21525932IntActPMID:10465784 and PMID:21525932
Traf6Mouseprotein binding enablesIPIUniProtKB:Q96CG32290270 PMID:15047173IntActPMID:15047173
Traf6Mouseprotein binding enablesIPIUniProtKB:P223662290270 PMID:16306937 and PMID:22011580IntActPMID:16306937 and PMID:22011580
Traf6Mouseprotein binding enablesIPIUniProtKB:Q9EQY02290270 PMID:23942232IntActPMID:23942232
Traf6Mouseprotein binding enablesIPIUniProtKB:Q8CBB92290270 PMID:21435586UniProtPMID:21435586
Traf6Mouseprotein binding enablesIPIUniProtKB:O353052290270 PMID:10097072IntActPMID:10097072
Traf6Mouseprotein binding enablesIPIUniProtKB:Q622272290270 PMID:21725320IntActPMID:21725320
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Imported Annotations - PID (archival)

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Original Reference(s)
Traf6Mouseinterleukin-1 signaling pathway   ISOTRAF6 (Homo sapiens)6484113 PIDPID:200089
Traf6Mousenuclear factor kappa B signaling pathway   ISOTRAF6 (Homo sapiens)6484113 PIDPID:200031
Traf6Mousep38 MAPK signaling pathway   ISOTRAF6 (Homo sapiens)6484113 PIDPID:200018
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Traf6Mouseabnormal brain commissure morphology  IEA 5509061 MGI 
Traf6Mouseabnormal brain morphology  IEA 5509061 MGI 
Traf6Mouseabnormal coat/ hair morphology  IAGP 5509061 MGIPMID:12060722
Traf6Mouseabnormal coronary sinus connection  IEA 5509061 MGI 
Traf6Mouseabnormal dendritic cell differentiation  IAGP 5509061 MGIPMID:14499111
Traf6Mouseabnormal dendritic cell physiology  IAGP 5509061 MGIPMID:14499111
Traf6Mouseabnormal ductus venosus valve topology  IEA 5509061 MGI 
Traf6Mouseabnormal endolymphatic sac topology  IEA 5509061 MGI 
Traf6Mouseabnormal eye muscle morphology  IEA 5509061 MGI 
Traf6Mouseabnormal forebrain morphology  IEA 5509061 MGI 
Traf6Mouseabnormal hair follicle development  IAGP 5509061 MGIPMID:12060722
Traf6Mouseabnormal kidney morphology  IEA 5509061 MGI 
Traf6Mouseabnormal long bone metaphysis morphology  IAGP 5509061 MGIPMID:10215628
Traf6Mouseabnormal long bone morphology  IAGP 5509061 MGIPMID:10215628
Traf6Mouseabnormal lymph node morphology  IAGP 5509061 MGIPMID:14499111
Traf6Mouseabnormal lymphocyte anergy  IAGP 5509061 MGIPMID:18097000
Traf6Mouseabnormal macrophage physiology  IAGP 5509061 MGIPMID:10215628
Traf6Mouseabnormal male preputial gland morphology  IAGP 5509061 MGIPMID:12060722
Traf6Mouseabnormal Meibomian gland development  IAGP 5509061 MGIPMID:12060722
Traf6Mouseabnormal Mullerian duct morphology  IEA 5509061 MGI 
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Reference Title
Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. Fernandes A, etal., Glia. 2011 Jan;59(1):14-25. doi: 10.1002/glia.21072. Epub 2010 Oct 21.
3. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX, etal., Nat Commun. 2016 Jun 1;7:11267. doi: 10.1038/ncomms11267.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
6. Ischemic Preconditioning-Induced SOCS-1 Protects Rat Intestinal Ischemia Reperfusion Injury via Degradation of TRAF6. Liu SZ, etal., Dig Dis Sci. 2017 Jan;62(1):105-114. doi: 10.1007/s10620-016-4277-0. Epub 2016 Aug 18.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential biomarker for the aggressive tumor phenotype in laryngeal carcinoma. Starska K, etal., Folia Histochem Cytobiol. 2009 Jan;47(3):401-10. doi: 10.2478/v10042-009-0075-2.
16. Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice. Sugase T, etal., Int J Cancer. 2017 Jun 1;140(11):2608-2621. doi: 10.1002/ijc.30666. Epub 2017 Mar 10.
17. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
18. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
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PMID:8889548   PMID:8910514   PMID:9610637   PMID:10097072   PMID:10215628   PMID:10349636   PMID:10421844   PMID:10465784   PMID:10747026   PMID:10748240   PMID:11007897   PMID:11042159  
PMID:11076861   PMID:11244088   PMID:11250893   PMID:11278268   PMID:11406619   PMID:11547829   PMID:11923871   PMID:11967542   PMID:11994463   PMID:12060722   PMID:12140561   PMID:12185073  
PMID:12230506   PMID:12354380   PMID:12459498   PMID:12477932   PMID:12566447   PMID:12616498   PMID:12631284   PMID:12637570   PMID:12711536   PMID:12787561   PMID:12902324   PMID:12958312  
PMID:14499111   PMID:14500659   PMID:14530355   PMID:14610273   PMID:14634083   PMID:14645259   PMID:14661019   PMID:14673102   PMID:14699584   PMID:15029200   PMID:15047173   PMID:15102471  
PMID:15125833   PMID:15147900   PMID:15305292   PMID:15308666   PMID:15322147   PMID:15361868   PMID:15385464   PMID:15492225   PMID:15548667   PMID:15618518   PMID:15665823   PMID:15678102  
PMID:15705807   PMID:15721744   PMID:15864310   PMID:15905851   PMID:16033648   PMID:16079148   PMID:16141072   PMID:16141073   PMID:16147974   PMID:16184196   PMID:16196101   PMID:16210631  
PMID:16221674   PMID:16237096   PMID:16246731   PMID:16252010   PMID:16263713   PMID:16306937   PMID:16362041   PMID:16378096   PMID:16393988   PMID:16436380   PMID:16446357   PMID:16630834  
PMID:16697380   PMID:16772369   PMID:16831874   PMID:16897814   PMID:16921377   PMID:17055451   PMID:17092936   PMID:17224624   PMID:17277780   PMID:17332487   PMID:17360955   PMID:17389358  
PMID:17462996   PMID:17507094   PMID:17562858   PMID:17572386   PMID:17633018   PMID:17703191   PMID:17709375   PMID:17878362   PMID:17947236   PMID:17974599   PMID:17982070   PMID:18079694  
PMID:18083102   PMID:18097000   PMID:18174161   PMID:18195092   PMID:18202703   PMID:18239685   PMID:18246070   PMID:18268035   PMID:18378686   PMID:18382763   PMID:18407828   PMID:18411265  
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Traf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392101,508,765 - 101,532,013 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2101,508,774 - 101,532,014 (+)EnsemblGRCm39 Ensembl
GRCm382101,678,420 - 101,701,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2101,678,429 - 101,701,669 (+)EnsemblGRCm38mm10GRCm38
MGSCv372101,518,597 - 101,541,133 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362101,479,279 - 101,501,815 (+)NCBIMGSCv36mm8
Celera2102,903,294 - 102,925,894 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map253.9NCBI
TRAF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381136,483,769 - 36,510,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1136,483,769 - 36,510,272 (-)EnsemblGRCh38hg38GRCh38
GRCh371136,505,319 - 36,531,822 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361136,467,302 - 36,488,398 (-)NCBINCBI36Build 36hg18NCBI36
Build 341136,467,298 - 36,488,398NCBI
Celera1136,661,891 - 36,684,256 (-)NCBICelera
Cytogenetic Map11p12NCBI
HuRef1136,207,402 - 36,234,755 (-)NCBIHuRef
CHM1_11136,504,096 - 36,530,410 (-)NCBICHM1_1
T2T-CHM13v2.01136,626,229 - 36,653,443 (-)NCBIT2T-CHM13v2.0
Traf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83108,418,537 - 108,443,330 (+)NCBIGRCr8
mRatBN7.2387,963,517 - 87,988,316 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl387,963,514 - 87,983,507 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx391,457,599 - 91,477,545 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03100,056,626 - 100,076,572 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0397,885,654 - 97,905,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0391,252,829 - 91,271,607 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl391,252,829 - 91,271,607 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0397,912,482 - 97,935,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4386,827,582 - 86,847,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1386,728,165 - 86,742,912 (+)NCBI
Celera387,069,225 - 87,089,051 (+)NCBICelera
Cytogenetic Map3q31NCBI
Traf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554229,932,680 - 9,949,100 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554229,925,765 - 9,950,354 (+)NCBIChiLan1.0ChiLan1.0
TRAF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2938,702,879 - 38,731,477 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11138,707,533 - 38,736,877 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,457,633 - 36,483,616 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11136,330,336 - 36,356,334 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1136,335,609 - 36,356,334 (-)Ensemblpanpan1.1panPan2
TRAF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11831,674,242 - 31,689,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1831,675,391 - 31,688,641 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1831,278,398 - 31,300,151 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01832,281,552 - 32,303,317 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1832,281,510 - 32,299,115 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11831,851,198 - 31,872,911 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01831,435,636 - 31,457,386 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01832,072,955 - 32,094,690 (+)NCBIUU_Cfam_GSD_1.0
Traf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494728,732,923 - 28,750,178 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365331,857,666 - 1,876,120 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365331,857,685 - 1,874,973 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl224,602,804 - 24,626,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1224,602,749 - 24,628,263 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2226,767,127 - 26,786,940 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRAF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1128,726,357 - 28,752,389 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl128,734,380 - 28,747,092 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038125,864,012 - 125,890,813 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Traf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476710,729,413 - 10,748,455 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476710,729,766 - 10,803,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Traf6
1267 total Variants

Predicted Target Of
Summary Value
Count of predictions:1719
Count of miRNA genes:751
Interacting mature miRNAs:973
Transcripts:ENSMUST00000004949, ENSMUST00000143341, ENSMUST00000144063
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 51 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
25394565Skmw50_mskeletal muscle weight 50, soleus (mouse)297783888102476127Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse

1 to 10 of 51 rows
D84655  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382101,697,774 - 101,697,922UniSTSGRCm38
MGSCv372101,537,931 - 101,538,079UniSTSGRCm37
Celera2102,922,692 - 102,922,840UniSTS
Cytogenetic Map2E2UniSTS
Whitehead/MRC_RH21397.91UniSTS
Traf6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382101,697,354 - 101,697,777UniSTSGRCm38
MGSCv372101,537,511 - 101,537,934UniSTSGRCm37
Celera2102,922,272 - 102,922,695UniSTS
Cytogenetic Map2E2UniSTS
cM Map2 UniSTS
D2Mit161  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382101,694,497 - 101,694,645UniSTSGRCm38
MGSCv372101,534,654 - 101,534,802UniSTSGRCm37
Celera2102,919,414 - 102,919,562UniSTS
Cytogenetic Map2E2UniSTS
cM Map250.3UniSTS
Whitehead Genetic250.3UniSTS
AI851288  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382101,701,272 - 101,701,407UniSTSGRCm38
MGSCv372101,541,429 - 101,541,564UniSTSGRCm37
Celera2102,926,190 - 102,926,325UniSTS
Cytogenetic Map2E2UniSTS
Whitehead/MRC_RH21387.2UniSTS
BE333972  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382101,699,015 - 101,699,132UniSTSGRCm38
MGSCv372101,539,172 - 101,539,289UniSTSGRCm37
Celera2102,923,933 - 102,924,050UniSTS
Cytogenetic Map2E2UniSTS
Whitehead/MRC_RH21397.91UniSTS
Traf6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E2UniSTS
cM Map2 UniSTS







Ensembl Acc Id: ENSMUST00000004949   ⟹   ENSMUSP00000004949
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2101,508,785 - 101,532,014 (+)Ensembl
GRCm38.p6 Ensembl2101,678,440 - 101,701,669 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2101,508,774 - 101,516,580 (+)Ensembl
GRCm38.p6 Ensembl2101,678,429 - 101,686,235 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2101,514,560 - 101,520,430 (+)Ensembl
GRCm38.p6 Ensembl2101,684,215 - 101,690,085 (+)Ensembl
RefSeq Acc Id: NM_001303273   ⟹   NP_001290202
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392101,508,765 - 101,532,013 (+)NCBI
GRCm382101,678,420 - 101,701,668 (+)NCBI
Celera2102,903,274 - 102,926,586 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009424   ⟹   NP_033450
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392101,508,765 - 101,532,013 (+)NCBI
GRCm382101,678,420 - 101,701,668 (+)NCBI
MGSCv372101,518,597 - 101,541,133 (+)RGD
Celera2102,903,274 - 102,926,586 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_001290202 (Get FASTA)   NCBI Sequence Viewer  
  NP_033450 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60705 (Get FASTA)   NCBI Sequence Viewer  
  BAA12705 (Get FASTA)   NCBI Sequence Viewer  
  BAC30850 (Get FASTA)   NCBI Sequence Viewer  
  BAE33263 (Get FASTA)   NCBI Sequence Viewer  
  EDL27656 (Get FASTA)   NCBI Sequence Viewer  
  EDL27657 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000004949
  ENSMUSP00000004949.8
GenBank Protein P70196 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_033450   ⟸   NM_009424
- UniProtKB: Q6P9M0 (UniProtKB/Swiss-Prot),   Q8BLV2 (UniProtKB/Swiss-Prot),   P70196 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001290202   ⟸   NM_001303273
- UniProtKB: Q6P9M0 (UniProtKB/Swiss-Prot),   Q8BLV2 (UniProtKB/Swiss-Prot),   P70196 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000004949   ⟸   ENSMUST00000004949
MATH

Name Modeler Protein Id AA Range Protein Structure
AF-P70196-F1-model_v2 AlphaFold P70196 1-530 view protein structure

RGD ID:6832978
Promoter ID:MM_KWN:30728
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000111225,   OTTMUST00000034583,   UC008LHN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362101,518,391 - 101,518,891 (+)MPROMDB
RGD ID:6878034
Promoter ID:EPDNEW_M2468
Type:initiation region
Name:Traf6_1
Description:Mus musculus TNF receptor-associated factor 6 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382101,678,429 - 101,678,489EPDNEW


1 to 40 of 41 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000027164 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000004949 ENTREZGENE
  ENSMUST00000004949.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
  Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A UniProtKB/Swiss-Prot
InterPro MATH/TRAF_dom UniProtKB/Swiss-Prot
  TNF_rcpt--assoc_TRAF UniProtKB/Swiss-Prot
  TRAF-like UniProtKB/Swiss-Prot
  TRAF6 UniProtKB/Swiss-Prot
  TRAF6_MATH UniProtKB/Swiss-Prot
  TRAF6_Z2 UniProtKB/Swiss-Prot
  TRAF_MEP1_MATH_dom UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_RING_CS UniProtKB/Swiss-Prot
  Znf_TRAF UniProtKB/Swiss-Prot
KEGG Report mmu:22034 UniProtKB/Swiss-Prot
MGD MGI:108072 ENTREZGENE
NCBI Gene 22034 ENTREZGENE
PANTHER PTHR10131 UniProtKB/Swiss-Prot
  TNF RECEPTOR-ASSOCIATED FACTOR 6 UniProtKB/Swiss-Prot
Pfam TRAF-mep_MATH UniProtKB/Swiss-Prot
  TRAF6_Z2 UniProtKB/Swiss-Prot
  zf-C3HC4_2 UniProtKB/Swiss-Prot
  zf-TRAF UniProtKB/Swiss-Prot
PhenoGen Traf6 PhenoGen
PIRSF TRAF UniProtKB/Swiss-Prot
PROSITE MATH UniProtKB/Swiss-Prot
  ZF_RING_1 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
  ZF_TRAF UniProtKB/Swiss-Prot
SMART MATH UniProtKB/Swiss-Prot
  RING UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  TRAF domain-like UniProtKB/Swiss-Prot
UniProt P70196 ENTREZGENE
  Q6P9M0 ENTREZGENE
  Q8BLV2 ENTREZGENE
  TRAF6_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6P9M0 UniProtKB/Swiss-Prot
1 to 40 of 41 rows