Traf6 (TNF receptor associated factor 6) - Rat Genome Database

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Pathways
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Gene: Traf6 (TNF receptor associated factor 6) Heterocephalus glaber
Analyze
Symbol: Traf6
Name: TNF receptor associated factor 6
RGD ID: 18908687
Description: ENCODES a protein that exhibits histone deacetylase binding (ortholog); identical protein binding (ortholog); protein kinase B binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); antiviral innate immune response (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH coronary artery disease (ortholog); genetic disease (ortholog); hypertrophic cardiomyopathy (ortholog); FOUND IN CD40 receptor complex (ortholog); cytoplasm (ortholog); cytoplasmic side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TNF receptor-associated factor 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476710,729,413 - 10,748,455 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476710,729,766 - 10,803,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (ISO)
antiviral innate immune response  (ISO)
autophagosome assembly  (ISO)
bone remodeling  (ISO)
bone resorption  (ISO)
canonical NF-kappaB signal transduction  (ISO)
cell development  (ISO)
cellular response to angiotensin  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to lipopolysaccharide  (ISO)
cytokine-mediated signaling pathway  (ISO)
cytoplasmic pattern recognition receptor signaling pathway  (ISO)
immune response  (ISO)
in utero embryonic development  (ISO)
innate immune response  (IEA)
interleukin-1-mediated signaling pathway  (ISO)
interleukin-17-mediated signaling pathway  (ISO)
interleukin-17A-mediated signaling pathway  (ISO)
interleukin-33-mediated signaling pathway  (ISO)
intracellular signaling cassette  (IEA)
JNK cascade  (ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural tube closure  (ISO)
non-canonical NF-kappaB signal transduction  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
ossification  (ISO)
osteoclast differentiation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of lipopolysaccharide-mediated signaling pathway  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell cytokine production  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of type I interferon production  (ISO)
protein autoubiquitination  (ISO)
protein K63-linked ubiquitination  (IEA)
protein polyubiquitination  (ISO)
protein ubiquitination  (IEA,ISO)
regulation of canonical NF-kappaB signal transduction  (IEA)
regulation of immunoglobulin production  (ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
response to interleukin-1  (ISO)
response to ischemia  (ISO)
signal transduction  (ISO)
T cell receptor signaling pathway  (ISO)
T-helper 1 type immune response  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
tumor necrosis factor-mediated signaling pathway  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Traf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476710,729,413 - 10,748,455 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476710,729,766 - 10,803,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TRAF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381136,483,769 - 36,510,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1136,483,769 - 36,510,272 (-)EnsemblGRCh38hg38GRCh38
GRCh371136,505,319 - 36,531,822 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361136,467,302 - 36,488,398 (-)NCBINCBI36Build 36hg18NCBI36
Build 341136,467,298 - 36,488,398NCBI
Celera1136,661,891 - 36,684,256 (-)NCBICelera
Cytogenetic Map11p12NCBI
HuRef1136,207,402 - 36,234,755 (-)NCBIHuRef
CHM1_11136,504,096 - 36,530,410 (-)NCBICHM1_1
T2T-CHM13v2.01136,626,229 - 36,653,443 (-)NCBIT2T-CHM13v2.0
Traf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392101,508,765 - 101,532,013 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2101,508,774 - 101,532,014 (+)EnsemblGRCm39 Ensembl
GRCm382101,678,420 - 101,701,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2101,678,429 - 101,701,669 (+)EnsemblGRCm38mm10GRCm38
MGSCv372101,518,597 - 101,541,133 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362101,479,279 - 101,501,815 (+)NCBIMGSCv36mm8
Celera2102,903,294 - 102,925,894 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map253.9NCBI
Traf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83108,418,537 - 108,443,330 (+)NCBIGRCr8
mRatBN7.2387,963,517 - 87,988,316 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl387,963,514 - 87,983,507 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx391,457,599 - 91,477,545 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03100,056,626 - 100,076,572 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0397,885,654 - 97,905,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0391,252,829 - 91,271,607 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl391,252,829 - 91,271,607 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0397,912,482 - 97,935,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4386,827,582 - 86,847,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1386,728,165 - 86,742,912 (+)NCBI
Celera387,069,225 - 87,089,051 (+)NCBICelera
Cytogenetic Map3q31NCBI
Traf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554229,932,680 - 9,949,100 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554229,925,765 - 9,950,354 (+)NCBIChiLan1.0ChiLan1.0
TRAF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2938,702,879 - 38,731,477 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11138,707,533 - 38,736,877 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,457,633 - 36,483,616 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11136,330,336 - 36,356,334 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1136,335,609 - 36,356,334 (-)Ensemblpanpan1.1panPan2
TRAF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11831,674,242 - 31,689,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1831,675,391 - 31,688,641 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1831,278,398 - 31,300,151 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01832,281,552 - 32,303,317 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1832,281,510 - 32,299,115 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11831,851,198 - 31,872,911 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01831,435,636 - 31,457,386 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01832,072,955 - 32,094,690 (+)NCBIUU_Cfam_GSD_1.0
Traf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494728,732,923 - 28,750,178 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365331,857,666 - 1,876,120 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365331,857,685 - 1,874,973 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl224,602,804 - 24,626,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1224,602,749 - 24,628,263 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2226,767,127 - 26,786,940 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRAF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1128,726,357 - 28,752,389 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl128,734,380 - 28,747,092 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038125,864,012 - 125,890,813 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000014830   ⟹   ENSHGLP00000014685
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476710,729,413 - 10,748,455 (+)Ensembl
RefSeq Acc Id: XM_004852025   ⟹   XP_004852082
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476710,729,766 - 10,753,792 (+)NCBI
RefSeq Acc Id: XM_013074828   ⟹   XP_012930282
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476710,729,767 - 10,793,357 (+)NCBI
RefSeq Acc Id: XM_013074829   ⟹   XP_012930283
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476710,729,771 - 10,764,640 (+)NCBI
RefSeq Acc Id: XM_021264336   ⟹   XP_021119995
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476710,729,771 - 10,781,199 (+)NCBI
RefSeq Acc Id: XR_002397315
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476710,729,767 - 10,803,253 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004852082 (Get FASTA)   NCBI Sequence Viewer  
  XP_012930282 (Get FASTA)   NCBI Sequence Viewer  
  XP_012930283 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119995 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB02993 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014685
  ENSHGLP00100043180
GenBank Protein JAO01799 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004852082   ⟸   XM_004852025
- Peptide Label: isoform X1
- UniProtKB: G5B132 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012930282   ⟸   XM_013074828
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021119995   ⟸   XM_021264336
- Peptide Label: isoform X3
RefSeq Acc Id: XP_012930283   ⟸   XM_013074829
- Peptide Label: isoform X4
RefSeq Acc Id: ENSHGLP00000014685   ⟸   ENSHGLT00000014830


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010513 Ensembl, ENTREZGENE
  ENSHGLG00100005898 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000014830 ENTREZGENE
  ENSHGLT00100075836 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro MATH/TRAF_dom UniProtKB/TrEMBL
  TRAF-like UniProtKB/TrEMBL
  TRAF6 UniProtKB/TrEMBL
  TRAF6_MATH UniProtKB/TrEMBL
  TRAF6_Z2 UniProtKB/TrEMBL
  TRAF_MEP1_MATH_dom UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
  Znf_TRAF UniProtKB/TrEMBL
KEGG Report hgl:101697126 UniProtKB/TrEMBL
NCBI Gene Traf6 ENTREZGENE
PANTHER PTHR10131 UniProtKB/TrEMBL
  TNF RECEPTOR-ASSOCIATED FACTOR 6 UniProtKB/TrEMBL
Pfam TRAF-mep_MATH UniProtKB/TrEMBL
  TRAF6_Z2 UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/TrEMBL
  zf-TRAF UniProtKB/TrEMBL
PROSITE MATH UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
  ZF_TRAF UniProtKB/TrEMBL
SMART MATH UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/TrEMBL
UniProt G5B132 ENTREZGENE, UniProtKB/TrEMBL