Tlr4 (toll-like receptor 4) - Rat Genome Database

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Gene: Tlr4 (toll-like receptor 4) Mus musculus
Symbol: Tlr4
Name: toll-like receptor 4
RGD ID: 737014
Description: Enables lipopolysaccharide immune receptor activity. Involved in several processes, including regulation of cytokine production; response to lipopolysaccharide; and toll-like receptor signaling pathway. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of cytokine production; and response to bacterium. Located in plasma membrane. Part of receptor complex. Is expressed in brain; early embryo; genitourinary system; inner cell mass; and intestine. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: lipopolysaccharide response; Lps; Ly87; Ran/M1; Ras; Rasl2-8; Toll like receptor 4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39466,745,788 - 66,765,338 (+)NCBIGRCm39mm39
GRCm39 Ensembl466,745,821 - 66,848,521 (+)Ensembl
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl466,827,584 - 66,930,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIGRCm37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBImm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acanthamoeba Keratitis  (ISO)
acne  (ISO)
Acne Conglobata  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (IEP,IMP,ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
acute pancreatitis  (IEP)
Acute Tubulointerstitial Nephritis  (IMP)
Acute-On-Chronic Liver Failure  (ISO)
age related macular degeneration 10  (ISO)
Alcoholic Fatty Liver  (IMP)
allergic conjunctivitis  (IMP,ISO)
allergic contact dermatitis  (IMP,ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
Angina, Stable  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (IMP,ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (IDA,IMP,ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Bacteremia  (ISO)
Bacterial Keratitis  (IMP)
bacterial pneumonia  (IMP)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (IMP)
carcinoma  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IMP,ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystic fibrosis  (IMP,ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (IMP)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dry eye syndrome  (IEP,ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP,IMP,ISO)
Entamoebiasis  (IMP)
Eosinophilia  (ISO)
esophagus adenocarcinoma  (ISO)
eumycotic mycetoma  (IEP)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
extrahepatic cholestasis  (ISO)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
Fungal Eye Infections  (ISO)
Fungal Keratitis  (IMP)
glomerulonephritis  (IDA,IMP)
Hearing Loss  (ISO)
Hemorrhagic Shock  (IMP)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (IMP,ISO)
Hyperalgesia  (IMP,ISO)
hypertension  (ISO)
ileitis  (IMP,ISO)
Inflammation  (ISO)
Insulin Resistance  (IAGP,ISO)
invasive aspergillosis  (ISO)
Kawasaki disease  (ISO)
keratitis  (IEP,IMP,ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (IEP,IMP,ISO)
learning disability  (ISO)
leptospirosis  (IMP)
liver cirrhosis  (ISO)
Liver Injury  (IMP)
Liver Reperfusion Injury  (IEP,IMP,ISO)
low tension glaucoma  (ISO)
lung disease  (IEP,IMP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
mastitis  (ISO)
mastoiditis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (IEP)
Meningitis, Escherichia Coli  (IEP)
meningococcal meningitis  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (ISO)
non-alcoholic fatty liver disease  (IMP,ISO)
obesity  (IAGP,ISO)
Onchocerciasis, Ocular  (IMP)
Optic Nerve Injuries  (IEP)
Oral Lichen Planus  (ISO)
otitis media  (IMP,ISO)
Otitis Media with Effusion  (IMP)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
Painful Neuropathy  (IMP)
pancreatitis  (IMP,ISO)
perinatal necrotizing enterocolitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (IEP)
pneumonia  (IMP,ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (IMP,ISO)
psoriasis  (ISO)
pulmonary edema  (IMP)
pulmonary emphysema  (IEA,IMP)
pulmonary fibrosis  (IMP)
pulmonary hypertension  (IMP)
pulmonary tuberculosis  (ISO)
pulpitis  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (IMP,ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (IMP,ISO)
Retina Reperfusion Injury  (IMP)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IEP,ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
sinusitis  (IMP,ISO)
Spinal Cord Injuries  (IMP)
Spinal Cord Reperfusion Injury  (ISO)
sporotrichosis  (IMP)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (IMP)
temporal arteritis  (ISO)
Transplant Rejection  (IMP)
tuberculosis  (IMP)
tympanosclerosis  (ISO)
type 1 diabetes mellitus  (IEP,ISO)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (IMP)
urinary tract infection  (ISO)
uveitis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
viral meningitis  (IEP)
vitiligo  (ISO)
Wallerian Degeneration  (IAGP)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
7alpha-hydroxycholesterol  (ISO)
acetamide  (ISO)
acetate ester  (ISO)
acetic acid  (EXP)
acrolein  (ISO)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (EXP)
alpha-pinene  (ISO)
aluminium hydroxide  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
artesunate  (ISO)
aspalathin  (ISO)
atorvastatin calcium  (ISO)
auranofin  (EXP)
azathioprine  (EXP)
baicalin  (ISO)
benazepril  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP)
benzylpenicillin  (EXP)
berberine  (EXP)
Besigomsin  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
casticin  (ISO)
catalpol  (EXP)
cerium trichloride  (EXP)
chaetoglobosin A  (EXP)
chitosan  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP)
chromium atom  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
crocin-1  (ISO)
cudratricusxanthone A  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
daunorubicin  (EXP)
dehydroepiandrosterone  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dienogest  (ISO)
dihydrogen  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
enalaprilat dihydrate  (ISO)
erythromycin A  (EXP)
esculetin  (EXP)
ethanol  (EXP,ISO)
ethion  (EXP)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
ferulic acid  (EXP)
fisetin  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP)
gallocatechin  (ISO)
ganglioside GM1  (ISO)
Gastrodin  (ISO)
geldanamycin  (ISO)
genistein  (EXP)
geraniol  (EXP)
Ginkgolide A  (EXP)
ginsenoside Re  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
halothane  (EXP)
helenalin  (EXP)
hexadecanoic acid  (EXP)
hyaluronic acid  (EXP,ISO)
hydroquinone  (EXP)
ifosfamide  (ISO)
indometacin  (EXP,ISO)
irinotecan  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoamylol  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
ketamine  (EXP)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lactulose  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
linsidomine  (EXP)
lipophosphoglycan  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (ISO)
liquiritin  (ISO)
lithium chloride  (ISO)
LY294002  (EXP)
lycopene  (ISO)
magnesium dihydroxide  (EXP)
malathion  (EXP)
melatonin  (ISO)
melittin  (EXP)
melphalan  (ISO)
metformin  (ISO)
methadone  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
Methylthiouracil  (ISO)
monocrotaline  (EXP,ISO)
monodansylcadaverine  (EXP)
morphine  (EXP,ISO)
Morphine-3-glucuronide  (ISO)
muramyl dipeptide  (EXP,ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naloxone  (ISO)
naproxen  (ISO)
nerolidol  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicorandil  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
Nonidet P-40  (ISO)
Nonylphenol  (EXP,ISO)
o-anisidine  (ISO)
omeprazole  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
pelargonidin  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylinositol dimannoside  (EXP)
phosphoramide mustard  (ISO)
picropodophyllotoxin  (EXP)
pipoxolan  (EXP)
pirinixic acid  (EXP)
platycodin D  (ISO)
polymyxin B2  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP)
progesterone  (ISO)
propofol  (EXP)
puerarin  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (ISO)
SB 431542  (ISO)
Scoparone  (EXP)
scopoletin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
sodium cholate  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sumatriptan  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetrachloropalladate(2-)  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (EXP)
toluene  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin D  (EXP,ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IMP)
activation of NF-kappaB-inducing kinase activity  (NAS)
astrocyte development  (IMP)
B cell proliferation involved in immune response  (IMP)
cellular response to amyloid-beta  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to lipopolysaccharide  (IDA,IMP,ISO,TAS)
cellular response to lipoteichoic acid  (IMP)
cellular response to mechanical stimulus  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IGI)
cellular response to platelet-derived growth factor stimulus  (IMP)
cellular response to retinoic acid  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (IBA,IMP)
detection of lipopolysaccharide  (IDA,ISO,TAS)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
I-kappaB phosphorylation  (IMP,ISO)
immune response  (IEA)
immune system process  (IEA)
immunoglobulin mediated immune response  (ISO)
inflammatory response  (IBA,IMP,ISO)
innate immune response  (TAS)
innate immune response-activating signal transduction  (ISO)
intestinal epithelial structure maintenance  (IMP)
leukotriene metabolic process  (ISO)
lipopolysaccharide-mediated signaling pathway  (IDA,IGI,ISO)
macrophage activation  (ISO,ISS,TAS)
mast cell activation  (NAS)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (IGI)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of interferon-gamma production  (IMP)
negative regulation of interleukin-17 production  (IMP)
negative regulation of interleukin-23 production  (IMP)
negative regulation of interleukin-6 production  (IMP)
negative regulation of tumor necrosis factor production  (IMP)
nitric oxide production involved in inflammatory response  (IMP)
phagocytosis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell proliferation  (IMP)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of chemokine production  (IDA,ISO)
positive regulation of cytokine production involved in inflammatory response  (IGI,ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of gene expression  (IGI,IMP,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IDA)
positive regulation of inflammatory response  (IGI,ISO)
positive regulation of interferon-alpha production  (IDA)
positive regulation of interferon-beta production  (IDA,IMP)
positive regulation of interferon-gamma production  (IMP)
positive regulation of interleukin-1 beta production  (IDA,ISO)
positive regulation of interleukin-1 production  (IDA,NAS)
positive regulation of interleukin-10 production  (IDA)
positive regulation of interleukin-12 production  (IDA,ISO)
positive regulation of interleukin-13 production  (NAS)
positive regulation of interleukin-6 production  (IDA,IMP,ISO,NAS)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (IDA,IGI)
positive regulation of lymphocyte proliferation  (IMP)
positive regulation of macrophage activation  (IGI)
positive regulation of macrophage cytokine production  (IMP)
positive regulation of MAP kinase activity  (IMP)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of MHC class II biosynthetic process  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP,ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric oxide biosynthetic process  (IGI,IMP)
positive regulation of nitric-oxide synthase biosynthetic process  (IDA)
positive regulation of NLRP3 inflammasome complex assembly  (IDA)
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (IDA)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IDA)
positive regulation of oxidative stress-induced neuron death  (IGI)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of platelet activation  (IMP)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of stress-activated MAPK cascade  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of tumor necrosis factor production  (IDA,IMP,ISO)
regulation of dendritic cell cytokine production  (IDA)
regulation of inflammatory response  (IMP)
regulation of sensory perception of pain  (ISO)
regulation of tumor necrosis factor production  (ISO)
response to activity  (ISO)
response to bacterium  (IMP)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to gold nanoparticle  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (IGI,IMP,ISO)
response to morphine  (ISO)
response to oxidative stress  (ISO)
response to progesterone  (ISO)
response to retinoic acid  (ISO)
response to toxic substance  (ISO)
signal transduction  (IEA)
skeletal muscle contraction  (ISO)
toll-like receptor 4 signaling pathway  (IDA)
toll-like receptor signaling pathway  (IBA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (IGI)
wound healing involved in inflammatory response  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute inflammation  (IAGP)
abnormal airway responsiveness  (IAGP)
abnormal artery morphology  (IAGP)
abnormal bile salt level  (IAGP)
abnormal bone structure  (IAGP)
abnormal cecum morphology  (IEA)
abnormal chemokine secretion  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating leptin level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal enterocyte differentiation  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal fatty acids level  (IAGP)
abnormal fibroblast proliferation  (IAGP)
abnormal gas homeostasis  (IAGP)
abnormal glial cell apoptosis  (IAGP)
abnormal glial cell physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal granulocyte physiology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal immune cell physiology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interleukin level  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal level of surface class II molecules  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver physiology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal lung interstitium morphology  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal muscle cell glucose uptake  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal nephron morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal phagocyte morphology  (IAGP)
abnormal proximal convoluted tubule brush border morphology  (IAGP)
abnormal pulmonary alveolar duct morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal pulmonary elastic fiber morphology  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal respiratory system morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal retinal layer morphology  (IAGP)
abnormal retinal pigment epithelium morphology  (IAGP)
abnormal retinal progenitor cell morphology  (IAGP)
abnormal retinal rod bipolar cell morphology  (IAGP)
abnormal retinal rod cell morphology  (IAGP)
abnormal spleen weight  (IAGP)
abnormal susceptibility to atherosclerosis  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal uterus morphology  (IEA)
abnormal vascular wound healing  (IAGP)
atherosclerotic lesions  (IAGP)
brain ischemia  (IAGP)
cellular necrosis  (IEA)
colitis  (IAGP)
decreased acute inflammation  (IAGP)
decreased angiogenesis  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased colon length  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased eye pigmentation  (IEA)
decreased fat cell size  (IAGP)
decreased heart weight  (IEA)
decreased hemoglobin content  (IAGP)
decreased hepatocyte apoptosis  (IAGP)
decreased IgG3 level  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased interferon-beta secretion  (IEA)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-1 beta secretion  (IEA)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased macrophage apoptosis  (IEA)
decreased macrophage cytokine production  (IEA)
decreased memory B cell number  (IEA)
decreased neuron apoptosis  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased respiratory quotient  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bone fracture  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to ischemic brain injury  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased susceptibility to Orthomyxoviridae infection  (IAGP)
decreased susceptibility to weight loss  (IAGP)
decreased tail pigmentation  (IEA)
decreased tumor necrosis factor secretion  (IAGP)
dilated pulmonary alveolar ducts  (IAGP)
dilated renal tubules  (IAGP)
diluted coat color  (IEA)
enlarged cecum  (IEA)
enlarged lung  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged uterus  (IEA)
focal hepatic necrosis  (IAGP)
hyperoxia  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
improved glucose tolerance  (IAGP)
increased adiponectin level  (IAGP)
increased apoptosis  (IAGP)
increased B-1 B cell number  (IAGP)
increased bone mass  (IAGP)
increased bone mineral content  (IAGP)
increased bone mineral density  (IAGP)
increased cell death  (IEA)
increased circulating interleukin-6 level  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased lung compliance  (IAGP)
increased oxygen consumption  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to Poxviridae infection induced morbidity/mortality  (IAGP)
increased thermal nociceptive threshold  (IAGP)
increased total body fat amount  (IEA)
large intestinal inflammation  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
no abnormal phenotype detected  (IEA)
polyphagia  (IAGP)
pulmonary edema  (IAGP)
rectal hemorrhage  (IAGP)
renal cast  (IAGP)
renal tubular necrosis  (IAGP)

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