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Gene: Tlr4 (toll-like receptor 4) Mus musculus
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Symbol: Tlr4
Name: toll-like receptor 4
Description: Exhibits lipopolysaccharide receptor activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of cytokine production; and regulation of intracellular signal transduction. Localizes to the plasma membrane and receptor complex. Predicted to colocalize with the membrane raft. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Is expressed in cumulus oophorus; early embryo; inner cell mass; and intestine. Orthologous to human TLR4 (toll like receptor 4).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Toll like receptor 4
Orthologs:
Homo sapiens (human) : TLR4 (toll like receptor 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tlr4 (toll-like receptor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr4 (toll like receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR4 (toll like receptor 4)
Canis lupus familiaris (dog) : TLR4 (toll like receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr4 (toll like receptor 4)
Sus scrofa (pig) : TLR4 (toll like receptor 4)
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Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIGRCm37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBImm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4 C1NCBI
cM Map434.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated