Tlr4 (toll-like receptor 4) - Rat Genome Database

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Gene: Tlr4 (toll-like receptor 4) Mus musculus
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Symbol: Tlr4
Name: toll-like receptor 4
RGD ID: 737014
MGI Page MGI
Description: Enables lipopolysaccharide immune receptor activity. Involved in several processes, including positive regulation of defense response; regulation of cytokine production; and response to lipopolysaccharide. Acts upstream of or within several processes, including positive regulation of signal transduction; regulation of cytokine production involved in immune response; and response to bacterium. Located in plasma membrane. Part of receptor complex. Is expressed in brain; early embryo; genitourinary system; inner cell mass; and intestine. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: lipopolysaccharide response; Lps; Ly87; Ran/M1; Ras; Rasl2-8; Toll like receptor 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39466,745,788 - 66,765,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl466,745,821 - 66,848,521 (+)EnsemblGRCm39 Ensembl
GRCm38466,827,551 - 66,846,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl466,827,584 - 66,930,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv37466,488,845 - 66,503,831 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36466,314,172 - 66,329,158 (+)NCBIMGSCv36mm8
Celera465,431,141 - 65,446,127 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acanthamoeba Keratitis  (ISO)
acne  (ISO)
Acne Conglobata  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (IEP,IMP,ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
acute pancreatitis  (IEP)
Acute Tubulointerstitial Nephritis  (IMP)
Acute-On-Chronic Liver Failure  (ISO)
age related macular degeneration 10  (ISO)
Alcoholic Fatty Liver  (IMP)
allergic conjunctivitis  (IMP,ISO)
allergic contact dermatitis  (IMP,ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (IMP,ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (IDA,IMP,ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Bacteremia  (ISO)
Bacterial Keratitis  (IMP)
bacterial pneumonia  (IMP)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (IMP)
carcinoma  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IMP,ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystic fibrosis  (IMP,ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (IMP)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
dry eye syndrome  (IEP,ISO)
Dysbiosis  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP,IMP,ISO)
Entamoebiasis  (IMP)
Eosinophilia  (ISO)
Escherichia Coli Meningitis  (IEP)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO)
eumycotic mycetoma  (IEP)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
extrahepatic cholestasis  (ISO)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
Fungal Eye Infections  (ISO)
Fungal Keratitis  (IMP)
glomerulonephritis  (IDA,IMP)
Hearing Loss  (ISO)
Hemorrhagic Shock  (IMP)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (IMP,ISO)
Hyperalgesia  (IMP,ISO)
hypertension  (ISO)
ileitis  (IMP,ISO)
Inflammation  (ISO)
Insulin Resistance  (IAGP,ISO)
invasive aspergillosis  (ISO)
Kawasaki disease  (ISO)
keratitis  (IEP,IMP,ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (IEP,IMP,ISO)
learning disability  (ISO)
leptospirosis  (IMP)
liver cirrhosis  (ISO)
Liver Injury  (IMP)
Liver Reperfusion Injury  (IEP,IMP,ISO)
low tension glaucoma  (ISO)
lung disease  (IEP,IMP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
mastitis  (ISO)
mastoiditis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (IEP)
meningococcal meningitis  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (ISO)
non-alcoholic fatty liver disease  (IMP,ISO)
obesity  (IAGP,ISO)
Ocular Onchocerciasis  (IMP)
Optic Nerve Injuries  (IEP)
Oral Lichen Planus  (ISO)
otitis media  (IMP,ISO)
Otitis Media with Effusion  (IMP)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
Painful Neuropathy  (IMP)
pancreatitis  (IMP,ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural tuberculosis  (ISO)
Pneumococcal Meningitis  (IEP)
pneumonia  (IMP,ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (IMP,ISO)
psoriasis  (ISO)
pulmonary edema  (IMP)
pulmonary emphysema  (IAGP,IMP)
pulmonary fibrosis  (IMP)
pulmonary hypertension  (IMP)
pulmonary tuberculosis  (ISO)
pulpitis  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (IMP,ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (IMP,ISO)
Retina Reperfusion Injury  (IMP)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IEP,ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
sinusitis  (IMP,ISO)
Spinal Cord Injuries  (IMP)
Spinal Cord Reperfusion Injury  (ISO)
sporotrichosis  (IMP)
Stable Angina  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (IMP)
temporal arteritis  (ISO)
Transplant Rejection  (IMP)
tuberculosis  (IMP)
tympanosclerosis  (ISO)
type 1 diabetes mellitus  (IEP,ISO)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (IMP)
urinary tract infection  (ISO)
uveitis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
viral meningitis  (IEP)
vitiligo  (ISO)
Wallerian Degeneration  (IAGP)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
7alpha-hydroxycholesterol  (ISO)
acetamide  (ISO)
acetate ester  (ISO)
acetic acid  (EXP)
acrolein  (ISO)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
aluminium hydroxide  (EXP)
ammonium chloride  (ISO)
ampicillin  (EXP)
anethole  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
artesunate  (ISO)
aspalathin  (ISO)
astaxanthin  (EXP)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
ATP  (EXP)
auranofin  (EXP)
azathioprine  (EXP)
baicalin  (ISO)
benazepril  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP)
benzylpenicillin  (EXP)
berberine  (EXP,ISO)
Besigomsin  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP,ISO)
boldenone  (ISO)
bortezomib  (ISO)
bosentan  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
casticin  (ISO)
catalpol  (EXP)
cerium trichloride  (EXP)
CGP 52608  (ISO)
chaetoglobosin A  (EXP)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chlorogenic acid  (EXP,ISO)
chloroquine  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP)
chromium atom  (ISO)
chrysin  (ISO)
cirsilineol  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
crocin-1  (ISO)
cudratricusxanthone A  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DAPT  (ISO)
daunorubicin  (EXP)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dienogest  (ISO)
dihydrogen  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
enalaprilat dihydrate  (ISO)
erythromycin A  (EXP)
esculetin  (EXP)
ethanol  (EXP,ISO)
ethion  (EXP)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
ferric oxide  (EXP)
ferulic acid  (EXP)
fisetin  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP,ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
ganglioside GM1  (ISO)
Gastrodin  (ISO)
geldanamycin  (ISO)
genistein  (EXP)
genkwanin  (ISO)
gentamycin  (ISO)
geraniol  (EXP)
Ginkgolide A  (EXP)
ginsenoside Re  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
halothane  (EXP)
helenalin  (EXP)
hexadecanoic acid  (EXP)
hyaluronic acid  (EXP,ISO)
hydrogen cyanide  (EXP)
hydroquinone  (EXP)
ifosfamide  (ISO)
indometacin  (EXP,ISO)
indoprofen  (ISO)
irinotecan  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoamylol  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
ketamine  (EXP)
Kukoamine B  (EXP)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lactulose  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lidocaine  (ISO)
linsidomine  (EXP)
lipophosphoglycan  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (ISO)
liquiritin  (ISO)
lithium chloride  (ISO)
LY294002  (EXP)
lycopene  (ISO)
magnesium dihydroxide  (EXP)
malathion  (EXP)
melatonin  (EXP,ISO)
melittin  (EXP)
melphalan  (ISO)
metformin  (ISO)
methadone  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
Methylthiouracil  (ISO)
metronidazole  (EXP)
monocrotaline  (EXP,ISO)
monodansylcadaverine  (EXP)
morphine  (EXP,ISO)
Morphine-3-glucuronide  (ISO)
Morroniside  (EXP)
muramyl dipeptide  (EXP,ISO)
myrtenol  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naloxone  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
neomycin  (EXP)
nerolidol  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicorandil  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
Nonidet P-40  (ISO)
Nonylphenol  (EXP,ISO)
o-anisidine  (ISO)
obeticholic acid  (EXP)
omeprazole  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylinositol dimannoside  (EXP)
phosphoramide mustard  (ISO)
picropodophyllotoxin  (EXP)
pipoxolan  (EXP)
pirinixic acid  (EXP)
platycodin D  (ISO)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP)
progesterone  (ISO)
propofol  (EXP)
puerarin  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (ISO)
SB 431542  (ISO)
scoparone  (EXP)
scopoletin  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (EXP)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
sumatriptan  (ISO)
tartrazine  (ISO)
tectorigenin  (EXP)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrachloropalladate(2-)  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (EXP)
toluene  (EXP)
trans-anethole  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin D  (EXP,ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IMP)
activation of NF-kappaB-inducing kinase activity  (NAS)
astrocyte development  (IMP)
B cell proliferation  (IMP)
B cell proliferation involved in immune response  (IMP)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (IDA,IMP,ISO,TAS)
cellular response to lipoteichoic acid  (IMP)
cellular response to mechanical stimulus  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IGI,ISO)
cellular response to platelet-derived growth factor stimulus  (IMP)
cellular response to retinoic acid  (ISO)
cellular response to type II interferon  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (IBA,IMP)
detection of lipopolysaccharide  (IDA,ISO,TAS)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
ERK1 and ERK2 cascade  (IDA)
gene expression  (IMP)
I-kappaB kinase/NF-kappaB signaling  (IDA)
I-kappaB phosphorylation  (IMP,ISO)
immune response  (IEA)
immune system process  (IEA)
immunoglobulin mediated immune response  (ISO)
inflammatory response  (IBA,IMP,ISO)
innate immune response  (TAS)
innate immune response-activating signaling pathway  (ISO)
intestinal epithelial structure maintenance  (IMP)
JNK cascade  (IDA,IGI)
leukotriene metabolic process  (ISO)
lipopolysaccharide-mediated signaling pathway  (IDA,IGI,ISO)
lymphocyte proliferation  (IMP)
macrophage activation  (ISO,ISS,TAS)
mast cell activation  (NAS)
MHC class II biosynthetic process  (IMP)
microglia differentiation  (IMP)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (IGI,ISO)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of interleukin-17 production  (IMP)
negative regulation of interleukin-23 production  (IMP)
negative regulation of interleukin-6 production  (IMP)
negative regulation of tumor necrosis factor production  (IMP)
negative regulation of type II interferon production  (IMP)
neurogenesis  (IMP)
nitric oxide biosynthetic process  (IMP)
nitric oxide production involved in inflammatory response  (IMP)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (IDA)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IDA)
phagocytosis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell proliferation  (IMP)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of chemokine production  (IDA,ISO)
positive regulation of cytokine production involved in inflammatory response  (IGI,ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of gene expression  (IGI,IMP,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IDA)
positive regulation of inflammatory response  (IGI,ISO)
positive regulation of interferon-alpha production  (IDA)
positive regulation of interferon-beta production  (IDA,IMP)
positive regulation of interleukin-1 beta production  (IDA,ISO)
positive regulation of interleukin-1 production  (IDA,NAS)
positive regulation of interleukin-10 production  (IDA)
positive regulation of interleukin-12 production  (IDA,ISO)
positive regulation of interleukin-13 production  (NAS)
positive regulation of interleukin-6 production  (IDA,IMP,ISO,NAS)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (IDA,IGI)
positive regulation of lymphocyte proliferation  (IMP)
positive regulation of macrophage activation  (IGI)
positive regulation of macrophage cytokine production  (IDA,IMP)
positive regulation of MAP kinase activity  (IMP)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of MHC class II biosynthetic process  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP,ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric oxide biosynthetic process  (IGI,IMP)
positive regulation of nitric-oxide synthase biosynthetic process  (IDA)
positive regulation of NLRP3 inflammasome complex assembly  (IDA)
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (IDA)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IDA)
positive regulation of oxidative stress-induced neuron death  (IGI)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of platelet activation  (IMP)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of stress-activated MAPK cascade  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of tumor necrosis factor production  (IDA,IMP,ISO)
positive regulation of type II interferon production  (IMP)
regulation of dendritic cell cytokine production  (IDA)
regulation of inflammatory response  (IMP)
regulation of sensory perception of pain  (ISO)
regulation of tumor necrosis factor production  (ISO)
response to activity  (ISO)
response to bacterium  (IMP)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to gold nanoparticle  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (IGI,IMP,ISO)
response to morphine  (ISO)
response to oxidative stress  (ISO)
response to progesterone  (ISO)
response to retinoic acid  (ISO)
response to toxic substance  (ISO)
signal transduction  (IEA)
skeletal muscle contraction  (ISO)
stress-activated MAPK cascade  (IDA)
toll-like receptor 4 signaling pathway  (IDA)
toll-like receptor signaling pathway  (IBA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (IGI)
wound healing involved in inflammatory response  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute inflammation  (IAGP)
abnormal airway responsiveness  (IAGP)
abnormal artery morphology  (IAGP)
abnormal bile salt level  (IAGP)
abnormal bone structure  (IAGP)
abnormal cecum morphology  (IEA)
abnormal chemokine secretion  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating leptin level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal enterocyte differentiation  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal fatty acids level  (IAGP)
abnormal fibroblast proliferation  (IAGP)
abnormal gas homeostasis  (IAGP)
abnormal glial cell apoptosis  (IAGP)
abnormal glial cell physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal granulocyte physiology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal immune cell physiology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interleukin level  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal level of surface class II molecules  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver physiology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal lung interstitium morphology  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal muscle cell glucose uptake  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal nephron morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal phagocyte morphology  (IAGP)
abnormal proximal convoluted tubule brush border morphology  (IAGP)
abnormal pulmonary alveolar duct morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal pulmonary elastic fiber morphology  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal respiratory system morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal retina layer morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina progenitor cell morphology  (IAGP)
abnormal retina rod bipolar cell morphology  (IAGP)
abnormal retina rod cell morphology  (IAGP)
abnormal spleen weight  (IAGP)
abnormal susceptibility to atherosclerosis  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal uterus morphology  (IEA)
abnormal vascular wound healing  (IAGP)
atherosclerotic lesions  (IAGP)
brain ischemia  (IAGP)
cellular necrosis  (IEA)
colitis  (IAGP)
decreased acute inflammation  (IAGP)
decreased angiogenesis  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased colon length  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased eye pigmentation  (IEA)
decreased fat cell size  (IAGP)
decreased hemoglobin content  (IAGP)
decreased hepatocyte apoptosis  (IAGP)
decreased IgG3 level  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased interferon-beta secretion  (IEA)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-1 beta secretion  (IEA)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased macrophage apoptosis  (IEA)
decreased macrophage cytokine production  (IEA)
decreased memory B cell number  (IEA)
decreased neuron apoptosis  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased respiratory quotient  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bone fracture  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to ischemic brain injury  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased susceptibility to Orthomyxoviridae infection  (IAGP)
decreased susceptibility to weight loss  (IAGP)
decreased tail pigmentation  (IEA)
decreased tumor necrosis factor secretion  (IAGP)
dilated pulmonary alveolar duct  (IAGP)
dilated renal tubule  (IAGP)
diluted coat color  (IEA)
enlarged cecum  (IEA)
enlarged lung  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged uterus  (IEA)
focal hepatic necrosis  (IAGP)
hyperoxia  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
improved glucose tolerance  (IAGP)
increased adiponectin level  (IAGP)
increased apoptosis  (IAGP)
increased B-1 B cell number  (IAGP)
increased bone mass  (IAGP)
increased bone mineral content  (IAGP)
increased bone mineral density  (IAGP)
increased cell death  (IEA)
increased circulating interleukin-6 level  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased lung compliance  (IAGP)
increased oxygen consumption  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to Poxviridae infection induced morbidity/mortality  (IAGP)
increased thermal nociceptive threshold  (IAGP)
large intestinal inflammation  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
no abnormal phenotype detected  (IEA)
polyphagia  (IAGP)
pulmonary edema  (IAGP)
rectal hemorrhage  (IAGP)
renal cast  (IAGP)
renal tubular necrosis  (IAGP)
References

References - curated
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72. Association of TLR4 polymorphisms with Behcet's disease in a Korean population. Horie Y, etal., Rheumatology (Oxford). 2009 Jun;48(6):638-42. doi: 10.1093/rheumatology/kep077. Epub 2009 Apr 24.
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74. Potential role of macrophages in experimental keratomycosis. Hu J, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2087-94. doi: 10.1167/iovs.07-1237. Epub 2008 Dec 13.
75. Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury. Hua J, etal., J Gastroenterol Hepatol. 2007 Jun;22(6):862-9. doi: 10.1111/j.1440-1746.2007.04896.x. Epub 2007 May 17.
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78. Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: a case-control analysis. Hussein YM, etal., Cell Immunol. 2012;274(1-2):34-8. doi: 10.1016/j.cellimm.2012.02.006. Epub 2012 Feb 17.
79. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Hutchinson MR, etal., Eur J Neurosci. 2008 Jul;28(1):20-9.
80. The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome. Illig T, etal., Diabetes. 2003 Nov;52(11):2861-4.
81. Role of Toll like receptor 4 signaling pathway in the secondary damage induced by experimental spinal cord injury. Impellizzeri D, etal., Immunobiology. 2015 Sep;220(9):1039-49. doi: 10.1016/j.imbio.2015.05.013. Epub 2015 May 11.
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83. Expression of Toll-Like Receptors 2, 4 and Nuclear Factor Kappa B in Mucosal Lesions of Human Otitis: Pattern and Relationship in a Clinical Immunohistochemical Study. Jesic S, etal., Ann Otol Rhinol Laryngol. 2014 Apr 1.
84. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Jeyaseelan S, etal., Infect Immun. 2005 Mar;73(3):1754-63.
85. Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease. Jia L, etal., Mol Metab. 2018 Aug;14:121-129. doi: 10.1016/j.molmet.2018.05.015. Epub 2018 May 23.
86. Inhibition of Toll-like receptor 4 with vasoactive intestinal peptide attenuates liver ischemia-reperfusion injury. Jiang W, etal., Transplant Proc. 2011 Jun;43(5):1462-7.
87. A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population. Jiang ZC, etal., Tumour Biol. 2014 Dec;35(12):12345-52. doi: 10.1007/s13277-014-2547-z. Epub 2014 Sep 2.
88. Activation of Toll-like receptors 2 and 4 in Aspergillus fumigatus keratitis. Jie Zhao, etal., Innate Immun. 2009 Jun;15(3):155-68.
89. Expression of toll-like receptors in the healthy and herpes simplex virus-infected cornea. Jin X, etal., Cornea. 2007 Aug;26(7):847-52.
90. Expression of toll-like receptors in the Fusarium solani infected cornea. Jin X, etal., Curr Eye Res. 2008 Apr;33(4):319-24. doi: 10.1080/02713680802008238.
91. The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection. Jin X, etal., Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):231-8. doi: 10.1007/s10096-009-0844-z. Epub 2009 Dec 13.
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93. Identification of polymorphisms in the Toll-like receptor gene and the association with allergic rhinitis. Kang I, etal., Eur Arch Otorhinolaryngol. 2010 Mar;267(3):385-9. Epub 2009 Sep 18.
94. TLR2 and TLR4 gene polymorphisms in Turkish vitiligo patients. Karaca N, etal., J Eur Acad Dermatol Venereol. 2013 Jan;27(1):e85-90. doi: 10.1111/j.1468-3083.2012.04514.x. Epub 2012 Mar 16.
95. Enhanced TLR4 endothelial cell immunohistochemical expression in symptomatic carotid atherosclerotic plaques. Katsargyris A, etal., Expert Opin Ther Targets. 2010 Jan;14(1):1-10. doi: 10.1517/14728220903401294.
96. Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Kerkhof M, etal., Thorax. 2010 Aug;65(8):690-7.
97. Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. Kim GT, etal., Clin Rheumatol. 2010 Mar;29(3):273-9. doi: 10.1007/s10067-009-1316-7. Epub 2009 Dec 2.
98. Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulating toll-like receptor recruitment into lipid rafts. Kim K, etal., Clin Nutr. 2013 Oct;32(5):855-62. doi: 10.1016/j.clnu.2012.11.026. Epub 2013 Jan 23.
99. Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia? Kim YM, etal., Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):921-7.
100. Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease. Kirino Y, etal., Arthritis Res Ther. 2008;10(1):R16. doi: 10.1186/ar2367. Epub 2008 Jan 31.
101. Expression of Toll-like receptor 4 in various organs in rats with D-galactosamine-induced acute hepatic failure. Kitazawa T, etal., J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e494-8. Epub 2007 Dec 7.
102. Salvage effect of E5564, Toll-like receptor 4 antagonist on d-galactosamine and lipopolysaccharide-induced acute liver failure in rats. Kitazawa T, etal., J Gastroenterol Hepatol. 2010 May;25(5):1009-12. doi: 10.1111/j.1440-1746.2009.06145.x.
103. Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia. Knapp S, etal., Am J Respir Crit Care Med. 2006 Jan 1;173(1):122-9. Epub 2005 Oct 6.
104. Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation. Koc M, etal., Nephrol Dial Transplant. 2011 Mar;26(3):955-63. doi: 10.1093/ndt/gfq500. Epub 2010 Aug 20.
105. Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes. Kolek MJ, etal., Am Heart J. 2004 Dec;148(6):1034-40.
106. TLR2 and TLR4 polymorphisms are not associated with acne vulgaris. Koreck A, etal., Dermatology. 2006;213(3):267-9.
107. Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. Kuang X, etal., Eur J Pharmacol. 2012 Feb 15;676(1-3):51-6. doi: 10.1016/j.ejphar.2011.11.037. Epub 2011 Dec 7.
108. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
109. TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. Kwok YH, etal., PLoS One. 2013 Oct 30;8(10):e77799. doi: 10.1371/journal.pone.0077799. eCollection 2013.
110. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus. Lartigue A, etal., J Immunol. 2009 Nov 15;183(10):6207-16. doi: 10.4049/jimmunol.0803219. Epub 2009 Oct 19.
111. TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis. Lauriello M, etal., Int J Otolaryngol. 2012;2012:925164. doi: 10.1155/2012/925164. Epub 2012 Apr 10.
112. Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis. Leal SM Jr, etal., PLoS Pathog. 2010 Jul 1;6:e1000976. doi: 10.1371/journal.ppat.1000976.
113. TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Leichtle A, etal., Innate Immun. 2009 Aug;15(4):205-15. doi: 10.1177/1753425909103170. Epub 2009 Jul 8.
114. [Polymorphism 896A/G of TLR4 gene rather than 1196C/T and 2258G/A of TLR2 gene determines severe and complicated course of atopic dermatitis in children]. Levchenko LIu, etal., Tsitol Genet. 2013 May-Jun;47(3):46-53.
115. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Li C, etal., Cardiovasc Res 2004 Feb 15;61(3):538-47.
116. Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. Li DQ, etal., J Allergy Clin Immunol. 2011 Dec;128(6):1318-1325.e2. doi: 10.1016/j.jaci.2011.06.041. Epub 2011 Aug 6.
117. Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice. Li H, etal., Anesthesiology. 2010 Sep;113(3):619-29.
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119. Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats. Li X, etal., Inflamm Res. 2013 Jul;62(7):703-9. doi: 10.1007/s00011-013-0624-1. Epub 2013 Apr 17.
120. Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways. Li X, etal., Toxicol Lett. 2016 Nov 2;261:1-12. doi: 10.1016/j.toxlet.2016.09.002. Epub 2016 Sep 4.
121. Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord. Li XQ, etal., PLoS One. 2016 Oct 19;11(10):e0163807. doi: 10.1371/journal.pone.0163807. eCollection 2016.
122. Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells. Lim SW, etal., Transplantation. 2005 Sep 15;80(5):691-9.
123. Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy. Lin M, etal., J Am Soc Nephrol. 2012 Jan;23(1):86-102. doi: 10.1681/ASN.2010111210. Epub 2011 Oct 21.
124. HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion in rat. Liu A, etal., Histochem Cell Biol. 2011 May;135(5):443-52. doi: 10.1007/s00418-011-0802-6. Epub 2011 Mar 24.
125. Changes in gut toll-like receptor-4 and nod-like receptor family pyrin domain containing-3 innate pathways in liver cirrhosis rats with bacterial translocation. Liu L, etal., Clin Res Hepatol Gastroenterol. 2016 Nov;40(5):575-583. doi: 10.1016/j.clinre.2016.02.008. Epub 2016 Apr 6.
126. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
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128. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Lubbad A, etal., Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11.
129. Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma. Lun SW, etal., J Clin Immunol. 2009 May;29(3):330-42. Epub 2008 Dec 6.
130. Evaluation of importance of Toll-like receptor 4 in acute Streptococcus pneumoniae sinusitis in mice. Luxameechanporn T, etal., Arch Otolaryngol Head Neck Surg. 2005 Nov;131(11):1001-6.
131. Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage. Ma CX, etal., Chin Med J (Engl). 2009 Jul 5;122(13):1575-81.
132. The innate immune response to Entamoeba histolytica lipopeptidophosphoglycan is mediated by toll-like receptors 2 and 4. Maldonado-Bernal C, etal., Parasite Immunol. 2005 Apr;27(4):127-37.
133. Comparison of Cellular Uptake and Inflammatory Response via Toll-Like Receptor 4 to Lipopolysaccharide and Titanium Dioxide Nanoparticles. Mano SS, etal., Int J Mol Sci. 2013 Jun 26;14(7):13154-70. doi: 10.3390/ijms140713154.
134. Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity. Martin SF, etal., J Exp Med. 2008 Sep 1;205(9):2151-62. doi: 10.1084/jem.20070509. Epub 2008 Aug 25.
135. Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease. Meguro A, etal., Ann Rheum Dis. 2008 May;67(5):725-7. doi: 10.1136/ard.2007.079871.
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137. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
138. MGDs mouse GO annotations MGD data from the GO Consortium
139. MGD IEA MGD IEA
140. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. Milanski M, etal., J Neurosci. 2009 Jan 14;29(2):359-70.
141. In situ TLR2 and TLR4 expression in a murine model of mycetoma caused by Nocardia brasiliensis. Millan-Chiu BE, etal., FEMS Immunol Med Microbiol. 2011 Apr;61(3):278-87. doi: 10.1111/j.1574-695X.2010.00775.x. Epub 2011 Jan 31.
142. Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma. Minmin S, etal., PLoS One. 2011 Apr 29;6(4):e19466. doi: 10.1371/journal.pone.0019466.
143. Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease. Minoretti P, etal., Neurosci Lett. 2006 Jan 2;391(3):147-9. Epub 2005 Sep 12.
144. Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse. Mohammad MK, etal., Int Immunol. 2006 Jul;18(7):1101-13. Epub 2006 May 25.
145. Respiratory syncytial virus activates innate immunity through Toll-like receptor 2. Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19.
146. Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence susceptibility and severity of pulmonary tuberculosis in the Asian Indian population. Najmi N, etal., Tissue Antigens. 2010 Aug;76(2):102-9. Epub 2010 Apr 8.
147. Involvement of innate immunity in the pathogenesis of intestinal Behcet's disease. Nara K, etal., Clin Exp Immunol. 2008 May;152(2):245-51. doi: 10.1111/j.1365-2249.2008.03626.x. Epub 2008 Mar 10.
148. Toll-like receptor 4 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation. Ohara K, etal., J Neuroinflammation. 2013 Nov 23;10:139. doi: 10.1186/1742-2094-10-139.
149. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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153. Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohn's disease and murine colitis. Pasternak BA, etal., Inflamm Bowel Dis. 2010 May;16(5):856-69. doi: 10.1002/ibd.21132.
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155. Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Paun A, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1198-205.
156. Deletion of toll-like receptor-4 downregulates protein kinase C-zeta and attenuates liver injury in experimental pancreatitis. Peng Y, etal., Surgery. 2008 May;143(5):679-85. doi: 10.1016/j.surg.2008.01.005.
157. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
158. C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Poggi M, etal., Diabetologia. 2007 Apr 11;.
159. TLR2 and TLR4 expression on the immune cells of tuberculous pleural fluid. Prabha C, etal., Immunol Lett. 2008 Apr 15;117(1):26-34. Epub 2007 Dec 3.
160. TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease. Puthothu B, etal., Dis Markers. 2006;22(5-6):303-8.
161. Toll-like receptor expression and activation in mice with experimental dry eye. Redfern RL, etal., Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1554-63. doi: 10.1167/iovs.12-10739.
162. Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia. Reismann P, etal., J Neurol. 2004 Jul;251(7):853-8.
163. Toll-like receptor 4 signalling pathway activation in a rat model of Acanthamoeba Keratitis. Ren MY and Wu XY, Parasite Immunol. 2011 Jan;33(1):25-33. doi: 10.1111/j.1365-3024.2010.01247.x.
164. Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Reyna SM, etal., Diabetes. 2008 Oct;57(10):2595-602. Epub 2008 Jul 15.
165. Mouse MP Annotation Import Pipeline RGD automated import pipeline
166. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
167. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
168. Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis. Rojo-Botello NR, etal., J Periodontal Res. 2012 Feb;47(1):62-73. doi: 10.1111/j.1600-0765.2011.01405.x. Epub 2011 Aug 17.
169. CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis. Rosas-Taraco AG, etal., J Infect Dis. 2007 Dec 1;196(11):1698-706. Epub 2007 Oct 25.
170. Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. Rudofsky G Jr, etal., Diabetes Care. 2004 Jan;27(1):179-83.
171. Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury. Rusai K, etal., Pediatr Nephrol. 2010 May;25(5):853-60. doi: 10.1007/s00467-009-1422-4. Epub 2010 Feb 4.
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173. Single-nucleotide polymorphism of Toll-like receptor 4 and interleukin-10 in response to interferon-based therapy in Egyptian chronic hepatitis C patients. Sadik NA, etal., Arch Virol. 2015 Sep;160(9):2181-95. doi: 10.1007/s00705-015-2493-0. Epub 2015 Jun 23.
174. The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Saint Andre Av, etal., Science. 2002 Mar 8;295(5561):1892-5.
175. Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis. Sarangi PP, etal., J Virol. 2007 Oct;81(20):11128-38. Epub 2007 Aug 8.
176. The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. Saraswathy S, etal., Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3680-6. doi: 10.1167/iovs.09-4575. Epub 2010 Mar 5.
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178. Expression of toll-like receptor 2 and 4 in intestinal mucosa in experimental severe acute pancreatitis. Sawa H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2247-51.
179. Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Schmidt M, etal., Nat Immunol. 2010 Sep;11(9):814-9. doi: 10.1038/ni.1919. Epub 2010 Aug 15.
180. Association of polymorphisms of toll-like receptor 4 with a reduced prevalence of hay fever and atopy. Senthilselvan A, etal., Ann Allergy Asthma Immunol. 2008 May;100(5):463-8.
181. Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression. Shah N, etal., J Hepatol. 2012 May;56(5):1047-53. Epub 2012 Jan 17.
182. TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. Shan JY, etal., Parasite Immunol. 2011 Dec;33(12):692-6. doi: 10.1111/j.1365-3024.2011.01335.x.
183. Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice. Sharif R, etal., Gut. 2009 Jun;58(6):813-9. Epub 2009 Feb 6.
184. TLR4 links innate immunity and fatty acid-induced insulin resistance. Shi H, etal., J Clin Invest. 2006 Nov;116(11):3015-25. Epub 2006 Oct 19.
185. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
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187. Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis. Shirai Y, etal., J Gastroenterol Hepatol. 2013 Apr;28(4):723-30. doi: 10.1111/jgh.12112.
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189. Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage. Silva MA, etal., Inflamm Bowel Dis. 2008 May;14(5):632-44.
190. Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients. Singh K, etal., Biomed Res Int. 2013;2013:318686. doi: 10.1155/2013/318686. Epub 2013 Jul 11.
191. TLR4 and TLR9 are induced in oral lichen planus. Siponen M, etal., J Oral Pathol Med. 2012 Nov;41(10):741-7. doi: 10.1111/j.1600-0714.2012.01169.x. Epub 2012 Jun 5.
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193. TLR2 and TLR4 polymorphisms in familial Mediterranean fever. Speletas M, etal., Hum Immunol. 2009 Sep;70(9):750-3. doi: 10.1016/j.humimm.2009.05.004. Epub 2009 May 13.
194. Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4. Sturges NC, etal., Pediatr Pulmonol. 2010 Sep;45(9):883-9.
195. Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population. Suh W, etal., Mol Vis. 2011;17:2343-8. Epub 2011 Aug 31.
196. Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Summers SA, etal., Kidney Int. 2010 Sep 15.
197. Biofilm formation and Toll-like receptor 2, Toll-like receptor 4, and NF-kappaB expression in sinus tissues of patients with chronic rhinosinusitis. Sun Y, etal., Am J Rhinol Allergy. 2012 Mar-Apr;26(2):104-9. doi: 10.2500/ajra.2012.26.3718. Epub 2011 Dec 16.
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199. Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma. Takano Y, etal., Am J Ophthalmol. 2012 Nov;154(5):825-832.e1. doi: 10.1016/j.ajo.2012.03.050. Epub 2012 Jul 24.
200. Oral administration of xanthan gum enhances antitumor activity through Toll-like receptor 4. Takeuchi A, etal., Int Immunopharmacol. 2009 Dec;9(13-14):1562-7. doi: 10.1016/j.intimp.2009.09.012. Epub 2009 Sep 27.
201. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Tanga FY, etal., Neurochem Int 2004 Jul-Aug;45(2-3):397-407.
202. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Tanga FY, etal., Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5856-61. Epub 2005 Apr 4.
203. Effects of antibiotics on expression and function of Toll-like receptors 2 and 4 on mononuclear cells in patients with advanced cirrhosis. Testro AG, etal., J Hepatol. 2010 Feb;52(2):199-205. doi: 10.1016/j.jhep.2009.11.006. Epub 2009 Dec 16.
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205. Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients. Tittarelli A, etal., Cancer Immunol Immunother. 2012 Nov;61(11):2067-77. doi: 10.1007/s00262-012-1268-7. Epub 2012 May 3.
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207. Modulation of immune signaling, bacterial clearance, and corneal integrity by toll-like receptors during streptococcus pneumoniae keratitis. Tullos NA, etal., Curr Eye Res. 2013 Oct;38(10):1036-48. doi: 10.3109/02713683.2013.804094. Epub 2013 Jul 10.
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209. Synergistic effect of Toll-like receptor 4 and CD14 polymorphisms on the total atherosclerosis burden in patients with peripheral arterial disease. Vainas T, etal., J Vasc Surg. 2006 Aug;44(2):326-32.
210. Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis. van Well GT, etal., PLoS One. 2012;7(5):e35837. doi: 10.1371/journal.pone.0035837. Epub 2012 May 25.
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212. NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. Velez DR, etal., Hum Genet. 2009 Nov;126(5):643-53. Epub 2009 Jul 3.
213. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Viriyakosol S, etal., Infect Immun. 2006 Feb;74(2):887-95.
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Additional References at PubMed
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