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Gene: Cd40lg (CD40 ligand) Mus musculus
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Symbol: Cd40lg
Name: CD40 ligand
Description: Predicted to have CD40 receptor binding activity and integrin binding activity. Involved in B cell activation; immunoglobulin secretion; and regulation of immunoglobulin secretion. Localizes to external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Used to study inflammatory bowel disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune hypersensitivity disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand); PARTICIPATES IN obesity pathway; interleukin-4 signaling pathway; allograft rejection pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ADP; asperentin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD154; CD40-L; Cd40l; gp39; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; T-cell antigen Gp39; TNF-related activation protein; Tnfsf5; Tnlg8b; TRAP; tumor necrosis factor (ligand) superfamily, member 5; tumor necrosis factor ligand 8b; tumor necrosis factor ligand superfamily member 5
Orthologs:
Homo sapiens (human) : CD40LG (CD40 ligand)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd40lg (CD40 ligand)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd40lg (CD40 ligand)
Pan paniscus (bonobo/pygmy chimpanzee) : CD40LG (CD40 ligand)
Canis lupus familiaris (dog) : CD40LG (CD40 ligand)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd40lg (CD40 ligand)
Sus scrofa (pig) : CD40LG (CD40 ligand)
Chlorocebus sabaeus (African green monkey) : CD40LG (CD40 ligand)
Heterocephalus glaber (naked mole-rat) : Cd40lg (CD40 ligand)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 EnsemblX57,212,143 - 57,224,042 (+)EnsemblGRCm38mm10GRCm38
GRCm38X57,212,143 - 57,224,042 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X54,465,320 - 54,477,219 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X53,558,927 - 53,570,826 (+)NCBImm8
CeleraX43,689,623 - 43,701,548 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX31.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cd40lg
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1615151
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.