Cd40lg (CD40 ligand) - Rat Genome Database

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Gene: Cd40lg (CD40 ligand) Mus musculus
Analyze
Symbol: Cd40lg
Name: CD40 ligand
RGD ID: 1615151
MGI Page MGI
Description: Predicted to enable CD40 receptor binding activity; integrin binding activity; and protein serine/threonine kinase activator activity. Involved in isotype switching. Acts upstream of or within B cell differentiation and regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Used to study inflammatory bowel disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD154; Cd40; CD40-L; Cd40l; gp3; gp39; HIGM; HIGM1; IGM; IMD; IMD3; Ly-6; Ly-62; Ly62; T-BA; T-BAM; T-cell antigen Gp39; TNF-related activation protein; Tnfs; Tnfsf5; Tnlg8b; TRAP; tumor necrosis factor (ligand) superfamily, member 5; tumor necrosis factor ligand 8b; tumor necrosis factor ligand superfamily member 5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X56,257,503 - 56,269,402 (+)NCBIGRCm39mm39
GRCm39 EnsemblX56,257,503 - 56,269,402 (+)Ensembl
GRCm38X57,212,143 - 57,224,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,212,143 - 57,224,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X54,465,320 - 54,477,219 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X53,558,927 - 53,570,826 (+)NCBImm8
CeleraX43,689,623 - 43,701,548 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX31.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (IMP)
Acute Coronary Syndrome  (ISO)
acute lymphoblastic leukemia  (IMP)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (IMP,ISO)
anti-basement membrane glomerulonephritis  (ISO)
antiphospholipid syndrome  (ISO)
aplastic anemia  (ISO)
asthma  (IMP)
atherosclerosis  (IMP,ISO)
autistic disorder  (ISO)
autoimmune disease  (IMP,ISO)
autoimmune thrombocytopenic purpura  (IEP,ISO)
B-Cell Chronic Lymphocytic Leukemia  (IMP)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
calcification of aortic valve  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
CD40 ligand deficiency  (IDA,ISO)
Cholangiofibrosis  (ISO)
Chromosome Breakage  (ISO)
Chromosome Xq26.3 Duplication Syndrome  (ISO)
Chronic Allograft Dysfunction  (ISO)
chronic lymphocytic leukemia  (ISO)
Colonic Neoplasms  (IMP)
combined T cell and B cell immunodeficiency  (ISO)
common variable immunodeficiency  (ISO)
Congenital Heart Defects, Multiple Types, 1, X-Linked  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
crescentic glomerulonephritis  (IMP)
cutaneous lupus erythematosus  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
Discoid Lupus Erythematosus  (ISO)
dysgammaglobulinemia  (ISO)
Ehrlich tumor carcinoma  (ISO)
end stage renal disease  (ISO)
eosinophilic esophagitis  (ISO)
erythema multiforme  (ISO)
essential thrombocythemia  (ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveoretinitis  (IMP)
Experimental Diabetes Mellitus  (IMP,ISO)
Experimental Liver Neoplasms  (IMP)
factor VIII deficiency  (IMP)
familial hyperlipidemia  (ISO)
Fibrosis  (IMP)
follicular lymphoma  (ISO)
genetic disease  (ISO)
Graft vs Host Disease  (IMP)
granulomatosis with polyangiitis  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
HELLP syndrome  (ISO)
hepatocellular carcinoma  (IMP)
herpes simplex  (IMP)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hyper IgM syndrome  (ISO)
Hypercholesterolemia  (ISO)
inflammatory bowel disease  (IEA)
Kawasaki disease  (ISO)
kidney disease  (IMP)
lichen planus  (ISO)
lupus nephritis  (IDA,IMP,ISO)
Lyme Neuroborreliosis  (ISO)
malaria  (IMP)
membranous glomerulonephritis  (IMP)
Metabolic Syndrome  (ISO)
Middle East respiratory syndrome  (IMP)
migraine  (ISO)
multiple myeloma  (IMP,ISO)
Murine Acquired Immunodeficiency Syndrome  (IMP)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
narcolepsy  (ISO)
Necrosis  (ISO)
nephrosis  (IMP)
obesity  (IMP,ISO)
ovarian disease  (IMP)
Ovarian Neoplasms  (IMP)
Overactive Urinary Bladder  (ISO)
pemphigus  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontal disease  (ISO)
periodontitis  (ISO)
peritonitis  (IEP)
pneumonia  (ISO)
pre-eclampsia  (ISO)
Primary Graft Dysfunction  (IMP)
pulmonary hypertension  (ISO)
Reperfusion Injury  (IMP,ISO)
Sepsis  (ISO)
Shock  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
Subacute Combined Degeneration  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
systemic lupus erythematosus  (IEA,IMP,ISO)
thrombocytopenia  (IMP)
thrombosis  (IMP,ISO)
tick-borne encephalitis  (ISO)
transient cerebral ischemia  (IMP)
Transplant Rejection  (IMP,ISO)
type 1 diabetes mellitus  (IDA,IMP,ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (IDA)
Vascular Calcification  (ISO)
Viral Myocarditis  (IDA,IMP,ISO)
visceral leishmaniasis  (IMP)
vitamin B12 deficiency  (ISO)
Wounds, Penetrating  (ISO)
X-linked hyper IgM syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
4-aminopyridine  (ISO)
5-fluorouracil  (ISO)
acetylsalicylic acid  (ISO)
ADP  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asperentin  (EXP)
atorvastatin calcium  (ISO)
barium sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
calcitriol  (ISO)
candesartan  (ISO)
carbon atom  (ISO)
ceric oxide  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
cisplatin  (EXP,ISO)
clopidogrel  (EXP,ISO)
curcumin  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (ISO)
elemental carbon  (ISO)
eptifibatide  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenofibrate  (ISO)
fingolimod hydrochloride  (ISO)
furan  (ISO)
Fusarenone X  (EXP)
gemcitabine  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
heparin  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
hydroxysafflor yellow A  (ISO)
ionomycin  (EXP)
isoflurane  (ISO)
lipopolysaccharide  (EXP)
medroxyprogesterone acetate  (ISO)
metformin  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N-acetyl-L-cysteine  (ISO)
neoechinulin A  (EXP)
nickel dichloride  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
pentobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sterigmatocystin  (EXP)
titanium dioxide  (EXP)
vemurafenib  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vinorelbine  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adaptive immunity  (IAGP)
abnormal antigen presentation  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal leukocyte adhesion  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal T cell clonal deletion  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal thrombosis  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
absent lymph node germinal center  (IAGP)
absent spleen germinal center  (IAGP)
alopecia  (IAGP)
amyloid beta deposits  (IAGP)
decreased autoantibody level  (IAGP)
decreased bone mineral density  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased compact bone mass  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgD level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased platelet aggregation  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased trabecular bone mass  (IAGP)
extended life span  (IAGP)
gliosis  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased bleeding time  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased IgG1 level  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to prion infection  (IAGP)
insulitis  (IAGP)
loss of cortex neurons  (IAGP)
lymph node hypoplasia  (IAGP)
microgliosis  (IAGP)
neurodegeneration  (IAGP)
skin lesions  (IAGP)
spongiform encephalopathy  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
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Additional References at PubMed
PMID:1374165   PMID:1377364   PMID:7514269   PMID:7517359   PMID:7517360   PMID:7520529   PMID:7521888   PMID:7529792   PMID:7529804   PMID:7541819   PMID:7542547   PMID:7615003  
PMID:7679801   PMID:7882172   PMID:7889406   PMID:7896266   PMID:7964465   PMID:8095800   PMID:8387892   PMID:8524395   PMID:8566008   PMID:8624816   PMID:8642323   PMID:8671613  
PMID:8683147   PMID:8790420   PMID:8791591   PMID:8791592   PMID:8943044   PMID:9190112   PMID:9379059   PMID:9498737   PMID:9530638   PMID:9547342   PMID:9560254   PMID:9671306  
PMID:9725199   PMID:9794385   PMID:9809548   PMID:9820506   PMID:9973382   PMID:9973457   PMID:10049949   PMID:10078224   PMID:10201970   PMID:10229827   PMID:10395655   PMID:10452982  
PMID:10477587   PMID:10477604   PMID:10528187   PMID:10544199   PMID:10546000   PMID:10583962   PMID:10590269   PMID:10623811   PMID:10637268   PMID:10673339   PMID:10678943   PMID:10678956  
PMID:10725727   PMID:10768958   PMID:10779746   PMID:10839815   PMID:10841521   PMID:10878373   PMID:10933709   PMID:10975872   PMID:10982766   PMID:11058568   PMID:11059686   PMID:11120867  
PMID:11147700   PMID:11160193   PMID:11160289   PMID:11178743   PMID:11207256   PMID:11207274   PMID:11230105   PMID:11239407   PMID:11342622   PMID:11403253   PMID:11466399   PMID:11698463  
PMID:11777943   PMID:11786400   PMID:11801637   PMID:11826760   PMID:11875009   PMID:11875495   PMID:11884443   PMID:11884445   PMID:11908941   PMID:11911825   PMID:11937525   PMID:11971013  
PMID:11981834   PMID:12036894   PMID:12049723   PMID:12067295   PMID:12096029   PMID:12099378   PMID:12111122   PMID:12147624   PMID:12177608   PMID:12208883   PMID:12370407   PMID:12391193  
PMID:12391201   PMID:12402041   PMID:12409507   PMID:12466851   PMID:12477932   PMID:12517934   PMID:12518444   PMID:12538659   PMID:12574376   PMID:12616498   PMID:12626529   PMID:12626556  
PMID:12829028   PMID:12860530   PMID:12871426   PMID:12871635   PMID:12874234   PMID:12946709   PMID:12958312   PMID:14500690   PMID:14607913   PMID:14627918   PMID:14634078   PMID:14647274  
PMID:14670300   PMID:14670304   PMID:14734751   PMID:15004136   PMID:15067060   PMID:15071493   PMID:15100283   PMID:15192149   PMID:15197224   PMID:15210777   PMID:15240715   PMID:15273748  
PMID:15294959   PMID:15308470   PMID:15320895   PMID:15340048   PMID:15356109   PMID:15356158   PMID:15379979   PMID:15466914   PMID:15467837   PMID:15485634   PMID:15494542   PMID:15633212  
PMID:15650212   PMID:15677502   PMID:15746436   PMID:15880047   PMID:15882983   PMID:15885854   PMID:15899982   PMID:15904977   PMID:15956287   PMID:16116198   PMID:16141403   PMID:16148169  
PMID:16172156   PMID:16213477   PMID:16272340   PMID:16291659   PMID:16365443   PMID:16365447   PMID:16369024   PMID:16380473   PMID:16402409   PMID:16424212   PMID:16470176   PMID:16493029  
PMID:16498500   PMID:16546101   PMID:16549596   PMID:16622023   PMID:16686755   PMID:16715101   PMID:16756565   PMID:16783845   PMID:16815973   PMID:16858289   PMID:16896157   PMID:16909433  
PMID:16920960   PMID:16936731   PMID:16966493   PMID:17043144   PMID:17062001   PMID:17082576   PMID:17082577   PMID:17163452   PMID:17202317   PMID:17220318   PMID:17237425   PMID:17277108  
PMID:17277123   PMID:17312128   PMID:17314081   PMID:17324402   PMID:17360404   PMID:17372166   PMID:17442938   PMID:17452522   PMID:17475847   PMID:17485453   PMID:17595332   PMID:17626103  
PMID:17626150   PMID:17668901   PMID:17705136   PMID:17712049   PMID:17804565   PMID:17827394   PMID:17964667   PMID:17982059   PMID:18055209   PMID:18097035   PMID:18180380   PMID:18184798  
PMID:18195092   PMID:18198277   PMID:18198347   PMID:18250437   PMID:18256321   PMID:18292503   PMID:18322171   PMID:18328742   PMID:18349125   PMID:18467653   PMID:18523272   PMID:18550809  
PMID:18600823   PMID:18606155   PMID:18640985   PMID:18641297   PMID:18680714   PMID:18768854   PMID:18768857   PMID:18778362   PMID:18799149   PMID:19017930   PMID:19033672   PMID:19077898  
PMID:19109169   PMID:19112095   PMID:19136631   PMID:19139082   PMID:19200758   PMID:19282242   PMID:19380637   PMID:19398542   PMID:19546834   PMID:19572319   PMID:19596991   PMID:19667096  
PMID:19670423   PMID:19841180   PMID:19890051   PMID:19950697   PMID:19952354   PMID:20010627   PMID:20021479   PMID:20048211   PMID:20133813   PMID:20525887   PMID:20691615   PMID:20811042  
PMID:20861360   PMID:20881183   PMID:20941460   PMID:21064031   PMID:21071692   PMID:21145762   PMID:21166993   PMID:21187391   PMID:21267068   PMID:21330346   PMID:21402892   PMID:21410936  
PMID:21419763   PMID:21496498   PMID:21605114   PMID:21677130   PMID:21700885   PMID:21704012   PMID:21844396   PMID:21873635   PMID:21949017   PMID:21991317   PMID:21998326   PMID:22067024  
PMID:22143783   PMID:22312128   PMID:22349180   PMID:22363608   PMID:22383805   PMID:22384195   PMID:22407920   PMID:22412980   PMID:22544940   PMID:22547698   PMID:22547827   PMID:22675201  
PMID:22692512   PMID:22761313   PMID:22802415   PMID:22988104   PMID:23042534   PMID:23071696   PMID:23108101   PMID:23113741   PMID:23144170   PMID:23152561   PMID:23251626   PMID:23284865  
PMID:23348953   PMID:23404288   PMID:23498798   PMID:23617547   PMID:23684987   PMID:23717671   PMID:23719298   PMID:23785403   PMID:23794631   PMID:23835849   PMID:23918977   PMID:24030045  
PMID:24056628   PMID:24061433   PMID:24082013   PMID:24098455   PMID:24106272   PMID:24114675   PMID:24337745   PMID:24420080   PMID:24652469   PMID:24664420   PMID:24706909   PMID:24736544  
PMID:24777309   PMID:24815981   PMID:24928989   PMID:25035957   PMID:25046439   PMID:25157823   PMID:25418472   PMID:25429072   PMID:25613092   PMID:25783157   PMID:25822797   PMID:25839125  
PMID:25856408   PMID:25892224   PMID:26110994   PMID:26223487   PMID:26304989   PMID:26363052   PMID:26646413   PMID:26821950   PMID:27488034   PMID:27562840   PMID:27622331   PMID:27753080  
PMID:27861835   PMID:28093524   PMID:28461568   PMID:28583714   PMID:28663244   PMID:29036612   PMID:29037856   PMID:29084838   PMID:29111976   PMID:29155846   PMID:29342141   PMID:29452567  
PMID:29519940   PMID:29521626   PMID:29522194   PMID:29867987   PMID:30315139   PMID:30593563   PMID:31225793   PMID:31328158   PMID:31467410   PMID:31488565   PMID:32454024   PMID:32632165  
PMID:32680956   PMID:32868928   PMID:32988867   PMID:33268774   PMID:33793599   PMID:33917019   PMID:34255742   PMID:34446808   PMID:34852236   PMID:35001849  


Genomics

Comparative Map Data
Cd40lg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X56,257,503 - 56,269,402 (+)NCBIGRCm39mm39
GRCm39 EnsemblX56,257,503 - 56,269,402 (+)Ensembl
GRCm38X57,212,143 - 57,224,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,212,143 - 57,224,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X54,465,320 - 54,477,219 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X53,558,927 - 53,570,826 (+)NCBImm8
CeleraX43,689,623 - 43,701,548 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX31.21NCBI
CD40LG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X136,648,158 - 136,660,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX136,648,158 - 136,660,390 (+)EnsemblGRCh38hg38GRCh38
GRCh37X135,730,317 - 135,742,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,558,002 - 135,570,215 (+)NCBINCBI36hg18NCBI36
Build 34X135,455,855 - 135,468,068NCBI
CeleraX136,094,012 - 136,106,224 (+)NCBI
Cytogenetic MapXq26.3NCBI
HuRefX125,001,305 - 125,013,640 (+)NCBIHuRef
CHM1_1X135,641,985 - 135,654,211 (+)NCBICHM1_1
T2T-CHM13v2.0X134,956,900 - 134,969,116 (+)NCBI
Cd40lg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X135,127,119 - 135,138,302 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX135,126,969 - 135,138,306 (+)Ensembl
Rnor_6.0X159,703,703 - 159,714,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,703,578 - 159,716,562 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X154,330,893 - 154,341,954 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,925,019 - 141,937,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X141,998,451 - 142,010,616 (+)NCBI
CeleraX143,160,596 - 143,171,765 (+)NCBICelera
Cytogenetic MapXq37NCBI
Cd40lg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554898,465,164 - 8,477,746 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554898,465,571 - 8,477,714 (-)NCBIChiLan1.0ChiLan1.0
CD40LG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X136,042,849 - 136,055,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX136,042,849 - 136,058,202 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X125,776,138 - 125,788,820 (+)NCBIMhudiblu_PPA_v0panPan3
CD40LG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X107,001,421 - 107,023,007 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX107,010,890 - 107,023,006 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX92,832,126 - 92,844,241 (+)NCBI
ROS_Cfam_1.0X108,980,873 - 109,002,662 (+)NCBI
ROS_Cfam_1.0 EnsemblX108,990,551 - 109,002,661 (+)Ensembl
UMICH_Zoey_3.1X106,131,221 - 106,143,392 (+)NCBI
UNSW_CanFamBas_1.0X108,322,638 - 108,334,748 (+)NCBI
UU_Cfam_GSD_1.0X107,964,432 - 107,976,548 (+)NCBI
Cd40lg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X104,994,220 - 105,007,112 (+)NCBI
SpeTri2.0NW_00493651310,607,617 - 10,620,403 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD40LG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX111,778,493 - 111,789,711 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X111,778,666 - 111,788,901 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X127,636,797 - 127,647,035 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD40LG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X111,655,301 - 111,667,602 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX111,655,397 - 111,666,639 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606549,341,810 - 49,354,077 (+)NCBIVero_WHO_p1.0
Cd40lg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480810,472,572 - 10,484,338 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462480810,472,028 - 10,484,407 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
PMC164515P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X57,212,170 - 57,212,286UniSTSGRCm38
MGSCv37X54,465,347 - 54,465,463UniSTSGRCm37
CeleraX43,689,650 - 43,689,766UniSTS
Cytogenetic MapXA5UniSTS
cM MapX18.0UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
27226780Femd12_mfemur midshaft diameter 12, 16 week (mouse)X3466365356845360Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
1301351Obq6_mobesity QTL 6 (mouse)Not determinedX5077237570434751Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
4142286Pubt1_mpubertal timing 1 (mouse)Not determined5241220061880496Mouse
4141126Lvic5_mliver iron content 5 (mouse)Not determined5241220063027567Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:339
Count of miRNA genes:257
Interacting mature miRNAs:301
Transcripts:ENSMUST00000033466
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033466   ⟹   ENSMUSP00000033466
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX56,257,503 - 56,269,402 (+)Ensembl
GRCm38.p6 EnsemblX57,212,143 - 57,224,042 (+)Ensembl
RefSeq Acc Id: NM_011616   ⟹   NP_035746
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X56,257,503 - 56,269,402 (+)NCBI
GRCm38X57,212,143 - 57,224,042 (+)ENTREZGENE
MGSCv37X54,465,320 - 54,477,219 (+)RGD
CeleraX43,689,623 - 43,701,549 (+)NCBI
cM MapX ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035746   ⟸   NM_011616
- UniProtKB: P27548 (UniProtKB/Swiss-Prot),   Q0VEI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033466   ⟸   ENSMUST00000033466
Protein Domains
TNF_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27548-F1-model_v2 AlphaFold P27548 1-260 view protein structure

Promoters
RGD ID:13680554
Promoter ID:EPDNEW_M24426
Type:initiation region
Name:Cd40lg_1
Description:Mus musculus CD40 ligand , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X57,212,088 - 57,212,148EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88337 AgrOrtholog
Ensembl Genes ENSMUSG00000031132 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000033466 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033466 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD40L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21947 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88337 ENTREZGENE
NCBI Gene 21947 ENTREZGENE
PANTHER PTHR11471:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd40lg PhenoGen
PIRSF TNF_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CD40LIGAND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CD40L_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0VEI3 ENTREZGENE, UniProtKB/TrEMBL