Cd40lg (CD40 ligand) - Rat Genome Database

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Gene: Cd40lg (CD40 ligand) Mus musculus
Symbol: Cd40lg
Name: CD40 ligand
RGD ID: 1615151
Description: Predicted to enable CD40 receptor binding activity; integrin binding activity; and protein serine/threonine kinase activator activity. Involved in isotype switching. Acts upstream of or within B cell differentiation and regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD154; Cd40; CD40-L; Cd40l; gp3; gp39; HIGM; HIGM1; IGM; IMD; IMD3; Ly-6; Ly-62; Ly62; T-BA; T-BAM; T-cell antigen Gp39; TNF-related activation protein; Tnfs; Tnfsf5; Tnlg8b; TRAP; tumor necrosis factor (ligand) superfamily, member 5; tumor necrosis factor ligand 8b; tumor necrosis factor ligand superfamily member 5
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X56,257,448 - 56,269,402 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX56,257,503 - 56,269,402 (+)EnsemblGRCm39 Ensembl
GRCm38X57,212,143 - 57,224,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,212,143 - 57,224,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X54,465,320 - 54,477,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X53,558,927 - 53,570,826 (+)NCBIMGSCv36mm8
CeleraX43,689,623 - 43,701,548 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX31.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (IMP)
Acute Coronary Syndrome  (ISO)
acute lymphoblastic leukemia  (IMP)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (IMP,ISO)
anti-basement membrane glomerulonephritis  (ISO)
antiphospholipid syndrome  (ISO)
aplastic anemia  (ISO)
asthma  (IMP)
atherosclerosis  (IMP,ISO)
autistic disorder  (ISO)
autoimmune disease  (IMP,ISO)
autoimmune thrombocytopenic purpura  (IEP,ISO)
B-Cell Chronic Lymphocytic Leukemia  (IMP)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
Calcification of Aortic Valve  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
CD40 ligand deficiency  (IDA,ISO)
Cholangiofibrosis  (ISO)
Christianson syndrome  (ISO)
Chromosome Breakage  (ISO)
Chromosome Xq26.3 Duplication Syndrome  (ISO)
Chronic Allograft Dysfunction  (ISO)
chronic lymphocytic leukemia  (ISO)
cocaine abuse  (ISO)
Colonic Neoplasms  (IMP)
combined T cell and B cell immunodeficiency  (ISO)
common variable immunodeficiency  (ISO)
Congenital Heart Defects, Multiple Types, 1, X-Linked  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
crescentic glomerulonephritis  (IMP)
cutaneous lupus erythematosus  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
Discoid Lupus Erythematosus  (ISO)
dysgammaglobulinemia  (ISO)
Ehrlich tumor carcinoma  (ISO)
end stage renal disease  (ISO)
eosinophilic esophagitis  (ISO)
erythema multiforme  (ISO)
essential thrombocythemia  (ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveoretinitis  (IMP)
Experimental Diabetes Mellitus  (IMP,ISO)
Experimental Liver Neoplasms  (IMP)
factor VIII deficiency  (IMP)
familial hyperlipidemia  (ISO)
Fibrosis  (IMP)
follicular lymphoma  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (IMP)
granulomatosis with polyangiitis  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
HELLP syndrome  (ISO)
hepatocellular carcinoma  (IMP)
herpes simplex  (IMP)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hyper IgM syndrome  (ISO)
Hypercholesterolemia  (ISO)
Kawasaki disease  (ISO)
kidney disease  (IMP)
lichen planus  (ISO)
lupus nephritis  (IDA,IMP,ISO)
Lyme Neuroborreliosis  (ISO)
malaria  (IMP)
membranous glomerulonephritis  (IMP)
Metabolic Syndrome  (ISO)
Middle East respiratory syndrome  (IMP)
migraine  (ISO)
multiple myeloma  (IMP,ISO)
Murine Acquired Immunodeficiency Syndrome  (IMP)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
narcolepsy  (ISO)
Necrosis  (ISO)
nephrosis  (IMP)
obesity  (IMP,ISO)
ovarian disease  (IMP)
Ovarian Neoplasms  (IMP)
overactive bladder syndrome  (ISO)
pemphigus  (ISO)
Penetrating Wounds  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontal disease  (ISO)
periodontitis  (ISO)
peritonitis  (IEP)
pneumonia  (ISO)
pre-eclampsia  (ISO)
Primary Graft Dysfunction  (IMP)
pulmonary hypertension  (ISO)
Reperfusion Injury  (IMP,ISO)
Sepsis  (ISO)
Shock  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
Subacute Combined Degeneration  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
systemic lupus erythematosus  (IMP,ISO)
thrombocytopenia  (IMP)
thrombosis  (IMP,ISO)
tick-borne encephalitis  (ISO)
transient cerebral ischemia  (IMP)
Transplant Rejection  (IMP,ISO)
type 1 diabetes mellitus  (IDA,IMP,ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (IDA)
Vascular Calcification  (ISO)
Viral Myocarditis  (IDA,IMP,ISO)
visceral leishmaniasis  (IMP)
vitamin B12 deficiency  (ISO)
X-linked hyper IgM syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
3,3'-diindolylmethane  (ISO)
4-aminopyridine  (ISO)
5-fluorouracil  (ISO)
acetylsalicylic acid  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asperentin  (EXP)
atorvastatin calcium  (ISO)
barium sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
Brevianamide A  (EXP)
calcitriol  (ISO)
candesartan  (ISO)
carbon atom  (ISO)
ceric oxide  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
cisplatin  (EXP,ISO)
clopidogrel  (EXP,ISO)
curcumin  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental carbon  (ISO)
eptifibatide  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenofibrate  (ISO)
fingolimod hydrochloride  (ISO)
fructose  (EXP)
furan  (ISO)
Fusarenone X  (EXP)
gemcitabine  (ISO)
glucose  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
heparin  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
hydroxysafflor yellow A  (ISO)
ionomycin  (EXP)
isoflurane  (ISO)
lipopolysaccharide  (EXP)
medroxyprogesterone acetate  (ISO)
metformin  (ISO)
mevalonic acid  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N-acetyl-L-cysteine  (ISO)
neoechinulin A  (EXP)
nickel dichloride  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
pentobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pyrethrins  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sterigmatocystin  (EXP)
titanium dioxide  (EXP)
TMC-120A  (EXP)
vemurafenib  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vinorelbine  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adaptive immunity  (IAGP)
abnormal antigen presentation  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal leukocyte adhesion  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal T cell clonal deletion  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal thrombosis  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
absent lymph node germinal center  (IAGP)
absent spleen germinal center  (IAGP)
alopecia  (IAGP)
amyloid beta deposits  (IAGP)
decreased autoantibody level  (IAGP)
decreased bone mineral density  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased compact bone mass  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgD level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased platelet aggregation  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased trabecular bone mass  (IAGP)
extended life span  (IAGP)
gliosis  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased bleeding time  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased IgG1 level  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to prion infection  (IAGP)
insulitis  (IAGP)
loss of cortex neurons  (IAGP)
lymph node hypoplasia  (IAGP)
microgliosis  (IAGP)
neurodegeneration  (IAGP)
skin lesions  (IAGP)
spongiform encephalopathy  (IAGP)
thrombocytopenia  (IAGP)

References - curated
# Reference Title Reference Citation
1. Tolerance induction by costimulator blockade in 100 cGy treated hosts with varying degrees of genetic disparity. Abedi M, etal., Leukemia. 2003 Sep;17(9):1871-9.
2. Differences of soluble CD40L in sera and plasma: implications on CD40L assay as a marker of thrombotic risk. Ahn ER, etal., Thromb Res. 2004;114(2):143-8.
3. The expression and concentration of CD40 ligand in normal pregnancy, preeclampsia, and hemolytic anemia, elevated liver enzymes and low platelet count (HELLP) syndrome. Azzam HA, etal., Blood Coagul Fibrinolysis. 2013 Jan;24(1):71-5. doi: 10.1097/MBC.0b013e32835a8aca.
4. Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance. Bagenstose LM, etal., J Immunol. 2005 Jul 1;175(1):124-30.
5. Costimulation and autoimmune diabetes in BB rats. Beaudette-Zlatanova BC, etal., Am J Transplant. 2006 May;6(5 Pt 1):894-902.
6. Inhibition of the CD40-CD40ligand pathway prevents murine membranous glomerulonephritis. Biancone L, etal., Kidney Int. 1995 Aug;48(2):458-68.
7. Soluble CD40 ligand, high sensitive C-reactive protein and fetuin-A levels in patients with essential thrombocythemia. Bilgir F, etal., Transfus Apher Sci. 2012 Feb;46(1):67-71. doi: 10.1016/j.transci.2011.11.013. Epub 2011 Dec 23.
8. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. Blanchard C, etal., J Allergy Clin Immunol. 2011 Jan;127(1):208-17, 217.e1-7.
9. Blocking the CD40-CD40L interaction by CD40-Ig reduces disease progress in murine myocarditis induced by CVB3. Bo H, etal., Cardiovasc Pathol. 2010 Nov-Dec;19(6):371-6. doi: 10.1016/j.carpath.2009.10.002. Epub 2009 Nov 14.
10. A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Boumpas DT, etal., Arthritis Rheum. 2003 Mar;48(3):719-27.
11. Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury. Calingasan NY, etal., Neurobiol Aging. 2002 Jan-Feb;23(1):31-9.
12. CD40-CD154 expression in calcified and non-calcified coronary lesions of patients with chronic renal failure. Campean V, etal., Atherosclerosis. 2007 Jan;190(1):156-66. Epub 2006 Feb 21.
13. The CD40/CD40 ligand system is involved in the pathogenesis of pemphigus. Caproni M, etal., Clin Immunol. 2007 Jul;124(1):22-5. Epub 2007 May 24.
14. The CD40/CD40 ligand system in the skin of patients with subacute cutaneous lupus erythematosus. Caproni M, etal., J Rheumatol. 2007 Dec;34(12):2412-6. Epub 2007 Nov 15.
15. Exploring the role of short-course cyclosporin a therapy in preventing homograft valve calcification after transplantation. Chang Q, etal., Cell Immunol. 2014 Jan;287(1):36-45. doi: 10.1016/j.cellimm.2013.11.008. Epub 2013 Dec 8.
16. The ginsenoside metabolite compound K exerts its anti-inflammatory activity by downregulating memory B cell in adjuvant-induced arthritis. Chen J, etal., Pharm Biol. 2016 Jul;54(7):1280-8. doi: 10.3109/13880209.2015.1074254. Epub 2016 May 24.
17. Evaluating antithrombotic activity of HY023016 on rat hypercoagulable model. Chen QF, etal., Eur J Pharmacol. 2016 Jun 15;781:190-7. doi: 10.1016/j.ejphar.2016.04.023. Epub 2016 Apr 13.
18. Soluble CD40L (CD154) is increased in patients with shock. Chew M, etal., Inflamm Res. 2010 Nov;59(11):979-82. Epub 2010 May 20.
19. Increased concentrations of soluble CD40 ligand may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuria. Chiarelli F, etal., Diabetes Metab Res Rev. 2008 Oct;24(7):570-6.
20. Norepinephrine induces systolic failure and inhibits antiapoptotic genes in a polymicrobial septic rat model. Chopra M, etal., Life Sci. 2010 Dec 18;87(23-26):672-8. doi: 10.1016/j.lfs.2010.09.029. Epub 2010 Oct 7.
21. Low CD40L levels and relative lymphopenia in narcoleptic patients. Coelho FM, etal., Hum Immunol. 2011 Oct;72(10):817-20. doi: 10.1016/j.humimm.2011.05.024. Epub 2011 May 30.
22. Blockade of CD40 ligand for intercellular communication reduces hypertension, placental oxidative stress, and AT1-AA in response to adoptive transfer of CD4+ T lymphocytes from RUPP rats. Cornelius DC, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Nov 15;309(10):R1243-50. doi: 10.1152/ajpregu.00273.2015. Epub 2015 Aug 26.
23. Enhancing antitumor efficacy of chimeric antigen receptor T cells through constitutive CD40L expression. Curran KJ, etal., Mol Ther. 2015 Apr;23(4):769-78. doi: 10.1038/mt.2015.4. Epub 2015 Jan 13.
24. Cilostazol exerts antiplatelet and anti-inflammatory effects through AMPK activation and NF-kB inhibition on hypercholesterolemic rats. da Motta NA and de Brito FC, Fundam Clin Pharmacol. 2016 Aug;30(4):327-37. doi: 10.1111/fcp.12195. Epub 2016 Mar 31.
25. Soluble CD40 ligand is predictive of combined cardiovascular morbidity and mortality in patients on haemodialysis at a relatively short-term follow-up. Desideri G, etal., Nephrol Dial Transplant. 2011 Sep;26(9):2983-8. doi: 10.1093/ndt/gfq823. Epub 2011 Feb 8.
26. Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes. Devaraj S, etal., Diabetes. 2006 Mar;55(3):774-9.
27. CD40 ligand induces an antileukemia immune response in vivo. Dilloo D, etal., Blood. 1997 Sep 1;90(5):1927-33.
28. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Durie FH, etal., Science. 1993 Sep 3;261(5126):1328-30.
29. Role of CD28/CD80-86 and CD40/CD154 costimulatory interactions in host defense to primary herpes simplex virus infection. Edelmann KH and Wilson CB, J Virol. 2001 Jan;75(2):612-21.
30. Anti-C1q antibodies, sCD40L, TWEAK and CD4/CD8 ratio in systemic lupus erythematosus and their relations to disease activity and renal involvement. ElGendi SS and El-Sherif WT, Egypt J Immunol. 2009;16(1):135-48.
31. Molecular genetic analysis of Hungarian patients with the hyper-immunoglobulin M syndrome. Erdos M, etal., Mol Immunol. 2008 Jan;45(1):278-82. Epub 2007 Jun 5.
32. Expression of cytokine signaling genes in morbidly obese patients with non-alcoholic steatohepatitis and hepatic fibrosis. Estep JM, etal., Obes Surg. 2009 May;19(5):617-24. Epub 2009 Mar 12.
33. Increased soluble CD40 ligand levels in cystic fibrosis. Falco A, etal., J Thromb Haemost. 2004 Apr;2(4):557-60.
34. Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2. Fateh-Moghadam S, etal., Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1299-303. Epub 2005 Apr 7.
35. Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura. Feng X, etal., J Thromb Haemost. 2012 Aug;10(8):1616-23. doi: 10.1111/j.1538-7836.2012.04757.x.
36. Platelet soluble CD40L and matrix metalloproteinase 9 activity are proinflammatory mediators in Behcet disease patients. Fernandez Bello I, etal., Thromb Haemost. 2012 Jan;107(1):88-98. doi: 10.1160/TH11-08-0556. Epub 2011 Nov 24.
37. Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target. Gocmen AY, etal., Appl Physiol Nutr Metab. 2011 Jun;36(3):323-30. doi: 10.1139/h11-022. Epub 2011 May 16.
38. Effect of atorvastatin on atherosclerotic plaque formation and platelet activation in hypercholesterolemic rats. Gocmen AY, etal., Can J Physiol Pharmacol. 2013 Sep;91(9):680-5. doi: 10.1139/cjpp-2012-0325. Epub 2013 Apr 8.
39. Soluble P-selectin and CD40L levels in subjects with prediabetes, diabetes mellitus, and metabolic syndrome--the Chennai Urban Rural Epidemiology Study. Gokulakrishnan K, etal., Metabolism. 2006 Feb;55(2):237-42.
40. Antibody to the ligand for CD40 (gp39) inhibits murine AIDS-associated splenomegaly, hypergammaglobulinemia, and immunodeficiency in disease-susceptible C57BL/6 mice. Green KA, etal., J Virol. 1996 Apr;70(4):2569-75.
41. Evidence for a continued requirement for CD40/CD40 ligand (CD154) interactions in the progression of LP-BM5 retrovirus-induced murine AIDS. Green KA, etal., Virology. 1998 Feb 15;241(2):260-8.
42. Platelet CD40 ligand and bleeding during P2Y12 inhibitor treatment in acute coronary syndrome. Grosdidier C, etal., Res Pract Thromb Haemost. 2019 Jul 26;3(4):684-694. doi: 10.1002/rth2.12244. eCollection 2019 Oct.
43. Soluble CD40 ligand and prolactin levels in migraine patients during interictal period. Guldiken S, etal., J Headache Pain. 2011 Jun;12(3):355-60. Epub 2011 Feb 18.
44. Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD154 on the pancreatic beta-cells. Haase C, etal., Diabetes. 2004 Oct;53(10):2588-95.
45. Platelet activation in patients with atherosclerotic renal artery stenosis undergoing stent revascularization. Haller S, etal., Clin J Am Soc Nephrol. 2011 Sep;6(9):2185-91. doi: 10.2215/CJN.03140411. Epub 2011 Aug 4.
46. Immunogene therapy by adenovirus vector expressing CD40 ligand for metastatic liver cancer in rats. Hanyu K, etal., Anticancer Res. 2008 Sep-Oct;28(5A):2785-9.
47. A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model. Hashem AM, etal., J Infect Dis. 2019 Oct 8;220(10):1558-1567. doi: 10.1093/infdis/jiz137.
48. Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. Higuchi T, etal., J Immunol. 2002 Jan 1;168(1):9-12.
49. Soluble CD154 is a unique predictor of nonfatal and fatal atherothrombotic events in patients who have end-stage renal disease and are on hemodialysis. Hocher B, etal., J Am Soc Nephrol. 2007 Apr;18(4):1323-30. Epub 2007 Feb 21.
50. Adenovirus-mediated CD40L gene therapy induced both humoral and cellular immunity against rat model of hepatocellular carcinoma. Iida T, etal., Cancer Sci. 2008 Oct;99(10):2097-103.
51. Immunogene therapy against colon cancer metastasis using an adenovirus vector expressing CD40 ligand. Iida T, etal., Surgery. 2010 Nov;148(5):925-35. Epub 2010 Apr 7.
52. Blockade of CD40 ligand suppresses chronic experimental myasthenia gravis by down-regulation of Th1 differentiation and up-regulation of CTLA-4. Im SH, etal., J Immunol. 2001 Jun 1;166(11):6893-8.
53. Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment. Imbeault M, etal., J Virol. 2011 Mar;85(5):2189-200. Epub 2010 Dec 22.
54. CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. Ishikawa M, etal., Circulation. 2005 Apr 5;111(13):1690-6. Epub 2005 Mar 28.
55. Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand. Jain A, etal., Blood. 2011 Aug 12.
56. A phase 1 study of prasugrel in patients with sickle cell disease: effects on biomarkers of platelet activation and coagulation. Jakubowski JA, etal., Thromb Res. 2014 Feb;133(2):190-5. doi: 10.1016/j.thromres.2013.12.008. Epub 2013 Dec 7.
57. Surface camouflage of pancreatic islets using 6-arm-PEG-catechol in combined therapy with tacrolimus and anti-CD154 monoclonal antibody for xenotransplantation. Jeong JH, etal., Biomaterials. 2011 Nov;32(31):7961-70. doi: 10.1016/j.biomaterials.2011.06.068. Epub 2011 Aug 9.
58. [Changes of soluble CD40 ligand in patients with hyperlipidemia of blood stasis syndrome and its clinical significance]. Jin L, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Mar;31(3):315-8.
59. Blockade of CD40-CD40 ligand protects against renal injury in chronic proteinuric renal disease. Kairaitis L, etal., Kidney Int. 2003 Oct;64(4):1265-72.
60. Serum soluble CD40L concentration depending on the stage of multiple myeloma and its correlation with selected angiogenic cytokines. Kaminska J, etal., Pol Arch Med Wewn. 2016 May 31;126(5):321-9. doi: 10.20452/pamw.3427. Epub 2016 May 31.
61. Association of soluble CD40 ligand with carotid atherosclerosis in Japanese type 1 diabetic patients. Katakami N, etal., Diabetologia. 2006 Jul;49(7):1670-6. Epub 2006 May 12.
62. Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse. Komura K, etal., Ann Rheum Dis. 2008 Jun;67(6):867-72. Epub 2007 Sep 6.
63. CD40/154 blockade and rejection of islet allografts in the streptozotocin and autoimmune diabetic rat. Kover KL, etal., Pediatr Diabetes. 2001 Dec;2(4):178-83.
64. CD40 Gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population. Kuo HC, etal., ScientificWorldJournal. 2012;2012:520865. doi: 10.1100/2012/520865. Epub 2012 May 2.
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76. Intratumoral administration of immature dendritic cells following the adenovirus vector encoding CD40 ligand elicits significant regression of established myeloma. Liu Y, etal., Cancer Gene Ther. 2005 Feb;12(2):122-32.
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78. AdCD40L gene therapy counteracts T regulatory cells and cures aggressive tumors in an orthotopic bladder cancer model. Loskog AS, etal., Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8816-21.
79. Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets. Mai G, etal., Transplant Proc. 2005 Jan-Feb;37(1):460-2.
80. Immune modulation and apoptosis induction: Two sides of antitumoural activity of a standardised herbal formulation of Withania somnifera. Malik F, etal., Eur J Cancer. 2009 May;45(8):1494-509. doi: 10.1016/j.ejca.2009.01.034. Epub 2009 Mar 5.
81. Blockade of T cell costimulatory signals using adenovirus vectors prevents both the induction and the progression of experimental autoimmune myocarditis. Matsui Y, etal., J Mol Cell Cardiol. 2002 Mar;34(3):279-95. doi: 10.1006/jmcc.2001.1511.
82. CD40 ligand (CD154) takes part in regulation of the transition to mononuclear cell dominance during peritonitis. Mazar J, etal., Kidney Int. 2005 Apr;67(4):1340-9.
83. Autoimmune thrombocytopenia: flow cytometric determination of platelet-associated CD154/CD40L and CD40 on peripheral blood T and B lymphocytes. Meabed MH, etal., Hematology. 2007 Aug;12(4):301-7.
84. Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. Mehling A, etal., J Exp Med. 2001 Sep 3;194(5):615-28.
85. Involvement of CD40-CD40L signaling in postischemic lung injury. Moore TM, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Dec;283(6):L1255-62. Epub 2002 Aug 9.
86. Prevention of autoimmune diabetes in the DRBB rat by CD40/154 blockade. Moore WV, etal., J Autoimmun. 2002 Nov;19(3):139-45.
87. Modulation of T-cell costimulation as immunotherapy or immunochemotherapy in experimental visceral leishmaniasis. Murray HW, etal., Infect Immun. 2003 Nov;71(11):6453-62.
88. Serum CD40/CD40L system in Graves' disease and Hashimoto's thyroiditis related to soluble Fas, FasL and humoral markers of autoimmune response. Mysliwiec J, etal., Immunol Invest. 2007;36(3):247-57.
89. Expression of CD40/CD40 ligand and Bcl-2 family proteins in labial salivary glands of patients with Sjogren's syndrome. Nakamura H, etal., Lab Invest. 1999 Mar;79(3):261-9.
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91. CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. Nesbeth YC, etal., J Immunol. 2010 May 15;184(10):5654-62. Epub 2010 Apr 16.
92. CD40, CD154, Bax and Bcl-2 expression in Sjogren's syndrome salivary glands: a putative anti-apoptotic role during its effector phases. Ohlsson M, etal., Scand J Immunol. 2002 Dec;56(6):561-71.
93. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
94. T cells primed by Leishmania major infection cross-react with alloantigens and alter the course of allograft rejection. Pantenburg B, etal., J Immunol. 2002 Oct 1;169(7):3686-93.
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100. Thrombocytopenia in an animal model of malaria is associated with an increased caspase-mediated death of thrombocytes. Piguet PF, etal., Apoptosis. 2002 Apr;7(2):91-8.
101. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
102. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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109. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
110. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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145. Soluble CD40 and soluble CD40L concentrations in the serum and the cerebrospinal fluid of patients with tick borne encephalitis and neuroborreliosis Zajkowska JM, etal., Neurol Neurochir Pol. 2006 Jan-Feb;40(1):22-7.
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Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X56,257,448 - 56,269,402 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX56,257,503 - 56,269,402 (+)EnsemblGRCm39 Ensembl
GRCm38X57,212,143 - 57,224,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,212,143 - 57,224,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X54,465,320 - 54,477,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X53,558,927 - 53,570,826 (+)NCBIMGSCv36mm8
CeleraX43,689,623 - 43,701,548 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX31.21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X136,648,158 - 136,660,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX136,648,158 - 136,660,390 (+)EnsemblGRCh38hg38GRCh38
GRCh37X135,730,317 - 135,742,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,558,002 - 135,570,215 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X135,455,855 - 135,468,068NCBI
CeleraX136,094,012 - 136,106,224 (+)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX125,001,305 - 125,013,640 (+)NCBIHuRef
CHM1_1X135,641,985 - 135,654,211 (+)NCBICHM1_1
T2T-CHM13v2.0X134,956,900 - 134,969,116 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2X135,127,052 - 135,138,768 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX135,126,969 - 135,138,306 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX137,323,952 - 137,335,135 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X140,881,620 - 140,892,805 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X138,451,019 - 138,462,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X159,703,703 - 159,714,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,703,578 - 159,716,562 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X154,330,893 - 154,341,954 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,925,019 - 141,937,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X141,998,451 - 142,010,616 (+)NCBI
CeleraX143,160,596 - 143,171,765 (+)NCBICelera
Cytogenetic MapXq36NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554898,465,164 - 8,477,746 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554898,465,571 - 8,477,714 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1X136,068,886 - 136,081,625 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X125,776,138 - 125,788,820 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X136,042,849 - 136,055,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX136,042,849 - 136,058,202 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1X107,001,421 - 107,023,007 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX107,010,890 - 107,023,006 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX92,832,126 - 92,844,241 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X108,980,873 - 109,002,662 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX108,990,551 - 109,002,661 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X106,131,221 - 106,143,392 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X108,322,638 - 108,334,748 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X107,964,432 - 107,976,548 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2X104,994,220 - 105,007,112 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651310,607,617 - 10,620,403 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651310,607,617 - 10,620,403 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 EnsemblX111,778,493 - 111,789,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X111,778,666 - 111,788,901 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X127,636,797 - 127,647,035 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1X111,655,301 - 111,667,602 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX111,655,397 - 111,666,639 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606549,341,810 - 49,354,077 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462480810,472,572 - 10,484,338 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480810,472,028 - 10,484,407 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cd40lg
289 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:339
Count of miRNA genes:257
Interacting mature miRNAs:301
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
27226780Femd12_mfemur midshaft diameter 12, 16 week (mouse)X3466365356845360Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
1301351Obq6_mobesity QTL 6 (mouse)Not determinedX5077237570434751Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
4142286Pubt1_mpubertal timing 1 (mouse)Not determined5241220061880496Mouse
4141126Lvic5_mliver iron content 5 (mouse)Not determined5241220063027567Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X57,212,170 - 57,212,286UniSTSGRCm38
MGSCv37X54,465,347 - 54,465,463UniSTSGRCm37
CeleraX43,689,650 - 43,689,766UniSTS
Cytogenetic MapXA5UniSTS
cM MapX18.0UniSTS



RefSeq Acc Id: ENSMUST00000033466   ⟹   ENSMUSP00000033466
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX56,257,503 - 56,269,402 (+)Ensembl
GRCm38.p6 EnsemblX57,212,143 - 57,224,042 (+)Ensembl
RefSeq Acc Id: NM_011616   ⟹   NP_035746
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39X56,257,448 - 56,269,402 (+)NCBI
GRCm38X57,212,143 - 57,224,042 (+)ENTREZGENE
MGSCv37X54,465,320 - 54,477,219 (+)RGD
CeleraX43,689,623 - 43,701,549 (+)NCBI
RefSeq Acc Id: NP_035746   ⟸   NM_011616
- UniProtKB: P27548 (UniProtKB/Swiss-Prot),   Q0VEI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033466   ⟸   ENSMUST00000033466
Protein Domains
TNF family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27548-F1-model_v2 AlphaFold P27548 1-260 view protein structure

RGD ID:13680554
Promoter ID:EPDNEW_M24426
Type:initiation region
Description:Mus musculus CD40 ligand , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38X57,212,088 - 57,212,148EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88337 AgrOrtholog
Ensembl Genes ENSMUSG00000031132 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033466 ENTREZGENE
  ENSMUST00000033466.2 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD40L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21947 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11471:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd40lg PhenoGen
PIRSF TNF_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CD40L_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE