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Gene: Cd40lg (CD40 ligand) Mus musculus
Symbol: Cd40lg
Name: CD40 ligand
Description: Predicted to have CD40 receptor binding activity and integrin binding activity. Involved in B cell activation; immunoglobulin secretion; and regulation of immunoglobulin secretion. Localizes to external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Used to study inflammatory bowel disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune hypersensitivity disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand); PARTICIPATES IN obesity pathway; interleukin-4 signaling pathway; allograft rejection pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ADP; asperentin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD154; CD40-L; Cd40l; gp39; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; T-cell antigen Gp39; TNF-related activation protein; Tnfsf5; Tnlg8b; TRAP; tumor necrosis factor (ligand) superfamily, member 5; tumor necrosis factor ligand 8b; tumor necrosis factor ligand superfamily member 5
Homo sapiens (human) : CD40LG (CD40 ligand)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd40lg (CD40 ligand)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd40lg (CD40 ligand)
Pan paniscus (bonobo/pygmy chimpanzee) : CD40LG (CD40 ligand)
Canis lupus familiaris (dog) : CD40LG (CD40 ligand)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd40lg (CD40 ligand)
Sus scrofa (pig) : CD40LG (CD40 ligand)
Chlorocebus sabaeus (African green monkey) : CD40LG (CD40 ligand)
Heterocephalus glaber (naked mole-rat) : Cd40lg (CD40 ligand)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 EnsemblX57,212,143 - 57,224,042 (+)EnsemblGRCm38mm10GRCm38
GRCm38X57,212,143 - 57,224,042 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X54,465,320 - 54,477,219 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X53,558,927 - 53,570,826 (+)NCBImm8
CeleraX43,689,623 - 43,701,548 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX31.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cd40lg
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1615151
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.