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Gene: Htra1 (HtrA serine peptidase 1) Mus musculus
Symbol: Htra1
Name: HtrA serine peptidase 1
Description: Exhibits serine-type peptidase activity. Involved in several processes, including chorionic trophoblast cell differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and placenta development. Localizes to the collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Is expressed in several structures, including alimentary system; brain; extraembryonic component; limb; and reproductive system. Orthologous to human HTRA1 (HtrA serine peptidase 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI429470; high-temperature requirement A serine peptidase 1; HTRA; insulin-like growth factor binding protein 5 protease; L56; protease, serine, 11 (Igf binding); Prss11; RSPP11; serine protease 11; serine protease HTRA1
Homo sapiens (human) : HTRA1 (HtrA serine peptidase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Htra1 (HtrA serine peptidase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htra1 (HtrA serine peptidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HTRA1 (HtrA serine peptidase 1)
Canis lupus familiaris (dog) : HTRA1 (HtrA serine peptidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htra1 (HtrA serine peptidase 1)
Sus scrofa (pig) : HTRA1 (HtrA serine peptidase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl7130,936,111 - 130,985,660 (+)Ensembl
GRCm387130,936,203 - 130,985,658 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377138,079,717 - 138,129,172 (+)NCBIGRCm37mm9NCBIm37
MGSCv367130,727,377 - 130,776,801 (+)NCBImm8
Celera7130,747,058 - 130,797,116 (+)NCBICelera
Cytogenetic Map7 F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Htra1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1621557
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.