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Gene: Htra1 (HtrA serine peptidase 1) Mus musculus
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Symbol: Htra1
Name: HtrA serine peptidase 1
Description: Exhibits serine-type peptidase activity. Involved in several processes, including chorionic trophoblast cell differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and placenta development. Localizes to the collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Is expressed in several structures, including alimentary system; brain; extraembryonic component; limb; and reproductive system. Orthologous to human HTRA1 (HtrA serine peptidase 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI429470; high-temperature requirement A serine peptidase 1; HTRA; insulin-like growth factor binding protein 5 protease; L56; protease, serine, 11 (Igf binding); Prss11; RSPP11; serine protease 11; serine protease HTRA1
Orthologs:
Homo sapiens (human) : HTRA1 (HtrA serine peptidase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Htra1 (HtrA serine peptidase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htra1 (HtrA serine peptidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HTRA1 (HtrA serine peptidase 1)
Canis lupus familiaris (dog) : HTRA1 (HtrA serine peptidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htra1 (HtrA serine peptidase 1)
Sus scrofa (pig) : HTRA1 (HtrA serine peptidase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl7130,936,111 - 130,985,660 (+)Ensembl
GRCm387130,936,203 - 130,985,658 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377138,079,717 - 138,129,172 (+)NCBIGRCm37mm9NCBIm37
MGSCv367130,727,377 - 130,776,801 (+)NCBImm8
Celera7130,747,058 - 130,797,116 (+)NCBICelera
Cytogenetic Map7 F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Htra1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1621557
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.