Psen2 (presenilin 2) - Rat Genome Database

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Gene: Psen2 (presenilin 2) Mus musculus
Analyze
Symbol: Psen2
Name: presenilin 2
RGD ID: 733570
MGI Page MGI
Description: Exhibits aspartic endopeptidase activity, intramembrane cleaving. Involved in several processes, including animal organ development; regulation of cellular protein metabolic process; and regulation of extrinsic apoptotic signaling pathway via death domain receptors. Localizes to several cellular components, including Z disc; ciliary basal body; and gamma-secretase complex. Is expressed in central nervous system; late tubule; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; Alzheimer's disease 4; breast cancer; and dilated cardiomyopathy 1V. Orthologous to human PSEN2 (presenilin 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Ad4; Ad4h; AI266870; ALG; ALG-3; Alg3; P; presenilin-2; PS; PS-2; PS2; Psnl2; STM2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,054,569 - 180,091,030 (-)NCBIGRCm39mm39
GRCm39 Ensembl1180,054,569 - 180,091,003 (-)Ensembl
GRCm381180,227,004 - 180,263,467 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,227,004 - 180,263,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,157,135 - 182,186,431 (-)NCBIGRCm37mm9NCBIm37
MGSCv361182,063,681 - 182,082,576 (-)NCBImm8
Celera1187,291,668 - 187,320,266 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid precursor protein catabolic process  (IBA,ISO)
amyloid-beta formation  (ISO)
amyloid-beta metabolic process  (IBA,IDA,IMP)
brain morphogenesis  (IGI)
calcium ion transport  (IBA,IPI)
cardiac muscle contraction  (IMP)
cell fate specification  (IGI)
cellular protein metabolic process  (IGI)
dorsal/ventral neural tube patterning  (IGI)
embryonic limb morphogenesis  (IGI)
endoplasmic reticulum calcium ion homeostasis  (IGI)
forebrain development  (IGI)
hair follicle development  (IGI)
hematopoietic progenitor cell differentiation  (IGI)
intracellular signal transduction  (IEA)
learning or memory  (IGI)
locomotion  (IGI)
lung alveolus development  (IMP)
membrane protein ectodomain proteolysis  (IBA,ISO)
memory  (IGI)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO)
myeloid leukocyte differentiation  (IGI)
negative regulation of apoptotic process  (IBA)
negative regulation of apoptotic signaling pathway  (IGI)
negative regulation of epidermal growth factor-activated receptor activity  (IMP)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IDA)
negative regulation of protein binding  (IDA)
negative regulation of protein phosphorylation  (IGI)
negative regulation of protein-containing complex assembly  (IDA)
negative regulation of transcription by RNA polymerase II  (IMP)
negative regulation of ubiquitin-dependent protein catabolic process  (IMP)
negative regulation of ubiquitin-protein transferase activity  (IMP)
neuroinflammatory response  (IGI,IMP)
neuron cellular homeostasis  (IGI)
Notch receptor processing  (IBA)
Notch signaling pathway  (IGI)
positive regulation of apoptotic process  (IGI)
positive regulation of catalytic activity  (ISO)
positive regulation of coagulation  (IMP)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IDA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IMP)
positive regulation of receptor recycling  (IMP)
protein maturation  (IGI)
protein processing  (IGI,ISO)
protein transport  (IGI)
proteolysis  (IEA)
regulation of calcium import into the mitochondrion  (ISO)
regulation of epidermal growth factor-activated receptor activity  (IGI)
regulation of protein binding  (IGI)
regulation of synaptic plasticity  (IGI)
response to hypoxia  (ISO)
skin morphogenesis  (IMP)
somitogenesis  (IGI)
T cell activation involved in immune response  (IGI)
T cell receptor signaling pathway  (IGI)
thymus development  (IGI)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apoptosis  (IAGP)
abnormal blood circulation  (IAGP)
abnormal brain development  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal chorioallantoic fusion  (IAGP)
abnormal corneal epithelium morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal hair follicle inner root sheath morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal heart looping  (IAGP)
abnormal hindbrain development  (IAGP)
abnormal hippocampus molecular cell layer  (IAGP)
abnormal midbrain development  (IAGP)
abnormal neocortex morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal object recognition memory  (IAGP)
abnormal paraxial mesoderm morphology  (IAGP)
abnormal pulmonary alveolus wall morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal skin condition  (IAGP)
abnormal somite development  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent sebocyte  (IAGP)
arteritis  (IAGP)
astrocytosis  (IAGP)
autoimmune response  (IAGP)
caudal body truncation  (IAGP)
chronic inflammation  (IAGP)
decreased body size  (IAGP)
decreased neuron number  (IAGP)
decreased paired-pulse facilitation  (IAGP)
delayed neural tube closure  (IAGP)
dermatitis  (IAGP)
distended pericardium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged lateral ventricles  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged third ventricle  (IAGP)
epidermal cyst  (IAGP)
epidermal hyperplasia  (IAGP)
esophagus hyperplasia  (IAGP)
failure of heart looping  (IAGP)
failure of somite differentiation  (IAGP)
focal hair loss  (IAGP)
gliosis  (IAGP)
glomerulonephritis  (IAGP)
hair follicle degeneration  (IAGP)
hematuria  (IAGP)
hyperactivity  (IAGP)
hyperkeratosis  (IAGP)
impaired synaptic plasticity  (IAGP)
increased anti-single stranded DNA antibody level  (IAGP)
increased immunoglobulin level  (IAGP)
increased incidence of corneal inflammation  (IAGP)
increased inflammatory response  (IAGP)
increased leukocyte cell number  (IAGP)
increased lung endothelial cell apoptosis  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased synaptic depression  (IAGP)
increased urine protein level  (IAGP)
kidney inflammation  (IAGP)
kinked neural tube  (IAGP)
lung hemorrhage  (IAGP)
microgliosis  (IAGP)
neurodegeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
pulmonary fibrosis  (IAGP)
reduced long term potentiation  (IAGP)
scaly skin  (IAGP)
short hair  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
small heart  (IAGP)
small second pharyngeal arch  (IAGP)
spontaneous skin ulceration  (IAGP)
thick epidermis  (IAGP)
thick skin  (IAGP)
weight loss  (IAGP)
References

Additional References at PubMed
PMID:8533168   PMID:8560270   PMID:8755489   PMID:8889548   PMID:8922407   PMID:8940094   PMID:8990127   PMID:9090377   PMID:9153393   PMID:9203550   PMID:9246482   PMID:9353287  
PMID:9450754   PMID:9535056   PMID:9648880   PMID:9928488   PMID:9950750   PMID:10349636   PMID:10356989   PMID:10497236   PMID:10537029   PMID:10557208   PMID:10662508   PMID:10846187  
PMID:10922068   PMID:11042159   PMID:11076861   PMID:11104755   PMID:11172053   PMID:11518718   PMID:11567612   PMID:11715026   PMID:11719200   PMID:11756438   PMID:11817902   PMID:11904448  
PMID:11937492   PMID:11943765   PMID:12039862   PMID:12093789   PMID:12198112   PMID:12388777   PMID:12460542   PMID:12477932   PMID:12646573   PMID:12684521   PMID:12885769   PMID:14566063  
PMID:14610273   PMID:14717705   PMID:15066262   PMID:15122901   PMID:15128703   PMID:15148382   PMID:15264228   PMID:15280425   PMID:15287885   PMID:15322084   PMID:15345711   PMID:15474363  
PMID:15489334   PMID:15525534   PMID:15537629   PMID:15613480   PMID:15649694   PMID:15858415   PMID:15866159   PMID:15886206   PMID:15922300   PMID:15951428   PMID:16000382   PMID:16103123  
PMID:16103124   PMID:16141072   PMID:16141073   PMID:16169548   PMID:16204356   PMID:16384915   PMID:16394273   PMID:16602821   PMID:16641999   PMID:16887746   PMID:17097608   PMID:17121184  
PMID:17222949   PMID:17292944   PMID:17499883   PMID:17556541   PMID:17614943   PMID:17626841   PMID:17698590   PMID:17728018   PMID:17874292   PMID:17920016   PMID:17980611   PMID:18195359  
PMID:18287559   PMID:18293935   PMID:18297083   PMID:18297084   PMID:18367332   PMID:18440065   PMID:18507503   PMID:18539391   PMID:18591429   PMID:18665263   PMID:18803281   PMID:18822370  
PMID:18834536   PMID:18971484   PMID:19005074   PMID:19111578   PMID:19297528   PMID:19369394   PMID:19376115   PMID:19382908   PMID:19457123   PMID:19494151   PMID:19573580   PMID:19573812  
PMID:19584449   PMID:19641596   PMID:19656855   PMID:19723764   PMID:19779553   PMID:19834068   PMID:20130175   PMID:20208556   PMID:20573903   PMID:20854432   PMID:20875805   PMID:20926667  
PMID:20953898   PMID:20974250   PMID:21084199   PMID:21146496   PMID:21206757   PMID:21267068   PMID:21285369   PMID:21296884   PMID:21414900   PMID:21597003   PMID:21677750   PMID:21703454  
PMID:21873635   PMID:21910732   PMID:21914807   PMID:22002539   PMID:22140537   PMID:22170863   PMID:22311977   PMID:22496554   PMID:22505025   PMID:22715045   PMID:22723704   PMID:22796216  
PMID:22897852   PMID:22935613   PMID:23103503   PMID:23341629   PMID:23359614   PMID:23365231   PMID:23370287   PMID:23589300   PMID:23792007   PMID:23918386   PMID:23924630   PMID:23952003  
PMID:24018889   PMID:24145027   PMID:24353058   PMID:24699228   PMID:24858037   PMID:24952961   PMID:25204494   PMID:25429133   PMID:25574842   PMID:25652771   PMID:25741723   PMID:25995356  
PMID:26081153   PMID:26593275   PMID:27177724   PMID:27239030   PMID:27240887   PMID:27349870   PMID:27354375   PMID:27889678   PMID:28215940   PMID:28879407   PMID:28994238   PMID:29229705  
PMID:29867447   PMID:30059908   PMID:30316051   PMID:30429473   PMID:30560948   PMID:31433986   PMID:31577226   PMID:31862541  


Genomics

Comparative Map Data
Psen2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,054,569 - 180,091,030 (-)NCBIGRCm39mm39
GRCm39 Ensembl1180,054,569 - 180,091,003 (-)Ensembl
GRCm381180,227,004 - 180,263,467 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,227,004 - 180,263,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,157,135 - 182,186,431 (-)NCBIGRCm37mm9NCBIm37
MGSCv361182,063,681 - 182,082,576 (-)NCBImm8
Celera1187,291,668 - 187,320,266 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.19NCBI
PSEN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1226,870,184 - 226,927,726 (+)EnsemblGRCh38hg38GRCh38
GRCh381226,870,594 - 226,903,829 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371227,058,317 - 227,083,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361225,124,896 - 225,150,427 (+)NCBINCBI36hg18NCBI36
Build 341223,365,694 - 223,390,532NCBI
Celera1200,249,068 - 200,274,610 (+)NCBI
Cytogenetic Map1q42.13NCBI
HuRef1197,575,178 - 197,600,711 (+)NCBIHuRef
CHM1_11228,331,030 - 228,356,564 (+)NCBICHM1_1
Psen2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21391,967,506 - 91,993,240 (-)NCBI
Rnor_6.0 Ensembl1398,513,570 - 98,530,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01398,513,600 - 98,539,347 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013103,521,460 - 103,547,174 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41395,934,674 - 95,951,836 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,123,177 - 96,145,989 (-)NCBI
Celera1391,515,731 - 91,532,398 (-)NCBICelera
Cytogenetic Map13q26NCBI
Psen2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554065,727,367 - 5,752,234 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554065,727,367 - 5,748,798 (+)NCBIChiLan1.0ChiLan1.0
PSEN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11207,320,937 - 207,346,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1207,320,937 - 207,346,295 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01202,328,987 - 202,354,440 (+)NCBIMhudiblu_PPA_v0panPan3
PSEN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,147,157 - 38,163,023 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,147,173 - 38,166,722 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,629,753 - 37,654,335 (-)NCBI
ROS_Cfam_1.0737,981,322 - 38,006,377 (-)NCBI
UMICH_Zoey_3.1737,820,678 - 37,845,261 (-)NCBI
UNSW_CanFamBas_1.0737,827,826 - 37,852,402 (-)NCBI
UU_Cfam_GSD_1.0738,098,241 - 38,122,853 (-)NCBI
Psen2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,135,578 - 51,163,137 (-)NCBI
SpeTri2.0NW_0049365263,584,194 - 3,611,719 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSEN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1014,532,550 - 14,561,858 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11014,532,556 - 14,561,862 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,862,708 - 16,891,775 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10p16-p11NCBI
PSEN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1252,862,354 - 2,888,735 (-)NCBI
ChlSab1.1 Ensembl252,862,251 - 2,877,386 (-)Ensembl
Vero_WHO_p1.0NW_0236660552,849,316 - 2,875,698 (-)NCBI
Psen2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477117,183,538 - 17,205,460 (-)NCBI

Position Markers
AI266870  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,227,192 - 180,227,295UniSTSGRCm38
MGSCv371182,157,323 - 182,157,426UniSTSGRCm37
Celera1187,291,856 - 187,291,959UniSTS
Cytogenetic Map1H4UniSTS
cM Map1101.0UniSTS
Whitehead/MRC_RH12255.55UniSTS
Psen2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H4UniSTS
cM Map1 UniSTS
PMC317124P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,245,343 - 180,245,694UniSTSGRCm38
MGSCv371182,175,474 - 182,175,825UniSTSGRCm37
Celera1187,309,199 - 187,309,550UniSTS
Cytogenetic Map1H4UniSTS
cM Map1101.0UniSTS
PMC317124P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,235,771 - 180,235,972UniSTSGRCm38
MGSCv371182,165,902 - 182,166,103UniSTSGRCm37
Celera1187,300,389 - 187,300,590UniSTS
Cytogenetic Map1H4UniSTS
cM Map1101.0UniSTS
PMC317124P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,238,241 - 180,238,890UniSTSGRCm38
MGSCv371182,168,372 - 182,169,021UniSTSGRCm37
Celera1187,302,928 - 187,303,577UniSTS
Cytogenetic Map1H4UniSTS
cM Map1101.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172571254195471971Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157628733191628870Mouse
1300960Hpic2_mhaloperidol induced catalepsy 2 (mouse)Not determined1175641251181573094Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155893961189895041Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156774467189571420Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157628733191628870Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162317638194429220Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157628733191628870Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152211172186211344Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167730317195471971Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167730317195471971Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1168222387195471971Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175529010195471971Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159435007193435127Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9148047933182048047Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158641251192641372Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164315658190802075Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155888654189888802Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150317922188627115Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167730317195471971Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1156004198190004325Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171804480192998742Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157628733191628870Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157628733191628870Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150317922188627115Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152211172186211344Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147249520183092234Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1172250913195471971Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152211172186211344Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155699229189699330Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157628733191628870Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150929168184929353Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167929168189571420Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1166092111195471971Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158641251192641372Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157628733191628870Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168481626195471971Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1156004198190004325Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170647303195471971Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156774467189571420Mouse
1301164Tir3c_mtrypansomiasis infection response 3c (mouse)Not determined1154804480188804689Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147249520189251027Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined156004198190004325Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152211172186211344Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1163149528186261999Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160285202194285317Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151358674185358833Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155888654189888802Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161373696195373830Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150317922188627115Mouse
4142119Bpq21_mblood pressure QTL 21 (mouse)Not determined1152211172186211344Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined152007542186007711Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155706491186261999Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152211172186211344Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171804480189571420Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172571254195471971Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1148047933182048047Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154582944188582944Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158641251192641372Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153848421187848536Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153885284187885284Mouse
10045887Cplaq13_mcircadian period of locomotor activity 13 (mouse)Not determined1173004198181573094Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152919071186706423Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155698056189699966Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1104005680191493284Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167758517191493284Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128800000181500000Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172571254195471971Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158641251192641372Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152305175186305175Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158641251192641372Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147391821181391821Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155888654189888802Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147391821181391821Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155175373189175373Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172800000195471971Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175641251194429220Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155175373189175373Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172900000195471971Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160269591194269591Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155175373189175373Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158641251192641372Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160269591194269591Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152305175186305175Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1156004198190004325Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1869
Count of miRNA genes:617
Interacting mature miRNAs:771
Transcripts:ENSMUST00000010753, ENSMUST00000111104, ENSMUST00000111105, ENSMUST00000111106, ENSMUST00000111108, ENSMUST00000128223, ENSMUST00000130029, ENSMUST00000130711, ENSMUST00000133340, ENSMUST00000136291, ENSMUST00000149590
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001128605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006496712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011238776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_373599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF038935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI118332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY864737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM935552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY136632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000010753   ⟹   ENSMUSP00000010753
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,227,006 - 180,245,950 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111104   ⟹   ENSMUSP00000106733
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,227,445 - 180,245,757 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111105   ⟹   ENSMUSP00000106734
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,227,443 - 180,248,150 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111106   ⟹   ENSMUSP00000106735
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,227,004 - 180,253,138 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111108   ⟹   ENSMUSP00000106737
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,227,004 - 180,256,300 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128223
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,235,174 - 180,239,222 (-)Ensembl
RefSeq Acc Id: ENSMUST00000130029
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,227,468 - 180,230,025 (-)Ensembl
RefSeq Acc Id: ENSMUST00000130711
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,227,004 - 180,230,065 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133340   ⟹   ENSMUSP00000120216
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,245,638 - 180,263,438 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136291
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,227,389 - 180,230,062 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149590
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,232,524 - 180,256,244 (-)Ensembl
RefSeq Acc Id: ENSMUST00000193897
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,227,006 - 180,229,568 (-)Ensembl
RefSeq Acc Id: NM_001128605   ⟹   NP_001122077
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,083,865 (-)NCBI
GRCm381180,227,004 - 180,256,300 (-)NCBI
MGSCv371182,157,135 - 182,186,431 (-)RGD
Celera1187,291,668 - 187,320,266 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011183   ⟹   NP_035313
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,073,515 (-)NCBI
GRCm381180,227,004 - 180,245,950 (-)NCBI
MGSCv371182,157,135 - 182,186,431 (-)RGD
Celera1187,291,668 - 187,320,266 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006496712   ⟹   XP_006496775
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,083,877 (-)NCBI
GRCm381180,227,004 - 180,256,329 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011238776   ⟹   XP_011237078
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,091,030 (-)NCBI
GRCm381180,227,004 - 180,263,467 (-)NCBI
Sequence:
RefSeq Acc Id: XR_373599
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,083,922 (-)NCBI
GRCm381180,227,004 - 180,256,329 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035313   ⟸   NM_011183
- UniProtKB: Q61144 (UniProtKB/Swiss-Prot),   Q3U4P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001122077   ⟸   NM_001128605
- UniProtKB: Q61144 (UniProtKB/Swiss-Prot),   Q3U4P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006496775   ⟸   XM_006496712
- Peptide Label: isoform X2
- UniProtKB: Q61144 (UniProtKB/Swiss-Prot),   A0A0R4J1F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011237078   ⟸   XM_011238776
- Peptide Label: isoform X1
- UniProtKB: Q61144 (UniProtKB/Swiss-Prot),   Q3U4P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106737   ⟸   ENSMUST00000111108
RefSeq Acc Id: ENSMUSP00000106733   ⟸   ENSMUST00000111104
RefSeq Acc Id: ENSMUSP00000106734   ⟸   ENSMUST00000111105
RefSeq Acc Id: ENSMUSP00000106735   ⟸   ENSMUST00000111106
RefSeq Acc Id: ENSMUSP00000120216   ⟸   ENSMUST00000133340
RefSeq Acc Id: ENSMUSP00000010753   ⟸   ENSMUST00000010753

Promoters
RGD ID:6875908
Promoter ID:EPDNEW_M1405
Type:initiation region
Name:Psen2_2
Description:Mus musculus presenilin 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1406  EPDNEW_M1407  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381180,229,966 - 180,230,026EPDNEW
RGD ID:6875910
Promoter ID:EPDNEW_M1406
Type:initiation region
Name:Psen2_3
Description:Mus musculus presenilin 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1405  EPDNEW_M1407  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381180,245,933 - 180,245,993EPDNEW
RGD ID:6875912
Promoter ID:EPDNEW_M1407
Type:multiple initiation site
Name:Psen2_1
Description:Mus musculus presenilin 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1405  EPDNEW_M1406  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381180,256,251 - 180,256,311EPDNEW
RGD ID:6818290
Promoter ID:MM_KWN:3113
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000050932,   OTTMUST00000050933,   OTTMUST00000050934
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361182,159,841 - 182,160,341 (-)MPROMDB
RGD ID:6818288
Promoter ID:MM_KWN:3114
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000050931
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361182,169,261 - 182,169,761 (-)MPROMDB
RGD ID:6818291
Promoter ID:MM_KWN:3115
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung,   Spleen
Transcripts:ENSMUST00000010753,   UC007DWB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361182,175,724 - 182,176,224 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109284 AgrOrtholog
Ensembl Genes ENSMUSG00000010609 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000010753 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000106733 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000106734 UniProtKB/TrEMBL
  ENSMUSP00000106735 UniProtKB/TrEMBL
  ENSMUSP00000106737 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000120216 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000010753 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000111104 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000111105 UniProtKB/TrEMBL
  ENSMUST00000111106 UniProtKB/TrEMBL
  ENSMUST00000111108 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000133340 UniProtKB/TrEMBL
Gene3D-CATH 1.10.472.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Pept_A22A_PS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_A22A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Preselin/SPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Presenilin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19165 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109284 ENTREZGENE
NCBI Gene 19165 ENTREZGENE
PANTHER PTHR10202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Presenilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Psen2 PhenoGen
PRINTS PRESENILIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRESENILIN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1F2 ENTREZGENE, UniProtKB/TrEMBL
  D3Z0X1_MOUSE UniProtKB/TrEMBL
  PSN2_MOUSE UniProtKB/Swiss-Prot
  Q3U4P5 ENTREZGENE, UniProtKB/TrEMBL
  Q5EM20_MOUSE UniProtKB/TrEMBL
  Q61144 ENTREZGENE
UniProt Secondary O54977 UniProtKB/Swiss-Prot
  P97934 UniProtKB/Swiss-Prot
  P97935 UniProtKB/Swiss-Prot
  Q91VS3 UniProtKB/Swiss-Prot
  Q9D616 UniProtKB/Swiss-Prot