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Gene: Psen2 (presenilin 2) Mus musculus
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Symbol: Psen2
Name: presenilin 2
Description: Exhibits endopeptidase activity. Involved in several processes, including animal organ development; regulation of cellular protein metabolic process; and regulation of extrinsic apoptotic signaling pathway via death domain receptors. Localizes to several cellular components, including the Z disc; ciliary basal body; and neuronal cell body. Human ortholog(s) of this gene implicated in Alzheimer's disease; Alzheimer's disease 4; breast cancer; and dilated cardiomyopathy 1V. Is expressed in central nervous system; late tubule; and sensory organ. Orthologous to human PSEN2 (presenilin 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Ad4h; AI266870; ALG-3; Alg3; presenilin-2; PS-2; PS2; Psnl2; STM2
Orthologs:
Homo sapiens (human) : PSEN2 (presenilin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Psen2 (presenilin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psen2 (presenilin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PSEN2 (presenilin 2)
Canis lupus familiaris (dog) : PSEN2 (presenilin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psen2 (presenilin 2)
Sus scrofa (pig) : PSEN2 (presenilin 2)
Chlorocebus sabaeus (African green monkey) : PSEN2 (presenilin 2)
Heterocephalus glaber (naked mole-rat) : Psen2 (presenilin 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1180,227,004 - 180,263,438 (-)Ensembl
GRCm381180,227,004 - 180,263,467 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371182,157,135 - 182,186,431 (-)NCBIGRCm37mm9NCBIm37
MGSCv361182,063,681 - 182,082,576 (-)NCBImm8
Celera1187,291,668 - 187,320,266 (-)NCBICelera
Cytogenetic Map1 H4NCBI
cM Map184.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Psen2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733570
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.