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Gene: Psen2 (presenilin 2) Mus musculus
Symbol: Psen2
Name: presenilin 2
Description: Exhibits endopeptidase activity. Involved in several processes, including animal organ development; regulation of cellular protein metabolic process; and regulation of extrinsic apoptotic signaling pathway via death domain receptors. Localizes to several cellular components, including the Z disc; ciliary basal body; and neuronal cell body. Human ortholog(s) of this gene implicated in Alzheimer's disease; Alzheimer's disease 4; breast cancer; and dilated cardiomyopathy 1V. Is expressed in central nervous system; late tubule; and sensory organ. Orthologous to human PSEN2 (presenilin 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Ad4h; AI266870; ALG-3; Alg3; presenilin-2; PS-2; PS2; Psnl2; STM2
Homo sapiens (human) : PSEN2 (presenilin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Psen2 (presenilin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psen2 (presenilin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PSEN2 (presenilin 2)
Canis lupus familiaris (dog) : PSEN2 (presenilin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psen2 (presenilin 2)
Sus scrofa (pig) : PSEN2 (presenilin 2)
Chlorocebus sabaeus (African green monkey) : PSEN2 (presenilin 2)
Heterocephalus glaber (naked mole-rat) : Psen2 (presenilin 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1180,227,004 - 180,263,438 (-)Ensembl
GRCm381180,227,004 - 180,263,467 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371182,157,135 - 182,186,431 (-)NCBIGRCm37mm9NCBIm37
MGSCv361182,063,681 - 182,082,576 (-)NCBImm8
Celera1187,291,668 - 187,320,266 (-)NCBICelera
Cytogenetic Map1 H4NCBI
cM Map184.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Psen2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733570
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.