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Gene: Cd40 (CD40 antigen) Mus musculus
Symbol: Cd40
Name: CD40 antigen
Description: Predicted to have antigen binding activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to other organism; positive regulation of B cell activation; and protein kinase B signaling. Localizes to the CD40 receptor complex; external side of plasma membrane; and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; arthritis (multiple); autoimmune hypersensitivity disease (multiple); hematologic cancer (multiple); and hyperimmunoglobulin syndrome (multiple). Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD40 (CD40 molecule); PARTICIPATES IN allograft rejection pathway; asthma pathway; autoimmune thyroiditis pathway; INTERACTS WITH (R)-mevalonic acid; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI326936; B-cell surface antigen CD40; Bp50; CD40L receptor; GP39; HIGM1; IGM; IMD3; p50; T-BAM; T-cell differentiation antigen; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
Homo sapiens (human) : CD40 (CD40 molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd40 (CD40 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd40 (CD40 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD40 (CD40 molecule)
Canis lupus familiaris (dog) : CD40 (CD40 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd40 (CD40 molecule)
Sus scrofa (pig) : CD40 (CD40 molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382165,055,614 - 165,071,654 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372164,881,136 - 164,897,154 (+)NCBIGRCm37mm9NCBIm37
MGSCv362164,746,841 - 164,762,859 (+)NCBImm8
Celera2170,992,951 - 171,008,953 (+)NCBICelera
Cytogenetic Map2 H3NCBI
cM Map285.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cd40
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1615152
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.