Cd40 (CD40 antigen) - Rat Genome Database
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Gene: Cd40 (CD40 antigen) Mus musculus
Analyze
Symbol: Cd40
Name: CD40 antigen
RGD ID: 1615152
Description: Predicted to have antigen binding activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Localizes to CD40 receptor complex; external side of plasma membrane; and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule); PARTICIPATES IN allograft rejection pathway; asthma pathway; autoimmune thyroiditis pathway; INTERACTS WITH (R)-mevalonic acid; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI326936; B-cell surface antigen CD40; Bp5; Bp50; CD40L receptor; GP39; HIGM1; IGM; IMD3; p5; p50; T-BAM; T-cell differentiation antigen; Tnfr; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
Orthologs:
Homo sapiens (human) : CD40 (CD40 molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd40 (CD40 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd40 (CD40 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD40 (CD40 molecule)
Canis lupus familiaris (dog) : CD40 (CD40 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd40 (CD40 molecule)
Sus scrofa (pig) : CD40 (CD40 molecule)
Chlorocebus sabaeus (African green monkey) : CD40 (CD40 molecule)
Heterocephalus glaber (naked mole-rat) : Cd40 (CD40 molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,897,535 - 164,913,574 (+)NCBI
GRCm382165,055,614 - 165,071,654 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2165,055,627 - 165,072,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv372164,881,136 - 164,897,154 (+)NCBIGRCm37mm9NCBIm37
MGSCv362164,746,841 - 164,762,859 (+)NCBImm8
Celera2170,992,951 - 171,008,953 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute myocarditis  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (IEP)
Animal Helminthiasis  (IEP)
Animal Mammary Neoplasms  (IMP)
Animal Viral Hepatitis  (IMP)
anti-basement membrane glomerulonephritis  (IMP)
arthritis  (ISO)
asthma  (IEP,ISO)
atherosclerosis  (IEP,ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-cell lymphoma  (ISO)
bacterial pneumonia  (IEP)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis  (ISO)
Burkitt lymphoma  (ISO)
chlamydia  (IEP)
Chronic Allograft Dysfunction  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
crescentic glomerulonephritis  (IMP)
Crohn's disease  (ISO)
cryptococcosis  (IMP)
cutaneous lupus erythematosus  (ISO)
Delayed Hypersensitivity  (IMP)
dermatomyositis  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
Discoid Lupus Erythematosus  (ISO)
Ehrlich tumor carcinoma  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IDA)
erythema multiforme  (ISO)
Experimental Arthritis  (IMP)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
follicular lymphoma  (ISO)
Graft vs Host Disease  (IDA)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IEP)
hyper IgM syndrome  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperimmunoglobulin syndrome  (ISO)
hyperinsulinism  (ISO)
hyperthyroidism  (IMP)
immunodeficiency with hyper IgM type 3  (ISO)
Inflammation  (IMP)
Insulin Resistance  (ISO)
insulinoma  (IMP)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
lichen planus  (ISO)
Liver Reperfusion Injury  (ISO)
lupus nephritis  (IDA,IMP)
Lyme Neuroborreliosis  (ISO)
Lymphatic Metastasis  (ISO)
malaria  (IMP)
malignant glioma  (IMP)
malignant mesothelioma  (IMP)
Mammary Neoplasms, Experimental  (IEP)
melanoma  (IMP,ISO)
membranous glomerulonephritis  (IMP,ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
Murine Acquired Immunodeficiency Syndrome  (IMP)
myelodysplastic syndrome  (ISO)
Myocardial Ischemia  (ISO)
Neisseriaceae Infections  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
pancreatic ductal carcinoma  (IDA,ISO)
pemphigus  (ISO)
Perennial Allergic Rhinitis  (IMP)
perinatal necrotizing enterocolitis  (ISO)
peritonitis  (IEP)
plasma cell leukemia  (ISO)
pneumocystosis  (IDA)
pre-eclampsia  (ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
renal artery obstruction  (ISO)
renal cell carcinoma  (IDA,IMP)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Schistosomiasis Mansoni  (IMP)
Sepsis  (ISO)
skin melanoma  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Subacute Combined Degeneration  (ISO)
systemic lupus erythematosus  (ISO)
thrombosis  (IMP)
tick-borne encephalitis  (ISO)
transient cerebral ischemia  (IMP)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
Vascular Calcification  (ISO)
Viral Myocarditis  (IEP)
visceral leishmaniasis  (IMP)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-demecolcine  (ISO)
(R)-mevalonic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-mercaptopropanoic acid  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-aminopyridine  (ISO)
4-DAMP(1+)  (ISO)
4-hydroxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
atropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucan  (EXP)
betamethasone valerate  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
carbachol  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
cortisol  (EXP)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (EXP)
daidzein  (EXP)
delta-tocotrienol  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fisetin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
furan  (ISO)
furosemide  (ISO)
gemcitabine  (ISO)
Genipin  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
helenalin  (ISO)
histamine  (ISO)
hydroxysafflor yellow A  (ISO)
imiquimod  (EXP)
immunological adjuvant  (ISO)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoflurane  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metam  (EXP)
mevastatin  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP)
muramyl dipeptide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
Niclosamide  (EXP)
nicotinamide  (EXP)
nystatin  (EXP)
o-anisidine  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
pevonedistat  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirenzepine  (ISO)
poly(I:C)  (ISO)
pravastatin  (EXP,ISO)
propanal  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirtinol  (EXP)
sodium aurothiosulfate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
succimer  (EXP)
tetrathiomolybdate(2-)  (ISO)
thimerosal  (ISO)
toluene 2,4-diisocyanate  (EXP)
trimellitic anhydride  (ISO)
triprolidine  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell activation  (IBA,IDA,ISO)
CD40 signaling pathway  (IBA,ISO)
cellular calcium ion homeostasis  (IMP,ISO)
cellular response to erythropoietin  (ISO)
cellular response to interleukin-1  (IBA)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to tumor necrosis factor  (IBA)
defense response to protozoan  (IBA,IDA)
defense response to virus  (IBA,IDA)
immune response-regulating cell surface receptor signaling pathway  (IBA,IDA)
immune system process  (IEA)
inflammatory response  (IBA,ISO)
positive regulation of angiogenesis  (IBA,ISO)
positive regulation of B cell proliferation  (IBA,IDA,IGI)
positive regulation of blood vessel endothelial cell migration  (IBA,ISO)
positive regulation of endothelial cell apoptotic process  (IBA,ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IBA)
positive regulation of interleukin-12 production  (IBA,IDA)
positive regulation of isotype switching to IgG isotypes  (IBA,IDA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IBA,ISO)
positive regulation of protein kinase C signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IBA,ISO)
protein kinase B signaling  (IDA)
regulation of immune response  (IDA)
regulation of immunoglobulin production  (IBA,IDA)
response to bacterium  (ISO)
response to cobalamin  (ISO)
response to interferon-gamma  (IBA)
response to nutrient levels  (ISO)
response to peptide  (ISO)
TRIF-dependent toll-like receptor signaling pathway  (IBA)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal circulating glucose level  (IEA)
abnormal class switch recombination  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal lymph node germinal center morphology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal thymus epithelium morphology  (IAGP)
abnormal thymus medulla morphology  (IAGP)
absent germinal center B cells  (IAGP)
absent lymph node germinal center  (IAGP)
absent spleen germinal center  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased bone mineral density  (IAGP)
decreased cerebral infarction size  (IAGP)
decreased compact bone mass  (IAGP)
decreased IgA level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased mature B cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased platelet aggregation  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased susceptibility to type II hypersensitivity reaction  (IAGP)
decreased trabecular bone mass  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
glomerulonephritis  (IAGP)
impaired humoral immune response  (IEA)
increased anti-double stranded DNA antibody level  (IAGP)
increased follicular B cell number  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased lymphocyte cell number  (IEA)
increased marginal zone B cell number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased T follicular helper cell number  (IAGP)
increased transitional stage B cell number  (IAGP)
increased urine protein level  (IAGP)
no abnormal phenotype detected  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
References

References - curated
1. Advani R, etal., J Clin Oncol. 2009 Sep 10;27(26):4371-7. doi: 10.1200/JCO.2008.21.3017. Epub 2009 Jul 27.
2. Beatty GL, etal., Clin Cancer Res. 2013 Nov 15;19(22):6286-95. doi: 10.1158/1078-0432.CCR-13-1320. Epub 2013 Aug 27.
3. Beatty GL, etal., Science. 2011 Mar 25;331(6024):1612-6.
4. Blair PA, etal., J Immunol. 2009 Mar 15;182(6):3492-502. doi: 10.4049/jimmunol.0803052.
5. Blanco-Kelly F, etal., PLoS One. 2010 Jul 12;5(7):e11520.
6. Bo H, etal., Cardiovasc Pathol. 2010 Nov-Dec;19(6):371-6. doi: 10.1016/j.carpath.2009.10.002. Epub 2009 Nov 14.
7. Borcherding F, etal., Am J Pathol. 2010 Apr;176(4):1816-27. Epub 2010 Feb 4.
8. Campean V, etal., Atherosclerosis. 2007 Jan;190(1):156-66. Epub 2006 Feb 21.
9. Caproni M, etal., J Rheumatol. 2007 Dec;34(12):2412-6. Epub 2007 Nov 15.
10. Chen CR, etal., Thyroid. 2006 May;16(5):427-34.
11. Chu Q, etal., Clin Experiment Ophthalmol. 2011 Mar;39(2):142-51. doi: 10.1111/j.1442-9071.2010.02437.x.
12. Contin C, etal., Immunology. 2003 Sep;110(1):131-40.
13. de Ramon L, etal., Kidney Int. 2015 Sep;88(3):538-49. doi: 10.1038/ki.2015.146. Epub 2015 May 20.
14. DU AL, etal., Chin Med J (Engl). 2013 Aug;126(15):2934-7.
15. Ellina O, etal., Clin Chem Lab Med. 2012 Jan;50(1):167-74. doi: 10.1515/cclm.2011.881.
16. Ferrari S, etal., Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12614-9.
17. Ferretti MT, etal., Neurobiol Aging. 2011 Mar 15.
18. Francisco JA, etal., Blood. 1997 Jun 15;89(12):4493-500.
19. Francisco JA, etal., Cancer Res. 2000 Jun 15;60(12):3225-31.
20. Gandhi KS, etal., Hum Mol Genet. 2010 Jun 1;19(11):2134-43. Epub 2010 Feb 27.
21. Gao D, etal., Gut. 2005 Jan;54(1):70-7.
22. Gocmen AY, etal., Appl Physiol Nutr Metab. 2011 Jun;36(3):323-30. doi: 10.1139/h11-022. Epub 2011 May 16.
23. Gocmen AY, etal., Can J Physiol Pharmacol. 2013 Sep;91(9):680-5. doi: 10.1139/cjpp-2012-0325. Epub 2013 Apr 8.
24. Godoy LC, etal., Shock. 2010 Jun;33(6):626-33.
25. Gong X, etal., Int Heart J. 2014;55(6):539-45. Epub 2014 Oct 7.
26. Green KA, etal., J Virol. 2002 Dec;76(24):13106-10.
27. Haase C and Markholst H, Ann N Y Acad Sci. 2007 Jun;1107:373-9.
28. Haller ST, etal., Hypertension. 2013 Apr;61(4):894-900. doi: 10.1161/HYPERTENSIONAHA.111.00685. Epub 2013 Feb 11.
29. Hammwohner M, etal., Exp Biol Med (Maywood). 2007 Apr;232(4):581-9.
30. Hang L, etal., J Immunol. 2010 Sep 15;185(6):3184-9. Epub 2010 Aug 11.
31. Hayashi C, etal., J Innate Immun. 2010;2(4):334-43. Epub 2010 May 10.
32. Hongjia L, etal., Cell Biochem Funct. 2010 Oct;28(7):597-603.
33. Horton HM, etal., Blood. 2010 Oct 21;116(16):3004-12. Epub 2010 Jul 8.
34. Houston FA, etal., Thyroid. 2004 Jul;14(7):506-9.
35. Hsiao JY, etal., Eur J Endocrinol. 2008 Nov;159(5):617-21. doi: 10.1530/EJE-08-0410. Epub 2008 Aug 28.
36. Hsieh YY, etal., Int J Biol Sci. 2009;5(1):74-81. Epub 2009 Jan 9.
37. Ishikawa M, etal., Circulation. 2005 Apr 5;111(13):1690-6. Epub 2005 Mar 28.
38. Jackaman C and Nelson DJ, Cancer Immunol Immunother. 2012 Apr;61(4):549-60. doi: 10.1007/s00262-011-1120-5. Epub 2011 Oct 15.
39. Jiang X, etal., Immunology. 2010 Apr;129(4):556-66. Epub 2009 Sep 11.
40. Jin YZ and Xie SS, Transplant Proc. 2003 Dec;35(8):3165-6.
41. Joo YB, etal., Rheumatology (Oxford). 2013 Apr;52(4):623-30. doi: 10.1093/rheumatology/kes339. Epub 2012 Dec 18.
42. Kalantari-Dehaghi M, etal., Exp Dermatol. 2011 Feb;20(2):154-6. doi: 10.1111/j.1600-0625.2010.01193.x.
43. Ke B, etal., Mol Ther. 2004 Jan;9(1):38-45.
44. Kim J, etal., J Immunol. 2008 Nov 15;181(10):7380-9.
45. Kim JH, etal., Mol Ther. 2005 Jun;11(6):941-9.
46. Komura K, etal., Ann Rheum Dis. 2008 Jun;67(6):867-72. Epub 2007 Sep 6.
47. Kosaka A, etal., Cancer Immunol Immunother. 2014 Aug;63(8):847-57. doi: 10.1007/s00262-014-1561-8. Epub 2014 May 31.
48. Krimmer DI, etal., Allergy. 2009 Jul;64(7):1074-82. Epub 2009 Feb 12.
49. Kuo HC, etal., ScientificWorldJournal. 2012;2012:520865. doi: 10.1100/2012/520865. Epub 2012 May 2.
50. Lehmann C, etal., PLoS One. 2010 Jun 14;5(6):e11110.
51. Liu C, etal., J Immunother. 2012 Apr;35(3):276-82. doi: 10.1097/CJI.0b013e31824e7f43.
52. Liu Y, etal., Zhong Yao Cai. 2009 Mar;32(3):380-3.
53. Luhrmann A, etal., Exp Lung Res. 2010 Mar;36(2):85-93. doi: 10.3109/01902140903144138.
54. Lukanov TH, etal., Clin Appl Thromb Hemost. 2010 Jun;16(3):306-12. doi: 10.1177/1076029608331229. Epub 2009 Feb 15.
55. Mai G, etal., Transplant Proc. 2005 Jan-Feb;37(1):460-2.
56. Malik F, etal., Eur J Cancer. 2009 May;45(8):1494-509. doi: 10.1016/j.ejca.2009.01.034. Epub 2009 Mar 5.
57. Martin DL, etal., J Immunol. 2000 Jan 15;164(2):779-85.
58. Mason RP, etal., J Atheroscler Thromb. 2011;18(9):774-83. Epub 2011 Jun 13.
59. Mazar J, etal., Kidney Int. 2005 Apr;67(4):1340-9.
60. Meabed MH, etal., Hematology. 2007 Aug;12(4):301-7.
61. Meers S, etal., Leukemia. 2007 Dec;21(12):2411-9. Epub 2007 Sep 6.
62. Mengel M, etal., Transpl Int. 2004 Jul;17(6):293-300. Epub 2004 Jun 19.
63. Moore TM, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Dec;283(6):L1255-62. Epub 2002 Aug 9.
64. Morales-Aza B, etal., Blood. 2009 Apr 30;113(18):4206-12. Epub 2009 Feb 6.
65. Murphy WJ, etal., J Immunol. 2003 Mar 1;170(5):2727-33.
66. Murray HW, etal., Infect Immun. 2003 Nov;71(11):6453-62.
67. Mysliwiec J, etal., Immunol Invest. 2007;36(3):247-57.
68. Nieters A, etal., Int J Cancer. 2011 Mar 15;128(6):1481-5. doi: 10.1002/ijc.25420.
69. Oflazoglu E, etal., Eur J Dermatol. 2008 Sep-Oct;18(5):527-33. Epub 2008 Aug 8.
70. OMIM Disease Annotation Pipeline
71. Orsini E, etal., Leuk Res. 2006 Jul;30(7):785-94. Epub 2006 Mar 9.
72. Otahal P, etal., J Immunol. 2007 Nov 15;179(10):6686-95.
73. Oz HS, etal., Microb Pathog. 2000 Sep;29(3):187-90.
74. Pawlak K, etal., Clin Biochem. 2010 Dec;43(18):1393-8. doi: 10.1016/j.clinbiochem.2010.09.002. Epub 2010 Sep 21.
75. Piguet PF, etal., Am J Pathol. 2001 Aug;159(2):733-42.
76. Pipeline to import KEGG annotations from KEGG into RGD
77. Plant D, etal., Ann Rheum Dis. 2010 Aug;69(8):1548-53. Epub 2010 May 24.
78. Puliaev R, etal., J Immunol. 2008 Jul 1;181(1):47-61.
79. Resetkova E, etal., Thyroid. 1996 Aug;6(4):267-73.
80. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
81. RGD automated import pipeline for gene-chemical interactions
82. Ripoll E, etal., Gene Ther. 2011 Oct;18(10):945-52. doi: 10.1038/gt.2011.39. Epub 2011 Apr 7.
83. Ripoll E, etal., PLoS One. 2013 Jun 14;8(6):e65068. doi: 10.1371/journal.pone.0065068. Print 2013.
84. Rodenburg W, etal., Proteomics Clin Appl. 2010 Jul;4(6-7):603-12. doi: 10.1002/prca.200900175. Epub 2010 Mar 24.
85. Ruth AJ, etal., J Am Soc Nephrol. 2003 Nov;14(11):2813-22.
86. Ruth AJ, etal., J Immunol. 2004 Jul 1;173(1):136-44.
87. Seko Y, etal., Circ Res. 1998 Aug 24;83(4):463-9.
88. Seko Y, etal., Circulation. 1998 Feb 24;97(7):637-9.
89. Seko Y, etal., J Pathol. 1999 Aug;188(4):423-30. doi: 10.1002/(SICI)1096-9896(199908)188:4<423::AID-PATH373>3.0.CO;2-8.
90. Shuang C, etal., PLoS One. 2011;6(8):e23762. doi: 10.1371/journal.pone.0023762. Epub 2011 Aug 30.
91. Suzuki M, etal., J Allergy Clin Immunol. 2010 Mar;125(3):737-43, 743.e1-743.e6.
92. Tjomsland V, etal., PLoS One. 2010 Oct 15;5(10):e13441.
93. Tkacova R, etal., Respiration. 2011;81(5):386-93. Epub 2010 Aug 12.
94. Toapanta FR and Ross TM, Respir Res. 2009 Nov 18;10:112.
95. Tomer Y, etal., Thyroid. 2002 Dec;12(12):1129-35.
96. van den Oord JJ, etal., Am J Pathol. 1996 Dec;149(6):1953-61.
97. Vazgiourakis VM, etal., Ann Rheum Dis. 2011 Sep 12.
98. Veber D, etal., J Neuroimmunol. 2006 Jul;176(1-2):24-33. Epub 2006 May 22.
99. Vonderheide RH, etal., J Clin Oncol. 2007 Mar 1;25(7):876-83.
100. Wang M, etal., DNA Cell Biol. 2011 Mar;30(3):173-8. Epub 2010 Nov 22.
101. Wang Y, etal., Kidney Int. 2013 Feb;83(2):223-32. doi: 10.1038/ki.2012.374. Epub 2012 Dec 5.
102. Welniak LA, etal., Biol Blood Marrow Transplant. 2004 Aug;10(8):534-9.
103. Westwood JA, etal., J Transl Med. 2010 Apr 28;8:42. doi: 10.1186/1479-5876-8-42.
104. Wu M and Li YG, Mol Cell Biochem. 2006 Jan;282(1-2):141-6.
105. Xu J, etal., J Pediatr Gastroenterol Nutr. 2011 Feb;52(2):140-6.
106. Yan J, etal., Hepatology. 2011 May;53(5):1455-67. doi: 10.1002/hep.24270.
107. Yang J, etal., World J Gastroenterol. 2012 Jul 21;18(27):3537-50. doi: 10.3748/wjg.v18.i27.3537.
108. YanYun P, etal., Cell Physiol Biochem. 2015;36(2):683-96.
109. Yuan M, etal., Clin Exp Pharmacol Physiol. 2010 Aug;37(8):848-51.
110. Zajkowska JM, etal., Neurol Neurochir Pol. 2006 Jan-Feb;40(1):22-7.
111. Zervou MI, etal., Hum Immunol. 2011 Sep;72(9):761-5. Epub 2011 May 24.
112. Zheng X, etal., J Immunol. 2010 Jun 1;184(11):6457-64. Epub 2010 Apr 30.
113. Zhou Q, etal., Infect Immun. 2006 Apr;74(4):2161-8.
114. Zhu P and Zou LP, Zhongguo Dang Dai Er Ke Za Zhi. 2009 May;11(5):354-6.
115. Zhu R, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Sep;22(17):780-2, 784.
116. Zhu W, etal., Neurobiol Dis. 2007 Mar;25(3):642-8. Epub 2006 Dec 22.
Additional References at PubMed
PMID:1281194   PMID:1370315   PMID:1431091   PMID:7517360   PMID:7517793   PMID:7519997   PMID:7527552   PMID:7529804   PMID:7533327   PMID:7534202   PMID:7542547   PMID:7564113  
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PMID:9291580   PMID:9317105   PMID:9373037   PMID:9457670   PMID:9498737   PMID:9514916   PMID:9545506   PMID:9616220   PMID:9671306   PMID:9725199   PMID:9820506   PMID:9923613  
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PMID:16434500   PMID:16511555   PMID:16517718   PMID:16546095   PMID:16549596   PMID:16571771   PMID:16602821   PMID:16622006   PMID:16622023   PMID:16670308   PMID:16708399   PMID:16715101  
PMID:16756565   PMID:16775321   PMID:16783845   PMID:16879309   PMID:16885377   PMID:16887999   PMID:16920960   PMID:16955139   PMID:16973390   PMID:17015698   PMID:17015727   PMID:17027924  
PMID:17043144   PMID:17045255   PMID:17062001   PMID:17082576   PMID:17114424   PMID:17114448   PMID:17163452   PMID:17182586   PMID:17202317   PMID:17202327   PMID:17223973   PMID:17237405  
PMID:17277123   PMID:17277142   PMID:17311995   PMID:17312128   PMID:17324402   PMID:17360936   PMID:17372166   PMID:17452522   PMID:17476359   PMID:17488293   PMID:17618911   PMID:17626103  
PMID:17626150   PMID:17682046   PMID:17689597   PMID:17827394   PMID:17878343   PMID:17878362   PMID:17919601   PMID:17967972   PMID:17975322   PMID:17989345   PMID:18006702   PMID:18195092  
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PMID:21071692   PMID:21098219   PMID:21166993   PMID:21217818   PMID:21262813   PMID:21262968   PMID:21383499   PMID:21410936   PMID:21430229   PMID:21441458   PMID:21441935   PMID:21460206  
PMID:21471446   PMID:21567389   PMID:21636296   PMID:21640399   PMID:21674065   PMID:21677750   PMID:21704012   PMID:21799861   PMID:21829693   PMID:21846723   PMID:21849683   PMID:21852502  
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PMID:27022143   PMID:27075414   PMID:27180986   PMID:27217585   PMID:27265505   PMID:27292635   PMID:27342845   PMID:27474370   PMID:27488034   PMID:27509492   PMID:27512950   PMID:27521344  
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PMID:29321275   PMID:29396161   PMID:29436413   PMID:29452567   PMID:30013024   PMID:30096208   PMID:30918005   PMID:30930899   PMID:31467410   PMID:31484732   PMID:31488565   PMID:31604965  
PMID:32213589   PMID:32411702   PMID:32559293  


Genomics

Comparative Map Data
Cd40
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,897,535 - 164,913,574 (+)NCBI
GRCm382165,055,614 - 165,071,654 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2165,055,627 - 165,072,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv372164,881,136 - 164,897,154 (+)NCBIGRCm37mm9NCBIm37
MGSCv362164,746,841 - 164,762,859 (+)NCBImm8
Celera2170,992,951 - 171,008,953 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.38NCBI
CD40
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2046,118,278 - 46,129,863 (+)EnsemblGRCh38hg38GRCh38
GRCh382046,118,242 - 46,129,858 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372044,746,899 - 44,758,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362044,180,313 - 44,191,791 (+)NCBINCBI36hg18NCBI36
Celera2041,458,363 - 41,469,842 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2041,488,189 - 41,499,674 (+)NCBIHuRef
CHM1_12044,649,527 - 44,661,003 (+)NCBICHM1_1
Cd40
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03161,519,789 - 161,534,943 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,519,743 - 161,534,704 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,704,285 - 167,719,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43156,092,602 - 156,107,427 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13155,998,622 - 156,006,374 (+)NCBI
Celera3152,395,702 - 152,410,527 (+)NCBICelera
Cytogenetic Map3q42NCBI
Cd40
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544511,190,603 - 11,202,093 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544511,191,817 - 11,202,156 (-)NCBIChiLan1.0ChiLan1.0
CD40
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12043,541,619 - 43,552,994 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2043,541,619 - 43,552,994 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02042,455,711 - 42,467,139 (+)NCBIMhudiblu_PPA_v0panPan3
CD40
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2433,372,930 - 33,383,301 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12433,352,992 - 33,383,488 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cd40
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365146,936,915 - 6,947,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD40
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1748,286,029 - 48,298,528 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,286,116 - 48,298,188 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,932,001 - 53,943,003 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD40
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl217,753,394 - 17,764,566 (-)Ensembl
ChlSab1.1217,753,713 - 17,765,134 (-)NCBI
Cd40
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247908,475,640 - 8,485,927 (-)NCBI

Position Markers
AI326936  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382165,071,501 - 165,071,600UniSTSGRCm38
MGSCv372164,897,001 - 164,897,100UniSTSGRCm37
Celera2171,008,800 - 171,008,899UniSTS
Cytogenetic Map2H3UniSTS
cM Map297.0UniSTS
Whitehead/MRC_RH21886.25UniSTS
Tnfrsf5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382165,071,475 - 165,071,585UniSTSGRCm38
MGSCv372164,896,975 - 164,897,085UniSTSGRCm37
Celera2171,008,774 - 171,008,884UniSTS
Cytogenetic Map2H3UniSTS
cM Map297.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163844614182113224Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145676855179677006Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132182239166182410Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162791700182113224Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152857301169276004Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145355029179355165Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142751556178800659Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145386799179386921Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162895006178800659Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135857301169857441Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162895006178800659Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2139124680173124809Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144673941181254801Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155982127182113224Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156354671182113224Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164873361182113224Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158236417178800659Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2150146982182113224Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151936377182113224Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163844614182113224Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150370301182113224Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143931525165823099Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149394987182113224Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143931525169276004Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148822973182113224Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135857301169857441Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135857301169857441Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135857301169857441Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150370301182113224Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142586427176586530Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150370301182113224Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148396284182113224Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133302991167303138Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133302991167303138Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151867353174547331Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152487900182113224Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
12801461Intim1_mintima modifier 1 (mouse)2142586427176586530Mouse
11353826Bdln10_mbody length 10 (mouse)2140599562174599562Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135590624173607823Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
12910810Pwbwq2_mpre-weaning body weight QTL 2 (mouse)2160769245169952882Mouse
12910800Pwgrq3_mpre-weaning growth rate QTL 3 (mouse)2160769245169952882Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1808
Count of miRNA genes:710
Interacting mature miRNAs:913
Transcripts:ENSMUST00000017799, ENSMUST00000073707, ENSMUST00000081310, ENSMUST00000140951, ENSMUST00000153105, ENSMUST00000154443, ENSMUST00000184221
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006499154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006499155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH001877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI385482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ401387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ401388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ401389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ401390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY259264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY743050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000017799   ⟹   ENSMUSP00000017799
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2165,055,627 - 165,072,948 (+)Ensembl
RefSeq Acc Id: ENSMUST00000073707   ⟹   ENSMUSP00000073386
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2165,055,636 - 165,071,654 (+)Ensembl
RefSeq Acc Id: ENSMUST00000081310   ⟹   ENSMUSP00000080059
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2165,055,680 - 165,070,745 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140951   ⟹   ENSMUSP00000122981
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2165,055,681 - 165,062,780 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153105
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2165,062,676 - 165,066,695 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154443   ⟹   ENSMUSP00000138707
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2165,055,627 - 165,062,723 (+)Ensembl
RefSeq Acc Id: ENSMUST00000184221   ⟹   ENSMUSP00000139193
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2165,055,704 - 165,071,000 (+)Ensembl
RefSeq Acc Id: NM_011611   ⟹   NP_035741
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,556 - 164,913,574 (+)NCBI
GRCm382165,055,636 - 165,071,654 (+)NCBI
MGSCv372164,881,136 - 164,897,154 (+)RGD
Celera2170,992,951 - 171,008,953 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_170702   ⟹   NP_733803
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,556 - 164,913,574 (+)NCBI
GRCm382165,055,636 - 165,071,654 (+)NCBI
MGSCv372164,881,136 - 164,897,154 (+)RGD
Celera2170,992,951 - 171,008,953 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_170703   ⟹   NP_733804
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,556 - 164,913,574 (+)NCBI
GRCm382165,055,636 - 165,071,654 (+)NCBI
MGSCv372164,881,136 - 164,897,154 (+)RGD
Celera2170,992,951 - 171,008,953 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_170704   ⟹   NP_733805
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,556 - 164,913,574 (+)NCBI
GRCm382165,055,636 - 165,071,654 (+)NCBI
MGSCv372164,881,136 - 164,897,154 (+)RGD
Celera2170,992,951 - 171,008,953 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_027852
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,556 - 164,913,574 (+)NCBI
GRCm382165,055,636 - 165,071,654 (+)NCBI
MGSCv372164,881,136 - 164,897,154 (+)RGD
Celera2170,992,951 - 171,008,953 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006499154   ⟹   XP_006499217
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,537 - 164,913,574 (+)NCBI
GRCm382165,055,615 - 165,071,654 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006499155   ⟹   XP_006499218
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,535 - 164,913,574 (+)NCBI
GRCm382165,055,614 - 165,071,654 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_035741 (Get FASTA)   NCBI Sequence Viewer  
  NP_733803 (Get FASTA)   NCBI Sequence Viewer  
  NP_733804 (Get FASTA)   NCBI Sequence Viewer  
  NP_733805 (Get FASTA)   NCBI Sequence Viewer  
  XP_006499217 (Get FASTA)   NCBI Sequence Viewer  
  XP_006499218 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37404 (Get FASTA)   NCBI Sequence Viewer  
  AAB08705 (Get FASTA)   NCBI Sequence Viewer  
  AAH29254 (Get FASTA)   NCBI Sequence Viewer  
  BAC40978 (Get FASTA)   NCBI Sequence Viewer  
  BAE29991 (Get FASTA)   NCBI Sequence Viewer  
  BAE31440 (Get FASTA)   NCBI Sequence Viewer  
  BAE31471 (Get FASTA)   NCBI Sequence Viewer  
  BAE31613 (Get FASTA)   NCBI Sequence Viewer  
  BAE33789 (Get FASTA)   NCBI Sequence Viewer  
  BAE36663 (Get FASTA)   NCBI Sequence Viewer  
  BAE36843 (Get FASTA)   NCBI Sequence Viewer  
  CAC29427 (Get FASTA)   NCBI Sequence Viewer  
  CAC29428 (Get FASTA)   NCBI Sequence Viewer  
  CAC29429 (Get FASTA)   NCBI Sequence Viewer  
  CAC29430 (Get FASTA)   NCBI Sequence Viewer  
  CAJ18551 (Get FASTA)   NCBI Sequence Viewer  
  EDL06442 (Get FASTA)   NCBI Sequence Viewer  
  EDL06443 (Get FASTA)   NCBI Sequence Viewer  
  EDL06444 (Get FASTA)   NCBI Sequence Viewer  
  EDL06445 (Get FASTA)   NCBI Sequence Viewer  
  EDL06446 (Get FASTA)   NCBI Sequence Viewer  
  P27512 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_035741   ⟸   NM_011611
- Peptide Label: isoform 1 precursor
- UniProtKB: P27512 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_733805   ⟸   NM_170704
- Peptide Label: isoform 4 precursor
- UniProtKB: P27512 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_733803   ⟸   NM_170702
- Peptide Label: isoform 5 precursor
- UniProtKB: P27512 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_733804   ⟸   NM_170703
- Peptide Label: isoform 2 precursor
- UniProtKB: P27512 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006499218   ⟸   XM_006499155
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006499217   ⟸   XM_006499154
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000139193   ⟸   ENSMUST00000184221
RefSeq Acc Id: ENSMUSP00000073386   ⟸   ENSMUST00000073707
RefSeq Acc Id: ENSMUSP00000122981   ⟸   ENSMUST00000140951
RefSeq Acc Id: ENSMUSP00000017799   ⟸   ENSMUST00000017799
RefSeq Acc Id: ENSMUSP00000138707   ⟸   ENSMUST00000154443
RefSeq Acc Id: ENSMUSP00000080059   ⟸   ENSMUST00000081310
Protein Domains
TNFR-Cys

Promoters
RGD ID:6830978
Promoter ID:MM_KWN:32985
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000109305,   NM_170702,   NM_170703,   NM_170704,   NR_027852_CD40,   OTTMUST00000039545,   OTTMUST00000039751,   OTTMUST00000039752
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362164,880,491 - 164,881,307 (+)MPROMDB
RGD ID:6830979
Promoter ID:MM_KWN:32986
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:OTTMUST00000039754
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362164,888,344 - 164,888,844 (+)MPROMDB
RGD ID:6879716
Promoter ID:EPDNEW_M3309
Type:initiation region
Name:Cd40_1
Description:Mus musculus CD40 antigen , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382165,055,680 - 165,055,740EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88336 AgrOrtholog
Ensembl Genes ENSMUSG00000017652 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000017799 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000073386 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000080059 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000122981 UniProtKB/TrEMBL
  ENSMUSP00000138707 UniProtKB/TrEMBL
  ENSMUSP00000139193 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000017799 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000073707 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000081310 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000140951 UniProtKB/TrEMBL
  ENSMUST00000154443 UniProtKB/TrEMBL
  ENSMUST00000184221 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_5 UniProtKB/Swiss-Prot
  TNFRSF5_N UniProtKB/Swiss-Prot
KEGG Report mmu:21939 UniProtKB/Swiss-Prot
MGD MGI:88336 ENTREZGENE
NCBI Gene 21939 ENTREZGENE
Pfam TNFR_c6 UniProtKB/Swiss-Prot
PhenoGen Cd40 PhenoGen
PRINTS TNFACTORR5 UniProtKB/Swiss-Prot
PROSITE TNFR_NGFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.271833 ENTREZGENE
UniProt A2A5L7_MOUSE UniProtKB/TrEMBL
  P27512 ENTREZGENE
  S4R2M8_MOUSE UniProtKB/TrEMBL
  TNR5_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3TS33 UniProtKB/Swiss-Prot
  Q3TSL2 UniProtKB/Swiss-Prot
  Q3U799 UniProtKB/Swiss-Prot
  Q3U7C9 UniProtKB/Swiss-Prot
  Q3UBH3 UniProtKB/Swiss-Prot
  Q542B1 UniProtKB/Swiss-Prot
  Q8K2X6 UniProtKB/Swiss-Prot
  Q99NE0 UniProtKB/Swiss-Prot
  Q99NE1 UniProtKB/Swiss-Prot
  Q99NE2 UniProtKB/Swiss-Prot
  Q99NE3 UniProtKB/Swiss-Prot