Cd40 (CD40 antigen) - Rat Genome Database

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Gene: Cd40 (CD40 antigen) Mus musculus
Analyze
Symbol: Cd40
Name: CD40 antigen
RGD ID: 1615152
MGI Page MGI
Description: Predicted to enable antigen binding activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Involved in B cell mediated immunity; CD40 signaling pathway; and intracellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI326936; B-cell surface antigen CD40; Bp5; Bp50; CD40L receptor; GP39; HIGM1; IGM; IMD3; p5; p50; T-BAM; T-cell differentiation antigen; Tnfr; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,897,535 - 164,913,574 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,897,547 - 164,914,868 (+)EnsemblGRCm39 Ensembl
GRCm382165,055,614 - 165,071,654 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2165,055,627 - 165,072,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv372164,881,136 - 164,897,154 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,746,841 - 164,762,859 (+)NCBIMGSCv36mm8
Celera2170,992,951 - 171,008,953 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute myocarditis  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (IEP)
Animal Helminthiasis  (IEP)
Animal Mammary Neoplasms  (IMP)
Animal Viral Hepatitis  (IMP)
anti-basement membrane glomerulonephritis  (IMP)
arthritis  (ISO)
asthma  (IEP,ISO)
atherosclerosis  (IEP,ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-cell lymphoma  (ISO)
bacterial pneumonia  (IEP)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis  (ISO)
Burkitt lymphoma  (ISO)
chlamydia  (IEP)
Chronic Allograft Dysfunction  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
crescentic glomerulonephritis  (IMP)
Crohn's disease  (ISO)
cryptococcosis  (IMP)
cutaneous lupus erythematosus  (ISO)
Delayed Hypersensitivity  (IMP)
dermatomyositis  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
Discoid Lupus Erythematosus  (ISO)
Ehrlich tumor carcinoma  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IDA)
erythema multiforme  (ISO)
Experimental Arthritis  (IMP)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Mammary Neoplasms  (IEP)
follicular lymphoma  (ISO)
graft-versus-host disease  (IDA)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
high grade glioma  (IMP)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IEP)
hyper IgM syndrome  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperimmunoglobulin syndrome  (ISO)
hyperinsulinism  (ISO)
hyperthyroidism  (IMP)
immunodeficiency with hyper IgM type 3  (ISO)
Inflammation  (IMP)
Insulin Resistance  (ISO)
insulinoma  (IMP)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
lichen planus  (ISO)
Liver Reperfusion Injury  (ISO)
lupus nephritis  (IDA,IMP)
Lyme Neuroborreliosis  (ISO)
Lymphatic Metastasis  (ISO)
malaria  (IMP)
malignant mesothelioma  (IMP)
melanoma  (IMP,ISO)
membranous glomerulonephritis  (IMP,ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
Murine Acquired Immunodeficiency Syndrome  (IMP)
myelodysplastic syndrome  (ISO)
Myocardial Ischemia  (ISO)
Neisseriaceae Infections  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
pancreatic ductal carcinoma  (IDA,ISO)
pemphigus  (ISO)
Perennial Allergic Rhinitis  (IMP)
perinatal necrotizing enterocolitis  (ISO)
peritonitis  (IEP)
plasma cell leukemia  (ISO)
pneumocystosis  (IDA)
pre-eclampsia  (ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
renal artery obstruction  (ISO)
renal cell carcinoma  (IDA,IMP)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Schistosomiasis Mansoni  (IMP)
Sepsis  (ISO)
skin melanoma  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Subacute Combined Degeneration  (ISO)
systemic lupus erythematosus  (ISO)
thrombosis  (IMP)
tick-borne encephalitis  (ISO)
transient cerebral ischemia  (IMP)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
Vascular Calcification  (ISO)
Viral Myocarditis  (IEP)
visceral leishmaniasis  (IMP)
visual epilepsy  (ISO)
X-linked hyper IgM syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-demecolcine  (ISO)
(R)-mevalonic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-mercaptopropanoic acid  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-aminopyridine  (ISO)
4-DAMP(1+)  (ISO)
4-hydroxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
atropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucan  (EXP)
betamethasone valerate  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbachol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
cortisol  (EXP)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (EXP)
daidzein  (EXP)
delta-tocotrienol  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
fisetin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
furan  (ISO)
furosemide  (ISO)
Genipin  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
helenalin  (ISO)
histamine  (ISO)
hydroxysafflor yellow A  (ISO)
imiquimod  (EXP)
immunological adjuvant  (ISO)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoflurane  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metam  (EXP)
methylarsonic acid  (EXP)
mevastatin  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP)
muramyl dipeptide  (ISO)
Myrtucommulone A  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP)
nicotinamide  (EXP)
nystatin  (EXP)
o-anisidine  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
pevonedistat  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirenzepine  (ISO)
poly(I:C)  (ISO)
pravastatin  (EXP,ISO)
propanal  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirtinol  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium aurothiosulfate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
succimer  (EXP)
tetrathiomolybdate(2-)  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
toluene 2,4-diisocyanate  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triprolidine  (ISO)
triptonide  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell activation  (IBA,IDA,ISO)
B cell mediated immunity  (IGI)
B cell proliferation  (IDA,IGI)
CD40 signaling pathway  (IBA,IGI,ISO)
cellular response to erythropoietin  (ISO)
cellular response to interleukin-1  (IBA,ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to tumor necrosis factor  (IBA,ISO)
defense response to protozoan  (IBA,IDA)
defense response to virus  (IBA,IDA)
immune response-regulating cell surface receptor signaling pathway  (IBA,IDA)
immune system process  (IEA)
inflammatory response  (IBA,ISO)
intracellular calcium ion homeostasis  (IMP,ISO)
positive regulation of angiogenesis  (IBA,ISO)
positive regulation of B cell proliferation  (IBA,IDA,IGI)
positive regulation of blood vessel endothelial cell migration  (IBA,ISO)
positive regulation of endothelial cell apoptotic process  (IBA,ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IBA)
positive regulation of interleukin-12 production  (IBA,IDA)
positive regulation of isotype switching to IgG isotypes  (IBA,IDA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IBA,ISO)
positive regulation of protein kinase C signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IBA,ISO)
protein kinase B signaling  (IDA)
regulation of immune response  (IDA)
regulation of immunoglobulin production  (IDA)
response to bacterium  (ISO)
response to cobalamin  (ISO)
response to nutrient levels  (ISO)
response to peptide  (ISO)
response to type II interferon  (IBA,ISO)
TRIF-dependent toll-like receptor signaling pathway  (IBA)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal lymph node germinal center morphology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal thymus epithelium morphology  (IAGP)
abnormal thymus medulla morphology  (IAGP)
absent germinal center B cells  (IAGP)
absent lymph node germinal center  (IAGP)
absent spleen germinal center  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased bone mineral density  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased compact bone mass  (IAGP)
decreased IgA level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased mature B cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased platelet aggregation  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased susceptibility to type II hypersensitivity reaction  (IAGP)
decreased trabecular bone mass  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
glomerulonephritis  (IAGP)
impaired humoral immune response  (IEA)
increased anti-double stranded DNA antibody level  (IAGP)
increased follicular B cell number  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased marginal zone B cell number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased T follicular helper cell number  (IAGP)
increased transitional stage B cell number  (IAGP)
increased urine protein level  (IAGP)
no abnormal phenotype detected  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. Advani R, etal., J Clin Oncol. 2009 Sep 10;27(26):4371-7. doi: 10.1200/JCO.2008.21.3017. Epub 2009 Jul 27.
2. A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. Beatty GL, etal., Clin Cancer Res. 2013 Nov 15;19(22):6286-95. doi: 10.1158/1078-0432.CCR-13-1320. Epub 2013 Aug 27.
3. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Beatty GL, etal., Science. 2011 Mar 25;331(6024):1612-6.
4. Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. Blair PA, etal., J Immunol. 2009 Mar 15;182(6):3492-502. doi: 10.4049/jimmunol.0803052.
5. CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility. Blanco-Kelly F, etal., PLoS One. 2010 Jul 12;5(7):e11520.
6. Blocking the CD40-CD40L interaction by CD40-Ig reduces disease progress in murine myocarditis induced by CVB3. Bo H, etal., Cardiovasc Pathol. 2010 Nov-Dec;19(6):371-6. doi: 10.1016/j.carpath.2009.10.002. Epub 2009 Nov 14.
7. The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease. Borcherding F, etal., Am J Pathol. 2010 Apr;176(4):1816-27. Epub 2010 Feb 4.
8. CD40-CD154 expression in calcified and non-calcified coronary lesions of patients with chronic renal failure. Campean V, etal., Atherosclerosis. 2007 Jan;190(1):156-66. Epub 2006 Feb 21.
9. The CD40/CD40 ligand system in the skin of patients with subacute cutaneous lupus erythematosus. Caproni M, etal., J Rheumatol. 2007 Dec;34(12):2412-6. Epub 2007 Nov 15.
10. Blockade of costimulation between T cells and antigen-presenting cells: an approach to suppress murine Graves' disease induced using thyrotropin receptor-expressing adenovirus. Chen CR, etal., Thyroid. 2006 May;16(5):427-34.
11. Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin. Chu Q, etal., Clin Experiment Ophthalmol. 2011 Mar;39(2):142-51. doi: 10.1111/j.1442-9071.2010.02437.x.
12. Potential role of soluble CD40 in the humoral immune response impairment of uraemic patients. Contin C, etal., Immunology. 2003 Sep;110(1):131-40.
13. CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury. de Ramon L, etal., Kidney Int. 2015 Sep;88(3):538-49. doi: 10.1038/ki.2015.146. Epub 2015 May 20.
14. Neuroprotective effect of AG490 in experimental traumatic brain injury of rats. DU AL, etal., Chin Med J (Engl). 2013 Aug;126(15):2934-7.
15. Extracellular matrix-associated (GAGs, CTGF), angiogenic (VEGF) and inflammatory factors (MCP-1, CD40, IFN-gamma) in type 1 diabetes mellitus nephropathy. Ellina O, etal., Clin Chem Lab Med. 2012 Jan;50(1):167-74. doi: 10.1515/cclm.2011.881.
16. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Ferrari S, etal., Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12614-9.
17. Intracellular Abeta-oligomers and early inflammation in a model of Alzheimer's disease. Ferretti MT, etal., Neurobiol Aging. 2011 Mar 15.
18. In vivo efficacy and toxicity of a single-chain immunotoxin targeted to CD40. Francisco JA, etal., Blood. 1997 Jun 15;89(12):4493-500.
19. Agonistic properties and in vivo antitumor activity of the anti-CD40 antibody SGN-14. Francisco JA, etal., Cancer Res. 2000 Jun 15;60(12):3225-31.
20. The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Gandhi KS, etal., Hum Mol Genet. 2010 Jun 1;19(11):2134-43. Epub 2010 Feb 27.
21. CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis. Gao D, etal., Gut. 2005 Jan;54(1):70-7.
22. Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target. Gocmen AY, etal., Appl Physiol Nutr Metab. 2011 Jun;36(3):323-30. doi: 10.1139/h11-022. Epub 2011 May 16.
23. Effect of atorvastatin on atherosclerotic plaque formation and platelet activation in hypercholesterolemic rats. Gocmen AY, etal., Can J Physiol Pharmacol. 2013 Sep;91(9):680-5. doi: 10.1139/cjpp-2012-0325. Epub 2013 Apr 8.
24. Loss of CD40 endogenous S-nitrosylation during inflammatory response in endotoxemic mice and patients with sepsis. Godoy LC, etal., Shock. 2010 Jun;33(6):626-33.
25. Attenuation of experimental autoimmune myocarditis by si-RNA mediated CD40 silencing. Gong X, etal., Int Heart J. 2014;55(6):539-45. Epub 2014 Oct 7.
26. The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules. Green KA, etal., J Virol. 2002 Dec;76(24):13106-10.
27. CD40 is required for development of islet inflammation in the RIP-CD154 transgenic mouse model of type 1 diabetes. Haase C and Markholst H, Ann N Y Acad Sci. 2007 Jun;1107:373-9.
28. Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis. Haller ST, etal., Hypertension. 2013 Apr;61(4):894-900. doi: 10.1161/HYPERTENSIONAHA.111.00685. Epub 2013 Feb 11.
29. Platelet expression of CD40/CD40 ligand and its relation to inflammatory markers and adhesion molecules in patients with atrial fibrillation. Hammwohner M, etal., Exp Biol Med (Maywood). 2007 Apr;232(4):581-9.
30. Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity. Hang L, etal., J Immunol. 2010 Sep 15;185(6):3184-9. Epub 2010 Aug 11.
31. Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses. Hayashi C, etal., J Innate Immun. 2010;2(4):334-43. Epub 2010 May 10.
32. House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells. Hongjia L, etal., Cell Biochem Funct. 2010 Oct;28(7):597-603.
33. Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies. Horton HM, etal., Blood. 2010 Oct 21;116(16):3004-12. Epub 2010 Jul 8.
34. Role of the CD40 locus in Graves' disease. Houston FA, etal., Thyroid. 2004 Jul;14(7):506-9.
35. Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients. Hsiao JY, etal., Eur J Endocrinol. 2008 Nov;159(5):617-21. doi: 10.1530/EJE-08-0410. Epub 2008 Aug 28.
36. STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma. Hsieh YY, etal., Int J Biol Sci. 2009;5(1):74-81. Epub 2009 Jan 9.
37. CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. Ishikawa M, etal., Circulation. 2005 Apr 5;111(13):1690-6. Epub 2005 Mar 28.
38. Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ -independent resolution of treated-tumors and CD4+ -dependent systemic and memory responses. Jackaman C and Nelson DJ, Cancer Immunol Immunother. 2012 Apr;61(4):549-60. doi: 10.1007/s00262-011-1120-5. Epub 2011 Oct 15.
39. Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection. Jiang X, etal., Immunology. 2010 Apr;129(4):556-66. Epub 2009 Sep 11.
40. Bicistronic adenovirus-mediated gene transfer of CTLA4Ig gene and CD40Ig gene result in indefinite survival of islet xenograft. Jin YZ and Xie SS, Transplant Proc. 2003 Dec;35(8):3165-6.
41. Association of genetic polymorphisms in CD40 with susceptibility to SLE in the Korean population. Joo YB, etal., Rheumatology (Oxford). 2013 Apr;52(4):623-30. doi: 10.1093/rheumatology/kes339. Epub 2012 Dec 18.
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PMID:24492375   PMID:24532579   PMID:24605938   PMID:24647739   PMID:24652469   PMID:24664276   PMID:24706909   PMID:24709684   PMID:24771135   PMID:24815981   PMID:24886282   PMID:24929185  
PMID:25035957   PMID:25072696   PMID:25172502   PMID:25187664   PMID:25477319   PMID:25586186   PMID:25613092   PMID:25616156   PMID:25646303   PMID:25783157   PMID:25786685   PMID:25816012  
PMID:25822797   PMID:25837251   PMID:25856408   PMID:25977307   PMID:26026056   PMID:26064940   PMID:26070485   PMID:26133577   PMID:26189370   PMID:26304989   PMID:26356194   PMID:26561586  
PMID:26562079   PMID:26658005   PMID:26821950   PMID:27022143   PMID:27075414   PMID:27180986   PMID:27217585   PMID:27265505   PMID:27292635   PMID:27342845   PMID:27474370   PMID:27488034  
PMID:27509492   PMID:27512950   PMID:27521344   PMID:27622331   PMID:27705788   PMID:27709293   PMID:27716849   PMID:27753080   PMID:27798262   PMID:27835742   PMID:28093524   PMID:28096086  
PMID:28137874   PMID:28153727   PMID:28192476   PMID:28276457   PMID:28378771   PMID:28542921   PMID:28566713   PMID:28746783   PMID:28767735   PMID:28768709   PMID:29037856   PMID:29084838  
PMID:29111976   PMID:29228057   PMID:29309879   PMID:29321275   PMID:29342141   PMID:29396161   PMID:29436413   PMID:29452567   PMID:30013024   PMID:30096208   PMID:30297432   PMID:30427069  
PMID:30471110   PMID:30918005   PMID:30930899   PMID:31467410   PMID:31484732   PMID:31488565   PMID:31604965   PMID:32135568   PMID:32213589   PMID:32324594   PMID:32411702   PMID:32441445  
PMID:32475820   PMID:32506167   PMID:32559293   PMID:32663195   PMID:32788723   PMID:32802892   PMID:32839611   PMID:32991668   PMID:33254074   PMID:33268774   PMID:33618394   PMID:33917019  
PMID:33976586   PMID:34062352   PMID:34084166   PMID:34443530   PMID:34446808   PMID:35061504   PMID:36055226   PMID:36223931   PMID:36309487   PMID:36520044  


Genomics

Comparative Map Data
Cd40
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,897,535 - 164,913,574 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,897,547 - 164,914,868 (+)EnsemblGRCm39 Ensembl
GRCm382165,055,614 - 165,071,654 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2165,055,627 - 165,072,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv372164,881,136 - 164,897,154 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,746,841 - 164,762,859 (+)NCBIMGSCv36mm8
Celera2170,992,951 - 171,008,953 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.38NCBI
CD40
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382046,118,314 - 46,129,858 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2046,118,271 - 46,129,863 (+)EnsemblGRCh38hg38GRCh38
GRCh372044,746,953 - 44,758,497 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362044,180,313 - 44,191,791 (+)NCBINCBI36Build 36hg18NCBI36
Celera2041,458,363 - 41,469,842 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2041,488,189 - 41,499,674 (+)NCBIHuRef
CHM1_12044,649,540 - 44,661,003 (+)NCBICHM1_1
T2T-CHM13v2.02047,854,355 - 47,865,910 (+)NCBIT2T-CHM13v2.0
Cd40
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23153,790,372 - 153,805,279 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,790,449 - 153,805,534 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,599,278 - 157,613,890 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03166,098,246 - 166,112,858 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03163,842,022 - 163,856,635 (+)NCBIRnor_WKY
Rnor_6.03161,519,789 - 161,534,943 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,519,743 - 161,534,704 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,704,285 - 167,719,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43156,092,602 - 156,107,427 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,998,622 - 156,006,374 (+)NCBI
Celera3152,395,702 - 152,410,527 (+)NCBICelera
Cytogenetic Map3q42NCBI
Cd40
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544511,190,603 - 11,202,093 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544511,191,817 - 11,202,156 (-)NCBIChiLan1.0ChiLan1.0
CD40
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12043,541,619 - 43,552,994 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2043,541,619 - 43,552,994 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02042,455,711 - 42,467,139 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CD40
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12433,352,992 - 33,383,488 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2433,372,930 - 33,383,301 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,899,232 - 32,909,488 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02434,062,814 - 34,092,886 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2434,082,384 - 34,092,875 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12433,340,743 - 33,351,000 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02433,456,512 - 33,466,773 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,995,494 - 34,005,757 (+)NCBIUU_Cfam_GSD_1.0
Cd40
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640191,483,088 - 191,493,621 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365146,936,572 - 6,947,280 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365146,936,915 - 6,947,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD40
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1748,286,029 - 48,298,528 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,286,116 - 48,298,188 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,932,001 - 53,943,003 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD40
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1217,753,713 - 17,765,134 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl217,753,394 - 17,764,566 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605066,388,299 - 66,399,227 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd40
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247908,476,158 - 8,485,856 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247908,475,640 - 8,485,927 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1808
Count of miRNA genes:710
Interacting mature miRNAs:913
Transcripts:ENSMUST00000017799, ENSMUST00000073707, ENSMUST00000081310, ENSMUST00000140951, ENSMUST00000153105, ENSMUST00000154443, ENSMUST00000184221
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158078337178442452Mouse
12910800Pwgrq3_mpre-weaning growth rate QTL 3 (mouse)2160611165169794802Mouse
12910810Pwbwq2_mpre-weaning body weight QTL 2 (mouse)2160611165169794802Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162433493181755017Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162736926178442452Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162736926178442452Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163486407181755017Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163486407181755017Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164515154181755017Mouse

Markers in Region
AI326936  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382165,071,501 - 165,071,600UniSTSGRCm38
MGSCv372164,897,001 - 164,897,100UniSTSGRCm37
Celera2171,008,800 - 171,008,899UniSTS
Cytogenetic Map2H3UniSTS
cM Map297.0UniSTS
Whitehead/MRC_RH21886.25UniSTS
Tnfrsf5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382165,071,475 - 165,071,585UniSTSGRCm38
MGSCv372164,896,975 - 164,897,085UniSTSGRCm37
Celera2171,008,774 - 171,008,884UniSTS
Cytogenetic Map2H3UniSTS
cM Map297.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006499154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006499155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH001877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI385482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ401387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ401388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ401389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ401390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY259264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY743050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000017799   ⟹   ENSMUSP00000017799
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,897,547 - 164,914,868 (+)Ensembl
GRCm38.p6 Ensembl2165,055,627 - 165,072,948 (+)Ensembl
RefSeq Acc Id: ENSMUST00000073707   ⟹   ENSMUSP00000073386
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,897,556 - 164,913,574 (+)Ensembl
GRCm38.p6 Ensembl2165,055,636 - 165,071,654 (+)Ensembl
RefSeq Acc Id: ENSMUST00000081310   ⟹   ENSMUSP00000080059
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,897,600 - 164,912,665 (+)Ensembl
GRCm38.p6 Ensembl2165,055,680 - 165,070,745 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140951   ⟹   ENSMUSP00000122981
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,897,601 - 164,904,700 (+)Ensembl
GRCm38.p6 Ensembl2165,055,681 - 165,062,780 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153105
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,904,596 - 164,908,615 (+)Ensembl
GRCm38.p6 Ensembl2165,062,676 - 165,066,695 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154443   ⟹   ENSMUSP00000138707
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,897,547 - 164,904,643 (+)Ensembl
GRCm38.p6 Ensembl2165,055,627 - 165,062,723 (+)Ensembl
RefSeq Acc Id: ENSMUST00000184221   ⟹   ENSMUSP00000139193
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,897,624 - 164,912,920 (+)Ensembl
GRCm38.p6 Ensembl2165,055,704 - 165,071,000 (+)Ensembl
RefSeq Acc Id: NM_011611   ⟹   NP_035741
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,556 - 164,913,574 (+)NCBI
GRCm382165,055,636 - 165,071,654 (+)NCBI
MGSCv372164,881,136 - 164,897,154 (+)RGD
Celera2170,992,951 - 171,008,953 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_170702   ⟹   NP_733803
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,556 - 164,913,574 (+)NCBI
GRCm382165,055,636 - 165,071,654 (+)NCBI
MGSCv372164,881,136 - 164,897,154 (+)RGD
Celera2170,992,951 - 171,008,953 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_170703   ⟹   NP_733804
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,556 - 164,913,574 (+)NCBI
GRCm382165,055,636 - 165,071,654 (+)NCBI
MGSCv372164,881,136 - 164,897,154 (+)RGD
Celera2170,992,951 - 171,008,953 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_170704   ⟹   NP_733805
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,556 - 164,913,574 (+)NCBI
GRCm382165,055,636 - 165,071,654 (+)NCBI
MGSCv372164,881,136 - 164,897,154 (+)RGD
Celera2170,992,951 - 171,008,953 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_027852
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,556 - 164,913,574 (+)NCBI
GRCm382165,055,636 - 165,071,654 (+)NCBI
MGSCv372164,881,136 - 164,897,154 (+)RGD
Celera2170,992,951 - 171,008,953 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006499154   ⟹   XP_006499217
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,537 - 164,913,574 (+)NCBI
GRCm382165,055,615 - 165,071,654 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006499155   ⟹   XP_006499218
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,897,535 - 164,913,574 (+)NCBI
GRCm382165,055,614 - 165,071,654 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_035741 (Get FASTA)   NCBI Sequence Viewer  
  NP_733803 (Get FASTA)   NCBI Sequence Viewer  
  NP_733804 (Get FASTA)   NCBI Sequence Viewer  
  NP_733805 (Get FASTA)   NCBI Sequence Viewer  
  XP_006499217 (Get FASTA)   NCBI Sequence Viewer  
  XP_006499218 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37404 (Get FASTA)   NCBI Sequence Viewer  
  AAB08705 (Get FASTA)   NCBI Sequence Viewer  
  AAH29254 (Get FASTA)   NCBI Sequence Viewer  
  BAC40978 (Get FASTA)   NCBI Sequence Viewer  
  BAE29991 (Get FASTA)   NCBI Sequence Viewer  
  BAE31440 (Get FASTA)   NCBI Sequence Viewer  
  BAE31471 (Get FASTA)   NCBI Sequence Viewer  
  BAE31613 (Get FASTA)   NCBI Sequence Viewer  
  BAE33789 (Get FASTA)   NCBI Sequence Viewer  
  BAE36663 (Get FASTA)   NCBI Sequence Viewer  
  BAE36843 (Get FASTA)   NCBI Sequence Viewer  
  CAC29427 (Get FASTA)   NCBI Sequence Viewer  
  CAC29428 (Get FASTA)   NCBI Sequence Viewer  
  CAC29429 (Get FASTA)   NCBI Sequence Viewer  
  CAC29430 (Get FASTA)   NCBI Sequence Viewer  
  CAJ18551 (Get FASTA)   NCBI Sequence Viewer  
  EDL06442 (Get FASTA)   NCBI Sequence Viewer  
  EDL06443 (Get FASTA)   NCBI Sequence Viewer  
  EDL06444 (Get FASTA)   NCBI Sequence Viewer  
  EDL06445 (Get FASTA)   NCBI Sequence Viewer  
  EDL06446 (Get FASTA)   NCBI Sequence Viewer  
  P27512 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_035741   ⟸   NM_011611
- Peptide Label: isoform 1 precursor
- UniProtKB: Q99NE3 (UniProtKB/Swiss-Prot),   P27512 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_733805   ⟸   NM_170704
- Peptide Label: isoform 4 precursor
- UniProtKB: P27512 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_733803   ⟸   NM_170702
- Peptide Label: isoform 5 precursor
- UniProtKB: P27512 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_733804   ⟸   NM_170703
- Peptide Label: isoform 2 precursor
- UniProtKB: P27512 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006499218   ⟸   XM_006499155
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006499217   ⟸   XM_006499154
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000139193   ⟸   ENSMUST00000184221
RefSeq Acc Id: ENSMUSP00000073386   ⟸   ENSMUST00000073707
RefSeq Acc Id: ENSMUSP00000122981   ⟸   ENSMUST00000140951
RefSeq Acc Id: ENSMUSP00000017799   ⟸   ENSMUST00000017799
RefSeq Acc Id: ENSMUSP00000138707   ⟸   ENSMUST00000154443
RefSeq Acc Id: ENSMUSP00000080059   ⟸   ENSMUST00000081310
Protein Domains
TNFR-Cys

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27512-F1-model_v2 AlphaFold P27512 1-289 view protein structure

Promoters
RGD ID:6830978
Promoter ID:MM_KWN:32985
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000109305,   NM_170702,   NM_170703,   NM_170704,   NR_027852_CD40,   OTTMUST00000039545,   OTTMUST00000039751,   OTTMUST00000039752
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362164,880,491 - 164,881,307 (+)MPROMDB
RGD ID:6830979
Promoter ID:MM_KWN:32986
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:OTTMUST00000039754
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362164,888,344 - 164,888,844 (+)MPROMDB
RGD ID:6879716
Promoter ID:EPDNEW_M3309
Type:initiation region
Name:Cd40_1
Description:Mus musculus CD40 antigen , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382165,055,680 - 165,055,740EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88336 AgrOrtholog
Ensembl Genes ENSMUSG00000017652 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000017799 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000073386 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000080059 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000122981.2 UniProtKB/TrEMBL
  ENSMUSP00000138707.2 UniProtKB/TrEMBL
  ENSMUSP00000139193 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000017799 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000073707 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000081310 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000140951.8 UniProtKB/TrEMBL
  ENSMUST00000154443.8 UniProtKB/TrEMBL
  ENSMUST00000184221 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_5 UniProtKB/Swiss-Prot
  TNFRSF5_N UniProtKB/Swiss-Prot
KEGG Report mmu:21939 UniProtKB/Swiss-Prot
MGD MGI:88336 ENTREZGENE
NCBI Gene 21939 ENTREZGENE
Pfam TNFR_c6 UniProtKB/Swiss-Prot
PhenoGen Cd40 PhenoGen
PRINTS TNFACTORR5 UniProtKB/Swiss-Prot
PROSITE TNFR_NGFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A5L7_MOUSE UniProtKB/TrEMBL
  P27512 ENTREZGENE
  Q99NE3 ENTREZGENE
  S4R2M8_MOUSE UniProtKB/TrEMBL
  TNR5_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3TS33 UniProtKB/Swiss-Prot
  Q3TSL2 UniProtKB/Swiss-Prot
  Q3U799 UniProtKB/Swiss-Prot
  Q3U7C9 UniProtKB/Swiss-Prot
  Q3UBH3 UniProtKB/Swiss-Prot
  Q542B1 UniProtKB/Swiss-Prot
  Q8K2X6 UniProtKB/Swiss-Prot
  Q99NE0 UniProtKB/Swiss-Prot
  Q99NE1 UniProtKB/Swiss-Prot
  Q99NE2 UniProtKB/Swiss-Prot
  Q99NE3 UniProtKB/Swiss-Prot