Myh2 (myosin, heavy polypeptide 2, skeletal muscle, adult) - Rat Genome Database
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Gene: Myh2 (myosin, heavy polypeptide 2, skeletal muscle, adult) Mus musculus
Analyze
Symbol: Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
RGD ID: 1616843
MGI Page MGI
Description: Is expressed in several structures, including alimentary system; forelimb bud mesenchyme; and skeletal musculature. Human ortholog(s) of this gene implicated in inclusion body myositis and proximal myopathy and ophthalmoplegia. Orthologous to human MYH2 (myosin heavy chain 2); PARTICIPATES IN myocarditis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MHC2; MHC2A; Myh2a; MyHC-; MyHC-IIa; Myhs-; Myhs-f; Myhs-f1; Myhsf; Myhsf1; myosin heavy chain 2A; myosin heavy chain IIa; myosin-2; skeletal muscle myosin heavy chain II-a
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391167,061,853 - 67,088,343 (+)NCBIGRCm39mm39
GRCm39 Ensembl1167,061,853 - 67,088,343 (+)Ensembl
GRCm381167,171,027 - 67,197,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1167,171,027 - 67,197,517 (+)EnsemblGRCm38mm10GRCm38
MGSCv371166,984,529 - 67,011,019 (+)NCBIGRCm37mm9NCBIm37
MGSCv361166,987,415 - 67,013,709 (+)NCBImm8
Celera1174,109,947 - 74,136,336 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1371481   PMID:1728586   PMID:1765007   PMID:3829126   PMID:6196357   PMID:6879174   PMID:6897916   PMID:7797078   PMID:8136524   PMID:8404542   PMID:8808709   PMID:8921409  
PMID:8948582   PMID:8950513   PMID:9307024   PMID:9434955   PMID:9479488   PMID:9514916   PMID:9585413   PMID:9988767   PMID:10077619   PMID:10349636   PMID:10444070   PMID:10588881  
PMID:10694423   PMID:10725239   PMID:10920230   PMID:11023856   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11409899   PMID:11551968   PMID:12235157   PMID:12466851   PMID:12477932  
PMID:12919077   PMID:12960431   PMID:14617807   PMID:14667415   PMID:15013776   PMID:15136151   PMID:15292239   PMID:15496418   PMID:15548599   PMID:15968549   PMID:16012337   PMID:16024798  
PMID:16124007   PMID:16141072   PMID:16141073   PMID:16407977   PMID:16494860   PMID:16575183   PMID:16819597   PMID:16895968   PMID:17009875   PMID:17519229   PMID:17559643   PMID:17584907  
PMID:17881575   PMID:18177667   PMID:18310078   PMID:18394644   PMID:18417546   PMID:18761673   PMID:18816853   PMID:19201857   PMID:19320717   PMID:19922871   PMID:20417199   PMID:20534536  
PMID:20625881   PMID:21061163   PMID:21216307   PMID:21677750   PMID:21884692   PMID:21985497   PMID:22174917   PMID:22351927   PMID:22750946   PMID:22940113   PMID:23190566   PMID:23339872  
PMID:23765941   PMID:23793062   PMID:23868259   PMID:24019467   PMID:24069389   PMID:24081490   PMID:24104522   PMID:24301466   PMID:24852826   PMID:24938781   PMID:24939696   PMID:25179606  
PMID:25330622   PMID:25980463   PMID:26062940   PMID:26207754   PMID:26237517   PMID:26299309   PMID:26586200   PMID:26644518   PMID:26993635   PMID:27184118   PMID:27597886   PMID:27906130  
PMID:28170423   PMID:28386024   PMID:28600496   PMID:28827394   PMID:28973166   PMID:29555813   PMID:29653945   PMID:29679560   PMID:29719249   PMID:29758057   PMID:29791846   PMID:30044719  
PMID:30237319   PMID:30695685   PMID:30737693   PMID:30962377   PMID:32094117  


Genomics

Comparative Map Data
Myh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391167,061,853 - 67,088,343 (+)NCBIGRCm39mm39
GRCm39 Ensembl1167,061,853 - 67,088,343 (+)Ensembl
GRCm381167,171,027 - 67,197,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1167,171,027 - 67,197,517 (+)EnsemblGRCm38mm10GRCm38
MGSCv371166,984,529 - 67,011,019 (+)NCBIGRCm37mm9NCBIm37
MGSCv361166,987,415 - 67,013,709 (+)NCBImm8
Celera1174,109,947 - 74,136,336 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.59NCBI
MYH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1710,521,148 - 10,549,700 (-)EnsemblGRCh38hg38GRCh38
GRCh381710,521,148 - 10,549,658 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371710,424,465 - 10,452,975 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361710,365,190 - 10,393,742 (-)NCBINCBI36hg18NCBI36
Build 341710,365,193 - 10,393,700NCBI
Celera1710,455,328 - 10,483,875 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef1710,324,058 - 10,352,633 (-)NCBIHuRef
CHM1_11710,434,312 - 10,462,875 (-)NCBICHM1_1
Myh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21051,856,738 - 51,883,236 (+)NCBI
Rnor_6.0 Ensembl1053,713,938 - 53,848,347 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01053,711,895 - 53,738,164 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01053,465,051 - 53,491,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41053,864,777 - 53,891,711 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1051,039,592 - 51,066,088 (+)NCBICelera
Cytogenetic Map10q24NCBI
Myh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554676,655,346 - 6,681,354 (+)NCBIChiLan1.0ChiLan1.0
MYH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11745,851,160 - 45,879,666 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1745,851,160 - 45,879,666 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01741,103,730 - 41,132,264 (+)NCBIMhudiblu_PPA_v0panPan3
Myh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365953,391,179 - 3,398,610 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11255,252,974 - 55,278,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21258,205,953 - 58,230,234 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242383
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1169,863,336 - 9,891,271 (-)NCBI
Myh2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478612,888,622 - 12,914,886 (-)NCBI

Position Markers
Myh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381167,197,376 - 67,197,518UniSTSGRCm38
MGSCv371167,010,878 - 67,011,020UniSTSGRCm37
Celera1174,136,195 - 74,136,337UniSTS
Cytogenetic Map11B3UniSTS
cM Map1135.0UniSTS
cM Map1135.0UniSTS
cM Map1135.0UniSTS
D11Mit5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381167,187,365 - 67,187,585UniSTSGRCm38
MGSCv371167,000,867 - 67,001,087UniSTSGRCm37
Celera1174,126,257 - 74,126,439UniSTS
Cytogenetic Map11B3UniSTS
cM Map1137.0UniSTS
Whitehead Genetic1136.1UniSTS
Whitehead_YAC11 UniSTS
Myh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381167,173,027 - 67,173,394UniSTSGRCm38
MGSCv371166,986,529 - 66,986,896UniSTSGRCm37
Celera1174,111,947 - 74,112,314UniSTS
Cytogenetic Map11B3UniSTS
cM Map1135.0UniSTS
Myh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381167,197,417 - 67,197,508UniSTSGRCm38
MGSCv371167,010,919 - 67,011,010UniSTSGRCm37
Celera1174,136,236 - 74,136,327UniSTS
Cytogenetic Map11B3UniSTS
cM Map1135.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111160000068600000Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1231863768609504Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111231863768609504Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111231863768609504Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1231863768609504Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1231863768609504Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111231863768609504Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1231863768609504Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1231863768609504Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1231863768609504Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111231863768609504Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111231863768609504Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111710617567187585Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111783196668609504Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115417484467187585Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
4141642Ltxs2_mlethal factor toxin susceptibility 2 (mouse)Not determined116315128768609504Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:232
Count of miRNA genes:133
Interacting mature miRNAs:138
Transcripts:ENSMUST00000018641, ENSMUST00000124337, ENSMUST00000170159
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000018641   ⟹   ENSMUSP00000018641
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1167,171,220 - 67,197,514 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124337
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1167,171,066 - 67,174,622 (+)Ensembl
RefSeq Acc Id: ENSMUST00000170159   ⟹   ENSMUSP00000129544
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1167,171,027 - 67,197,517 (+)Ensembl
RefSeq Acc Id: NM_001039545   ⟹   NP_001034634
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391167,061,853 - 67,088,343 (+)NCBI
GRCm381167,171,027 - 67,197,517 (+)ENTREZGENE
MGSCv371166,984,529 - 67,011,019 (+)RGD
Celera1174,109,947 - 74,136,336 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001034634   ⟸   NM_001039545
- UniProtKB: G3UW82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000129544   ⟸   ENSMUST00000170159
RefSeq Acc Id: ENSMUSP00000018641   ⟸   ENSMUST00000018641
Promoters
RGD ID:8675068
Promoter ID:EPDNEW_M15565
Type:initiation region
Name:Myh2_1
Description:Mus musculus myosin, heavy polypeptide 2, skeletal muscle, adult, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381167,171,066 - 67,171,126EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339710 AgrOrtholog
Ensembl Genes ENSMUSG00000033196 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000018641 UniProtKB/TrEMBL
  ENSMUSP00000129544 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018641 UniProtKB/TrEMBL
  ENSMUST00000170159 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.360 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  4.10.270.10 UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  Myosin_IQ_contain_sf UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/TrEMBL
  Myosin_tail UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report mmu:17882 UniProtKB/TrEMBL
MGD MGI:1339710 ENTREZGENE
NCBI Gene 17882 ENTREZGENE
Pfam Myosin_head UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/TrEMBL
PhenoGen Myh2 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/TrEMBL
SMART MYSc UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP Myosin_S1_N UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt G3UW82 ENTREZGENE, UniProtKB/TrEMBL
  I6L963_MOUSE UniProtKB/TrEMBL
  Q1WNQ9_MOUSE UniProtKB/TrEMBL
  Q9WUS5_MOUSE UniProtKB/TrEMBL