Pdpk1 (3-phosphoinositide dependent protein kinase 1) - Rat Genome Database

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Gene: Pdpk1 (3-phosphoinositide dependent protein kinase 1) Mus musculus
Analyze
Symbol: Pdpk1
Name: 3-phosphoinositide dependent protein kinase 1
RGD ID: 732665
MGI Page MGI
Description: Enables 3-phosphoinositide-dependent protein kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; negative regulation of cardiac muscle cell apoptotic process; and type B pancreatic cell development. Acts upstream of or within hyperosmotic response. Located in cytoplasmic vesicle and postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; gonad; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; mPDK1; Pdk; Pdk1; Pkb kinase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Note: Pdk1 (Gene ID: 228026) and Pdpk1 (Gene ID: 18607) share the Pdk1 symbol/alias in common. Pdk1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (Pdpk1), which can be confused with the official symbol for pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1). [03 Apr 2019]
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,292,654 - 24,370,957 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,292,654 - 24,369,898 (-)EnsemblGRCm39 Ensembl
GRCm381724,073,680 - 24,155,619 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,073,680 - 24,150,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,210,647 - 24,278,561 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,806,503 - 23,869,181 (-)NCBIMGSCv36mm8
Celera1724,579,774 - 24,646,541 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
allyl isothiocyanate  (ISO)
alpha-pinene  (ISO)
amiloride  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
Asiaticoside  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beryllium sulfate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (EXP,ISO)
diclofenac  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
finasteride  (ISO)
folic acid  (EXP)
gemcitabine  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
icariside II  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
maleic acid  (ISO)
mechlorethamine  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
microcystin-LR  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-succinylsulfathiazole  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
ochratoxin A  (ISO)
OSU-03012  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
progesterone  (ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
selenium atom  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirtinol  (EXP)
sodium arsenite  (ISO)
testosterone  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
calcium-mediated signaling  (IEA)
cell migration  (IEA)
cellular response to brain-derived neurotrophic factor stimulus  (ISO)
cellular response to epidermal growth factor stimulus  (IEA)
cellular response to insulin stimulus  (ISO)
chromatin remodeling  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
extrinsic apoptotic signaling pathway  (IEA)
focal adhesion assembly  (ISO)
hyperosmotic response  (IDA)
insulin receptor signaling pathway  (IDA,IMP)
insulin-like growth factor receptor signaling pathway  (IDA,IMP)
intracellular signal transduction  (IBA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of endothelial cell apoptotic process  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of toll-like receptor signaling pathway  (IMP)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (IEA)
positive regulation of phospholipase activity  (ISO)
positive regulation of protein localization to plasma membrane  (IEA)
positive regulation of release of sequestered calcium ion into cytosol  (IEA)
positive regulation of sprouting angiogenesis  (IEA)
positive regulation of vascular endothelial cell proliferation  (IEA)
protein phosphorylation  (ISO)
regulation of canonical NF-kappaB signal transduction  (IEA)
regulation of endothelial cell migration  (IMP)
regulation of mast cell degranulation  (IMP)
signal transduction  (TAS)
type B pancreatic cell development  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal cephalic neural fold morphology  (IAGP)
abnormal circulating leptin level  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal eye pigmentation  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal head development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart right ventricle morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hypodermis fat layer morphology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal kidney size  (IAGP)
abnormal melanotroph morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal neural crest cell physiology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal NK T cell morphology  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreas physiology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pituitary intermediate lobe morphology  (IAGP)
abnormal placenta development  (IAGP)
abnormal presomitic mesoderm morphology  (IAGP)
abnormal regulatory T cell number  (IAGP)
abnormal rostral-caudal body axis extension  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal Z line morphology  (IAGP)
absent dorsal root ganglion  (IAGP)
absent forebrain  (IAGP)
absent heart  (IAGP)
absent heart tube  (IAGP)
absent NK T cells  (IAGP)
absent pharyngeal arches  (IAGP)
absent somites  (IAGP)
anophthalmia  (IAGP)
cachexia  (IAGP)
decreased adrenal gland zona fasciculata size  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased corticotroph cell number  (IAGP)
decreased embryo size  (IAGP)
decreased forebrain size  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased NK T cell number  (IAGP)
decreased response to leptin  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
dermatitis  (IAGP)
dilated cardiomyopathy  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
female infertility  (IAGP)
hair follicle degeneration  (IAGP)
heart right ventricle hypertrophy  (IAGP)
hyperglycemia  (IAGP)
hyperkeratosis  (IAGP)
hypoglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
impaired skin barrier function  (IAGP)
improved glucose tolerance  (IAGP)
incomplete embryo turning  (IAGP)
increased body weight  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased corticotroph apoptosis  (IAGP)
increased food intake  (IAGP)
increased heart atrium size  (IAGP)
increased insulin sensitivity  (IAGP)
increased lung non-small cell carcinoma incidence  (IAGP)
increased melanotroph apoptosis  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased pituitary gland apoptosis  (IAGP)
increased total body fat amount  (IAGP)
insulin resistance  (IAGP)
maternal effect  (IAGP)
myocardium hypoplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreatic islet hyperplasia  (IAGP)
pancreatic islet hypoplasia  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
polyphagia  (IAGP)
premature death  (IAGP)
premature hair loss  (IAGP)
prenatal lethality, complete penetrance  (IEA)
prenatal lethality, incomplete penetrance  (IAGP)
scaly skin  (IAGP)
short mandible  (IAGP)
skin fibrosis  (IAGP)
skin hyperplasia  (IAGP)
skin lesions  (IAGP)
small allantois  (IAGP)
small heart  (IAGP)
small pancreas  (IAGP)
small pancreatic islets  (IAGP)
small spleen  (IAGP)
small testis  (IAGP)
thick skin  (IAGP)
thin ventricular wall  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling. Fiory F, etal., Mol Cell Biol. 2005 Dec;25(24):10803-14.
2. Prognostic potential of microRNA-138 and its target mRNA PDK1 in sera for patients with non-small cell lung cancer. Han L, etal., Med Oncol. 2014 Sep;31(9):129. doi: 10.1007/s12032-014-0129-y. Epub 2014 Jul 27.
3. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
4. A Novel Inhibitor of AKT1-PDPK1 Interaction Efficiently Suppresses the Activity of AKT Pathway and Restricts Tumor Growth In Vivo. Maemets-Allas K, etal., Mol Cancer Ther. 2015 Nov;14(11):2486-96. doi: 10.1158/1535-7163.MCT-15-0281. Epub 2015 Aug 20.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer. Sargeant AM, etal., Toxicol Pathol. 2007 Jun;35(4):549-61. doi: 10.1080/01926230701338966.
15. Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. Taniyama Y, etal., Mol Cell Biol. 2003 Nov;23(22):8019-29.
Additional References at PubMed
PMID:8889548   PMID:10075713   PMID:10349636   PMID:10608855   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11877406   PMID:11964154   PMID:12006370   PMID:12054753   PMID:12110585  
PMID:12177059   PMID:12372837   PMID:12420226   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12711546   PMID:12783890   PMID:12855688   PMID:12904583   PMID:12912918   PMID:12923190  
PMID:12970179   PMID:14500370   PMID:14610273   PMID:14623982   PMID:14749367   PMID:15077109   PMID:15116068   PMID:15187024   PMID:15309345   PMID:15389876   PMID:15531926   PMID:15713628  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16150867   PMID:16166629   PMID:16217033   PMID:16219676   PMID:16243031   PMID:16336268   PMID:16337591   PMID:16551362   PMID:16563390  
PMID:16581004   PMID:16581799   PMID:16602821   PMID:16642023   PMID:16741145   PMID:16751192   PMID:16785309   PMID:16825708   PMID:16831426   PMID:16887794   PMID:16923125   PMID:17027005  
PMID:17077284   PMID:17077298   PMID:17114649   PMID:17267763   PMID:17371830   PMID:17456549   PMID:17599070   PMID:17617409   PMID:17899170   PMID:17967808   PMID:17991746   PMID:18042254  
PMID:18184863   PMID:18347057   PMID:18396135   PMID:18430722   PMID:18514190   PMID:18591395   PMID:18718528   PMID:18799693   PMID:19047061   PMID:19065678   PMID:19088454   PMID:19088455  
PMID:19122654   PMID:19146951   PMID:19246967   PMID:19380828   PMID:19423553   PMID:19429709   PMID:19443706   PMID:19549840   PMID:19605683   PMID:19635472   PMID:19703999   PMID:19716369  
PMID:19808258   PMID:19843540   PMID:19920149   PMID:19943849   PMID:20004186   PMID:20051528   PMID:20103739   PMID:20376577   PMID:20457809   PMID:20511717   PMID:20564261   PMID:20584979  
PMID:20685850   PMID:20687898   PMID:20930845   PMID:20944007   PMID:20959631   PMID:20978239   PMID:21034549   PMID:21059917   PMID:21063107   PMID:21074460   PMID:21267068   PMID:21295499  
PMID:21297860   PMID:21493594   PMID:21677750   PMID:21694754   PMID:21705713   PMID:21775285   PMID:21865646   PMID:21873635   PMID:21906027   PMID:22094257   PMID:22108800   PMID:22119465  
PMID:22133875   PMID:22147265   PMID:22390626   PMID:22544756   PMID:22586579   PMID:23131847   PMID:23183047   PMID:23275438   PMID:23393571   PMID:23444402   PMID:23453624   PMID:23453634  
PMID:23455320   PMID:23463102   PMID:23472139   PMID:23727383   PMID:23823620   PMID:23955714   PMID:23979601   PMID:24037523   PMID:24105743   PMID:24169049   PMID:24662050   PMID:24979759  
PMID:25326799   PMID:25601552   PMID:25624444   PMID:25645675   PMID:25670795   PMID:25769952   PMID:25781322   PMID:25912234   PMID:26099023   PMID:26202351   PMID:26244796   PMID:26401001  
PMID:26455327   PMID:26476238   PMID:26633882   PMID:26764350   PMID:26809587   PMID:26876212   PMID:27103434   PMID:27133822   PMID:27170189   PMID:27184845   PMID:27286918   PMID:27339458  
PMID:27582005   PMID:27644329   PMID:27901468   PMID:28009291   PMID:28137869   PMID:28190767   PMID:28262664   PMID:28314444   PMID:28322786   PMID:28462077   PMID:28694518   PMID:29055016  
PMID:29104535   PMID:29358916   PMID:29420689   PMID:29575487   PMID:29705701   PMID:29991705   PMID:30622306   PMID:30718289   PMID:30951706   PMID:31055616   PMID:31208986   PMID:31504280  
PMID:31527197   PMID:31578203   PMID:31894307   PMID:32036560   PMID:32048762   PMID:32184125   PMID:32325033   PMID:32366272   PMID:32393635   PMID:32398474   PMID:32457586   PMID:32487697  
PMID:32626968   PMID:32979304   PMID:33052068   PMID:33276084   PMID:33300048   PMID:33377210   PMID:33567274   PMID:33568757   PMID:33579325   PMID:33595435   PMID:33660780   PMID:33789982  
PMID:34646383   PMID:34789718   PMID:34913989   PMID:34918060   PMID:35061720   PMID:35704246   PMID:36698722   PMID:36726025   PMID:36878279   PMID:36988860   PMID:37561545   PMID:38091840  
PMID:38795634  


Genomics

Comparative Map Data
Pdpk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,292,654 - 24,370,957 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,292,654 - 24,369,898 (-)EnsemblGRCm39 Ensembl
GRCm381724,073,680 - 24,155,619 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,073,680 - 24,150,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,210,647 - 24,278,561 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,806,503 - 23,869,181 (-)NCBIMGSCv36mm8
Celera1724,579,774 - 24,646,541 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.23NCBI
PDPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,538,021 - 2,603,188 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,537,979 - 2,603,190 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,588,022 - 2,653,189 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,527,971 - 2,593,190 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,527,970 - 2,593,189NCBI
Cytogenetic Map16p13.3NCBI
HuRef162,533,939 - 2,579,217 (+)NCBIHuRef
CHM1_1162,587,908 - 2,653,167 (+)NCBICHM1_1
T2T-CHM13v2.0162,560,174 - 2,625,339 (+)NCBIT2T-CHM13v2.0
Pdpk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,610,000 - 13,687,226 (-)NCBIGRCr8
mRatBN7.21013,105,435 - 13,182,664 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,105,498 - 13,174,623 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,855,532 - 17,919,448 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,344,364 - 17,408,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,842,927 - 12,906,749 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,446,373 - 13,525,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,451,624 - 13,515,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,262,177 - 13,339,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,329,708 - 13,394,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,329,707 - 13,394,080 (-)NCBI
Celera1012,796,598 - 12,860,647 (-)NCBICelera
Cytogenetic Map10q12NCBI
Pdpk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,685,153 - 14,772,870 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,685,089 - 14,772,870 (-)NCBIChiLan1.0ChiLan1.0
PDPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,039,537 - 3,108,833 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,820,580 - 6,889,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,394,447 - 1,463,735 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PDPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,426,464 - 38,506,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,431,600 - 38,499,295 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,665,293 - 39,744,671 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,736,122 - 38,815,513 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,739,163 - 38,809,280 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,421,263 - 38,500,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,393,915 - 38,473,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,869,968 - 38,949,380 (-)NCBIUU_Cfam_GSD_1.0
Pdpk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,173,175 - 105,264,644 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,526,653 - 1,537,386 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049366941,444,880 - 1,488,265 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,444,819 - 1,487,628 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,432,058 - 39,512,601 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,429,928 - 39,512,623 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,792,968 - 42,830,074 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606828,533,894 - 28,612,865 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdpk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824293,374 - 383,156 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624824279,893 - 383,220 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdpk1
2973 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3854
Count of miRNA genes:917
Interacting mature miRNAs:1279
Transcripts:ENSMUST00000052462, ENSMUST00000102927, ENSMUST00000115407, ENSMUST00000115409, ENSMUST00000115411, ENSMUST00000128997, ENSMUST00000140906, ENSMUST00000144533, ENSMUST00000147199, ENSMUST00000150578, ENSMUST00000154982
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171263668226401133Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
4142507Obrq13_mobesity resistance QTL 13 (mouse)Not determined1219832925076769Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17126194456Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17126189355Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125662076Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17397489026401133Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
12910769Rtmq1_mrenal tumor modifier QTL 1 (mouse)172290003625721472Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse

Markers in Region
UniSTS:237590  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381724,076,076 - 24,076,216UniSTSGRCm38
MGSCv371724,213,043 - 24,213,183UniSTSGRCm37
Celera1724,582,172 - 24,582,312UniSTS
Cytogenetic Map17A3.3UniSTS
PMC175797P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381724,106,696 - 24,107,155UniSTSGRCm38
MGSCv371724,243,663 - 24,244,122UniSTSGRCm37
Celera1724,612,030 - 24,612,489UniSTS
Cytogenetic Map17A3.3UniSTS
Pdpk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
cM Map1712.23UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001080773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017317326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF079535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF086625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF126294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY062008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY162410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC146001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC146003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ175596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY257456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY267833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ046953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000052462   ⟹   ENSMUSP00000061942
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,297,902 - 24,369,898 (-)Ensembl
GRCm38.p6 Ensembl1724,078,928 - 24,150,924 (-)Ensembl
Ensembl Acc Id: ENSMUST00000102927   ⟹   ENSMUSP00000099991
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,292,654 - 24,360,569 (-)Ensembl
GRCm38.p6 Ensembl1724,073,680 - 24,141,595 (-)Ensembl
Ensembl Acc Id: ENSMUST00000115407   ⟹   ENSMUSP00000111066
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,297,855 - 24,360,550 (-)Ensembl
GRCm38.p6 Ensembl1724,078,881 - 24,141,576 (-)Ensembl
Ensembl Acc Id: ENSMUST00000115409   ⟹   ENSMUSP00000111068
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,294,786 - 24,360,544 (-)Ensembl
GRCm38.p6 Ensembl1724,075,812 - 24,141,570 (-)Ensembl
Ensembl Acc Id: ENSMUST00000115411   ⟹   ENSMUSP00000111070
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,292,657 - 24,360,527 (-)Ensembl
GRCm38.p6 Ensembl1724,073,683 - 24,141,553 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128997   ⟹   ENSMUSP00000120548
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,329,866 - 24,360,102 (-)Ensembl
GRCm38.p6 Ensembl1724,110,892 - 24,141,128 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140906
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,310,558 - 24,369,890 (-)Ensembl
GRCm38.p6 Ensembl1724,091,584 - 24,150,916 (-)Ensembl
Ensembl Acc Id: ENSMUST00000144533   ⟹   ENSMUSP00000121771
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,325,809 - 24,359,781 (-)Ensembl
GRCm38.p6 Ensembl1724,106,835 - 24,140,807 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147199
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,307,155 - 24,312,772 (-)Ensembl
GRCm38.p6 Ensembl1724,088,181 - 24,093,798 (-)Ensembl
Ensembl Acc Id: ENSMUST00000150578
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,322,984 - 24,360,530 (-)Ensembl
GRCm38.p6 Ensembl1724,104,010 - 24,141,556 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154982   ⟹   ENSMUSP00000115618
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1724,325,861 - 24,339,768 (-)Ensembl
GRCm38.p6 Ensembl1724,106,887 - 24,120,794 (-)Ensembl
RefSeq Acc Id: NM_001080773   ⟹   NP_001074242
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,654 - 24,360,568 (-)NCBI
GRCm381724,073,680 - 24,141,594 (-)NCBI
MGSCv371724,210,647 - 24,278,561 (-)RGD
Celera1724,579,774 - 24,656,202 (-)NCBI
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001286662   ⟹   NP_001273591
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,654 - 24,369,896 (-)NCBI
GRCm381724,073,680 - 24,150,922 (-)NCBI
Celera1724,579,774 - 24,656,202 (-)NCBI
Sequence:
RefSeq Acc Id: NM_011062   ⟹   NP_035192
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,654 - 24,360,568 (-)NCBI
GRCm381724,073,680 - 24,141,594 (-)NCBI
MGSCv371724,210,647 - 24,278,561 (-)RGD
Celera1724,579,774 - 24,656,202 (-)NCBI
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017317320   ⟹   XP_017172809
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,656 - 24,360,405 (-)NCBI
GRCm381724,073,682 - 24,141,459 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017317321   ⟹   XP_017172810
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,656 - 24,360,458 (-)NCBI
GRCm381724,073,682 - 24,141,389 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017317322   ⟹   XP_017172811
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,656 - 24,331,462 (-)NCBI
GRCm381724,073,682 - 24,112,488 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017317324   ⟹   XP_017172813
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,656 - 24,370,957 (-)NCBI
GRCm381724,073,682 - 24,151,402 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017317325   ⟹   XP_017172814
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,656 - 24,360,574 (-)NCBI
GRCm381724,073,682 - 24,141,614 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017317326   ⟹   XP_017172815
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,656 - 24,369,763 (-)NCBI
GRCm381724,073,823 - 24,150,790 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030249574   ⟹   XP_030105434
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,656 - 24,370,957 (-)NCBI
GRCm381724,073,682 - 24,151,409 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030249575   ⟹   XP_030105435
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391724,292,656 - 24,360,563 (-)NCBI
GRCm381724,073,682 - 24,141,605 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001074242 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273591 (Get FASTA)   NCBI Sequence Viewer  
  NP_035192 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172809 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172810 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172811 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172813 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172814 (Get FASTA)   NCBI Sequence Viewer  
  XP_017172815 (Get FASTA)   NCBI Sequence Viewer  
  XP_030105434 (Get FASTA)   NCBI Sequence Viewer  
  XP_030105435 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC67544 (Get FASTA)   NCBI Sequence Viewer  
  AAC96115 (Get FASTA)   NCBI Sequence Viewer  
  AAD38505 (Get FASTA)   NCBI Sequence Viewer  
  AAI46002 (Get FASTA)   NCBI Sequence Viewer  
  AAI46004 (Get FASTA)   NCBI Sequence Viewer  
  AAL47185 (Get FASTA)   NCBI Sequence Viewer  
  AAO17164 (Get FASTA)   NCBI Sequence Viewer  
  BAE27716 (Get FASTA)   NCBI Sequence Viewer  
  BAE28171 (Get FASTA)   NCBI Sequence Viewer  
  BAE28793 (Get FASTA)   NCBI Sequence Viewer  
  BAE37017 (Get FASTA)   NCBI Sequence Viewer  
  EDL22291 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000061942
  ENSMUSP00000061942.7
  ENSMUSP00000099991
  ENSMUSP00000099991.4
  ENSMUSP00000111066.3
  ENSMUSP00000111068.3
  ENSMUSP00000111070
  ENSMUSP00000111070.2
  ENSMUSP00000115618.2
  ENSMUSP00000120548.2
  ENSMUSP00000121771.2
GenBank Protein Q9Z2A0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035192   ⟸   NM_011062
- Peptide Label: isoform A
- UniProtKB: Q9R1D8 (UniProtKB/Swiss-Prot),   A6H6U3 (UniProtKB/Swiss-Prot),   Q9R215 (UniProtKB/Swiss-Prot),   Q9Z2A0 (UniProtKB/Swiss-Prot),   Q3UHZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001074242   ⟸   NM_001080773
- Peptide Label: isoform B
- UniProtKB: Q3TRL2 (UniProtKB/TrEMBL),   Q3UGN6 (UniProtKB/TrEMBL),   Q3UHZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273591   ⟸   NM_001286662
- Peptide Label: isoform C
- UniProtKB: F2Z3X6 (UniProtKB/TrEMBL),   Q8K3L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172813   ⟸   XM_017317324
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017172814   ⟸   XM_017317325
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017172809   ⟸   XM_017317320
- Peptide Label: isoform X1
- UniProtKB: F2Z3X6 (UniProtKB/TrEMBL),   Q8K3L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172810   ⟸   XM_017317321
- Peptide Label: isoform X1
- UniProtKB: F2Z3X6 (UniProtKB/TrEMBL),   Q8K3L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172811   ⟸   XM_017317322
- Peptide Label: isoform X1
- UniProtKB: F2Z3X6 (UniProtKB/TrEMBL),   Q8K3L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172815   ⟸   XM_017317326
- Peptide Label: isoform X1
- UniProtKB: F2Z3X6 (UniProtKB/TrEMBL),   Q8K3L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030105434   ⟸   XM_030249574
- Peptide Label: isoform X3
RefSeq Acc Id: XP_030105435   ⟸   XM_030249575
- Peptide Label: isoform X3
Ensembl Acc Id: ENSMUSP00000061942   ⟸   ENSMUST00000052462
Ensembl Acc Id: ENSMUSP00000121771   ⟸   ENSMUST00000144533
Ensembl Acc Id: ENSMUSP00000111068   ⟸   ENSMUST00000115409
Ensembl Acc Id: ENSMUSP00000111066   ⟸   ENSMUST00000115407
Ensembl Acc Id: ENSMUSP00000111070   ⟸   ENSMUST00000115411
Ensembl Acc Id: ENSMUSP00000115618   ⟸   ENSMUST00000154982
Ensembl Acc Id: ENSMUSP00000120548   ⟸   ENSMUST00000128997
Ensembl Acc Id: ENSMUSP00000099991   ⟸   ENSMUST00000102927
Protein Domains
PH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2A0-F1-model_v2 AlphaFold Q9Z2A0 1-559 view protein structure

Promoters
RGD ID:13674992
Promoter ID:EPDNEW_M21645
Type:initiation region
Name:Pdpk1_1
Description:Mus musculus 3-phosphoinositide dependent protein kinase 1 ,transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381724,141,552 - 24,141,612EPDNEW
RGD ID:6828457
Promoter ID:MM_KWN:22488
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000048469
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,257,971 - 24,258,471 (-)MPROMDB
RGD ID:6828458
Promoter ID:MM_KWN:22489
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000115407,   ENSMUST00000115409,   OTTMUST00000039074,   OTTMUST00000048467,   OTTMUST00000048468,   UC008AUI.1,   UC008AUJ.1,   UC008AUL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,277,986 - 24,278,987 (-)MPROMDB
RGD ID:6828459
Promoter ID:MM_KWN:22490
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain
Transcripts:OTTMUST00000048330,   UC008AUK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361724,287,786 - 24,288,337 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1338068 AgrOrtholog
Ensembl Genes ENSMUSG00000024122 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000052462 ENTREZGENE
  ENSMUST00000052462.13 UniProtKB/TrEMBL
  ENSMUST00000102927 ENTREZGENE
  ENSMUST00000102927.10 UniProtKB/Swiss-Prot
  ENSMUST00000115407.9 UniProtKB/TrEMBL
  ENSMUST00000115409.9 UniProtKB/TrEMBL
  ENSMUST00000115411 ENTREZGENE
  ENSMUST00000115411.8 UniProtKB/TrEMBL
  ENSMUST00000128997.2 UniProtKB/TrEMBL
  ENSMUST00000144533.8 UniProtKB/TrEMBL
  ENSMUST00000154982.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDK1-typ_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDPK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser_Thr_kinase_AGC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18607 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1338068 ENTREZGENE
NCBI Gene 18607 ENTREZGENE
PANTHER 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PH_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdpk1 PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6H6U3 ENTREZGENE
  F2Z3V6_MOUSE UniProtKB/TrEMBL
  F2Z3X6 ENTREZGENE, UniProtKB/TrEMBL
  F2Z3X9_MOUSE UniProtKB/TrEMBL
  F2Z3Z9_MOUSE UniProtKB/TrEMBL
  F2Z400_MOUSE UniProtKB/TrEMBL
  F2Z4A5_MOUSE UniProtKB/TrEMBL
  PDPK1_MOUSE UniProtKB/Swiss-Prot
  Q3TRL2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UEW8_MOUSE UniProtKB/TrEMBL
  Q3UGN6 ENTREZGENE, UniProtKB/TrEMBL
  Q3UHZ0 ENTREZGENE, UniProtKB/TrEMBL
  Q8K3L3 ENTREZGENE, UniProtKB/TrEMBL
  Q9R1D8 ENTREZGENE
  Q9R215 ENTREZGENE
  Q9Z2A0 ENTREZGENE
UniProt Secondary A6H6U3 UniProtKB/Swiss-Prot
  Q9R1D8 UniProtKB/Swiss-Prot
  Q9R215 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Pdpk1  3-phosphoinositide dependent protein kinase 1  Pdpk1  3-phosphoinositide dependent protein kinase-1  Symbol and/or name change 5135510 APPROVED