Pdpk1 (3-phosphoinositide dependent protein kinase 1) - Rat Genome Database

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Gene: Pdpk1 (3-phosphoinositide dependent protein kinase 1) Chinchilla lanigera
Analyze
Symbol: Pdpk1
Name: 3-phosphoinositide dependent protein kinase 1
RGD ID: 8925112
Description: ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase activity (ortholog); insulin receptor binding (ortholog); phospholipase activator activity (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); calcium-mediated signaling (ortholog); cell migration (ortholog); PARTICIPATES IN adenosine signaling pathway; angiotensin II signaling pathway; FasL mediated signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); congestive heart failure (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN cell projection (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,685,153 - 14,772,870 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,685,089 - 14,772,870 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
calcium-mediated signaling  (ISO)
cell migration  (ISO)
cellular response to brain-derived neurotrophic factor stimulus  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
focal adhesion assembly  (ISO)
hyperosmotic response  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
intracellular signal transduction  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of toll-like receptor signaling pathway  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of phospholipase activity  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
protein phosphorylation  (ISO)
regulation of canonical NF-kappaB signal transduction  (ISO)
regulation of endothelial cell migration  (ISO)
regulation of mast cell degranulation  (ISO)
type B pancreatic cell development  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pdpk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,685,153 - 14,772,870 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,685,089 - 14,772,870 (-)NCBIChiLan1.0ChiLan1.0
PDPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,538,021 - 2,603,188 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,537,979 - 2,603,190 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,588,022 - 2,653,189 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,527,971 - 2,593,190 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,527,970 - 2,593,189NCBI
Cytogenetic Map16p13.3NCBI
HuRef162,533,939 - 2,579,217 (+)NCBIHuRef
CHM1_1162,587,908 - 2,653,167 (+)NCBICHM1_1
T2T-CHM13v2.0162,560,174 - 2,625,339 (+)NCBIT2T-CHM13v2.0
Pdpk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,292,654 - 24,370,957 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,292,654 - 24,369,898 (-)EnsemblGRCm39 Ensembl
GRCm381724,073,680 - 24,155,619 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,073,680 - 24,150,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,210,647 - 24,278,561 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,806,503 - 23,869,181 (-)NCBIMGSCv36mm8
Celera1724,579,774 - 24,646,541 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.23NCBI
Pdpk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,610,000 - 13,687,226 (-)NCBIGRCr8
mRatBN7.21013,105,435 - 13,182,664 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,105,498 - 13,174,623 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,855,532 - 17,919,448 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,344,364 - 17,408,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,842,927 - 12,906,749 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,446,373 - 13,525,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,451,624 - 13,515,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,262,177 - 13,339,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,329,708 - 13,394,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,329,707 - 13,394,080 (-)NCBI
Celera1012,796,598 - 12,860,647 (-)NCBICelera
Cytogenetic Map10q12NCBI
PDPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,039,537 - 3,108,833 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,820,580 - 6,889,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,394,447 - 1,463,735 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PDPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,426,464 - 38,506,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,431,600 - 38,499,295 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,665,293 - 39,744,671 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,736,122 - 38,815,513 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,739,163 - 38,809,280 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,421,263 - 38,500,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,393,915 - 38,473,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,869,968 - 38,949,380 (-)NCBIUU_Cfam_GSD_1.0
Pdpk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,173,175 - 105,264,644 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,526,653 - 1,537,386 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049366941,444,880 - 1,488,265 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,444,819 - 1,487,628 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,432,058 - 39,512,601 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,429,928 - 39,512,623 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,792,968 - 42,830,074 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606828,533,894 - 28,612,865 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdpk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824293,374 - 383,156 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624824279,893 - 383,220 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000019975   ⟹   ENSCLAP00000019782
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544214,685,153 - 14,772,718 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000019976   ⟹   ENSCLAP00000019783
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544214,690,693 - 14,772,870 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000019977   ⟹   ENSCLAP00000019784
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544214,690,693 - 14,772,718 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000019978   ⟹   ENSCLAP00000019785
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544214,690,693 - 14,759,755 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000019979   ⟹   ENSCLAP00000019786
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544214,690,693 - 14,738,117 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000019980   ⟹   ENSCLAP00000019787
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544214,690,788 - 14,772,718 (-)Ensembl
RefSeq Acc Id: XM_005391417   ⟹   XP_005391474
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544214,685,089 - 14,772,870 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005391418   ⟹   XP_005391475
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544214,685,089 - 14,759,386 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005391419   ⟹   XP_005391476
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544214,685,089 - 14,772,624 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005391420   ⟹   XP_005391477
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544214,685,089 - 14,727,261 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517782   ⟹   XP_013373236
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544214,685,089 - 14,772,386 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517783   ⟹   XP_013373237
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544214,685,089 - 14,772,870 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005391474   ⟸   XM_005391417
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VS98 (UniProtKB/TrEMBL),   A0A8C2VWA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005391476   ⟸   XM_005391419
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VUB9 (UniProtKB/TrEMBL),   A0A8C2VWA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005391475   ⟸   XM_005391418
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VUB9 (UniProtKB/TrEMBL),   A0A8C2VWA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005391477   ⟸   XM_005391420
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013373237   ⟸   XM_013517783
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VUB9 (UniProtKB/TrEMBL),   A0A8C2VWA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373236   ⟸   XM_013517782
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VUB9 (UniProtKB/TrEMBL),   A0A8C2VWA8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000019786   ⟸   ENSCLAT00000019979
Ensembl Acc Id: ENSCLAP00000019785   ⟸   ENSCLAT00000019978
Ensembl Acc Id: ENSCLAP00000019784   ⟸   ENSCLAT00000019977
Ensembl Acc Id: ENSCLAP00000019783   ⟸   ENSCLAT00000019976
Ensembl Acc Id: ENSCLAP00000019782   ⟸   ENSCLAT00000019975
Ensembl Acc Id: ENSCLAP00000019787   ⟸   ENSCLAT00000019980
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013566 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019975.1 UniProtKB/TrEMBL
  ENSCLAT00000019976 ENTREZGENE
  ENSCLAT00000019976.1 UniProtKB/TrEMBL
  ENSCLAT00000019977.1 UniProtKB/TrEMBL
  ENSCLAT00000019978 ENTREZGENE
  ENSCLAT00000019978.1 UniProtKB/TrEMBL
  ENSCLAT00000019979.1 UniProtKB/TrEMBL
  ENSCLAT00000019980.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  PDK1-typ_PH UniProtKB/TrEMBL
  PDPK1 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser_Thr_kinase_AGC UniProtKB/TrEMBL
NCBI Gene Pdpk1 ENTREZGENE
PANTHER 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam PH_3 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2VS98 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VUB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VWA8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VZ47_CHILA UniProtKB/TrEMBL
  A0A8C2VZJ4_CHILA UniProtKB/TrEMBL
  A0A8C2YSD0_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Pdpk1  3-phosphoinositide dependent protein kinase 1    3-phosphoinositide dependent protein kinase-1  Symbol and/or name change 5135510 APPROVED