Bak1 (BCL2-antagonist/killer 1) - Rat Genome Database

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Gene: Bak1 (BCL2-antagonist/killer 1) Mus musculus
Analyze
Symbol: Bak1
Name: BCL2-antagonist/killer 1
RGD ID: 1552456
MGI Page MGI
Description: Enables identical protein binding activity. Involved in cellular response to UV and release of cytochrome c from mitochondria. Acts upstream of or within several processes, including apoptotic signaling pathway; cellular calcium ion homeostasis; and lymphocyte apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial membrane. Is integral component of mitochondrial outer membrane. Part of BAK complex. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1); PARTICIPATES IN intrinsic apoptotic pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-dexrazoxane; 1,1-dichloroethene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apoptosis regulator BAK; Ba; Bak; bcl-2 homologous antagonist/killer; Bcl2 homologous antagonist/killer; N-B; N-Bak; N-BAK1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,238,786 - 27,247,601 (-)NCBIGRCm39mm39
GRCm39 Ensembl1727,238,784 - 27,247,983 (-)Ensembl
GRCm381727,019,812 - 27,028,627 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,019,810 - 27,029,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,156,757 - 27,165,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,747,401 - 26,756,216 (-)NCBImm8
Celera1727,556,267 - 27,565,056 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-amphetamine  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
alantolactone  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
auranofin  (EXP)
benzo[a]pyrene  (ISO)
betulinic acid  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (EXP,ISO)
Brusatol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium sulfide  (ISO)
camptothecin  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carvedilol  (ISO)
casticin  (ISO)
cefaloridine  (ISO)
celecoxib  (ISO)
chrysophanol  (ISO)
cisplatin  (EXP,ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
curcumin  (EXP,ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
Deguelin  (ISO)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diepoxybutane  (ISO)
dioscin  (EXP,ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (EXP,ISO)
epichlorohydrin  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (EXP,ISO)
farnesol  (ISO)
fisetin  (ISO)
flavonoids  (EXP)
flufenamic acid  (ISO)
flufenoxuron  (EXP)
folic acid  (EXP,ISO)
fonofos  (ISO)
furan  (ISO)
furosemide  (ISO)
geraniol  (ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
hyperforin  (ISO)
indometacin  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
isoflurane  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
levamisole  (ISO)
LGK974  (ISO)
Licochalcone A  (ISO)
linalool  (ISO)
lithocholic acid  (EXP)
losartan  (ISO)
Luteolin 7-methyl ether  (ISO)
maneb  (EXP,ISO)
mechlorethamine  (ISO)
melatonin  (EXP,ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
minocycline  (ISO)
Mitotane  (ISO)
MK-2206  (ISO)
morphine  (ISO)
mycophenolic acid  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
navitoclax  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
osthole  (ISO)
oxybenzone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parthenolide  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perifosine  (ISO)
perillyl alcohol  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
platycodin D  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
promethazine  (ISO)
propylparaben  (ISO)
prostaglandin E2  (EXP)
pterostilbene  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rottlerin  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sodium arsenite  (EXP)
sorafenib  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
tamibarotene  (ISO)
TEMPO  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
Thiotepa  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP,ISO)
tunicamycin  (ISO)
urethane  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (EXP)
veliparib  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IGI,IMP)
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  (IMP)
aging  (ISO)
animal organ regeneration  (ISO)
apoptotic process  (IGI,ISO)
apoptotic process involved in blood vessel morphogenesis  (IGI)
apoptotic signaling pathway  (ISO)
B cell apoptotic process  (IGI)
B cell homeostasis  (IGI,IMP)
B cell negative selection  (IGI)
blood vessel remodeling  (IGI)
brain development  (ISO)
cell population proliferation  (IDA)
cellular response to mechanical stimulus  (ISO)
cellular response to UV  (IMP,ISO)
endocrine pancreas development  (ISO)
establishment or maintenance of transmembrane electrochemical gradient  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,IGI)
fibroblast apoptotic process  (IMP)
homeostasis of number of cells  (IGI)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,IGI,IMP)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IGI)
leukocyte homeostasis  (IGI)
limb morphogenesis  (IGI)
mitochondrial fusion  (IGI)
myeloid cell homeostasis  (IGI)
negative regulation of cell population proliferation  (ISO)
negative regulation of endoplasmic reticulum calcium ion concentration  (IGI)
negative regulation of gene expression  (ISO)
negative regulation of peptidyl-serine phosphorylation  (IGI)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of calcium ion transport into cytosol  (IGI)
positive regulation of endoplasmic reticulum unfolded protein response  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
post-embryonic camera-type eye morphogenesis  (IGI)
regulation of apoptotic process  (IEA)
regulation of cell cycle  (IGI)
regulation of mitochondrial membrane permeability  (ISO)
regulation of mitochondrial membrane potential  (ISO)
release of cytochrome c from mitochondria  (IMP,ISO)
response to ethanol  (ISO)
response to fungus  (IMP)
response to gamma radiation  (IMP)
response to hydrogen peroxide  (ISO)
response to mycotoxin  (IMP)
response to organic cyclic compound  (ISO)
response to UV-C  (ISO)
response to xenobiotic stimulus  (ISO)
thymocyte apoptotic process  (IGI)
vagina development  (IGI)
viral process  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell morphology  (IAGP)
abnormal B cell number  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal hearing physiology  (IAGP)
abnormal platelet morphology  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal splenocyte physiology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
anemia  (IAGP)
arthritis  (IAGP)
circling  (IAGP)
decreased cellular sensitivity to gamma-irradiation  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased thymocyte apoptosis  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
glomerulonephritis  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased B cell number  (IAGP)
increased B-2 B cell number  (IAGP)
increased bone marrow cell number  (IAGP)
increased brain size  (IAGP)
increased follicular B cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased immunoglobulin level  (IAGP)
increased leukocyte cell number  (IAGP)
increased lymphocyte cell number  (IAGP)
increased neuron number  (IAGP)
increased pre-B cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased regulatory T cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased spleen white pulp amount  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased transitional stage B cell number  (IAGP)
interdigital webbing  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
seizures  (IAGP)
thrombocytopenia  (IAGP)
thrombocytosis  (IAGP)
vagina atresia  (IAGP)
References

Additional References at PubMed
PMID:7715729   PMID:7715730   PMID:7715731   PMID:8521816   PMID:8889548   PMID:9176392   PMID:9299236   PMID:9356461   PMID:10200490   PMID:10349636   PMID:10377054   PMID:10444588  
PMID:10618441   PMID:10894153   PMID:10950869   PMID:11042159   PMID:11076861   PMID:11146504   PMID:11163212   PMID:11217851   PMID:11278671   PMID:11784036   PMID:11836241   PMID:11840165  
PMID:11932420   PMID:11980919   PMID:12142566   PMID:12244308   PMID:12477932   PMID:12624178   PMID:12689595   PMID:12799143   PMID:12808108   PMID:12847083   PMID:12881569   PMID:14505568  
PMID:14610273   PMID:14627695   PMID:14657169   PMID:15136728   PMID:15145826   PMID:15272317   PMID:15574336   PMID:15590665   PMID:15613488   PMID:15615879   PMID:15640352   PMID:15680329  
PMID:15776018   PMID:15782199   PMID:15818416   PMID:15861188   PMID:15901672   PMID:15955981   PMID:15967824   PMID:16055554   PMID:16141072   PMID:16141073   PMID:16172118   PMID:16227588  
PMID:16270031   PMID:16330765   PMID:16464852   PMID:16514420   PMID:16645094   PMID:16651384   PMID:16676001   PMID:16705087   PMID:16799968   PMID:16893972   PMID:17035996   PMID:17068116  
PMID:17074758   PMID:17204849   PMID:17382885   PMID:17409097   PMID:17417626   PMID:17447897   PMID:17470554   PMID:17606912   PMID:17676052   PMID:17692540   PMID:17869640   PMID:17917679  
PMID:18048346   PMID:18056423   PMID:18056701   PMID:18230621   PMID:18251703   PMID:18252892   PMID:18272391   PMID:18288109   PMID:18299329   PMID:18426910   PMID:18437160   PMID:18437166  
PMID:18451609   PMID:18462686   PMID:18471982   PMID:18524770   PMID:18547146   PMID:18563702   PMID:18589438   PMID:18614015   PMID:18678651   PMID:18691924   PMID:18799693   PMID:18835564  
PMID:19017630   PMID:19056676   PMID:19074266   PMID:19079139   PMID:19139105   PMID:19139267   PMID:19139629   PMID:19168699   PMID:19185578   PMID:19261612   PMID:19300452   PMID:19332555  
PMID:19339988   PMID:19373582   PMID:19387006   PMID:19454696   PMID:19521510   PMID:19632182   PMID:19647221   PMID:19706873   PMID:19768117   PMID:19816507   PMID:19816509   PMID:19820692  
PMID:19875445   PMID:19901338   PMID:19917256   PMID:19920074   PMID:19934009   PMID:19941828   PMID:19955184   PMID:20019247   PMID:20057504   PMID:20094062   PMID:20128842   PMID:20172858  
PMID:20457813   PMID:20503275   PMID:20530288   PMID:20539308   PMID:20605789   PMID:20671748   PMID:20713620   PMID:20799797   PMID:20813900   PMID:20885444   PMID:21041309   PMID:21127253  
PMID:21146511   PMID:21151029   PMID:21224042   PMID:21241252   PMID:21245196   PMID:21278801   PMID:21364649   PMID:21367852   PMID:21368834   PMID:21425311   PMID:21613222   PMID:21727192  
PMID:21746883   PMID:21820438   PMID:21873635   PMID:21896738   PMID:21911424   PMID:21926988   PMID:21997190   PMID:22015606   PMID:22015607   PMID:22031758   PMID:22036586   PMID:22056880  
PMID:22179045   PMID:22197342   PMID:22294729   PMID:22297299   PMID:22357545   PMID:22365665   PMID:22385963   PMID:22414765   PMID:22442658   PMID:22491404   PMID:22493254   PMID:22493436  
PMID:22538851   PMID:22613767   PMID:22671997   PMID:22673615   PMID:22710714   PMID:22719850   PMID:22790873   PMID:22820179   PMID:22933114   PMID:22960223   PMID:22986529   PMID:23042294  
PMID:23132593   PMID:23140172   PMID:23175186   PMID:23197294   PMID:23201261   PMID:23248281   PMID:23345450   PMID:23349374   PMID:23375500   PMID:23377280   PMID:23389440   PMID:23395376  
PMID:23404709   PMID:23466994   PMID:23468630   PMID:23558951   PMID:23697557   PMID:23744350   PMID:23767404   PMID:23770239   PMID:23784543   PMID:23805138   PMID:23852275   PMID:23881917  
PMID:23893415   PMID:23969856   PMID:23991283   PMID:24095739   PMID:24227720   PMID:24265320   PMID:24292555   PMID:24337568   PMID:24464220   PMID:24493802   PMID:24632563   PMID:24637330  
PMID:24837741   PMID:24876160   PMID:24912196   PMID:25124553   PMID:25146925   PMID:25228770   PMID:25242145   PMID:25296312   PMID:25299344   PMID:25301392   PMID:25565426   PMID:25627690  
PMID:25697356   PMID:25815636   PMID:25880232   PMID:25987560   PMID:26030884   PMID:26059977   PMID:26159699   PMID:26180237   PMID:26344567   PMID:26417093   PMID:26476335   PMID:26585277  
PMID:26682723   PMID:26702098   PMID:26785948   PMID:26795252   PMID:26943318   PMID:26949185   PMID:27001308   PMID:27055867   PMID:27137932   PMID:27144312   PMID:27197166   PMID:27217060  
PMID:27307572   PMID:27488021   PMID:27505430   PMID:27803059   PMID:27811852   PMID:27888447   PMID:27918563   PMID:28009284   PMID:28017613   PMID:28213497   PMID:28317867   PMID:28378742  
PMID:28472660   PMID:28574506   PMID:28663253   PMID:28673969   PMID:28972012   PMID:28986568   PMID:29122578   PMID:29148970   PMID:29149594   PMID:29244050   PMID:29358089   PMID:29409032  
PMID:29444424   PMID:29487339   PMID:29768206   PMID:29775594   PMID:29849154   PMID:30361616   PMID:30413413   PMID:30485804   PMID:30485805   PMID:30503207   PMID:30635284   PMID:30655546  
PMID:30970242   PMID:30970248   PMID:30995482   PMID:31296963   PMID:31534164   PMID:31891351   PMID:32414809   PMID:32471877   PMID:32620813   PMID:32633719   PMID:32710818   PMID:33208470  
PMID:33794146   PMID:33959612  


Genomics

Comparative Map Data
Bak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,238,786 - 27,247,601 (-)NCBIGRCm39mm39
GRCm39 Ensembl1727,238,784 - 27,247,983 (-)Ensembl
GRCm381727,019,812 - 27,028,627 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,019,810 - 27,029,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,156,757 - 27,165,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,747,401 - 26,756,216 (-)NCBImm8
Celera1727,556,267 - 27,565,056 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
BAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl633,572,547 - 33,580,293 (-)EnsemblGRCh38hg38GRCh38
GRCh38633,572,552 - 33,580,296 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,540,329 - 33,548,053 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,648,301 - 33,656,048 (-)NCBINCBI36hg18NCBI36
Build 34633,648,306 - 33,655,959NCBI
Celera635,094,701 - 35,102,448 (-)NCBI
Cytogenetic Map6p21.31NCBI
HuRef633,281,784 - 33,289,531 (-)NCBIHuRef
CHM1_1633,542,641 - 33,550,388 (-)NCBICHM1_1
Bak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2205,100,480 - 5,109,669 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl205,609,625 - 5,618,260 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0205,609,620 - 5,618,899 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0207,675,062 - 7,683,731 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,255,954 - 5,264,593 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1205,256,180 - 5,264,820 (-)NCBI
Celera206,681,267 - 6,689,805 (-)NCBICelera
Cytogenetic Map20p12NCBI
Bak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,036,415 - 2,041,997 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,036,415 - 2,041,997 (-)NCBIChiLan1.0ChiLan1.0
BAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1634,255,769 - 34,263,211 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,255,769 - 34,263,211 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0633,146,998 - 33,154,755 (-)NCBIMhudiblu_PPA_v0panPan3
BAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,950,359 - 2,957,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,948,364 - 2,957,018 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,967,686 - 2,970,924 (-)NCBI
ROS_Cfam_1.0123,282,315 - 3,289,076 (-)NCBI
UMICH_Zoey_3.1122,950,651 - 2,953,887 (-)NCBI
UNSW_CanFamBas_1.0123,031,622 - 3,034,860 (-)NCBI
UU_Cfam_GSD_1.0123,129,752 - 3,132,990 (-)NCBI
Bak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,605,488 - 38,612,704 (-)NCBI
SpeTri2.0NW_00493647625,347,608 - 25,354,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1729,808,849 - 29,815,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,279,191 - 34,286,287 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,492,776 - 38,502,534 (+)NCBI
ChlSab1.1 Ensembl1738,492,858 - 38,501,281 (+)Ensembl
Vero_WHO_p1.0NW_02366604433,412,290 - 33,419,643 (-)NCBI
Bak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475423,297,077 - 23,302,366 (+)NCBI

Position Markers
Bak1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381727,019,897 - 27,020,083UniSTSGRCm38
MGSCv371727,156,842 - 27,157,028UniSTSGRCm37
Celera1727,556,352 - 27,556,538UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map17BUniSTS
cM Map17 UniSTS
D17Jcs15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381727,025,541 - 27,025,780UniSTSGRCm38
MGSCv371727,162,486 - 27,162,725UniSTSGRCm37
Celera1727,561,998 - 27,562,216UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map17BUniSTS
cM Map17 UniSTS
Bak1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17BUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17128979566Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17128979566Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17128979566Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17130809908Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17480447727496965Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17765701129268449Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171661519333600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172536594043665344Mouse
12903990Opfaq5_mopen field activity QTL 5 (mouse)172573195128773124Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172628636340794146Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
12904013Cfq12_mconditioned fear QTL 12 (mouse)172660980730445981Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir125b-1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21880154
Mir125b-1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21823019
Mir125b-2mmu-miR-125b-5pOncomiRDBexternal_infoNANA21880154
Mir125b-2mmu-miR-125b-5pOncomiRDBexternal_infoNANA21823019
Mir125b-2mmu-miR-125b-5pOncomiRDBexternal_infoNANA20460378
Mir125b-1mmu-miR-125b-5pOncomiRDBexternal_infoNANA20460378

Predicted Target Of
Summary Value
Count of predictions:1635
Count of miRNA genes:541
Interacting mature miRNAs:647
Transcripts:ENSMUST00000025034, ENSMUST00000078691, ENSMUST00000133448, ENSMUST00000143158
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000025034   ⟹   ENSMUSP00000025034
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1727,019,812 - 27,028,578 (-)Ensembl
RefSeq Acc Id: ENSMUST00000078691   ⟹   ENSMUSP00000077757
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1727,019,810 - 27,029,009 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143158   ⟹   ENSMUSP00000122521
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1727,020,666 - 27,028,694 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237411   ⟹   ENSMUSP00000158395
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1727,019,812 - 27,028,587 (-)Ensembl
RefSeq Acc Id: NM_007523   ⟹   NP_031549
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391727,238,786 - 27,247,601 (-)NCBI
GRCm381727,019,812 - 27,028,627 (-)NCBI
MGSCv371727,156,757 - 27,165,571 (-)RGD
Celera1727,556,267 - 27,565,056 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_149749
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391727,238,786 - 27,247,601 (-)NCBI
GRCm381727,019,812 - 27,028,627 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031549   ⟸   NM_007523
- UniProtKB: O08734 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000158395   ⟸   ENSMUST00000237411
RefSeq Acc Id: ENSMUSP00000122521   ⟸   ENSMUST00000143158
RefSeq Acc Id: ENSMUSP00000077757   ⟸   ENSMUST00000078691
RefSeq Acc Id: ENSMUSP00000025034   ⟸   ENSMUST00000025034

Promoters
RGD ID:13675274
Promoter ID:EPDNEW_M21786
Type:initiation region
Name:Bak1_2
Description:Mus musculus BCL2-antagonist/killer 1 , transcript variant 2,non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21787  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381727,020,678 - 27,020,738EPDNEW
RGD ID:13675276
Promoter ID:EPDNEW_M21787
Type:initiation region
Name:Bak1_1
Description:Mus musculus BCL2-antagonist/killer 1 , transcript variant 2,non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21786  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381727,028,563 - 27,028,623EPDNEW
RGD ID:6827848
Promoter ID:MM_KWN:22714
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000076755
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361727,159,241 - 27,160,427 (-)MPROMDB
RGD ID:6827847
Promoter ID:MM_KWN:22715
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000076752,   OTTMUST00000076754,   UC008BFG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361727,165,296 - 27,165,796 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1097161 AgrOrtholog
Ensembl Genes ENSMUSG00000057789 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000025034 UniProtKB/TrEMBL
  ENSMUSP00000077757 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000122521 UniProtKB/TrEMBL
  ENSMUSP00000158395 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025034 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000078691 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000143158 UniProtKB/TrEMBL
  ENSMUST00000237411 UniProtKB/TrEMBL
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BAK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH2_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Blc2_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12018 UniProtKB/Swiss-Prot
MGD MGI:1097161 ENTREZGENE
NCBI Gene 12018 ENTREZGENE
PANTHER PTHR11256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11256:SF41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/Swiss-Prot
PharmGKB BAK1 RGD
PhenoGen Bak1 PhenoGen
PRINTS BCL2FAMILY UniProtKB/Swiss-Prot
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH1 UniProtKB/Swiss-Prot
  BH2 UniProtKB/Swiss-Prot
  BH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BCL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BB74_MOUSE UniProtKB/TrEMBL
  BAK_MOUSE UniProtKB/Swiss-Prot
  F7CUQ1_MOUSE UniProtKB/TrEMBL
  O08734 ENTREZGENE
  Q91WX5_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QM21 UniProtKB/Swiss-Prot
  Q8C264 UniProtKB/Swiss-Prot