Cd14 (CD14 antigen) - Rat Genome Database

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Gene: Cd14 (CD14 antigen) Mus musculus
Symbol: Cd14
Name: CD14 antigen
RGD ID: 733890
Description: Predicted to enable lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production; and toll-like receptor 4 signaling pathway. Located in external side of plasma membrane and membrane raft. Is expressed in several structures, including femur; gallbladder; intestine; reproductive system; and telencephalon. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and perinatal necrotizing enterocolitis. Orthologous to human CD14 (CD14 molecule).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391836,858,117 - 36,859,868 (-)NCBIGRCm39mm39
GRCm39 Ensembl1836,858,120 - 36,859,851 (-)Ensembl
GRCm381836,725,064 - 36,726,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,725,067 - 36,726,798 (-)EnsemblGRCm38mm10GRCm38
MGSCv371836,884,721 - 36,886,308 (-)NCBIGRCm37mm9NCBIm37
MGSCv361836,851,041 - 36,852,628 (-)NCBImm8
Celera1837,177,144 - 37,178,731 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
allergic disease  (ISO)
asthma  (ISO)
autosomal dominant intellectual developmental disorder 31  (ISO)
autosomal dominant nonsyndromic deafness 1  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (IEP,ISO)
bacterial pneumonia  (IMP)
biliary atresia  (ISO)
Brain Injuries  (ISO)
Bronchial Hyperreactivity  (ISO)
Burns  (ISO)
carotid artery disease  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cholestasis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
diarrhea  (ISO)
Eczema  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Neuritis  (ISO)
familial adenomatous polyposis 1  (ISO)
gout  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hirschsprung's disease  (ISO)
Human Influenza  (IMP)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
Intestinal Reperfusion Injury  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Reperfusion Injury  (IEP)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IEP,IMP)
Middle East respiratory syndrome  (IEP)
myocardial infarction  (ISO)
Neuralgia  (ISO)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
obstructive jaundice  (ISO)
pancreatitis  (IMP)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
Pneumococcal Pneumonia  (IMP)
pneumonia  (ISO)
pulmonary tuberculosis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
Seizures, Cortical Blindness, and Microcephaly Syndrome  (ISO)
severe acute respiratory syndrome  (ISO)
type 1 diabetes mellitus  (IMP,ISO)
ureteral obstruction  (IEP)
Viral Bronchiolitis  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-methylhistamine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (EXP)
adenosine  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
aldehydo-D-glucose  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (EXP)
amlexanox  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
carbofuran  (ISO)
carbon nanotube  (EXP,ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
cimetidine  (ISO)
ciprofibrate  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP,ISO)
diclofenac  (EXP)
diethylstilbestrol  (EXP)
Dimaprit  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
ferric oxide  (EXP)
fipronil  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
ganglioside GM1  (ISO)
gefitinib  (ISO)
Genipin  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glucose  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
graphene oxide  (EXP)
griseofulvin  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP)
histamine  (ISO)
hydrogen cyanide  (EXP)
hydroxychloroquine  (ISO)
indole-3-methanol  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (EXP,ISO)
kaempferol  (ISO)
L-methionine  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
Licochalcone B  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
malathion  (ISO)
melatonin  (ISO)
metacetamol  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl beta-cyclodextrin  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
obeticholic acid  (ISO)
oligomycin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pipoxolan  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(propylene imine) macromolecule  (ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
progesterone  (EXP)
propiconazole  (EXP)
pyrithione  (ISO)
pyrrolidine dithiocarbamate  (ISO)
razoxane  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
sertraline  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenylstannane  (ISO)
triprolidine  (ISO)
troglitazone  (ISO)
undecane  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
vancomycin  (EXP)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vitamin D  (ISO)
xestospongin C  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function


References - curated
# Reference Title Reference Citation
1. CD14 and toll-like receptor 4: a link between infection and acute coronary events? Arroyo-Espliguero R, etal., Heart. 2004 Sep;90(9):983-8.
2. Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population. Banerjee I, etal., J Thromb Thrombolysis. 2009 Jan;27(1):88-94. Epub 2007 Dec 23.
3. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. Bresson D, etal., J Clin Invest. 2006 May;116(5):1371-81. Epub 2006 Apr 20.
4. Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis: pathogenesis and therapeutic implications. Chan KL, etal., World J Gastroenterol. 2009 Oct 14;15(38):4745-52.
5. Endotoxin and CD14 in the progression of biliary atresia. Chou MH, etal., J Transl Med. 2010 Dec 21;8:138. doi: 10.1186/1479-5876-8-138.
6. Effects of hepatocyte CD14 upregulation during cholestasis on endotoxin sensitivity. Chou MH, etal., PLoS One. 2012;7(4):e34903. doi: 10.1371/journal.pone.0034903. Epub 2012 Apr 12.
7. CD14 facilitates invasive respiratory tract infection by Streptococcus pneumoniae. Dessing MC, etal., Am J Respir Crit Care Med. 2007 Mar 15;175(6):604-11. Epub 2006 Dec 21.
8. CD14 plays a limited role during influenza A virus infection in vivo. Dessing MC, etal., Immunol Lett. 2007 Oct 31;113(1):47-51. Epub 2007 Aug 22.
9. Frequencies of genetic polymorphisms of TLR4 and CD14 and of HLA-DQ genotypes in children with celiac disease, type 1 diabetes mellitus, or both. Dezsofi A, etal., J Pediatr Gastroenterol Nutr. 2008 Sep;47(3):283-7.
10. Lipopolysaccharide-binding protein and lipopolysaccharide receptor CD14 gene expression after thermal injury and its potential mechanism(s). Fang CW, etal., J Trauma. 2002 Nov;53(5):957-67.
11. Serum LBP levels reflect the impaired synthetic capacity of the remnant liver after partial hepatectomy in rats. Fang H, etal., J Immunol Methods. 2012 Aug 31;382(1-2):68-75. doi: 10.1016/j.jim.2012.05.006. Epub 2012 May 8.
12. [Gene expression of lipopolysaccharide receptor CD14 and tumor necrosis factor-alpha in rats after thermal injury]. Fang W, etal., Zhonghua Wai Ke Za Zhi. 1999 May;37(5):271-3.
13. Association of MBL2, TGF-beta1 and CD14 gene polymorphisms with lung disease severity in cystic fibrosis. Faria EJ, etal., J Bras Pneumol. 2009 Apr;35(4):334-42.
14. Association between CD14 gene polymorphisms and disease phenotype in sarcoidosis. Fridlender ZG, etal., Respir Med. 2010 Sep;104(9):1336-43. Epub 2010 Apr 28.
15. Expression of CD14 protein and its gene in liver sinusoidal endothelial cells during endotoxemia. Gong JP, etal., World J Gastroenterol 2002 Jun;8(3):551-4.
16. The local and systemic inflammatory transcriptome after acute kidney injury. Grigoryev DN, etal., J Am Soc Nephrol. 2008 Mar;19(3):547-58. Epub 2008 Jan 30.
17. Association of the CD14 gene polymorphism C-159T with allergic rhinitis. Han D, etal., Am J Rhinol Allergy. 2010 Jan-Feb;24(1):e1-3.
18. Association study of CD14 polymorphism with myocardial infarction in a Japanese population. Hohda S, etal., Jpn Heart J. 2003 Sep;44(5):613-22.
19. TNF-alpha (-308 G/A) and CD14 (-159T/C) polymorphisms in the bronchial responsiveness of Korean children with asthma. Hong SJ, etal., J Allergy Clin Immunol. 2007 Feb;119(2):398-404. Epub 2006 Dec 28.
20. CD14 -550 C/T, which is related to the serum level of soluble CD14, is associated with the development of respiratory syncytial virus bronchiolitis in the Japanese population. Inoue Y, etal., J Infect Dis. 2007 Jun 1;195(11):1618-24. Epub 2007 Apr 23.
21. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Jeyaseelan S, etal., Infect Immun. 2005 Mar;73(3):1754-63.
22. The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population. Kedda MA, etal., Thorax. 2005 Mar;60(3):211-4.
23. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
24. Expression of Toll-like receptor 4 in various organs in rats with D-galactosamine-induced acute hepatic failure. Kitazawa T, etal., J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e494-8. Epub 2007 Dec 7.
25. CD14 triggers autoimmune Type 1 diabetes in the NOD mouse. Kloting N, etal., Diabetologia. 2004 Jan;47(1):151-2. Epub 2003 Nov 12.
26. Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia. Knapp S, etal., Am J Respir Crit Care Med. 2006 Jan 1;173(1):122-9. Epub 2005 Oct 6.
27. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
28. Toll-like receptors and CD14 genes polymorphisms and susceptibility to asthma in Tunisian children. Lachheb J, etal., Tissue Antigens. 2008 May;71(5):417-25. Epub 2008 Feb 28.
29. Association between farm exposure and atopy, according to the CD14 C-159T polymorphism. Leynaert B, etal., J Allergy Clin Immunol. 2006 Sep;118(3):658-65. Epub 2006 Jul 28.
30. Association of the -159C/T polymorphism of the endotoxin receptor (CD14) with carotid artery disease and cardiovascular mortality in dialysis patients. Losito A, etal., Blood Purif. 2005;23(2):128-33. Epub 2005 Jan 6.
31. The role of CD14 and Toll-like receptor 4 of Kupffer cells in hepatic ischemia-reperfusion injury in rats. Luan X, etal., Transplant Proc. 2012 May;44(4):937-41. doi: 10.1016/j.transproceed.2011.11.001.
32. Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases. Marcos V, etal., Respir Res. 2010 Mar 19;11:32.
33. Genetic and acquired inflammatory conditions are synergistically associated with early carotid atherosclerosis. Markus HS, etal., Stroke. 2006 Sep;37(9):2253-9. Epub 2006 Jul 27.
34. Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. Martin AC, etal., Am J Respir Crit Care Med. 2006 Mar 15;173(6):617-22. Epub 2005 Dec 30.
35. MGDs mouse GO annotations MGD data from the GO Consortium
37. Induction of CD14 in tubular epithelial cells during kidney disease. Morrissey J, etal., J Am Soc Nephrol. 2000 Sep;11(9):1681-90.
38. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
39. Myeloid differentiation 2 as a therapeutic target of inflammatory disorders. Park SH, etal., Pharmacol Ther. 2012 Mar;133(3):291-8. doi: 10.1016/j.pharmthera.2011.11.001. Epub 2011 Nov 19.
40. Circulating monocytes in patients with diabetes mellitus, arterial disease, and increased CD14 expression. Patino R, etal., Am J Cardiol. 2000 Jun 1;85(11):1288-91.
41. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
42. Increased serum endotoxin and elevated CD14 and IL-1beta expression in a rat model of cerebrogenic multiple organ dysfunction syndrome. Qu C, etal., Med Chem. 2009 Sep;5(5):462-7. Epub 2009 Sep 1.
43. CD14 gene polymorphism 159C/T in a group of patients with coronary artery disease from a population with high morbidity of cardiovascular diseases. Rechcinski T, etal., Kardiol Pol. 2007 Mar;65(3):237-44; discussion 245.
44. Mouse MP Annotation Import Pipeline RGD automated import pipeline
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis. Rosas-Taraco AG, etal., J Infect Dis. 2007 Dec 1;196(11):1698-706. Epub 2007 Oct 25.
47. Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice. Sharif R, etal., Gut. 2009 Jun;58(6):813-9. Epub 2009 Feb 6.
48. Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy. Shinzawa M, etal., Clin Exp Nephrol. 2012 Apr;16(2):250-8. doi: 10.1007/s10157-011-0553-7. Epub 2011 Nov 11.
49. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Smit LA, etal., Am J Respir Crit Care Med. 2009 Mar 1;179(5):363-8. Epub 2008 Dec 18.
50. Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat. Suzuki T, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G638-46. Epub 2004 Apr 29.
51. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Tanga FY, etal., Neurochem Int 2004 Jul-Aug;45(2-3):397-407.
52. The Kinetic Expression of Lipopolysaccharide-Binding Protein and CD14 Gene in Obstructive Jaundice. Tsai CH, etal., J Invest Surg. 2014 Aug 5.
53. A new promoter polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile. Unkelbach K, etal., Arterioscler Thromb Vasc Biol. 1999 Apr;19(4):932-8.
54. [Role of endotoxin translocation on mesenteric lymph reperfusion aggravating multiple organ injury in SMAO shock rats]. Yang LN, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Jan;28(1):74-8.
55. Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy. Yoon HJ, etal., J Med Genet. 2003 Feb;40(2):104-8.
56. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study. Zambelli-Weiner A, etal., J Allergy Clin Immunol. 2005 Jun;115(6):1203-9.
57. [Expression of lipopolysaccharide receptors CD14 and TLR4 in a model of rat molar apical periodontitis]. Zhang C and Hou BX, Zhonghua Kou Qiang Yi Xue Za Zhi. 2007 Mar;42(3):148-9.
58. Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy. Zhang G, etal., Allergy. 2009 Sep;64(9):1333-41. Epub 2009 Feb 14.
59. Toll-like receptor-2, CD14 and heat-shock protein 70 in inflammatory lesions of rat experimental autoimmune neuritis. Zhang ZY, etal., Neuroscience. 2009 Mar 3;159(1):136-42. Epub 2009 Jan 1.
60. Renal CD14 expression correlates with the progression of cystic kidney disease. Zhou J, etal., Kidney Int. 2010 Sep;78(6):550-60. doi: 10.1038/ki.2010.175. Epub 2010 Jun 16.
Additional References at PubMed
PMID:1694207   PMID:2467257   PMID:2472171   PMID:7532683   PMID:7534618   PMID:8612135   PMID:8706013   PMID:8921956   PMID:9127007   PMID:9353071   PMID:9665271   PMID:10047547  
PMID:10202023   PMID:10221645   PMID:10349636   PMID:10679400   PMID:11035061   PMID:11042159   PMID:11062499   PMID:11076861   PMID:11123339   PMID:11145687   PMID:11217851   PMID:11254735  
PMID:11779220   PMID:11796577   PMID:11870620   PMID:12146799   PMID:12165539   PMID:12171914   PMID:12196527   PMID:12239221   PMID:12244136   PMID:12244198   PMID:12370383   PMID:12391013  
PMID:12424240   PMID:12427659   PMID:12477932   PMID:12482856   PMID:12496149   PMID:12639839   PMID:12935356   PMID:12964032   PMID:14516777   PMID:14517279   PMID:14742577   PMID:14752288  
PMID:15034566   PMID:15142274   PMID:15194867   PMID:15208271   PMID:15240706   PMID:15271679   PMID:15306695   PMID:15322035   PMID:15331624   PMID:15459483   PMID:15489334   PMID:15493995  
PMID:15522312   PMID:15541715   PMID:15557205   PMID:15585870   PMID:15611337   PMID:15644310   PMID:15661914   PMID:15670766   PMID:15724245   PMID:15755524   PMID:15795240   PMID:15814723  
PMID:15895089   PMID:15896296   PMID:15941778   PMID:16081822   PMID:16141072   PMID:16141073   PMID:16148141   PMID:16163057   PMID:16188968   PMID:16204620   PMID:16225933   PMID:16229899  
PMID:16237099   PMID:16428731   PMID:16439470   PMID:16456013   PMID:16473828   PMID:16480837   PMID:16574244   PMID:16602821   PMID:16675630   PMID:16705022   PMID:16751412   PMID:16889948  
PMID:16980981   PMID:16995947   PMID:17039565   PMID:17056568   PMID:17114485   PMID:17167049   PMID:17202362   PMID:17283106   PMID:17292937   PMID:17339472   PMID:17384086   PMID:17456769  
PMID:17456850   PMID:17474083   PMID:17657310   PMID:17709409   PMID:17950615   PMID:18027846   PMID:18057002   PMID:18156186   PMID:18250425   PMID:18292574   PMID:18305141   PMID:18339426  
PMID:18354210   PMID:18383566   PMID:18393969   PMID:18461018   PMID:18462086   PMID:18606699   PMID:18686098   PMID:18701460   PMID:18761356   PMID:18799693   PMID:18855560   PMID:18976692  
PMID:18988922   PMID:19109191   PMID:19122641   PMID:19160083   PMID:19264904   PMID:19299737   PMID:19362712   PMID:19424969   PMID:19521507   PMID:19525933   PMID:19540594   PMID:19637338  
PMID:19666536   PMID:19672969   PMID:19710907   PMID:19776284   PMID:19786543   PMID:19840871   PMID:19841074   PMID:19847289   PMID:20011115   PMID:20037584   PMID:20113368   PMID:20133493  
PMID:20335569   PMID:20348223   PMID:20382883   PMID:20419140   PMID:20432233   PMID:20456021   PMID:20519121   PMID:20643814   PMID:20869044   PMID:21029863   PMID:21078886   PMID:21084593  
PMID:21178007   PMID:21217012   PMID:21281805   PMID:21308776   PMID:21308778   PMID:21309947   PMID:21441453   PMID:21683771   PMID:21700881   PMID:21873635   PMID:21940410   PMID:21949737  
PMID:22031950   PMID:22078883   PMID:22253759   PMID:22265692   PMID:22445606   PMID:22466648   PMID:22523073   PMID:22591691   PMID:22662179   PMID:22865855   PMID:22970242   PMID:23012479  
PMID:23144170   PMID:23166489   PMID:23201091   PMID:23416151   PMID:23508573   PMID:23537804   PMID:23548899   PMID:23565187   PMID:23589304   PMID:23636320   PMID:23656919   PMID:23698118  
PMID:23708119   PMID:23887873   PMID:24049740   PMID:24062059   PMID:24089559   PMID:24116867   PMID:24120921   PMID:24380872   PMID:24489448   PMID:24516606   PMID:24659539   PMID:24703105  
PMID:24790148   PMID:24866794   PMID:24891322   PMID:25362351   PMID:25431457   PMID:25450368   PMID:25497142   PMID:25633197   PMID:25825741   PMID:25862090   PMID:25869127   PMID:25889660  
PMID:25965346   PMID:26106158   PMID:26431947   PMID:26515416   PMID:26637175   PMID:26683584   PMID:26831104   PMID:27191968   PMID:27228163   PMID:27418354   PMID:27448760   PMID:27480124  
PMID:27510408   PMID:27729526   PMID:27908440   PMID:28105518   PMID:28411859   PMID:28443393   PMID:28489816   PMID:28705936   PMID:28743992   PMID:28765651   PMID:28963650   PMID:29018138  
PMID:29045901   PMID:29128406   PMID:29212908   PMID:29335601   PMID:29343440   PMID:29719169   PMID:29755470   PMID:29777767   PMID:30353127   PMID:30485272   PMID:30529429   PMID:30830879  
PMID:31142629   PMID:31335985   PMID:31955888   PMID:33168941   PMID:33397971   PMID:33927296  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391836,858,117 - 36,859,868 (-)NCBIGRCm39mm39
GRCm39 Ensembl1836,858,120 - 36,859,851 (-)Ensembl
GRCm381836,725,064 - 36,726,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,725,067 - 36,726,798 (-)EnsemblGRCm38mm10GRCm38
MGSCv371836,884,721 - 36,886,308 (-)NCBIGRCm37mm9NCBIm37
MGSCv361836,851,041 - 36,852,628 (-)NCBImm8
Celera1837,177,144 - 37,178,731 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.46NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385140,631,732 - 140,633,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5140,631,728 - 140,633,700 (-)EnsemblGRCh38hg38GRCh38
GRCh375140,011,317 - 140,013,286 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365139,991,501 - 139,993,439 (-)NCBINCBI36hg18NCBI36
Build 345139,991,504 - 139,992,956NCBI
Celera5136,088,058 - 136,090,031 (-)NCBI
Cytogenetic Map5q31.3NCBI
HuRef5135,156,588 - 135,158,561 (-)NCBIHuRef
CHM1_15139,444,555 - 139,446,528 (-)NCBICHM1_1
T2T-CHM13v2.05141,157,140 - 141,159,109 (-)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21828,335,522 - 28,337,383 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1828,335,340 - 28,337,261 (-)Ensembl
Rnor_6.01829,560,341 - 29,562,290 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,560,365 - 29,562,153 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,265,328 - 29,267,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,374,593 - 29,376,190 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11829,401,242 - 29,402,836 (-)NCBI
Celera1828,056,118 - 28,057,715 (-)NCBICelera
Cytogenetic Map18p11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541873,897 - 75,224 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541873,736 - 75,345 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.15142,113,082 - 142,115,023 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5142,113,082 - 142,118,966 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05135,996,265 - 135,997,909 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1235,790,505 - 35,792,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha232,830,342 - 32,831,881 (-)NCBI
ROS_Cfam_1.0236,246,733 - 36,248,272 (-)NCBI
ROS_Cfam_1.0 Ensembl236,246,328 - 36,248,163 (-)Ensembl
UMICH_Zoey_3.1233,299,603 - 33,301,142 (-)NCBI
UNSW_CanFamBas_1.0234,167,141 - 34,168,680 (-)NCBI
UU_Cfam_GSD_1.0234,919,848 - 34,921,387 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213152,034,627 - 152,037,248 (+)NCBI
SpeTri2.0NW_0049365319,572,392 - 9,575,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2142,346,360 - 142,349,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12142,348,036 - 142,349,686 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22148,291,971 - 148,293,621 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q28NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12343,264,917 - 43,266,825 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2343,264,336 - 43,266,993 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603434,617,693 - 34,619,669 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474333,367,898 - 33,373,922 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474333,372,023 - 33,374,438 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381836,725,735 - 36,726,109UniSTSGRCm38
MGSCv371836,885,389 - 36,885,763UniSTSGRCm37
Celera1837,177,812 - 37,178,186UniSTS
Cytogenetic Map18B2UniSTS
cM Map1831.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381836,725,152 - 36,725,294UniSTSGRCm38
MGSCv371836,884,806 - 36,884,948UniSTSGRCm37
Celera1837,177,229 - 37,177,371UniSTS
Cytogenetic Map18B2UniSTS
cM Map1831.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381836,724,799 - 36,724,898UniSTSGRCm38
MGSCv371836,884,453 - 36,884,552UniSTSGRCm37
Celera1837,176,876 - 37,176,975UniSTS
Cytogenetic Map18B2UniSTS
cM Map1831.0UniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
11041903Lmr27_mleishmaniasis resistance 27 (mouse)183618756745109518Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:90
Interacting mature miRNAs:94
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_009841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB039054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC027740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY498446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EH108279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000061829   ⟹   ENSMUSP00000056669
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1836,858,120 - 36,859,851 (-)Ensembl
GRCm38.p6 Ensembl1836,725,067 - 36,726,798 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237042
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1836,858,924 - 36,859,791 (-)Ensembl
GRCm38.p6 Ensembl1836,725,871 - 36,726,738 (-)Ensembl
RefSeq Acc Id: NM_009841   ⟹   NP_033971
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm391836,858,117 - 36,859,868 (-)NCBI
GRCm381836,725,064 - 36,726,815 (-)NCBI
MGSCv371836,884,721 - 36,886,308 (-)RGD
Celera1837,177,141 - 37,178,892 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_033971   ⟸   NM_009841
- Peptide Label: precursor
- UniProtKB: P10810 (UniProtKB/Swiss-Prot),   Q3UB18 (UniProtKB/TrEMBL),   Q3UE54 (UniProtKB/TrEMBL),   Q4FJP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000056669   ⟸   ENSMUST00000061829

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10810-F1-model_v2 AlphaFold P10810 1-366 view protein structure

RGD ID:13677478
Promoter ID:EPDNEW_M22888
Type:initiation region
Description:Mus musculus CD14 antigen , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M22889  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381836,726,603 - 36,726,663EPDNEW
RGD ID:13677480
Promoter ID:EPDNEW_M22889
Type:initiation region
Description:Mus musculus CD14 antigen , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M22888  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381836,726,809 - 36,726,869EPDNEW
RGD ID:6829136
Promoter ID:MM_KWN:24985
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   MEF_B4,   MEF_B6
Mouse AssemblyChrPosition (strand)Source
MGSCv361836,885,781 - 36,886,281 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88318 AgrOrtholog
Ensembl Genes ENSMUSG00000051439 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000056669 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000061829 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Monocyte_diff_Ag_CD14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12475 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd14 PhenoGen
PIRSF CD14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CD14_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE