Acacb (acetyl-Coenzyme A carboxylase beta) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Acacb (acetyl-Coenzyme A carboxylase beta) Mus musculus
Analyze
Symbol: Acacb
Name: acetyl-Coenzyme A carboxylase beta
RGD ID: 1619056
MGI Page MGI
Description: Enables acetyl-CoA carboxylase activity. Involved in several processes, including malonyl-CoA biosynthetic process; positive regulation of heart growth; and regulation of small molecule metabolic process. Acts upstream of or within fatty acid biosynthetic process. Located in mitochondrion. Is expressed in axial skeleton; cranium; and liver. Orthologous to human ACACB (acetyl-CoA carboxylase beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acc; ACC-beta; Acc2; Accb; acetyl-CoA carboxylase 2; AI597064; AW743042
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,284,748 - 114,388,822 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,284,596 - 114,388,822 (+)EnsemblGRCm39 Ensembl
GRCm385114,146,321 - 114,250,761 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,146,535 - 114,250,761 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,615,527 - 114,700,767 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,426,517 - 114,510,733 (+)NCBIMGSCv36mm8
Celera5111,267,324 - 111,357,484 (+)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
(R)-camphor  (ISO)
(R)-carnitine  (ISO)
(R)-linalyl acetate  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,8-cineole  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetamide  (ISO)
Acetyl tributyl citrate  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
ampicillin  (EXP)
aristolochic acids  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
aspartame  (EXP)
atorvastatin calcium  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
camphor  (ISO)
cantharidin  (EXP)
capsaicin  (ISO)
carbon nanotube  (EXP)
carnitine  (ISO)
chlordecone  (EXP)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
curcumin  (EXP)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
D-mannitol  (EXP)
dexamethasone  (EXP,ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
fipronil  (ISO)
folic acid  (EXP,ISO)
fructose  (EXP,ISO)
furan  (EXP)
genistein  (EXP)
glucose  (ISO)
glycine betaine  (EXP)
glyphosate  (EXP)
GW 4064  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
iron dichloride  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
metronidazole  (EXP)
mevalonic acid  (ISO)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (ISO)
neomycin  (EXP)
nickel atom  (ISO)
nordihydroguaiaretic acid  (ISO)
O-methyleugenol  (ISO)
olaparib  (EXP)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (EXP)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
puerarin  (EXP)
resveratrol  (ISO)
rimonabant  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sabinene  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
spathulenol  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP)
triptonide  (EXP)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion. Choi YS, etal., J Mol Cell Cardiol. 2016 Nov;100:64-71. doi: 10.1016/j.yjmcc.2016.09.001. Epub 2016 Sep 28.
2. The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics. Gertz K, etal., Exp Neurol. 2018 Aug;306:34-44. doi: 10.1016/j.expneurol.2018.04.004. Epub 2018 Apr 21.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis. Ritterhoff J, etal., Circ Res. 2020 Jan 17;126(2):182-196. doi: 10.1161/CIRCRESAHA.119.315483. Epub 2019 Nov 11.
8. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. Savage DB, etal., J Clin Invest. 2006 Mar;116(3):817-24. Epub 2006 Feb 16.
9. Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition of AMP-Activated Protein Kinase Downstream Signals in Cardiac Tissues. Sayed-Ahmed MM, etal., Cardiovasc Toxicol. 2019 Aug;19(4):344-356. doi: 10.1007/s12012-018-9500-0.
10. WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARα pathway. Yan J, etal., Life Sci. 2021 Feb 1;266:118888. doi: 10.1016/j.lfs.2020.118888. Epub 2020 Dec 10.
11. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:10349636   PMID:10677481   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11283375   PMID:12466851   PMID:12477932   PMID:12920182   PMID:14610273  
PMID:14662765   PMID:14681479   PMID:15677334   PMID:15749055   PMID:16141072   PMID:16141073   PMID:17210641   PMID:17923673   PMID:18487439   PMID:18614015   PMID:18799693   PMID:19217427  
PMID:19564420   PMID:20074529   PMID:20368432   PMID:21267068   PMID:21436046   PMID:21677750   PMID:21873635   PMID:22090424   PMID:22362781   PMID:22532389   PMID:22563100   PMID:22730442  
PMID:22922362   PMID:24185692   PMID:24338821   PMID:24913514   PMID:24944901   PMID:25001074   PMID:25282359   PMID:26367121   PMID:26378152   PMID:27381369   PMID:27635760   PMID:27689697  
PMID:27997827   PMID:28290443   PMID:28768177   PMID:28877461   PMID:29175208   PMID:29433631   PMID:29438065   PMID:29931154   PMID:29976587   PMID:30018077   PMID:30043753   PMID:30244972  
PMID:30457570   PMID:31990961   PMID:32215608   PMID:32592696   PMID:32597196   PMID:32694673   PMID:33505018   PMID:34255743   PMID:34668531   PMID:36001969   PMID:36076520   PMID:36114006  
PMID:36417534   PMID:36417873   PMID:36421460   PMID:37163372   PMID:38447582   PMID:38972757  


Genomics

Comparative Map Data
Acacb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,284,748 - 114,388,822 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,284,596 - 114,388,822 (+)EnsemblGRCm39 Ensembl
GRCm385114,146,321 - 114,250,761 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,146,535 - 114,250,761 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,615,527 - 114,700,767 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,426,517 - 114,510,733 (+)NCBIMGSCv36mm8
Celera5111,267,324 - 111,357,484 (+)NCBICelera
Cytogenetic Map5FNCBI
ACACB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812109,111,189 - 109,268,226 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12109,116,587 - 109,268,226 (+)EnsemblGRCh38hg38GRCh38
GRCh3712109,548,994 - 109,706,031 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,061,585 - 108,190,414 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412108,039,930 - 108,166,887NCBI
Celera12109,201,352 - 109,330,479 (+)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12106,595,722 - 106,724,234 (+)NCBIHuRef
CHM1_112109,544,852 - 109,673,937 (+)NCBICHM1_1
T2T-CHM13v2.012109,086,220 - 109,243,208 (+)NCBIT2T-CHM13v2.0
Acacb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,026,394 - 48,138,214 (-)NCBIGRCr8
mRatBN7.21242,365,800 - 42,477,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,366,548 - 42,457,655 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,534,259 - 43,644,789 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01244,147,852 - 44,258,379 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,208,360 - 43,318,896 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,127,149 - 48,238,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,127,149 - 48,238,887 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,914,427 - 50,000,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,388,679 - 43,492,993 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,252,066 - 43,356,381 (-)NCBI
Celera1243,976,897 - 44,062,163 (-)NCBICelera
Cytogenetic Map12q16NCBI
Acacb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545510,308,192 - 10,426,076 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545510,282,308 - 10,427,439 (+)NCBIChiLan1.0ChiLan1.0
ACACB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210117,176,414 - 117,335,004 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112117,172,919 - 117,331,402 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012106,692,668 - 106,845,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112110,086,374 - 110,239,847 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,086,374 - 110,239,847 (+)Ensemblpanpan1.1panPan2
ACACB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,763,531 - 17,895,319 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,747,362 - 17,894,400 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2617,906,250 - 18,037,960 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02618,106,936 - 18,239,349 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2618,106,944 - 18,239,179 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12618,115,480 - 18,247,107 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02618,097,758 - 18,229,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02618,116,847 - 18,248,772 (-)NCBIUU_Cfam_GSD_1.0
Acacb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,422,223 - 144,525,063 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936769950,845 - 1,051,887 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936769950,970 - 1,053,671 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACACB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,621,574 - 41,739,916 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,621,574 - 41,739,916 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21444,153,373 - 44,271,216 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACACB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111104,325,250 - 104,488,567 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11104,349,573 - 104,488,003 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037140,614,337 - 140,773,620 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acacb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474712,307,541 - 12,424,897 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474712,287,817 - 12,426,340 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acacb
7280 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1300
Count of miRNA genes:551
Interacting mature miRNAs:657
Transcripts:ENSMUST00000031583, ENSMUST00000102582, ENSMUST00000142489, ENSMUST00000143276, ENSMUST00000146841
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
25314310Syncl4_msynaptonemal complex length 4 (mouse)5103047866115538059Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
25314317Sccor3_msynaptonemal complex length to mean MLH1 count ratio 3 (mouse)5104347866114738061Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined598019649116876624Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
1357886Diht_mdopamine-induced hypothermia (mouse)Not determined5104498738115101540Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104386871120711986Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5114021753129632606Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4141652Mrdq2_mmodifier of retinal degeneration QTL 2 (mouse)Not determined110253106118093673Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
AW743042  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385114,248,469 - 114,248,717UniSTSGRCm38
MGSCv375114,698,478 - 114,698,726UniSTSGRCm37
Celera5111,355,198 - 111,355,446UniSTS
Cytogenetic Map5FUniSTS
Whitehead/MRC_RH51387.1UniSTS
C87246  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385114,218,509 - 114,218,751UniSTSGRCm38
MGSCv375114,668,518 - 114,668,760UniSTSGRCm37
Celera5111,325,023 - 111,325,266UniSTS
Cytogenetic Map5FUniSTS
Whitehead/MRC_RH51409.76UniSTS
AI597064  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385114,250,408 - 114,250,513UniSTSGRCm38
MGSCv375114,700,417 - 114,700,522UniSTSGRCm37
Celera5111,357,134 - 111,357,239UniSTS
Cytogenetic Map5FUniSTS
Whitehead/MRC_RH51409.43UniSTS
Acacb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
cM Map5 UniSTS
Acacb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
cM Map5 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000031583   ⟹   ENSMUSP00000031583
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5114,303,579 - 114,388,816 (+)Ensembl
GRCm38.p6 Ensembl5114,165,518 - 114,250,755 (+)Ensembl
Ensembl Acc Id: ENSMUST00000102582   ⟹   ENSMUSP00000099642
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5114,284,596 - 114,388,822 (+)Ensembl
GRCm38.p6 Ensembl5114,146,535 - 114,250,761 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142489
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5114,386,394 - 114,387,019 (+)Ensembl
GRCm38.p6 Ensembl5114,248,333 - 114,248,958 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143276
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5114,337,840 - 114,388,820 (+)Ensembl
GRCm38.p6 Ensembl5114,199,779 - 114,250,759 (+)Ensembl
Ensembl Acc Id: ENSMUST00000146841   ⟹   ENSMUSP00000115432
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5114,313,967 - 114,328,399 (+)Ensembl
GRCm38.p6 Ensembl5114,175,906 - 114,190,338 (+)Ensembl
RefSeq Acc Id: NM_001403527   ⟹   NP_001390456
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395114,284,748 - 114,388,822 (+)NCBI
RefSeq Acc Id: NM_001403528   ⟹   NP_001390457
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395114,337,695 - 114,388,822 (+)NCBI
RefSeq Acc Id: NM_001403529   ⟹   NP_001390458
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395114,350,108 - 114,388,822 (+)NCBI
RefSeq Acc Id: NM_133904   ⟹   NP_598665
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395114,284,748 - 114,388,822 (+)NCBI
GRCm385114,165,518 - 114,250,758 (+)NCBI
MGSCv375114,615,527 - 114,700,767 (+)RGD
Celera5111,267,324 - 111,357,484 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530112   ⟹   XP_006530175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395114,293,516 - 114,388,822 (+)NCBI
GRCm385114,155,453 - 114,250,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006530114   ⟹   XP_006530177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395114,313,945 - 114,388,822 (+)NCBI
GRCm385114,175,881 - 114,250,761 (+)NCBI
Sequence:
RefSeq Acc Id: NP_598665   ⟸   NM_133904
- Peptide Label: isoform 2 precursor
- UniProtKB: Q6JIZ0 (UniProtKB/Swiss-Prot),   E9Q4Z2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530175   ⟸   XM_006530112
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006530177   ⟸   XM_006530114
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSMUSP00000031583   ⟸   ENSMUST00000031583
Ensembl Acc Id: ENSMUSP00000115432   ⟸   ENSMUST00000146841
Ensembl Acc Id: ENSMUSP00000099642   ⟸   ENSMUST00000102582
RefSeq Acc Id: NP_001390456   ⟸   NM_001403527
- Peptide Label: isoform 1 precursor
RefSeq Acc Id: NP_001390457   ⟸   NM_001403528
- Peptide Label: isoform 3
- UniProtKB: Q3UHC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001390458   ⟸   NM_001403529
- Peptide Label: isoform 4
Protein Domains
ATP-grasp   Biotin carboxylation   Biotinyl-binding   CoA carboxyltransferase C-terminal   CoA carboxyltransferase N-terminal   Lipoyl-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9Q4Z2-F1-model_v2 AlphaFold E9Q4Z2 1-2448 view protein structure

Promoters
RGD ID:6836978
Promoter ID:MM_KWN:43540
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000034177
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365114,625,571 - 114,626,071 (+)MPROMDB
RGD ID:6836979
Promoter ID:MM_KWN:43541
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000040880
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365114,649,396 - 114,649,896 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2140940 AgrOrtholog
Ensembl Genes ENSMUSG00000042010 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031583.15 UniProtKB/Swiss-Prot
  ENSMUST00000102582 ENTREZGENE
  ENSMUST00000102582.8 UniProtKB/Swiss-Prot
  ENSMUST00000143276 ENTREZGENE
  ENSMUST00000146841.2 UniProtKB/TrEMBL
Gene3D-CATH 2-enoyl-CoA Hydratase, Chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.50.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1490.20 UniProtKB/Swiss-Prot
  3.40.50.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin dependent carboxylase carboxyltransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PreATP-grasp domain UniProtKB/Swiss-Prot
InterPro ACCA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACCA_BT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcCoA_carboxyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcCoA_COase_cen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-grasp UniProtKB/Swiss-Prot
  ATP_grasp_subdomain_1 UniProtKB/Swiss-Prot
  BC-like_N UniProtKB/TrEMBL
  Biotin_carboxylation_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_COase_C UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_N UniProtKB/Swiss-Prot
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/Swiss-Prot
  ClpP/crotonase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COA_CT_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COA_CT_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PreATP-grasp_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rudment_hybrid_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:100705 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2140940 ENTREZGENE
NCBI Gene 100705 ENTREZGENE
PANTHER ACETYL-COA CARBOXYLASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACETYL-COA CARBOXYLASE, ISOFORM A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ACC_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACCA_BT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_carb_C UniProtKB/Swiss-Prot
  Biotin_carb_N UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSase_L_chain UniProtKB/Swiss-Prot
  CPSase_L_D2 UniProtKB/Swiss-Prot
PhenoGen Acacb PhenoGen
PROSITE ATP_GRASP UniProtKB/Swiss-Prot
  BIOTINYL_LIPOYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COA_CT_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COA_CT_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSASE_1 UniProtKB/Swiss-Prot
  CPSASE_2 UniProtKB/Swiss-Prot
  PS50979 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Biotin_carb_C UniProtKB/Swiss-Prot
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot
  SSF51230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51246 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ACACB_MOUSE UniProtKB/Swiss-Prot
  D3Z0B3_MOUSE UniProtKB/TrEMBL
  E9Q4Z2 ENTREZGENE
  Q3UHC8 ENTREZGENE, UniProtKB/TrEMBL
  Q6JIZ0 ENTREZGENE
  Q8C697_MOUSE UniProtKB/TrEMBL
  Q8R5C9_MOUSE UniProtKB/TrEMBL
  Q9ESZ3_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q6JIZ0 UniProtKB/Swiss-Prot
  Q9ESZ2 UniProtKB/TrEMBL