Abcg5 (ATP binding cassette subfamily G member 5) - Rat Genome Database

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Gene: Abcg5 (ATP binding cassette subfamily G member 5) Mus musculus
Analyze
Symbol: Abcg5
Name: ATP binding cassette subfamily G member 5
RGD ID: 732220
MGI Page MGI
Description: Enables protein heterodimerization activity. Contributes to cholesterol transfer activity. Involved in cholesterol efflux. Located in apical plasma membrane. Is integral component of plasma membrane. Part of receptor complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in arteriosclerosis and sitosterolemia. Orthologous to human ABCG5 (ATP binding cassette subfamily G member 5).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ATP-binding cassette sub-family G member 5; ATP-binding cassette, sub-family G (WHITE), member 5; ATP-binding cassette, subfamily G, member 5; AW112016; cm; cmp; MGC123400; Ster; sterolin 1; sterolin-1; tr; trac
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391784,965,602 - 84,990,439 (-)NCBIGRCm39mm39
GRCm39 Ensembl1784,965,662 - 84,990,439 (-)Ensembl
GRCm381784,658,174 - 84,683,011 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,658,234 - 84,683,011 (-)EnsemblGRCm38mm10GRCm38
MGSCv371785,057,574 - 85,082,263 (-)NCBIGRCm37mm9NCBIm37
MGSCv361784,566,560 - 84,591,249 (-)NCBImm8
Celera1789,024,999 - 89,050,375 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2,3-trilinolenoylglycerol  (EXP)
1,2,3-trilinoleoylglycerol  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7-ketocholesterol  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
androst-4-ene-3,17-dione  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP)
azathioprine  (ISO)
aztreonam  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorohydrocarbon  (ISO)
cholate  (EXP)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
chromium(6+)  (EXP)
clavulanic acid  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (EXP,ISO)
dibenz[a,h]anthracene  (EXP)
dichloroacetic acid  (EXP)
diosgenin  (EXP,ISO)
doxycycline  (ISO)
erythromycin estolate  (ISO)
fenofibrate  (ISO)
fipronil  (EXP,ISO)
furan  (ISO)
genistein  (ISO)
glafenine  (ISO)
glyburide  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
guggulsterone  (ISO)
GW 3965  (EXP)
GW 4064  (EXP,ISO)
imipenem hydrate  (EXP)
indole-3-methanol  (ISO)
L-ethionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (EXP,ISO)
lovastatin  (EXP)
metformin  (ISO)
methylmercury chloride  (ISO)
methyltestosterone  (ISO)
mirex  (ISO)
Muraglitazar  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
O-methyleugenol  (ISO)
oltipraz  (EXP)
omeprazole  (ISO)
oxycodone  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rotenone  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
spironolactone  (ISO)
stigmasterol  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
tamoxifen  (EXP)
tartrazine  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thioacetamide  (ISO)
tianeptine  (ISO)
toluene  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
triolein  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bile secretion  (IAGP)
abnormal cellular cholesterol metabolism  (IAGP)
abnormal cholesterol homeostasis  (IAGP)
abnormal circulating cholesterol level  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal feces composition  (IAGP)
abnormal intestinal cholesterol absorption  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver physiology  (IAGP)
abnormal megakaryocyte differentiation  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal megakaryocyte progenitor cell morphology  (IAGP)
abnormal metabolism  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal phospholipid level  (IAGP)
abnormal phytosterol level  (IAGP)
abnormal platelet activation  (IAGP)
abnormal platelet alpha-granule morphology  (IAGP)
abnormal platelet morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
anisocytosis  (IAGP)
cardiac fibrosis  (IAGP)
cardiomyopathy  (IAGP)
decreased body size  (IAGP)
decreased cholesterol efflux  (IAGP)
decreased cholesterol level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased hematocrit  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased phytosterol level  (IAGP)
decreased platelet aggregation  (IAGP)
enlarged liver  (IAGP)
female infertility  (IAGP)
giant platelets  (IAGP)
hemolytic anemia  (IAGP)
hunched posture  (IAGP)
increased bleeding time  (IAGP)
increased cholesterol level  (IAGP)
increased circulating phytosterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating VLDL triglyceride level  (IAGP)
increased erythrocyte osmotic fragility  (IAGP)
increased intestinal phytosterol absorption  (IAGP)
increased liver weight  (IAGP)
increased mean platelet volume  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased phytosterol level  (IAGP)
male infertility  (IAGP)
premature death  (IAGP)
reticulocytosis  (IAGP)
stomatocytosis  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Berge KE, etal., Science 2000 Dec 1;290(5497):1771-5.
2. Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes. Bloks VW, etal., Diabetologia 2004 Jan;47(1):104-12. Epub 2003 Nov 14.
3. Searching QTL by gene expression: analysis of diabesity. Brown AC, etal., BMC Genet 2005 Mar 10;6(1):12.
4. The missense mutation in Abcg5 gene in spontaneously hypertensive rats (SHR) segregates with phytosterolemia but not hypertension. Chen J, etal., BMC Genet. 2005 Jul 18;6:40.
5. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
6. An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. Côté I, etal., Eur J Nutr. 2013 Aug;52(5):1523-32. doi: 10.1007/s00394-012-0459-5. Epub 2012 Nov 2.
7. Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition. Ghoneim RH, etal., Br J Nutr. 2015 Feb 14;113(3):507-16. doi: 10.1017/S0007114514003717. Epub 2015 Jan 23.
8. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Lu K, etal., Am J Hum Genet 2001 Aug;69(2):278-90.
9. Effect of maternal cholestasis and treatment with ursodeoxycholic acid on the expression of genes involved in the secretion of biliary lipids by the neonatal rat liver. Macias RI, etal., Life Sci. 2006 Aug 1;79(10):1014-9. Epub 2006 May 20.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. Repa JJ, etal., J Biol Chem 2002 May 24;277(21):18793-800. Epub 2002 Mar 18.
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Yu L, etal., Proc Natl Acad Sci U S A 2002 Dec 10;99(25):16237-42. Epub 2002 Nov 20.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11138003   PMID:11217851   PMID:11907139   PMID:12150943   PMID:12208859   PMID:12208867   PMID:12208868   PMID:12477932   PMID:12601003  
PMID:12763362   PMID:12777468   PMID:12949731   PMID:14504269   PMID:14657202   PMID:14681479   PMID:14699507   PMID:14701919   PMID:14872007   PMID:14993241   PMID:15040800   PMID:15102882  
PMID:15372105   PMID:15611112   PMID:15930515   PMID:16141072   PMID:16141073   PMID:16151694   PMID:16179600   PMID:16602821   PMID:16614371   PMID:16677856   PMID:16685081   PMID:16857831  
PMID:16867993   PMID:17060690   PMID:17561514   PMID:17571164   PMID:17825296   PMID:18156627   PMID:18356535   PMID:18402465   PMID:18466903   PMID:18509196   PMID:18796403   PMID:19047482  
PMID:19416968   PMID:19637290   PMID:19846887   PMID:21209088   PMID:21267068   PMID:21315718   PMID:21738715   PMID:21855652   PMID:21873635   PMID:21885848   PMID:22454430   PMID:22669916  
PMID:22715101   PMID:22829162   PMID:23129576   PMID:23180829   PMID:23380580   PMID:23401258   PMID:23926302   PMID:24811295   PMID:24929016   PMID:25060694   PMID:25378657   PMID:25676339  
PMID:26365598   PMID:26520893   PMID:27014967   PMID:27746211   PMID:28268212   PMID:31641224   PMID:34510707  


Genomics

Comparative Map Data
Abcg5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391784,965,602 - 84,990,439 (-)NCBIGRCm39mm39
GRCm39 Ensembl1784,965,662 - 84,990,439 (-)Ensembl
GRCm381784,658,174 - 84,683,011 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,658,234 - 84,683,011 (-)EnsemblGRCm38mm10GRCm38
MGSCv371785,057,574 - 85,082,263 (-)NCBIGRCm37mm9NCBIm37
MGSCv361784,566,560 - 84,591,249 (-)NCBImm8
Celera1789,024,999 - 89,050,375 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.02NCBI
ABCG5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38243,806,211 - 43,839,231 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl243,812,472 - 43,838,865 (-)EnsemblGRCh38hg38GRCh38
GRCh37244,039,611 - 44,065,978 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36243,893,115 - 43,919,462 (-)NCBINCBI36hg18NCBI36
Build 34243,951,261 - 43,977,609NCBI
Celera243,878,347 - 43,904,690 (-)NCBI
Cytogenetic Map2p21NCBI
HuRef243,776,307 - 43,802,654 (-)NCBIHuRef
CHM1_1243,969,007 - 43,995,357 (-)NCBICHM1_1
T2T-CHM13v2.0243,817,805 - 43,844,170 (-)NCBI
Abcg5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.269,965,118 - 9,990,563 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl69,965,118 - 9,990,563 (+)Ensembl
Rnor_6.067,935,771 - 7,961,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,935,771 - 7,961,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.067,871,269 - 7,896,799 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,027,647 - 8,064,425 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.168,027,646 - 8,064,425 (-)NCBI
Celera69,686,706 - 9,712,114 (+)NCBICelera
Cytogenetic Map6q12NCBI
Abcg5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,964,858 - 10,986,967 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544110,964,588 - 10,987,771 (-)NCBIChiLan1.0ChiLan1.0
ABCG5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A44,745,183 - 44,771,012 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A44,745,183 - 44,771,012 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A43,896,188 - 43,922,756 (-)NCBIMhudiblu_PPA_v0panPan3
ABCG5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,261,747 - 46,300,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,271,772 - 46,299,773 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1046,123,805 - 46,173,246 (-)NCBI
ROS_Cfam_1.01047,140,680 - 47,190,102 (-)NCBI
ROS_Cfam_1.0 Ensembl1047,151,472 - 47,178,440 (-)Ensembl
UMICH_Zoey_3.11046,849,037 - 46,898,531 (-)NCBI
UNSW_CanFamBas_1.01047,138,987 - 47,188,120 (-)NCBI
UU_Cfam_GSD_1.01047,322,375 - 47,371,811 (-)NCBI
Abcg5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,665,097 - 36,688,553 (+)NCBI
SpeTri2.0NW_0049365088,093,804 - 8,117,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCG5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,616,246 - 96,656,889 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,616,304 - 96,656,893 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,776,822 - 102,782,661 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCG5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11463,414,241 - 63,439,193 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1463,413,691 - 63,438,917 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604548,447,921 - 48,472,592 (-)NCBIVero_WHO_p1.0
Abcg5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,287,841 - 25,309,828 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473825,287,574 - 25,310,643 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BE626218  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,223,831 - 54,223,951UniSTSGRCm38
MGSCv371454,843,506 - 54,843,626UniSTSGRCm37
Celera1452,019,728 - 52,019,854UniSTS
Celera1450,703,815 - 50,703,935UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14C2UniSTS
cM Map1427.7UniSTS
Whitehead/MRC_RH14615.39UniSTS
RH67867  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera1739,079,775 - 39,079,900UniSTS
Celera1451,822,719 - 51,822,844UniSTS
Cytogenetic Map16C3.3UniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map17B1UniSTS
AW112016  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381784,658,314 - 84,658,395UniSTSGRCm38
MGSCv371785,057,654 - 85,057,735UniSTSGRCm37
Celera1789,025,079 - 89,025,160UniSTS
Cytogenetic Map17E4UniSTS
cM Map1754.5UniSTS
Whitehead/MRC_RH171060.38UniSTS
M14506  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,223,739 - 54,223,843UniSTSGRCm38
MGSCv371454,843,414 - 54,843,518UniSTSGRCm37
Celera1452,019,654 - 52,019,740UniSTS
Celera1450,703,723 - 50,703,827UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14C2UniSTS
cM Map1427.7UniSTS
Whitehead_YAC14 UniSTS
D14Mit142  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,192,728 - 54,192,863UniSTSGRCm38
MGSCv371454,812,403 - 54,812,538UniSTSGRCm37
Celera1451,988,536 - 51,988,651UniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.5UniSTS
Whitehead Genetic1428.4UniSTS
Whitehead/MRC_RH14615.39UniSTS
Whitehead_YAC14 UniSTS
D14Mit259  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,109,825 - 54,109,949UniSTSGRCm38
MGSCv371454,729,500 - 54,729,624UniSTSGRCm37
Celera1451,910,467 - 51,910,606UniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.5UniSTS
Whitehead Genetic1428.4UniSTS
Whitehead/MRC_RH14615.39UniSTS
Whitehead_YAC14 UniSTS
RH46901  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera1739,079,723 - 39,079,901UniSTS
Celera1451,822,667 - 51,822,845UniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map16C3.3UniSTS
Cytogenetic Map14C1UniSTS
PMC15475P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,122,173 - 54,122,413UniSTSGRCm38
MGSCv371454,741,848 - 54,742,088UniSTSGRCm37
Celera1451,922,825 - 51,923,065UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14C2UniSTS
Tcrd  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,145,965 - 54,146,092UniSTSGRCm38
MGSCv371454,765,640 - 54,765,767UniSTSGRCm37
Celera1451,939,830 - 51,939,957UniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map14C1UniSTS
cM Map1419.5UniSTS
Tcra-C  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C2UniSTS
cM Map1427.7UniSTS
cM Map1419.7UniSTS
PMC200946P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera1739,079,722 - 39,079,958UniSTS
Celera1451,822,666 - 51,822,902UniSTS
Cytogenetic Map16C3.3UniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map17B1UniSTS
Atp5j  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera1739,079,727 - 39,080,010UniSTS
Celera1451,822,671 - 51,822,954UniSTS
Cytogenetic Map16C3.3UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14C2UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175175842585758612Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175175842585758612Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5758908991589197Mouse
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176230101095294699Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176230101095294699Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176388554895294699Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176521493895294699Mouse
14928308Manh82_mmandible shape 82 (mouse)176631524395294699Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176894131995294699Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177070119895294699Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177070119895294699Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177070119895294699Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177070119895294699Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177339513295294699Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177339513295294699Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7410765193507179Mouse
1357646Axtq3_manxiety QTL 3 (mouse)Not determined177458908990395270Mouse
1357552Aaj4_manxiety in A/J 4 (mouse)Not determined177458908990395270Mouse
14697708Stsl5_mSalmonella typhimurium susceptibility locus 5 (mouse)178080742991407428Mouse
1300889Lith9_mlithogenic gene 9 (mouse)Not determined178496566284990439Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:547
Count of miRNA genes:355
Interacting mature miRNAs:406
Transcripts:ENSMUST00000066175, ENSMUST00000163375, ENSMUST00000171544, ENSMUST00000172439
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000066175   ⟹   ENSMUSP00000069495
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1784,965,662 - 84,990,439 (-)Ensembl
GRCm38.p6 Ensembl1784,658,234 - 84,683,011 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163375   ⟹   ENSMUSP00000130783
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1784,965,916 - 84,989,630 (-)Ensembl
GRCm38.p6 Ensembl1784,658,488 - 84,682,202 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171544
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1784,977,345 - 84,981,798 (-)Ensembl
GRCm38.p6 Ensembl1784,669,917 - 84,674,370 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172439
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1784,977,823 - 84,983,854 (-)Ensembl
GRCm38.p6 Ensembl1784,670,395 - 84,676,426 (-)Ensembl
RefSeq Acc Id: NM_031884   ⟹   NP_114090
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391784,965,602 - 84,990,439 (-)NCBI
GRCm381784,658,174 - 84,683,011 (-)NCBI
MGSCv371785,057,574 - 85,082,263 (-)RGD
Celera1789,024,999 - 89,050,375 (-)RGD
cM Map17 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_114090   ⟸   NM_031884
- UniProtKB: Q99PE8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000069495   ⟸   ENSMUST00000066175
RefSeq Acc Id: ENSMUSP00000130783   ⟸   ENSMUST00000163375
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99PE8-F1-model_v2 AlphaFold Q99PE8 1-652 view protein structure

Promoters
RGD ID:13676896
Promoter ID:EPDNEW_M22597
Type:initiation region
Name:Abcg5_1
Description:Mus musculus ATP binding cassette subfamily G member 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381784,682,893 - 84,682,953EPDNEW
RGD ID:6827743
Promoter ID:MM_KWN:24336
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000112322
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361785,075,366 - 85,075,866 (-)MPROMDB
RGD ID:6827744
Promoter ID:MM_KWN:24337
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000066175,   NM_026180,   UC008DTB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361785,082,166 - 85,082,666 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351659 AgrOrtholog
Ensembl Genes ENSMUSG00000040505 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000069495 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000130783.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066175 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000163375.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_2_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABCG_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:27409 UniProtKB/Swiss-Prot
MGD MGI:1351659 ENTREZGENE
NCBI Gene 27409 ENTREZGENE
Pfam ABC2_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC2_membrane_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Abcg5 PhenoGen
PROSITE ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ABCG5_MOUSE UniProtKB/Swiss-Prot
  E9QA91_MOUSE UniProtKB/TrEMBL
  Q7TSR8_MOUSE UniProtKB/TrEMBL
  Q923S0_MOUSE UniProtKB/TrEMBL
  Q99PE8 ENTREZGENE
UniProt Secondary Q540E8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Abcg5  ATP binding cassette subfamily G member 5    ATP-binding cassette, sub-family G (WHITE), member 5  Symbol and/or name change 5135510 APPROVED
2011-08-17 Abcg5  ATP-binding cassette, sub-family G (WHITE), member 5  Abcg5  ATP-binding cassette, sub-family G (WHITE), member 5  Symbol and/or name change 5135510 APPROVED