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Gene: Chuk (conserved helix-loop-helix ubiquitous kinase) Mus musculus
Symbol: Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Description: Exhibits protein kinase activity. Predicted to contribute to IkappaB kinase activity. Involved in several processes, including mammary gland development; positive regulation of interferon-alpha secretion; and response to virus. Localizes to the CD40 receptor complex and cytoplasmic side of plasma membrane. Used to study cocoon syndrome. Human ortholog(s) of this gene implicated in cocoon syndrome and prostate cancer. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; interleukin-1 signaling pathway; INTERACTS WITH 1,4-dithiothreitol; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI256658; Chuk1; Fbx24; Fbxo24; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase alpha; IkappaB kinase alpha; IKBKA; IKK alpha; IKK-A; IKK1; Ikka; inhibitor of nuclear factor kappa-B kinase subunit alpha; MGC25325; NFKBIKA; nuclear factor NF-kappa-B inhibitor kinase alpha
Related Pseudogenes: Gm17809  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1944,073,335 - 44,107,480 (-)Ensembl
GRCm381944,073,334 - 44,107,505 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371944,147,824 - 44,181,967 (-)NCBIGRCm37mm9NCBIm37
MGSCv361944,126,647 - 44,160,756 (-)NCBImm8
Celera1944,858,810 - 44,892,945 (-)NCBICelera
Cytogenetic Map19 C3NCBI
cM Map1936.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Chuk
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315402
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.