Chuk (conserved helix-loop-helix ubiquitous kinase) - Rat Genome Database

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Gene: Chuk (conserved helix-loop-helix ubiquitous kinase) Mus musculus
Analyze
Symbol: Chuk
Name: conserved helix-loop-helix ubiquitous kinase
RGD ID: 1315402
MGI Page MGI
Description: Enables protein kinase activity. Involved in positive regulation of interferon-alpha production; protein phosphorylation; and response to virus. Acts upstream of or within several processes, including mammary gland development; osteoclast differentiation; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb. Used to study fetal encasement syndrome. Human ortholog(s) of this gene implicated in fetal encasement syndrome; liver cancer; and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI256658; Chuk1; Fbx24; Fbxo24; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase alpha; IkappaB kinase alpha; IKBKA; IKK; IKK alpha; IKK-; IKK-A; IKK1; IKK[; Ikka; inhibitor of nuclear factor kappa-B kinase subunit alpha; MGC25325; NFKBIKA; nuclear factor NF-kappa-B inhibitor kinase alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm17809  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,061,773 - 44,095,940 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,061,774 - 44,095,919 (-)EnsemblGRCm39 Ensembl
GRCm381944,073,334 - 44,107,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,073,335 - 44,107,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv371944,147,824 - 44,181,967 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,126,647 - 44,160,756 (-)NCBIMGSCv36mm8
Celera1944,858,810 - 44,892,945 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-Tetrandrine  (ISO)
(R)-mevalonic acid  (ISO)
(Z)-ligustilide  (EXP)
1'-acetoxychavicol acetate  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-ribose  (EXP)
alpinumisoflavone  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
aristolochic acid  (ISO)
arjunolic acid  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
astragaloside IV  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
auranofin  (EXP,ISO)
Aurothioglucose  (EXP)
benzo[a]pyrene  (EXP,ISO)
Berbamine  (ISO)
beta-D-glucosamine  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
bisphenol A  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
cerium trichloride  (EXP)
CGP 52608  (ISO)
chloroquine  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-ribofuranose  (EXP)
Decursin  (EXP)
deferiprone  (ISO)
deguelin  (ISO)
deoxynivalenol  (EXP,ISO)
Destruxin B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
doxorubicin  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
filipin III  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
geldanamycin  (ISO)
gentamycin  (ISO)
ginsenoside Re  (EXP)
glutathione  (EXP)
graphene oxide  (ISO)
homoeriodictyol  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
ibuprofen  (ISO)
indole-3-methanol  (ISO)
ionomycin  (EXP)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoliquiritigenin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
kaempferol  (EXP,ISO)
L-1,4-dithiothreitol  (EXP)
L-gamma-glutamyl-L-cysteine  (EXP)
lead diacetate  (ISO)
lead nitrate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
maneb  (EXP)
manganese(II) chloride  (ISO)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
melittin  (EXP,ISO)
melphalan  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
monosodium L-glutamate  (EXP,ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
Neferine  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nicotinamide  (ISO)
nimesulide  (ISO)
nitroprusside  (EXP,ISO)
notoginsenoside R1  (EXP)
oleanolic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
ozone  (ISO)
Paeonol  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
parthenolide  (ISO)
phenobarbital  (EXP)
phenylbutazone  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
resiquimod  (EXP,ISO)
resveratrol  (EXP,ISO)
rocaglamide  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (EXP)
sodium dichromate  (EXP)
streptozocin  (ISO)
succimer  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
testosterone  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
thiopental  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
Tylophorine  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
wedelolactone  (ISO)
Xanthorrhizol  (ISO)
Y-27632  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc sulfate  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cadmium ion  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to virus  (IMP,ISO)
defense response to virus  (IMP)
I-kappaB kinase/NF-kappaB signaling  (IGI,IMP,ISO)
I-kappaB phosphorylation  (TAS)
lactation  (IGI,IMP)
mammary gland alveolus development  (IGI,IMP)
mammary gland epithelial cell proliferation  (IGI,IMP)
morphogenesis of an epithelial sheet  (IMP)
negative regulation of NF-kappaB transcription factor activity  (ISO)
NIK/NF-kappaB signaling  (ISO)
odontogenesis of dentin-containing tooth  (IMP)
osteoclast differentiation  (IGI,IMP)
peptidyl-serine phosphorylation  (IBA)
phosphorylation  (IEA)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IGI,IMP,ISO)
positive regulation of interferon-alpha production  (IMP,ISO)
positive regulation of NF-kappaB transcription factor activity  (IBA)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
protein phosphorylation  (IDA,ISO)
response to acetate  (ISO)
response to amino acid  (ISO)
response to cholecystokinin  (ISO)
response to hydroperoxide  (ISO)
response to lipopolysaccharide  (ISO)
response to muscle stretch  (IMP)
response to organic substance  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
Rho protein signal transduction  (ISO)
skeletal muscle contraction  (ISO)
striated muscle cell differentiation  (ISO)
tumor necrosis factor-mediated signaling pathway  (IBA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior eye segment morphology  (IAGP)
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal B cell activation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal bile canaliculus morphology  (IAGP)
abnormal bile duct morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal chondrocyte differentiation  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal conjunctiva morphology  (IAGP)
abnormal corneal stroma morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal enamel knot morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal epidermis stratum spinosum morphology  (IAGP)
abnormal epidermis suprabasal layer morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal fibroblast migration  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal head morphology  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal lactation  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal nasal capsule morphology  (IAGP)
abnormal neural fold elevation formation  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal presphenoid bone morphology  (IAGP)
abnormal sacral vertebrae morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skin appearance  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin morphology  (IAGP)
abnormal skin physiology  (IAGP)
abnormal sternebra morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal tail morphology  (IAGP)
abnormal vibrissa follicle morphology  (IAGP)
abnormal vomer bone morphology  (IAGP)
abnormal xiphoid process morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent epidermis stratum corneum  (IAGP)
absent epidermis stratum granulosum  (IAGP)
absent lymph nodes  (IAGP)
absent spleen marginal zone  (IAGP)
absent vibrissae  (IAGP)
anotia  (IAGP)
asymmetric sternocostal joints  (IAGP)
broad limb buds  (IAGP)
cachexia  (IAGP)
cervical vertebral fusion  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
curly tail  (IAGP)
decreased birth body size  (IAGP)
decreased bone mineralization  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased cranium height  (IAGP)
decreased fibroblast cell migration  (IAGP)
decreased fibroblast chemotaxis  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased survivor rate  (IAGP)
delayed bone ossification  (IAGP)
dilated gallbladder  (IAGP)
disorganized corneal epithelium  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged lung  (IAGP)
epidermal desquamation  (IAGP)
epidermal hyperplasia  (IAGP)
esophageal atresia  (IAGP)
esophagus hyperplasia  (IAGP)
eyelids open at birth  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired neutrophil recruitment  (IAGP)
impaired skin barrier function  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased carcinoma incidence  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cholesterol level  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased embryonic neuroepithelium apoptosis  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased hindbrain apoptosis  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased lung squamous cell carcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased macrophage cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased skin papilloma incidence  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased spinal cord apoptosis  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased transitional stage B cell number  (IAGP)
increased urine protein level  (IAGP)
interdigital webbing  (IAGP)
intrahepatic cholestasis  (IAGP)
jaundice  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver degeneration  (IAGP)
lung inflammation  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
omphalocele  (IAGP)
open neural tube  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
parakeratosis  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
sacral vertebral fusion  (IAGP)
shiny skin  (IAGP)
short limbs  (IAGP)
short mandible  (IAGP)
short snout  (IAGP)
short sternum  (IAGP)
short tail  (IAGP)
short vertebral column  (IAGP)
shortened head  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
small cranium  (IAGP)
small embryonic telencephalon  (IAGP)
small esophagus  (IAGP)
small incisors  (IAGP)
small interparietal bone  (IAGP)
small nasal septum  (IAGP)
small parietal bone  (IAGP)
small sacral vertebrae  (IAGP)
small stomach  (IAGP)
small thoracic cage  (IAGP)
small vomer bone  (IAGP)
sparse hair  (IAGP)
split xiphoid process  (IAGP)
stomach mucosa hyperplasia  (IAGP)
syndactyly  (IAGP)
thick epidermis  (IAGP)
thick skin  (IAGP)
tight skin  (IAGP)
translucent skin  (IAGP)
weight loss  (IAGP)
wide frontal bone  (IAGP)
wide sternum  (IAGP)
wrinkled skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Increased IKKa expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors. Alameda JP, etal., PLoS One. 2011;6(7):e21984. doi: 10.1371/journal.pone.0021984. Epub 2011 Jul 6.
2. Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis. An J, etal., Oncotarget. 2016 Aug 2;7(31):50131-50149. doi: 10.18632/oncotarget.10321.
3. Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. Chung S, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L192-203. Epub 2010 May 14.
4. Effect of inhibition of the ubiquitin-proteasome-system and IkappaB kinase on airway inflammation and hyperresponsiveness in a murine model of asthma. El-Hashim AZ, etal., Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):33-42.
5. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Fillmann H, etal., Toxicology. 2007 Jul 17;236(3):217-26. Epub 2007 Apr 27.
6. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia. Lim JH, etal., Cell Microbiol. 2008 Nov;10(11):2247-56. Epub 2008 Jul 16.
9. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Luo JL, etal., Nature. 2007 Apr 5;446(7136):690-4. Epub 2007 Mar 18.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. Park KA, etal., Carcinogenesis. 2007 Jan;28(1):71-80. doi: 10.1093/carcin/bgl094. Epub 2006 Jun 14.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Apigenin blocks IKKa activation and suppresses prostate cancer progression. Shukla S, etal., Oncotarget. 2015 Oct 13;6(31):31216-32. doi: 10.18632/oncotarget.5157.
22. Suppression of NF-¿B and NF-¿B-Regulated Gene Expression by Apigenin through I¿Ba and IKK Pathway in TRAMP Mice. Shukla S, etal., PLoS One. 2015 Sep 17;10(9):e0138710. doi: 10.1371/journal.pone.0138710. eCollection 2015.
23. Suppression of NFkappaB and its Regulated Gene Products by Oral Administration of Green Tea Polyphenols in an Autochthonous Mouse Prostate Cancer Model. Siddiqui IA, etal., Pharm Res. 2008 Mar 4;.
24. The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy. Van Gammeren D, etal., FASEB J. 2009 Feb;23(2):362-70. doi: 10.1096/fj.08-114249. Epub 2008 Sep 30.
25. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
Additional References at PubMed
PMID:7558004   PMID:7590248   PMID:8777433   PMID:9520401   PMID:9597130   PMID:9813230   PMID:9819420   PMID:9883582   PMID:10051411   PMID:10072378   PMID:10195894   PMID:10195895  
PMID:10195896   PMID:10232975   PMID:10346820   PMID:10349636   PMID:10523854   PMID:10593965   PMID:10725249   PMID:10733566   PMID:10748240   PMID:10898787   PMID:10922068   PMID:11042159  
PMID:11053261   PMID:11076861   PMID:11181694   PMID:11203384   PMID:11238593   PMID:11466366   PMID:11520989   PMID:11747812   PMID:11937522   PMID:12070292   PMID:12221085   PMID:12477932  
PMID:12517978   PMID:12704203   PMID:12717433   PMID:12740444   PMID:12789342   PMID:12789343   PMID:12808104   PMID:12823437   PMID:12904583   PMID:14585846   PMID:14610273   PMID:14642849  
PMID:14654787   PMID:14660645   PMID:14741691   PMID:14960276   PMID:14966265   PMID:15021910   PMID:15071597   PMID:15084260   PMID:15102471   PMID:15148408   PMID:15470505   PMID:15485831  
PMID:15489334   PMID:15528353   PMID:15550384   PMID:15677466   PMID:15684432   PMID:15692052   PMID:15695520   PMID:15746257   PMID:15761153   PMID:15782199   PMID:15829915   PMID:15858576  
PMID:15897281   PMID:15989949   PMID:16103118   PMID:16116086   PMID:16141072   PMID:16141073   PMID:16169504   PMID:16260493   PMID:16498412   PMID:16547234   PMID:16547522   PMID:16612387  
PMID:16973390   PMID:16984773   PMID:17041601   PMID:17041603   PMID:17079494   PMID:17202344   PMID:17237423   PMID:17351639   PMID:17360634   PMID:17361131   PMID:17404218   PMID:17429444  
PMID:17452332   PMID:17526490   PMID:17537731   PMID:17540171   PMID:17616684   PMID:17643371   PMID:17890319   PMID:17909021   PMID:18000063   PMID:18068231   PMID:18216269   PMID:18239189  
PMID:18263801   PMID:18266467   PMID:18268325   PMID:18287559   PMID:18299349   PMID:18321726   PMID:18344980   PMID:18372427   PMID:18391940   PMID:18508047   PMID:18539148   PMID:18541671  
PMID:18542057   PMID:18550535   PMID:18575226   PMID:18604171   PMID:18606991   PMID:18635759   PMID:18688039   PMID:18713867   PMID:18772111   PMID:18799693   PMID:18818691   PMID:18922877  
PMID:19136968   PMID:19150425   PMID:19201871   PMID:19237504   PMID:19278579   PMID:19382893   PMID:19412180   PMID:19448637   PMID:19488402   PMID:19500387   PMID:19501643   PMID:19626033  
PMID:19631348   PMID:19666475   PMID:19703589   PMID:19774455   PMID:19800575   PMID:19897484   PMID:19897746   PMID:20080131   PMID:20125184   PMID:20149620   PMID:20164171   PMID:20195534  
PMID:20200270   PMID:20200955   PMID:20231695   PMID:20304950   PMID:20351780   PMID:20434986   PMID:20442316   PMID:20448200   PMID:20534538   PMID:20614026   PMID:20622870   PMID:20671747  
PMID:20817876   PMID:20818435   PMID:20855622   PMID:20881962   PMID:20961246   PMID:21093383   PMID:21209217   PMID:21267068   PMID:21402739   PMID:21435444   PMID:21455181   PMID:21490922  
PMID:21537326   PMID:21566664   PMID:21606193   PMID:21677750   PMID:21703539   PMID:21765415   PMID:21784860   PMID:21873635   PMID:21887257   PMID:21983082   PMID:21997190   PMID:22169952  
PMID:22227519   PMID:22253230   PMID:22287708   PMID:22301546   PMID:22318993   PMID:22351927   PMID:22366192   PMID:22474019   PMID:22544702   PMID:22547678   PMID:22560875   PMID:22649058  
PMID:22660635   PMID:22685314   PMID:22833419   PMID:22992283   PMID:23016877   PMID:23349802   PMID:23422957   PMID:23459942   PMID:23538752   PMID:23563314   PMID:23597566   PMID:23602409  
PMID:23649820   PMID:23776175   PMID:23796898   PMID:23871670   PMID:23960234   PMID:24023802   PMID:24115035   PMID:24215713   PMID:24239354   PMID:24240172   PMID:24247900   PMID:24269682  
PMID:24290756   PMID:24345681   PMID:24378336   PMID:24498325   PMID:24519526   PMID:24747690   PMID:24784232   PMID:24825920   PMID:24832470   PMID:24882009   PMID:24912162   PMID:25133425  
PMID:25170774   PMID:25266676   PMID:25376833   PMID:25523394   PMID:26035380   PMID:26311312   PMID:26371187   PMID:26378077   PMID:26518140   PMID:26539991   PMID:26848161   PMID:27184845  
PMID:27302476   PMID:27486771   PMID:27678221   PMID:28017833   PMID:28082356   PMID:28190767   PMID:28214532   PMID:28461486   PMID:28667162   PMID:29153842   PMID:29311298   PMID:29438366  
PMID:29588349   PMID:29717061   PMID:29740197   PMID:29958295   PMID:29993183   PMID:30070632   PMID:30131424   PMID:30153439   PMID:30170810   PMID:30737145   PMID:30737385   PMID:30988283  
PMID:31222033   PMID:31481626   PMID:31792060   PMID:32239614   PMID:32325033   PMID:32968282   PMID:32978373   PMID:33119032   PMID:33414459   PMID:33523920   PMID:34253059   PMID:34649141  
PMID:34755089   PMID:34917688   PMID:35318397   PMID:36042192  


Genomics

Comparative Map Data
Chuk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,061,773 - 44,095,940 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,061,774 - 44,095,919 (-)EnsemblGRCm39 Ensembl
GRCm381944,073,334 - 44,107,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,073,335 - 44,107,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv371944,147,824 - 44,181,967 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,126,647 - 44,160,756 (-)NCBIMGSCv36mm8
Celera1944,858,810 - 44,892,945 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.71NCBI
CHUK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,186,319 - 100,229,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10100,188,300 - 100,229,596 (-)EnsemblGRCh38hg38GRCh38
GRCh3710101,948,057 - 101,989,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,938,114 - 101,979,334 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410101,938,114 - 101,979,366NCBI
Celera1095,686,067 - 95,727,300 (-)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1095,577,055 - 95,618,304 (-)NCBIHuRef
CHM1_110102,232,811 - 102,274,037 (-)NCBICHM1_1
T2T-CHM13v2.010101,072,542 - 101,113,853 (-)NCBIT2T-CHM13v2.0
Chuk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21242,959,539 - 242,995,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,109,858 - 251,145,433 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01257,806,623 - 257,842,185 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01250,460,007 - 250,495,589 (-)NCBIRnor_WKY
Rnor_6.01263,848,829 - 263,884,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,293,821 - 271,329,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,122,845 - 249,158,369 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,381,683 - 249,416,016 (+)NCBI
Celera1238,777,027 - 238,812,551 (-)NCBICelera
Cytogenetic Map1q54NCBI
Chuk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555076,067,203 - 6,102,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555076,066,026 - 6,102,066 (-)NCBIChiLan1.0ChiLan1.0
CHUK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110100,276,290 - 100,317,082 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,280,490 - 100,316,918 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01096,794,228 - 96,835,449 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CHUK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,964,670 - 13,001,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,965,479 - 13,001,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,147,837 - 13,184,707 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,433,260 - 13,470,158 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,433,260 - 13,470,130 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,980,085 - 13,016,958 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,017,918 - 13,055,038 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,152,231 - 13,189,348 (-)NCBIUU_Cfam_GSD_1.0
Chuk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,995,060 - 34,039,500 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493663633,933 - 78,990 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHUK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,315,141 - 111,351,868 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,316,178 - 111,351,669 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,757,214 - 120,854,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHUK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,219,374 - 93,263,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl993,219,383 - 93,262,700 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604854,220,658 - 54,264,717 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chuk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473712,022,419 - 12,052,131 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473712,022,081 - 12,052,128 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1150
Count of miRNA genes:506
Interacting mature miRNAs:614
Transcripts:ENSMUST00000026217, ENSMUST00000119591, ENSMUST00000123806, ENSMUST00000134495, ENSMUST00000144286, ENSMUST00000146861, ENSMUST00000147423, ENSMUST00000149091
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse

Markers in Region
RH136061  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,073,432 - 44,073,562UniSTSGRCm38
MGSCv371944,147,922 - 44,148,052UniSTSGRCm37
Celera1944,858,908 - 44,859,038UniSTS
Cytogenetic Map19C3UniSTS
cM Map1945.0UniSTS
U12473  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,074,256 - 44,074,406UniSTSGRCm38
MGSCv371944,148,746 - 44,148,896UniSTSGRCm37
Celera1944,859,732 - 44,859,882UniSTS
Cytogenetic Map19C3UniSTS
cM Map1945.0UniSTS
Whitehead_YAC19 UniSTS
Chuk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
cM Map1945.0UniSTS
Chuk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,073,445 - 44,073,580UniSTSGRCm38
GRCm381655,881,482 - 55,881,605UniSTSGRCm38
MGSCv371944,147,935 - 44,148,070UniSTSGRCm37
MGSCv371655,881,595 - 55,881,718UniSTSGRCm37
Celera1656,196,795 - 56,196,918UniSTS
Celera1944,858,921 - 44,859,056UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map16C1.1UniSTS
cM Map1945.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001162410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003952741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003952742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC125101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000026217   ⟹   ENSMUSP00000026217
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,061,774 - 44,095,919 (-)Ensembl
GRCm38.p6 Ensembl1944,073,335 - 44,107,480 (-)Ensembl
RefSeq Acc Id: ENSMUST00000119591   ⟹   ENSMUSP00000113809
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,061,775 - 44,095,916 (-)Ensembl
GRCm38.p6 Ensembl1944,073,336 - 44,107,477 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123806
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,065,377 - 44,067,474 (-)Ensembl
GRCm38.p6 Ensembl1944,076,938 - 44,079,035 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134495
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,065,684 - 44,072,889 (-)Ensembl
GRCm38.p6 Ensembl1944,077,245 - 44,084,450 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144286
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,066,729 - 44,067,721 (-)Ensembl
GRCm38.p6 Ensembl1944,078,290 - 44,079,282 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146861
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,085,636 - 44,095,721 (-)Ensembl
GRCm38.p6 Ensembl1944,097,197 - 44,107,282 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147423
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,069,854 - 44,095,908 (-)Ensembl
GRCm38.p6 Ensembl1944,081,415 - 44,107,469 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149091
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1944,062,812 - 44,064,343 (-)Ensembl
GRCm38.p6 Ensembl1944,074,373 - 44,075,904 (-)Ensembl
RefSeq Acc Id: NM_001162410   ⟹   NP_001155882
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391944,061,773 - 44,095,916 (-)NCBI
GRCm381944,073,334 - 44,107,477 (-)NCBI
MGSCv371944,147,824 - 44,181,967 (-)RGD
Celera1944,858,810 - 44,892,945 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_007700   ⟹   NP_031726
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391944,061,773 - 44,095,916 (-)NCBI
GRCm381944,073,334 - 44,107,477 (-)NCBI
MGSCv371944,147,824 - 44,181,967 (-)RGD
Celera1944,858,810 - 44,892,945 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030250732   ⟹   XP_030106592
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391944,064,205 - 44,095,938 (-)NCBI
GRCm381944,075,766 - 44,107,503 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003952741
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391944,061,774 - 44,095,940 (-)NCBI
GRCm381944,073,335 - 44,107,505 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003952742
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391944,061,774 - 44,095,940 (-)NCBI
GRCm381944,073,335 - 44,107,505 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031726   ⟸   NM_007700
- Peptide Label: isoform 1
- UniProtKB: E9QNL4 (UniProtKB/TrEMBL),   Q3TPN9 (UniProtKB/TrEMBL),   Q3UDK0 (UniProtKB/TrEMBL),   Q8CBT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001155882   ⟸   NM_001162410
- Peptide Label: isoform 2
- UniProtKB: E9Q605 (UniProtKB/TrEMBL),   Q3TPN9 (UniProtKB/TrEMBL),   Q8CBT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030106592   ⟸   XM_030250732
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000113809   ⟸   ENSMUST00000119591
RefSeq Acc Id: ENSMUSP00000026217   ⟸   ENSMUST00000026217
Protein Domains
IKKbetaNEMObind   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q60680-F1-model_v2 AlphaFold Q60680 1-745 view protein structure

Promoters
RGD ID:13679570
Promoter ID:EPDNEW_M23934
Type:initiation region
Name:Chuk_1
Description:Mus musculus conserved helix-loop-helix ubiquitous kinase , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381944,107,433 - 44,107,493EPDNEW
RGD ID:6829909
Promoter ID:MM_KWN:27152
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000112015,   NM_001162410,   OTTMUST00000073744,   OTTMUST00000073746,   OTTMUST00000073747
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361944,181,786 - 44,182,762 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99484 AgrOrtholog
Ensembl Genes ENSMUSG00000025199 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000026217 ENTREZGENE
  ENSMUSP00000026217.5 UniProtKB/TrEMBL
  ENSMUSP00000113809 ENTREZGENE
  ENSMUSP00000113809.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026217 ENTREZGENE
  ENSMUST00000026217.11 UniProtKB/TrEMBL
  ENSMUST00000119591 ENTREZGENE
  ENSMUST00000119591.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.250 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IKBKB_SDD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IKBKB_SDD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12675 UniProtKB/TrEMBL
MGD MGI:99484 ENTREZGENE
NCBI Gene 12675 ENTREZGENE
Pfam IKBKB_SDD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Chuk PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IKKbetaNEMObind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AUV3_MOUSE UniProtKB/TrEMBL
  E9Q605 ENTREZGENE, UniProtKB/TrEMBL
  E9QNL4 ENTREZGENE, UniProtKB/TrEMBL
  IKKA_MOUSE UniProtKB/Swiss-Prot
  Q3TPN9 ENTREZGENE, UniProtKB/TrEMBL
  Q3U2A3_MOUSE UniProtKB/TrEMBL
  Q3U2E5_MOUSE UniProtKB/TrEMBL
  Q3UDK0 ENTREZGENE, UniProtKB/TrEMBL
  Q60680 ENTREZGENE
  Q8CBT3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q80VU2 UniProtKB/Swiss-Prot
  Q9D2X3 UniProtKB/Swiss-Prot