Gene: Adam12 (a disintegrin and metallopeptidase domain 12 (meltrin alpha)) Mus musculus
Symbol: Adam12
Name: a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Description: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein that localizes to the cell surface. About a third of the mice lacking the encoded protein die before weaning. Overexpression of the encoded protein in a mouse model of Duchenne muscular dystrophy alleviates the muscle pathology by preventing cell necrosis and inflammation. [provided by RefSeq, May 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: a disintegrin and metalloprotease domain 12; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM 12; disintegrin and metalloproteinase domain-containing protein 12; KIAA4001; meltrin alpha; meltrin-alpha; mKIAA4001; Mltna; OTTMUSP00000023508
Homo sapiens (human) : ADAM12 (ADAM metallopeptidase domain 12)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Adam12 (ADAM metallopeptidase domain 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam12 (ADAM metallopeptidase domain 12)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM12 (ADAM metallopeptidase domain 12)
Canis lupus familiaris (dog) : ADAM12 (ADAM metallopeptidase domain 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam12 (ADAM metallopeptidase domain 12)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm387133,883,199 - 134,225,097 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377141,074,882 - 141,416,780 (-)NCBIGRCm37mm9NCBIm37
MGSCv367133,722,315 - 134,063,440 (-)NCBImm8
Celera7133,687,776 - 134,032,137 (-)NCBICelera
Cytogenetic Map7 F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Adam12
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317266
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2018-04-10
Status: ACTIVE