Hdac3 (histone deacetylase 3) - Rat Genome Database

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Gene: Hdac3 (histone deacetylase 3) Mus musculus
Analyze
Symbol: Hdac3
Name: histone deacetylase 3
RGD ID: 731327
MGI Page MGI
Description: Enables chromatin DNA binding activity; histone deacetylase activity; and histone decrotonylase activity. Involved in several processes, including cornified envelope assembly; establishment of skin barrier; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including negative regulation of cardiac muscle cell differentiation; regulation of DNA-templated transcription; and regulation of mitotic cell cycle. Located in cytoplasm and nucleus. Is active in chromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW537363; HD3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391838,070,024 - 38,088,073 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1838,068,897 - 38,088,069 (-)EnsemblGRCm39 Ensembl
GRCm381837,936,971 - 37,955,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1837,935,844 - 37,955,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv371838,096,625 - 38,114,642 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361838,062,953 - 38,080,909 (-)NCBIMGSCv36mm8
Celera1839,280,295 - 39,298,302 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1819.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcium oxalate  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (EXP)
cisplatin  (EXP)
clobetasol  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
dexamethasone  (EXP)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
ethylene glycol  (ISO)
fenthion  (EXP)
folic acid  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
glyphosate  (ISO)
Honokiol  (ISO)
inulin  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methoxyacetic acid  (ISO)
methylmercury chloride  (EXP,ISO)
metiram  (ISO)
mocetinostat  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel dichloride  (ISO)
ochratoxin A  (ISO)
oxalic acid  (ISO)
ozone  (ISO)
p-toluidine  (ISO)
pelargonidin  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
resveratrol  (ISO)
RGFP966  (ISO)
rifampicin  (ISO)
silmitasertib  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
sulfadimethoxine  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
tangeretin  (EXP)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (ISO)
theophylline  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
Trapoxin B  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to fluid shear stress  (ISO,ISS)
cellular response to mechanical stimulus  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
chromatin organization  (TAS)
circadian regulation of gene expression  (IGI,IMP)
cornified envelope assembly  (IMP)
DNA repair-dependent chromatin remodeling  (IEA,ISO)
epidermis development  (IMP)
epigenetic regulation of gene expression  (IBA)
establishment of mitotic spindle orientation  (IEA,ISO)
establishment of skin barrier  (IMP)
gene expression  (IMP)
in utero embryonic development  (IMP)
negative regulation of cardiac muscle cell differentiation  (IMP)
negative regulation of DNA-binding transcription factor activity  (IDA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of interleukin-1 production  (ISO)
negative regulation of JNK cascade  (IEA,ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of protein export from nucleus  (ISO)
negative regulation of transcription by RNA polymerase II  (IGI,ISO,ISS)
negative regulation of tumor necrosis factor production  (ISO)
neural precursor cell proliferation  (IDA)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein import into nucleus  (ISO,ISS)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of protein ubiquitination  (IMP)
positive regulation of TOR signaling  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of type B pancreatic cell apoptotic process  (ISO)
protein deacetylation  (ISO)
protein modification process  (ISO)
random inactivation of X chromosome  (IMP)
regulation of circadian rhythm  (IMP)
regulation of mitotic cell cycle  (IDA)
regulation of multicellular organism growth  (IGI)
regulation of protein stability  (ISO,ISS)
response to dexamethasone  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
spindle assembly  (IEA,ISO)
transcription by RNA polymerase II  (IGI)

Cellular Component
chromatin  (IDA,ISO)
cytoplasm  (IDA,ISO,ISS,TAS)
cytosol  (ISO,ISS)
Golgi apparatus  (IEA,ISO)
histone deacetylase complex  (ISO,TAS)
mitotic spindle  (IEA,ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IDA,IPI,ISO,TAS)
plasma membrane  (IEA,ISO)
transcription repressor complex  (ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cell cycle  (IAGP)
abnormal cell death  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cellular respiration  (IAGP)
abnormal decidualization  (IAGP)
abnormal DNA repair  (IAGP)
abnormal embryo attachment  (IAGP)
abnormal endometrium morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart size  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal mitochondrial crista morphology  (IAGP)
abnormal myocardial fiber mitochondrial morphology  (IAGP)
abnormal uterine receptivity  (IAGP)
abnormal uterus physiology  (IAGP)
cachexia  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
decreased body size  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating glucagon level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased liver glycogen level  (IAGP)
decreased total body fat amount  (IAGP)
dilated heart left ventricle  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
endometrium fibrosis  (IAGP)
enhanced long-term object recognition memory  (IAGP)
enlarged liver  (IAGP)
failure of embryo implantation  (IAGP)
female infertility  (IAGP)
hepatic steatosis  (IAGP)
hypoglycemia  (IAGP)
increased cardiac muscle triglyceride level  (IAGP)
increased cholesterol level  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased collagen level  (IAGP)
increased fibroblast apoptosis  (IAGP)
increased heart weight  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
no abnormal phenotype detected  (IAGP)
pale liver  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death. Bardai FH, etal., J Biol Chem. 2012 Oct 12;287(42):35444-53. doi: 10.1074/jbc.M112.394544. Epub 2012 Aug 23.
2. Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells. Dhar SS, etal., J Biol Chem. 2014 Mar 14;289(11):7483-96. doi: 10.1074/jbc.M113.521625. Epub 2014 Jan 30.
3. Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis. Eom S, etal., J Biol Chem. 2014 Apr 25;289(17):12126-44. doi: 10.1074/jbc.M113.521245. Epub 2014 Mar 11.
4. Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats. Hannan JL, etal., J Sex Med. 2014 Jun;11(6):1442-51. doi: 10.1111/jsm.12522. Epub 2014 Mar 18.
5. Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems. Jia H, etal., Hum Mol Genet. 2012 Dec 15;21(24):5280-93. doi: 10.1093/hmg/dds379. Epub 2012 Sep 10.
6. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Khabele D, etal., Cancer Biol Ther. 2007 May;6(5):795-801. Epub 2007 Feb 14.
7. High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-gamma and LXR-alpha-pathways in E3 rats. Li D, etal., Mol Cell Endocrinol. 2011 Sep 15;344(1-2):69-80. doi: 10.1016/j.mce.2011.06.028. Epub 2011 Jul 8.
8. Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Lundh M, etal., Diabetologia. 2012 Sep;55(9):2421-31. doi: 10.1007/s00125-012-2615-0. Epub 2012 Jul 7.
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. Sakao Y, etal., Clin Exp Nephrol. 2011 Jun;15(3):363-72. doi: 10.1007/s10157-011-0421-5. Epub 2011 Mar 18.
14. Effect of Histone Deacetylase HDAC3 on Cytokines IL-18, IL-12 and TNF-α in Patients with Intrahepatic Cholestasis of Pregnancy. Shao Y, etal., Cell Physiol Biochem. 2017;42(4):1294-1302. doi: 10.1159/000478958. Epub 2017 Jul 11.
15. HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. Stypula-Cyrus Y, etal., PLoS One. 2013 May 28;8(5):e64600. doi: 10.1371/journal.pone.0064600. Print 2013.
16. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Weichert W, etal., Br J Cancer. 2008 Feb 12;98(3):604-10. Epub 2008 Jan 22.
17. Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas. Weichert W, etal., Neoplasia. 2008 Sep;10(9):1021-7.
18. Chronic cerebrovascular hypoperfusion affects global DNA methylation and histone acetylation in rat brain. Wu X, etal., Neurosci Bull. 2013 Dec;29(6):685-92. doi: 10.1007/s12264-013-1345-8. Epub 2013 May 28.
19. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Zhao L, etal., Circulation. 2012 Jul 24;126(4):455-67. doi: 10.1161/CIRCULATIONAHA.112.103176. Epub 2012 Jun 18.
20. Inhibited HDAC3 or Elevated MicroRNA-494-3p Plays a Protective Role in Myocardial Ischemia-Reperfusion Injury via Suppression of BRD4. Zheng W, etal., Mol Neurobiol. 2021 Sep;58(9):4268-4279. doi: 10.1007/s12035-021-02369-y. Epub 2021 May 12.
21. Histone deacetylase 3 implicated in the pathogenesis of children glioma by promoting glioma cell proliferation and migration. Zhu J, etal., Brain Res. 2013 Jul 3;1520:15-22. doi: 10.1016/j.brainres.2013.04.061. Epub 2013 May 15.
Additional References at PubMed
PMID:10349636   PMID:10393429   PMID:10491319   PMID:10542131   PMID:10748092   PMID:10922068   PMID:10984530   PMID:11022042   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11358320  
PMID:11641275   PMID:11923873   PMID:12032080   PMID:12052888   PMID:12130660   PMID:12239342   PMID:12370291   PMID:12466851   PMID:12477932   PMID:12711221   PMID:12833141   PMID:14610273  
PMID:14980219   PMID:15060137   PMID:15260977   PMID:15292260   PMID:15367668   PMID:15537544   PMID:15601857   PMID:15681609   PMID:15695367   PMID:15711539   PMID:15782199   PMID:15832170  
PMID:15917248   PMID:16127449   PMID:16129885   PMID:16141072   PMID:16141073   PMID:16227606   PMID:16239345   PMID:16326862   PMID:16371367   PMID:16431920   PMID:16602821   PMID:16873063  
PMID:16982804   PMID:17158926   PMID:17244530   PMID:17255939   PMID:17322895   PMID:17464331   PMID:17767906   PMID:17873065   PMID:18206970   PMID:18241125   PMID:18354499   PMID:18406327  
PMID:18443042   PMID:18458156   PMID:18501342   PMID:18625706   PMID:18824292   PMID:18830415   PMID:19015268   PMID:19037247   PMID:19204783   PMID:19341714   PMID:19463978   PMID:19542223  
PMID:19778926   PMID:20026773   PMID:20059953   PMID:20097764   PMID:20129917   PMID:20427468   PMID:20470885   PMID:20596014   PMID:20628553   PMID:20719946   PMID:20979029   PMID:21030595  
PMID:21059642   PMID:21075309   PMID:21173110   PMID:21203589   PMID:21228185   PMID:21251616   PMID:21267068   PMID:21343542   PMID:21393543   PMID:21406501   PMID:21677750   PMID:21731673  
PMID:21807117   PMID:21808063   PMID:21873635   PMID:21959220   PMID:22156208   PMID:22253232   PMID:22297488   PMID:22347433   PMID:22561686   PMID:22570481   PMID:22647876   PMID:22651689  
PMID:22679019   PMID:22802645   PMID:22891325   PMID:22922362   PMID:22989952   PMID:23085085   PMID:23087373   PMID:23192980   PMID:23213415   PMID:23292142   PMID:23297220   PMID:23300083  
PMID:23408427   PMID:23475113   PMID:23481390   PMID:23506836   PMID:23575859   PMID:23624624   PMID:23698124   PMID:23770565   PMID:23798429   PMID:23864673   PMID:23892456   PMID:23905631  
PMID:23921131   PMID:24045946   PMID:24062260   PMID:24160175   PMID:24185009   PMID:24268577   PMID:24565863   PMID:24569637   PMID:24594842   PMID:24808536   PMID:24821725   PMID:25007801  
PMID:25011550   PMID:25088465   PMID:25161285   PMID:25196196   PMID:25261965   PMID:25339172   PMID:25412078   PMID:25437555   PMID:25556659   PMID:25610877   PMID:25642770   PMID:25666992  
PMID:25911107   PMID:25915022   PMID:26044300   PMID:26077467   PMID:26163592   PMID:26211746   PMID:26283270   PMID:26324326   PMID:26356530   PMID:26420484   PMID:26447190   PMID:26712002  
PMID:26712006   PMID:26776516   PMID:26786103   PMID:26832331   PMID:26859354   PMID:26883953   PMID:27068467   PMID:27141870   PMID:27279370   PMID:27292126   PMID:27428650   PMID:27507649  
PMID:27542279   PMID:27638301   PMID:27651463   PMID:27662443   PMID:27798112   PMID:27864380   PMID:27866836   PMID:27874833   PMID:27991918   PMID:28028172   PMID:28074065   PMID:28077597  
PMID:28123935   PMID:28188262   PMID:28300292   PMID:28416226   PMID:28494866   PMID:28526298   PMID:28614293   PMID:28671696   PMID:28724935   PMID:28733645   PMID:28739911   PMID:28771976  
PMID:28782836   PMID:28840938   PMID:28860191   PMID:28864822   PMID:28890149   PMID:28916805   PMID:28935703   PMID:29033129   PMID:29035278   PMID:29184203   PMID:29212474   PMID:29431744  
PMID:29449454   PMID:29486577   PMID:29523594   PMID:29540666   PMID:29634312   PMID:29688375   PMID:29689264   PMID:29802126   PMID:30126161   PMID:30127461   PMID:30179675   PMID:30186101  
PMID:30279482   PMID:30323246   PMID:30517863   PMID:30626694   PMID:30626716   PMID:30657451   PMID:30664766   PMID:30804042   PMID:30973865   PMID:31000586   PMID:31024170   PMID:31097476  
PMID:31134059   PMID:31498540   PMID:31510852   PMID:31569049   PMID:31586401   PMID:31600191   PMID:31604271   PMID:31669733   PMID:31693860   PMID:31757939   PMID:31844300   PMID:31858687  
PMID:31858814   PMID:32142834   PMID:32325033   PMID:32374402   PMID:32467224   PMID:32731255   PMID:32732898   PMID:32760002   PMID:32772249   PMID:32803489   PMID:32863951   PMID:32868749  
PMID:32937100   PMID:32971093   PMID:32990597   PMID:33143661   PMID:33311522   PMID:33454009   PMID:33602824   PMID:33634377   PMID:33756273   PMID:33907245   PMID:33909924   PMID:33939832  
PMID:33973278   PMID:34119632   PMID:34244427   PMID:34321999   PMID:34398198   PMID:34854376   PMID:34857762   PMID:35081346   PMID:35167946   PMID:35251047   PMID:35306425   PMID:35658939  
PMID:35722872   PMID:35933343   PMID:36341403   PMID:36397300   PMID:36499148   PMID:36602872   PMID:36801398   PMID:36930718   PMID:36992838   PMID:37215106   PMID:37404376   PMID:37423931  
PMID:37666082   PMID:37690341   PMID:37735154   PMID:37735473   PMID:37752418   PMID:37788331   PMID:37890360   PMID:38011375   PMID:38286179   PMID:38295798   PMID:38355793   PMID:38446877  
PMID:38679196   PMID:38701782   PMID:38711064   PMID:38733301   PMID:38755146   PMID:38782893   PMID:38903915   PMID:38997746   PMID:39079624   PMID:39331726   PMID:39738540   PMID:39744685  


Genomics

Comparative Map Data
Hdac3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391838,070,024 - 38,088,073 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1838,068,897 - 38,088,069 (-)EnsemblGRCm39 Ensembl
GRCm381837,936,971 - 37,955,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1837,935,844 - 37,955,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv371838,096,625 - 38,114,642 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361838,062,953 - 38,080,909 (-)NCBIMGSCv36mm8
Celera1839,280,295 - 39,298,302 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1819.81NCBI
HDAC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385141,620,881 - 141,636,849 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5141,620,876 - 141,636,849 (-)EnsemblGRCh38hg38GRCh38
GRCh375141,000,448 - 141,016,416 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365140,980,627 - 140,996,607 (-)NCBINCBI36Build 36hg18NCBI36
Build 345140,980,626 - 140,996,596NCBI
Celera5137,077,171 - 137,093,151 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5136,145,083 - 136,160,930 (-)NCBIHuRef
CHM1_15140,433,725 - 140,449,704 (-)NCBICHM1_1
T2T-CHM13v2.05142,146,886 - 142,162,855 (-)NCBIT2T-CHM13v2.0
Hdac3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81830,021,847 - 30,041,061 (-)NCBIGRCr8
mRatBN7.21829,770,637 - 29,789,850 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1829,770,636 - 29,793,856 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1829,874,943 - 29,894,123 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01830,636,921 - 30,656,319 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01829,972,266 - 29,991,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01831,073,057 - 31,094,347 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,073,058 - 31,094,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01830,764,344 - 30,782,387 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41830,857,209 - 30,875,986 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11830,883,855 - 30,902,632 (-)NCBI
Celera1829,414,681 - 29,434,382 (-)NCBICelera
Cytogenetic Map18p11NCBI
Hdac3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541512,138,870 - 12,154,234 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541512,138,520 - 12,154,234 (+)NCBIChiLan1.0ChiLan1.0
HDAC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24136,869,766 - 136,885,755 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15135,009,317 - 135,025,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05136,981,790 - 136,997,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15143,094,406 - 143,110,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5143,094,406 - 143,110,322 (-)Ensemblpanpan1.1panPan2
HDAC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1236,583,283 - 36,598,121 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl236,583,283 - 36,597,682 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha233,635,234 - 33,650,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0237,037,462 - 37,052,393 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl237,037,381 - 37,052,025 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1234,112,034 - 34,126,890 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0234,923,559 - 34,938,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0235,730,823 - 35,745,706 (-)NCBIUU_Cfam_GSD_1.0
Hdac3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213150,956,557 - 150,972,579 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650412,530,528 - 12,546,556 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650412,530,546 - 12,546,556 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2143,273,192 - 143,287,399 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12143,273,188 - 143,287,421 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22149,475,764 - 149,490,030 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12344,246,296 - 44,263,127 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603433,589,487 - 33,606,357 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdac3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624774845,358 - 863,809 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624774845,970 - 864,080 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hdac3
502 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:377
Count of miRNA genes:257
Interacting mature miRNAs:298
Transcripts:ENSMUST00000043498, ENSMUST00000143660, ENSMUST00000144471, ENSMUST00000153945
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11041903Lmr27_mleishmaniasis resistance 27 (mouse)183618756745109518Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse

Markers in Region
AW537363  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381837,937,331 - 37,937,420UniSTSGRCm38
MGSCv371838,096,985 - 38,097,074UniSTSGRCm37
Celera1839,280,655 - 39,280,744UniSTS
Cytogenetic Map18B3UniSTS
cM Map1817.0UniSTS
Whitehead/MRC_RH17660.95UniSTS
AF074881  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381837,937,401 - 37,937,509UniSTSGRCm38
MGSCv371838,097,055 - 38,097,163UniSTSGRCm37
Celera1839,280,725 - 39,280,833UniSTS
Cytogenetic Map18B3UniSTS
cM Map1817.0UniSTS
Whitehead/MRC_RH18564.07UniSTS
Hdac3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381837,937,246 - 37,937,462UniSTSGRCm38
MGSCv371838,096,900 - 38,097,116UniSTSGRCm37
Celera1839,280,570 - 39,280,786UniSTS
Cytogenetic Map18B3UniSTS
cM Map1817.0UniSTS
Hdac3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_385976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC129315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF074881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF074882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF098295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF125536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC139300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC139301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ932476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ166955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN651901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN651902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN651903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN651904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000043498   ⟹   ENSMUSP00000037981
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1838,070,025 - 38,088,069 (-)Ensembl
GRCm38.p6 Ensembl1837,936,972 - 37,955,016 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143660
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1838,068,897 - 38,078,617 (-)Ensembl
GRCm38.p6 Ensembl1837,935,844 - 37,945,564 (-)Ensembl
Ensembl Acc Id: ENSMUST00000144471
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1838,070,025 - 38,077,128 (-)Ensembl
GRCm38.p6 Ensembl1837,936,972 - 37,944,075 (-)Ensembl
Ensembl Acc Id: ENSMUST00000153945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1838,070,463 - 38,077,044 (-)Ensembl
GRCm38.p6 Ensembl1837,937,410 - 37,943,991 (-)Ensembl
Ensembl Acc Id: ENSMUST00000235700   ⟹   ENSMUSP00000157755
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1838,076,731 - 38,088,027 (-)Ensembl
GRCm38.p6 Ensembl1837,943,678 - 37,954,974 (-)Ensembl
Ensembl Acc Id: ENSMUST00000236756   ⟹   ENSMUSP00000158234
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1838,070,616 - 38,087,971 (-)Ensembl
GRCm38.p6 Ensembl1837,937,563 - 37,954,918 (-)Ensembl
RefSeq Acc Id: NM_010411   ⟹   NP_034541
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391838,070,024 - 38,088,041 (-)NCBI
GRCm381837,936,971 - 37,954,988 (-)NCBI
MGSCv371838,096,625 - 38,114,642 (-)RGD
Celera1839,280,295 - 39,298,302 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_385976
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391838,070,031 - 38,088,073 (-)NCBI
GRCm381837,936,978 - 37,955,015 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034541   ⟸   NM_010411
- UniProtKB: O88896 (UniProtKB/Swiss-Prot),   O88895 (UniProtKB/Swiss-Prot),   Q9JLX5 (UniProtKB/TrEMBL),   Q3UM33 (UniProtKB/TrEMBL),   Q9JM08 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000158234   ⟸   ENSMUST00000236756
Ensembl Acc Id: ENSMUSP00000157755   ⟸   ENSMUST00000235700
Ensembl Acc Id: ENSMUSP00000037981   ⟸   ENSMUST00000043498
Protein Domains
Histone deacetylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88895-F1-model_v2 AlphaFold O88895 1-428 view protein structure

Promoters
RGD ID:13677604
Promoter ID:EPDNEW_M22951
Type:initiation region
Name:Hdac3_1
Description:Mus musculus histone deacetylase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381837,954,974 - 37,955,034EPDNEW
RGD ID:6829300
Promoter ID:MM_KWN:25071
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000041790
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361838,104,276 - 38,104,776 (-)MPROMDB
RGD ID:6829301
Promoter ID:MM_KWN:25072
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000041789
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361838,105,731 - 38,106,231 (-)MPROMDB
RGD ID:6829299
Promoter ID:MM_KWN:25073
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   MEF_B4
Transcripts:ENSMUST00000091933,   NM_010411,   OTTMUST00000041788
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361838,114,334 - 38,114,834 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1343091 AgrOrtholog
Ensembl Genes ENSMUSG00000024454 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000043498 ENTREZGENE
  ENSMUST00000043498.9 UniProtKB/Swiss-Prot
  ENSMUST00000235700.2 UniProtKB/TrEMBL
  ENSMUST00000236756.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.800.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HDAC_PDAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15183 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1343091 ENTREZGENE
NCBI Gene 15183 ENTREZGENE
PANTHER HISTONE DEACETYLASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTONE DEACETYLASE HDAC1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hist_deacetyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hdac3 PhenoGen
PIRSF His_deacetylse_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HDASUPER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISDACETLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B9Q7_MOUSE UniProtKB/TrEMBL
  G3X9M4_MOUSE UniProtKB/TrEMBL
  H6UK59_MOUSE UniProtKB/TrEMBL
  H6UK60_MOUSE UniProtKB/TrEMBL
  H6UK62_MOUSE UniProtKB/TrEMBL
  HDAC3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  O88896 ENTREZGENE
  Q3UM33 ENTREZGENE
  Q9JLX5 ENTREZGENE, UniProtKB/TrEMBL
  Q9JM08 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O88896 UniProtKB/Swiss-Prot
  Q3UM33 UniProtKB/Swiss-Prot