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Gene: Hdac3 (histone deacetylase 3) Mus musculus
Symbol: Hdac3
Name: histone deacetylase 3
Description: Exhibits chromatin DNA binding activity; protein deacetylase activity; and transcription factor binding activity. Involved in several processes, including histone H4-K12 deacetylation; positive regulation of cold-induced thermogenesis; and regulation of gene expression. Localizes to cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; exocrine gland; oocyte; and retina. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3); PARTICIPATES IN histone modification pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW537363; HD3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma
Homo sapiens (human) : HDAC3 (histone deacetylase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hdac3 (histone deacetylase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac3 (histone deacetylase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC3 (histone deacetylase 3)
Canis lupus familiaris (dog) : HDAC3 (histone deacetylase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac3 (histone deacetylase 3)
Sus scrofa (pig) : HDAC3 (histone deacetylase 3)
Chlorocebus sabaeus (African green monkey) : HDAC3 (histone deacetylase 3)
Heterocephalus glaber (naked mole-rat) : Hdac3 (histone deacetylase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1837,935,844 - 37,955,016 (-)EnsemblGRCm38mm10GRCm38
GRCm381837,936,971 - 37,955,015 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371838,096,625 - 38,114,642 (-)NCBIGRCm37mm9NCBIm37
MGSCv361838,062,953 - 38,080,909 (-)NCBImm8
Celera1839,280,295 - 39,298,302 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1819.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hdac3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731327
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.