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Gene: HDAC3 (histone deacetylase 3) Homo sapiens
Symbol: HDAC3
Name: histone deacetylase 3
Description: Exhibits several functions, including NF-kappaB binding activity; cyclin binding activity; and histone deacetylase binding activity. Involved in several processes, including positive regulation of protein import into nucleus; regulation of protein phosphorylation; and regulation of transcription by RNA polymerase II. Localizes to several cellular components, including the Golgi apparatus; histone deacetylase complex; and mitotic spindle. Implicated in lung non-small cell carcinoma. Biomarker of several diseases, including colorectal cancer; intrahepatic cholestasis of pregnancy; pulmonary hypertension; reproductive organ cancer (multiple); and type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HD3; KDAC3; RPD3; RPD3-2; SMAP45
Mus musculus (house mouse) : Hdac3 (histone deacetylase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdac3 (histone deacetylase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac3 (histone deacetylase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC3 (histone deacetylase 3)
Canis lupus familiaris (dog) : HDAC3 (histone deacetylase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac3 (histone deacetylase 3)
Sus scrofa (pig) : HDAC3 (histone deacetylase 3)
Chlorocebus sabaeus (African green monkey) : HDAC3 (histone deacetylase 3)
Heterocephalus glaber (naked mole-rat) : Hdac3 (histone deacetylase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5141,620,876 - 141,636,849 (-)Ensembl
GRCh385141,620,876 - 141,636,856 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375141,000,443 - 141,016,423 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365140,980,627 - 140,996,607 (-)NCBINCBI36hg18NCBI36
Build 345140,980,626 - 140,996,596NCBI
Celera5137,077,171 - 137,093,151 (-)NCBI
Cytogenetic Map5q31.3NCBI
HuRef5136,145,083 - 136,160,930 (-)NCBIHuRef
CHM1_15140,433,725 - 140,449,704 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HDAC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731326
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.