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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10368
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc2
Name: ATP-binding cassette, sub-family member 2
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2increases expressionEXP 6480464CTDAtorvastatin results in increased expression of ABCC2 mRNAPMID:25278499
Abcc2decreases activityISOAbcc2 (Rattus norvegicus)6480464CTDAtorvastatin analog results in decreased activity of ABCC2 proteinPMID:15616150
Abcc2decreases activityISOABCC2 (Homo sapiens)6480464CTDAtorvastatin analog results in decreased activity of ABCC2 proteinPMID:15616150
Abcc2multiple interactionsISOAbcc2 (Rattus norvegicus)6480464CTDABCC2 protein binds to and results in increased uptake of Atorvastatin analog; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]PMID:15616150 PMID:23562342
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTDABCC2 protein binds to and results in increased uptake of Atorvastatin analog; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]PMID:15616150 PMID:23562342
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