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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730945
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb11
Name: ATP-binding cassette, sub-family B member 11
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11decreases activityISOABCB11 (Homo sapiens)6480464CTDAtorvastatin results in decreased activity of ABCB11 proteinPMID:23956101 PMID:24014644
Abcb11multiple interactionsISOABCB11 (Homo sapiens)6480464CTDAtorvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]; Atorvastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]PMID:15901796 PMID:24014644
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