GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos3 | multiple interactions | EXP | | 6480464 | CTD | Atorvastatin inhibits the reaction [Homocysteine results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of NOS3 protein] | PMID:20305681 | Nos3 | affects response to substance | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | NOS3 promoter SNP affects the susceptibility to Atorvastatin | PMID:16962929 | Nos3 | increases expression | ISO | Nos3 (Rattus norvegicus) | 6480464 | CTD | Atorvastatin results in increased expression of NOS3 mRNA; Atorvastatin results in increased expression of NOS3 protein | PMID:12490971 PMID:15166393 PMID:23091284 | Nos3 | increases expression | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | Atorvastatin results in increased expression of NOS3 mRNA; Atorvastatin results in increased expression of NOS3 protein | PMID:16410222 PMID:25517390 | Nos3 | multiple interactions | ISO | Nos3 (Rattus norvegicus) | 6480464 | CTD | [Dexamethasone co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; [Losartan co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [sodium arsenite results in decreased expression of and results in decreased phosphorylation of NOS3 protein]; Atorvastatin inhibits the reaction [sodium arsenite results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOS3 protein]; Atorvastatin inhibits the reaction [Streptozocin results in decreased expression of NOS3 protein] | PMID:17042910 PMID:17589825 PMID:23091284 PMID:25058445 PMID:25218292 | Nos3 | multiple interactions | ISO | NOS3 (Homo sapiens) | 6480464 | CTD | Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]; Melatonin promotes the reaction [Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]] | PMID:21585521 | | ||||||||||||||||||||||
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