Lcn2 (lipocalin 2) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Lcn2 (lipocalin 2) Mus musculus
Symbol: Lcn2
Name: lipocalin 2
RGD ID: 69454
Description: Enables iron ion binding activity. Involved in innate immune response; positive regulation of cold-induced thermogenesis; and siderophore transport. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; response to bacterium; and response to virus. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Human ortholog(s) of this gene implicated in intrahepatic cholangiocarcinoma and urinary tract infection. Orthologous to human LCN2 (lipocalin 2).
Type: protein-coding
Previously known as: 24p; 24p3; AW212229; lipocalin-2; N; neu-related lipocalin; neutrophil gelatinase-associated lipocalin; NRL; oncogene 24p3; p25; secreted inducible protein 24; siderocalin LCN2; Sip24; SV-40-induced 24P3 protein
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39232,274,649 - 32,277,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,274,645 - 32,278,264 (-)EnsemblGRCm39 Ensembl
GRCm38232,384,637 - 32,387,739 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,384,633 - 32,388,252 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,240,157 - 32,243,259 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,206,646 - 32,209,748 (-)NCBIMGSCv36mm8
Celera232,090,046 - 32,093,150 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Abscess  (ISO)
acute cystitis  (ISO)
acute kidney failure  (ISO)
adult respiratory distress syndrome  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Hepatitis  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
beta thalassemia  (ISO)
calcinosis  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chlamydophila Infections  (IMP)
chronic kidney disease  (IMP,ISO)
colon cancer  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Iu  (ISO)
contact dermatitis  (ISO)
Contrast-Induced Nephropathy  (ISO)
developmental and epileptic encephalopathy  (ISO)
developmental and epileptic encephalopathy 31A  (ISO)
Diabetic Nephropathies  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
early infantile epileptic encephalopathy  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP)
Escherichia Coli Infections  (IEP,IMP)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Radiation Injuries  (ISO)
genetic disease  (ISO)
Haemophilus Infections  (IEP)
heart valve disease  (ISO)
Helicobacter Infections  (ISO)
hidradenitis suppurativa  (ISO)
hydronephrosis  (ISO)
hyperuricemia  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP,ISO)
Klebsiella pneumonia  (IEP,IGI,IMP)
myocardial infarction  (IMP)
myocarditis  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
oral candidiasis  (IEP,IMP)
pneumonia  (IMP)
polycystic kidney disease  (IEP)
pre-eclampsia  (ISO)
primary coenzyme Q10 deficiency 7  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (IMP)
renal fibrosis  (IEP)
Renal Ischemia  (IEP)
renovascular hypertension  (ISO)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (IMP)
Streptococcal Infections  (IEP)
Stroke  (ISO)
Subarachnoid Hemorrhage  (IMP)
transient cerebral ischemia  (ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (ISO)
urinary tract infection  (IEP,IMP,ISO)
uveitis  (ISO)
West Nile encephalitis  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-citrinin  (ISO)
1,1-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
8-anilinonaphthalene-1-sulfonic acid  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
Actein  (ISO)
adefovir  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
agomelatine  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (EXP)
ammonium chloride  (ISO)
amphotericin B  (ISO)
amphotericin B methyl ester  (EXP)
anthocyanin  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
bacitracin  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (EXP)
beta-D-glucosamine  (EXP)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
Botulinum toxin type A  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
carnosic acid  (EXP)
cerium trichloride  (EXP)
chlordecone  (EXP)
chloroquine  (ISO)
cholesterol  (EXP)
choline  (EXP)
ciprofibrate  (EXP)
ciprofloxacin  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (ISO)
crocidolite asbestos  (EXP)
curcumin  (EXP,ISO)
cyanuric acid  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
dapagliflozin  (ISO)
decabromodiphenyl ether  (ISO)
deferasirox  (EXP,ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
diuron  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
enilconazole  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (EXP)
ferrostatin-1  (EXP)
fluconazole  (ISO)
folic acid  (EXP)
fragrance  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gefitinib  (EXP)
gemfibrozil  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
graphene oxide  (EXP)
graphite  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexachlorobenzene  (ISO)
hydroquinone  (ISO)
iomeprol  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isocyanuric acid  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP)
lovastatin  (EXP)
maleic acid  (ISO)
Mecamylamine  (EXP)
medroxyprogesterone acetate  (ISO)
melamine  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (EXP)
morphine  (EXP)
Muraglitazar  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
natamycin  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nitrofen  (ISO)
nystatin  (EXP)
ochratoxin A  (EXP,ISO)
Ondansetron  (EXP)
ozone  (EXP,ISO)
palmitoyl ethanolamide  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
potassium bromate  (EXP)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (EXP)
progesterone  (EXP)
propanal  (ISO)
propiconazole  (EXP)
protein kinase inhibitor  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (EXP)
ritodrine  (EXP)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
senecionine  (EXP)
serpentine asbestos  (EXP)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
tannic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP,ISO)
trimethyltin  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vanillin  (ISO)
vildagliptin  (ISO)
vinclozolin  (ISO)
xylazine  (EXP)
zoledronic acid  (ISO)
zomepirac  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
apoptotic process  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to increased oxygen levels  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to X-ray  (ISO)
defense response to bacterium  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IDA)
immune system process  (IEA)
innate immune response  (IMP)
iron ion transport  (IEA)
long-term memory  (ISO)
monoatomic ion transport  (IEA)
negative regulation of hippocampal neuron apoptotic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell projection organization  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial tube morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hippocampal neuron apoptotic process  (ISO)
positive regulation of iron ion import across plasma membrane  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
response to bacterium  (IEP,ISO)
response to blue light  (ISO)
response to fructose  (ISO)
response to herbicide  (ISO)
response to iron(II) ion  (ISO)
response to kainic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to mycotoxin  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (ISO)
response to toxic substance  (ISO)
response to virus  (IDA)
response to xenobiotic stimulus  (ISO)
short-term memory  (ISO)
siderophore transport  (IDA,IMP)

Cellular Component
cytoplasmic vesicle  (IEA)
cytosol  (TAS)
extracellular region  (IDA,TAS)
extracellular space  (HDA,IBA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal erythropoiesis  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal myelopoiesis  (IAGP)
decreased apoptosis  (IAGP)
decreased circulating adiponectin level  (IAGP)
decreased circulating glucose level  (IEA)
decreased circulating iron level  (IEA)
decreased circulating serum albumin level  (IEA)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased thigmotaxis  (IEA)
decreased thymocyte apoptosis  (IAGP)
hepatic steatosis  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired glucose tolerance  (IAGP)
increased B cell number  (IAGP)
increased bone marrow cell number  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased erythroblast number  (IAGP)
increased erythrocyte cell number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased fasting circulating glucose level  (IAGP)
increased fat cell size  (IAGP)
increased heart weight  (IAGP)
increased hematocrit  (IAGP)
increased kidney weight  (IAGP)
increased leukocyte cell number  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased lymphocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased mean corpuscular hemoglobin  (IAGP)
increased mean corpuscular volume  (IEA)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased spleen weight  (IAGP)
increased splenocyte number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased urine microalbumin level  (IEA)
increased white adipose tissue amount  (IAGP)
insulin resistance  (IAGP)
myeloid hyperplasia  (IAGP)
reduced female fertility  (IAGP)
sepsis  (IAGP)
spleen hyperplasia  (IAGP)
thrombocytopenia  (IAGP)
thymus hyperplasia  (IAGP)

References - curated
# Reference Title Reference Citation
1. Urinary NGAL and KIM-1: biomarkers for assessment of acute ischemic kidney injury following nephron sparing surgery. Abassi Z, etal., J Urol. 2013 Apr;189(4):1559-66. doi: 10.1016/j.juro.2012.10.029. Epub 2012 Oct 22.
2. Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori. Alpízar-Alpízar W, etal., Virchows Arch. 2009 Sep;455(3):225-33. doi: 10.1007/s00428-009-0825-8.
3. Early urinary and plasma biomarkers for experimental diabetic nephropathy. Alter ML, etal., Clin Lab. 2012;58(7-8):659-71.
4. Fructose induces tubulointerstitial injury in the kidney of mice. Aoyama M, etal., Biochem Biophys Res Commun. 2012 Mar 9;419(2):244-9. doi: 10.1016/j.bbrc.2012.02.001. Epub 2012 Feb 8.
5. Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis. Bellmann-Weiler R, etal., Immunobiology. 2013 Jul;218(7):969-78. doi: 10.1016/j.imbio.2012.11.004. Epub 2012 Nov 21.
6. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Berger T, etal., Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1834-9. doi: 10.1073/pnas.0510847103. Epub 2006 Jan 30.
7. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study. Bhavsar NA, etal., Am J Kidney Dis. 2012 Aug;60(2):233-40. doi: 10.1053/j.ajkd.2012.02.336. Epub 2012 Apr 28.
8. Reactive astrocytes secrete lcn2 to promote neuron death. Bi F, etal., Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4069-74. doi: 10.1073/pnas.1218497110. Epub 2013 Feb 19.
9. Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis. Bousserouel S, etal., Oncol Rep. 2010 Feb;23(2):511-7.
10. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. Chan YR, etal., J Immunol. 2009 Apr 15;182(8):4947-56. doi: 10.4049/jimmunol.0803282.
11. Chemopreventive and chemotherapeutic effect of dietary supplementation of vitamin D on cholangiocarcinoma in a Chemical-Induced animal model. Chiang KC, etal., Oncotarget. 2014 Jun 15;5(11):3849-61. doi: 10.18632/oncotarget.2000.
12. Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis. Dahl SL, etal., Front Immunol. 2018 Nov 26;9:2717. doi: 10.3389/fimmu.2018.02717. eCollection 2018.
13. The gonadal expression pattern of lipocalin‑2 and 24p3 receptor is modified in the gonads of the offspring of obese rats. De La Chesnaye E, etal., Mol Med Rep. 2020 Aug;22(2):1409-1419. doi: 10.3892/mmr.2020.11226. Epub 2020 Jun 12.
14. Lipocalin-2/Neutrophil Gelatinase-B Associated Lipocalin is Strongly Induced in Hearts of Rats With Autoimmune Myocarditis and in Human Myocarditis. Ding L, etal., Circ J. 2010 Jan 7.
15. Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats. Dong M, etal., Brain Res. 2013 Apr 10;1505:86-92. doi: 10.1016/j.brainres.2013.02.008. Epub 2013 Feb 15.
16. Lipocalin 2 and Blood-Brain Barrier Disruption in White Matter after Experimental Subarachnoid Hemorrhage. Egashira Y, etal., Acta Neurochir Suppl. 2016;121:131-4. doi: 10.1007/978-3-319-18497-5_23.
17. Chronic renovascular hypertension is associated with elevated levels of neutrophil gelatinase-associated lipocalin. Eirin A, etal., Nephrol Dial Transplant. 2012 Nov;27(11):4153-61. doi: 10.1093/ndt/gfs370. Epub 2012 Aug 23.
18. Novel urinary biomarkers and the early detection of acute kidney injury after open cardiac surgeries. Elmedany SM, etal., J Crit Care. 2017 Aug;40:171-177. doi: 10.1016/j.jcrc.2017.03.029. Epub 2017 Apr 6.
19. Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis. Ferreira MC, etal., Infect Immun. 2014 Mar;82(3):1030-5. doi: 10.1128/IAI.01389-13. Epub 2013 Dec 16.
20. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
21. Changes of the tubular markers in type 2 diabetes mellitus with glomerular hyperfiltration. Fu WJ, etal., Diabetes Res Clin Pract. 2012 Jan;95(1):105-9. doi: 10.1016/j.diabres.2011.09.031. Epub 2011 Oct 20.
22. Expression of acute-phase response proteins in retinal Muller cells in diabetes. Gerhardinger C, etal., Invest Ophthalmol Vis Sci. 2005 Jan;46(1):349-57.
23. Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. Ip JP, etal., J Neuroinflammation. 2011 Sep 26;8:124. doi: 10.1186/1742-2094-8-124.
24. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
25. Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition. Ko GJ, etal., Am J Physiol Renal Physiol. 2010 Jun;298(6):F1472-83. doi: 10.1152/ajprenal.00619.2009. Epub 2010 Feb 24.
26. Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin-2 and neutrophil extracellular traps. Li H, etal., Hepatology. 2018 Oct;68(4):1604-1620. doi: 10.1002/hep.29919. Epub 2018 May 10.
27. Urinary Biomarkers in Relapsing Antineutrophil Cytoplasmic Antibody-associated Vasculitis. Lieberthal JG, etal., J Rheumatol. 2013 May;40(5):674-683. Epub 2013 Apr 1.
28. Downregulation of lipocalin-2 and Bim expression after remote limb preconditioning in the ischemic rat brain. Liu M, etal., Brain Res. 2018 Jan 15;1679:1-9. doi: 10.1016/j.brainres.2017.11.003. Epub 2017 Nov 6.
29. MGDs mouse GO annotations MGD data from the GO Consortium
31. Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance. Moreno-Navarrete JM, etal., Int J Obes (Lond). 2010 Feb;34(2):240-9. doi: 10.1038/ijo.2009.242. Epub 2009 Dec 1.
32. Bacterial colonization of nasal mucosa induces expression of siderocalin, an iron-sequestering component of innate immunity. Nelson AL, etal., Cell Microbiol. 2005 Oct;7(10):1404-17. doi: 10.1111/j.1462-5822.2005.00566.x.
33. The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. Noçon AL, etal., J Virol. 2014 Jan;88(1):679-89. doi: 10.1128/JVI.02094-13. Epub 2013 Oct 30.
34. Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis. Oh SW, etal., BMC Nephrol. 2013 May 17;14(1):105.
35. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
36. The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study. Panidis D, etal., Reprod Biol Endocrinol. 2010 Dec 9;8:151. doi: 10.1186/1477-7827-8-151.
37. α-Intercalated cells defend the urinary system from bacterial infection. Paragas N, etal., J Clin Invest. 2014 Jul;124(7):2963-76. doi: 10.1172/JCI71630. Epub 2014 Jun 17.
38. Evaluation of urine biomarkers of kidney injury in polycystic kidney disease. Parikh CR, etal., Kidney Int. 2012 Apr;81(8):784-90. doi: 10.1038/ki.2011.465. Epub 2012 Jan 18.
39. High urinary excretion of kidney injury molecule-1 is an independent predictor of end-stage renal disease in patients with IgA nephropathy. Peters HP, etal., Nephrol Dial Transplant. 2011 Nov;26(11):3581-8. doi: 10.1093/ndt/gfr135. Epub 2011 Apr 5.
40. Cardiotrophin-1 administration prevents the renal toxicity of iodinated contrast media in rats. Quiros Y, etal., Toxicol Sci. 2013 Apr;132(2):493-501. doi: 10.1093/toxsci/kft007. Epub 2013 Jan 18.
41. Mouse MP Annotation Import Pipeline RGD automated import pipeline
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Kidney injury biomarkers in hypertensive, diabetic, and nephropathy rat models treated with contrast media. Rouse RL, etal., Toxicol Pathol. 2013;41(4):662-80. doi: 10.1177/0192623312464122. Epub 2012 Oct 19.
44. Time-dependent hemeoxygenase-1, lipocalin-2 and ferritin induction after non-contusion traumatic brain injury. Russell NH, etal., Brain Res. 2019 Dec 15;1725:146466. doi: 10.1016/j.brainres.2019.146466. Epub 2019 Sep 17.
45. Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium. Saiga H, etal., J Immunol. 2008 Dec 15;181(12):8521-7. doi: 10.4049/jimmunol.181.12.8521.
46. Calprotectin and neutrophil gelatinase-associated lipocalin in the differentiation of pre-renal and intrinsic acute kidney injury. Seibert FS, etal., Acta Physiol (Oxf). 2013 Apr;207(4):700-8. doi: 10.1111/apha.12064. Epub 2013 Feb 14.
47. Phosphodiesterase-5 inhibition attenuates early renal ischemia-reperfusion-induced acute kidney injury: assessment by quantitative measurement of urinary NGAL and KIM-1. Sohotnik R, etal., Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1099-104. doi: 10.1152/ajprenal.00649.2012. Epub 2013 Jan 30.
48. Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. Srinivasan G, etal., J Immunol. 2012 Aug 15;189(4):1911-9. doi: 10.4049/jimmunol.1200892. Epub 2012 Jul 11.
49. Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection. Steigedal M, etal., J Immunol. 2014 Dec 15;193(12):6081-9. doi: 10.4049/jimmunol.1401528. Epub 2014 Nov 14.
50. Serum Lipocalin2 is a potential biomarker of liver irradiation damage. Sultan S, etal., Liver Int. 2013 Mar;33(3):459-68. doi: 10.1111/liv.12073. Epub 2013 Jan 18.
51. LIPOCALIN-2 is a major acute-phase protein in a rat and mouse model of sterile abscess. Sultan S, etal., Shock. 2012 Feb;37(2):191-6. doi: 10.1097/SHK.0b013e31823918c2.
52. Lipocalin-2 (NGAL) Attenuates Autophagy to Exacerbate Cardiac Apoptosis Induced by Myocardial Ischemia. Sung HK, etal., J Cell Physiol. 2017 Aug;232(8):2125-2134. doi: 10.1002/jcp.25672. Epub 2017 Mar 24.
53. Spermatogonia-dependent expression of testicular genes in mice. Tanaka K, etal., Dev Biol 2002 Jun 15;246(2):466-79.
54. Lipocalin 2 Suppresses Ocular Inflammation by Inhibiting the Activation of NF-κβ Pathway in Endotoxin-Induced Uveitis. Tang W, etal., Cell Physiol Biochem. 2018;46(1):375-388. doi: 10.1159/000488472. Epub 2018 Mar 23.
55. Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration. Tang W, etal., Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):6014-6025. doi: 10.1167/iovs.18-25213.
56. Urine NGAL and KIM-1 in children and adolescents with hyperuricemia. Tomczak J, etal., Pediatr Nephrol. 2013 May 15.
57. Lipocalin 2 as a new biomarker for fetal lung hypoplasia in congenital diaphragmatic hernia. Tsuda H, etal., Clin Chim Acta. 2016 Nov 1;462:71-76. doi: 10.1016/j.cca.2016.08.023. Epub 2016 Aug 31.
58. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. Viau A, etal., J Clin Invest. 2010 Nov;120(11):4065-76. doi: 10.1172/JCI42004.
59. Up-regulated lipocalin-2 in pulmonary hypertension involving in pulmonary artery SMC resistance to apoptosis. Wang G, etal., Int J Biol Sci. 2014 Jul 17;10(7):798-806. doi: 10.7150/ijbs.9470. eCollection 2014.
60. KIM-1 and NGAL: new markers of obstructive nephropathy. Wasilewska A, etal., Pediatr Nephrol. 2011 Apr;26(4):579-86. doi: 10.1007/s00467-011-1773-5. Epub 2011 Jan 31.
61. Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa. Wolk K, etal., Br J Dermatol. 2017 Nov;177(5):1385-1393. doi: 10.1111/bjd.15424. Epub 2017 Sep 19.
62. Lipocalin 2 is protective against E. coli pneumonia. Wu H, etal., Respir Res. 2010 Jul 15;11:96. doi: 10.1186/1465-9921-11-96.
63. Combined biomarkers evaluation for diagnosing kidney injury in preeclampsia. Xiao J, etal., Hypertens Pregnancy. 2013 Nov;32(4):439-49. doi: 10.3109/10641955.2013.827203. Epub 2013 Aug 19.
64. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Xing C, etal., Stroke. 2014 Jul;45(7):2085-92. doi: 10.1161/STROKEAHA.114.005733. Epub 2014 Jun 10.
65. Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3. Xu MJ, etal., Hepatology. 2015 Feb;61(2):692-702. doi: 10.1002/hep.27447.
66. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Zhang J, etal., Mol Endocrinol. 2008 Jun;22(6):1416-26. Epub 2008 Feb 21.
Additional References at PubMed
PMID:1723819   PMID:1834059   PMID:2542864   PMID:7504460   PMID:7544071   PMID:7545679   PMID:7829063   PMID:7957904   PMID:8570173   PMID:8666241   PMID:8687399   PMID:8966221  
PMID:9611252   PMID:10349636   PMID:10922068   PMID:11017920   PMID:11042159   PMID:11076861   PMID:11838544   PMID:12067275   PMID:12477932   PMID:12974471   PMID:14703690   PMID:15055523  
PMID:15194480   PMID:15363845   PMID:15531878   PMID:15579510   PMID:15637066   PMID:15665292   PMID:15691834   PMID:15711640   PMID:15735695   PMID:15895393   PMID:16141072   PMID:16141073  
PMID:16157692   PMID:16222708   PMID:16254208   PMID:16322095   PMID:16328885   PMID:16377569   PMID:16602821   PMID:16798734   PMID:16804897   PMID:17060628   PMID:17065407   PMID:17229997  
PMID:17304338   PMID:17350462   PMID:17391123   PMID:17490638   PMID:17639021   PMID:17709539   PMID:17895910   PMID:18264110   PMID:18398717   PMID:18519167   PMID:18615580   PMID:18663364  
PMID:18815220   PMID:18974761   PMID:19009554   PMID:19077278   PMID:19124469   PMID:19148153   PMID:19152427   PMID:19344630   PMID:19454351   PMID:19700664   PMID:19732769   PMID:19834550  
PMID:19887608   PMID:20068130   PMID:20121435   PMID:20133630   PMID:20332347   PMID:20362461   PMID:20376565   PMID:20412141   PMID:20504881   PMID:20550936   PMID:20581821   PMID:20939024  
PMID:20974668   PMID:21234651   PMID:21240264   PMID:21267068   PMID:21408140   PMID:21507940   PMID:21601942   PMID:21649922   PMID:21677750   PMID:21771968   PMID:21873635   PMID:21940434  
PMID:21969573   PMID:22025214   PMID:22030398   PMID:22038916   PMID:22038922   PMID:22075378   PMID:22117066   PMID:22234464   PMID:22441986   PMID:22497726   PMID:22499213   PMID:22514649  
PMID:22614012   PMID:22706314   PMID:22737251   PMID:22957064   PMID:22965758   PMID:23012479   PMID:23046379   PMID:23159059   PMID:23169997   PMID:23185529   PMID:23207546   PMID:23219901  
PMID:23234871   PMID:23272119   PMID:23280250   PMID:23376114   PMID:23543755   PMID:23593384   PMID:23606520   PMID:23701109   PMID:23836894   PMID:23861783   PMID:23863624   PMID:23875831  
PMID:23884139   PMID:23885013   PMID:23908604   PMID:23940770   PMID:24006456   PMID:24089194   PMID:24194573   PMID:24194600   PMID:24240113   PMID:24391115   PMID:24440229   PMID:24465207  
PMID:24548407   PMID:24599361   PMID:24721803   PMID:24803661   PMID:24808182   PMID:24818605   PMID:24853299   PMID:24885531   PMID:24893611   PMID:24909826   PMID:24917675   PMID:24948478  
PMID:24998227   PMID:25010215   PMID:25031461   PMID:25040147   PMID:25086218   PMID:25112732   PMID:25127375   PMID:25217696   PMID:25227123   PMID:25257511   PMID:25359467   PMID:25467539  
PMID:25468909   PMID:25702801   PMID:25740061   PMID:25814363   PMID:25853903   PMID:25890235   PMID:25893429   PMID:25987661   PMID:26047170   PMID:26129883   PMID:26193341   PMID:26311113  
PMID:26332507   PMID:26367277   PMID:26595644   PMID:26682726   PMID:26702876   PMID:26729763   PMID:26787103   PMID:26824608   PMID:26869387   PMID:26968114   PMID:27008859   PMID:27028054  
PMID:27038000   PMID:27078067   PMID:27120970   PMID:27152948   PMID:27194339   PMID:27229458   PMID:27296697   PMID:27315541   PMID:27335464   PMID:27353364   PMID:27416888   PMID:27427417  
PMID:27430980   PMID:27489104   PMID:27734904   PMID:27997859   PMID:28004388   PMID:28193238   PMID:28234242   PMID:28249896   PMID:28273060   PMID:28341240   PMID:28358362   PMID:28393227  
PMID:28396286   PMID:28396494   PMID:28432145   PMID:28485407   PMID:28581123   PMID:28615213   PMID:28705898   PMID:29138470   PMID:29234288   PMID:29289651   PMID:29378951   PMID:29402223  
PMID:29444358   PMID:29602770   PMID:29688375   PMID:29960897   PMID:30106954   PMID:30174216   PMID:30219682   PMID:30257107   PMID:30279516   PMID:30340040   PMID:30404645   PMID:30501637  
PMID:30615971   PMID:30733506   PMID:30782214   PMID:30928474   PMID:31033725   PMID:31057545   PMID:31278904   PMID:31426811   PMID:31488870   PMID:31552301   PMID:31568658   PMID:31722218  
PMID:31781104   PMID:31889023   PMID:31967970   PMID:32059851   PMID:32075741   PMID:32188161   PMID:32188494   PMID:32204099   PMID:32272958   PMID:32296847   PMID:32325033   PMID:32330729  
PMID:32433970   PMID:32487561   PMID:32534984   PMID:32622362   PMID:32628083   PMID:32630021   PMID:32718038   PMID:32730093   PMID:32758668   PMID:32883997   PMID:32959226   PMID:32968110  
PMID:33065981   PMID:33122517   PMID:33129840   PMID:33153107   PMID:33197428   PMID:33214705   PMID:33251681   PMID:33360775   PMID:33421207   PMID:33510144   PMID:33637683   PMID:33824339  
PMID:33905460   PMID:34224151   PMID:34292881   PMID:34298880   PMID:34342930   PMID:34359830   PMID:34417948   PMID:34518636   PMID:34565419   PMID:34572499   PMID:34616693   PMID:34699654  
PMID:34794340   PMID:34823217   PMID:34884961   PMID:34903175   PMID:34933182   PMID:34969358   PMID:35055145   PMID:35120997   PMID:35159293   PMID:35241660   PMID:35383354   PMID:35413913  
PMID:35440572   PMID:35470375   PMID:35473441   PMID:35504189   PMID:35560370   PMID:35720180   PMID:35793678   PMID:35817941   PMID:35856297   PMID:35995279   PMID:36034743   PMID:36054235  
PMID:36076483   PMID:36142843   PMID:36243318   PMID:36263611   PMID:36508119   PMID:36520031   PMID:36522157   PMID:36621850   PMID:36718277   PMID:36797502   PMID:36806084   PMID:36920644  
PMID:36923935   PMID:36941809   PMID:37088550   PMID:37168715   PMID:37201358   PMID:37298232   PMID:37328088   PMID:37353794   PMID:37517520   PMID:37712270   PMID:37748675   PMID:37872178  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39232,274,649 - 32,277,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,274,645 - 32,278,264 (-)EnsemblGRCm39 Ensembl
GRCm38232,384,637 - 32,387,739 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,384,633 - 32,388,252 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,240,157 - 32,243,259 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,206,646 - 32,209,748 (-)NCBIMGSCv36mm8
Celera232,090,046 - 32,093,150 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389128,149,453 - 128,153,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,149,071 - 128,153,453 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,911,732 - 130,915,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,951,553 - 129,955,555 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,991,271 - 127,995,288NCBI
Celera9101,562,624 - 101,566,626 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,525,402 - 100,529,404 (+)NCBIHuRef
CHM1_19131,062,742 - 131,066,744 (+)NCBICHM1_1
T2T-CHM13v2.09140,356,542 - 140,360,542 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2315,680,688 - 15,684,033 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,680,687 - 15,684,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,749,510 - 18,752,856 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,334,505 - 27,337,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,585,359 - 25,588,705 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,414,189 - 11,417,534 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,414,186 - 11,417,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,763,059 - 16,766,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,511,402 - 11,514,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,407,773 - 11,411,119 (-)NCBI
Celera310,423,569 - 10,426,914 (-)NCBICelera
Cytogenetic Map3p12NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1911,201,421 - 11,216,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,259,278 - 99,274,494 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,940,799 - 127,944,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,940,799 - 127,944,798 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1955,328,118 - 55,342,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,328,133 - 55,332,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,522,898 - 54,537,231 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,250,316 - 56,264,670 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,250,331 - 56,254,237 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,010,191 - 55,024,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,324,906 - 55,339,237 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,416,588 - 55,430,934 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947195,953,204 - 195,956,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,721,684 - 15,728,221 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,721,752 - 15,725,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1268,609,887 - 268,614,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,609,975 - 268,614,651 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,600,679 - 302,609,836 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1129,976,278 - 9,981,087 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,976,614 - 9,980,870 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660796,251,600 - 6,256,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Lcn2
91 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:828
Count of miRNA genes:447
Interacting mature miRNAs:532
Transcripts:ENSMUST00000050785, ENSMUST00000136509, ENSMUST00000144569, ENSMUST00000147219, ENSMUST00000155830
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
12904008Cfq6_mconditioned fear QTL 6 (mouse)23120303544508204Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38232,384,704 - 32,384,807UniSTSGRCm38
MGSCv37232,240,224 - 32,240,327UniSTSGRCm37
Celera232,090,113 - 32,090,216UniSTS
Cytogenetic Map2A3UniSTS
cM Map227.0UniSTS



RefSeq Acc Id: ENSMUST00000050785   ⟹   ENSMUSP00000053962
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl232,274,645 - 32,277,809 (-)Ensembl
GRCm38.p6 Ensembl232,384,633 - 32,387,797 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136509
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl232,276,568 - 32,277,771 (-)Ensembl
GRCm38.p6 Ensembl232,386,556 - 32,387,759 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144569
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl232,274,651 - 32,276,011 (-)Ensembl
GRCm38.p6 Ensembl232,384,639 - 32,385,999 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147219
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl232,274,645 - 32,277,734 (-)Ensembl
GRCm38.p6 Ensembl232,384,633 - 32,387,722 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155830
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl232,275,195 - 32,276,119 (-)Ensembl
GRCm38.p6 Ensembl232,385,183 - 32,386,107 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192241   ⟹   ENSMUSP00000141430
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl232,275,457 - 32,278,264 (-)Ensembl
GRCm38.p6 Ensembl232,385,445 - 32,388,252 (-)Ensembl
RefSeq Acc Id: NM_008491   ⟹   NP_032517
Mouse AssemblyChrPosition (strand)Source
GRCm39232,274,649 - 32,277,751 (-)NCBI
GRCm38232,384,637 - 32,387,739 (-)ENTREZGENE
MGSCv37232,240,157 - 32,243,259 (-)RGD
Celera232,090,046 - 32,093,150 (-)RGD
RefSeq Acc Id: NP_032517   ⟸   NM_008491
- Peptide Label: precursor
- UniProtKB: Q3UE34 (UniProtKB/Swiss-Prot),   P11672 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000141430   ⟸   ENSMUST00000192241
RefSeq Acc Id: ENSMUSP00000053962   ⟸   ENSMUST00000050785
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11672-F1-model_v2 AlphaFold P11672 1-200 view protein structure

RGD ID:6831689
Promoter ID:MM_KWN:28706
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_4Hour
Transcripts:OTTMUST00000031186,   OTTMUST00000031187
Mouse AssemblyChrPosition (strand)Source
MGSCv36232,241,641 - 32,242,482 (-)MPROMDB
RGD ID:6831688
Promoter ID:MM_KWN:28707
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000091086,   OTTMUST00000031183,   OTTMUST00000031184,   OTTMUST00000031185
Mouse AssemblyChrPosition (strand)Source
MGSCv36232,242,909 - 32,243,409 (-)MPROMDB
RGD ID:6877000
Promoter ID:EPDNEW_M1951
Type:multiple initiation site
Description:Mus musculus lipocalin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38232,387,770 - 32,387,830EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96757 AgrOrtholog
Ensembl Genes ENSMUSG00000026822 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000050785 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000192241.2 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LCN2/LCN12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16819 UniProtKB/Swiss-Prot
  PTHR11430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lcn2 PhenoGen
  NGELATINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q3UE34 UniProtKB/Swiss-Prot